BR112018013184A2 - processo para preparação de um granulado revestido entérico compreendendo dimetilfumarato - Google Patents
processo para preparação de um granulado revestido entérico compreendendo dimetilfumaratoInfo
- Publication number
- BR112018013184A2 BR112018013184A2 BR112018013184-9A BR112018013184A BR112018013184A2 BR 112018013184 A2 BR112018013184 A2 BR 112018013184A2 BR 112018013184 A BR112018013184 A BR 112018013184A BR 112018013184 A2 BR112018013184 A2 BR 112018013184A2
- Authority
- BR
- Brazil
- Prior art keywords
- enteric coated
- dimethyl fumarate
- preparing
- coated granulate
- preparation
- Prior art date
Links
- LDCRTTXIJACKKU-ONEGZZNKSA-N dimethyl fumarate Chemical compound COC(=O)\C=C\C(=O)OC LDCRTTXIJACKKU-ONEGZZNKSA-N 0.000 title abstract 2
- 229960004419 dimethyl fumarate Drugs 0.000 title abstract 2
- 239000008187 granular material Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000007931 coated granule Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000008183 oral pharmaceutical preparation Substances 0.000 abstract 2
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15460146 | 2015-12-31 | ||
EP15460146.2 | 2015-12-31 | ||
PCT/EP2016/002175 WO2017114593A1 (en) | 2015-12-31 | 2016-12-23 | Process for preparation of an enteric coated granulate comprising dimethyl fumarate |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018013184A2 true BR112018013184A2 (pt) | 2018-12-11 |
Family
ID=55129503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018013184-9A BR112018013184A2 (pt) | 2015-12-31 | 2016-12-23 | processo para preparação de um granulado revestido entérico compreendendo dimetilfumarato |
Country Status (11)
Country | Link |
---|---|
US (1) | US11013693B2 (pt) |
EP (1) | EP3397247B1 (pt) |
CN (1) | CN108472260B (pt) |
AU (1) | AU2016382661B2 (pt) |
BR (1) | BR112018013184A2 (pt) |
CA (1) | CA3007483C (pt) |
EA (1) | EA201800403A1 (pt) |
ES (1) | ES2953440T3 (pt) |
PL (1) | PL3397247T3 (pt) |
UA (1) | UA124456C2 (pt) |
WO (1) | WO2017114593A1 (pt) |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101056624A (zh) * | 2004-10-08 | 2007-10-17 | Adi技术制药股份公司 | 包含富马酸酯的控释药物组合物 |
CN101304732A (zh) * | 2005-10-07 | 2008-11-12 | Adi技术制药股份公司 | 包含富马酸酯的控释药物组合物 |
US20080299196A1 (en) * | 2005-10-07 | 2008-12-04 | Aditech Pharma Ab | Controlled Release Pharmaceutical Compositions Comprising a Fumaric Acid Ester |
KR101699912B1 (ko) * | 2009-01-09 | 2017-01-25 | 포워드 파마 에이/에스 | 1종 이상의 푸마르산 에스테르를 침식 매트릭스에 함유하는 제제 |
RU2014125430A (ru) | 2011-11-24 | 2015-12-27 | Синтон Бв | Контролируемое высвобождение частиц, содержащих диметилфумарат |
MX370785B (es) * | 2012-02-07 | 2020-01-06 | Biogen Ma Inc | Composiciones farmacéuticas que contienen fumarato de dimetilo. |
WO2014160633A1 (en) | 2013-03-24 | 2014-10-02 | Xenoport, Inc. | Pharmaceutical compositions of dimethyl fumarate |
CN109223725A (zh) * | 2013-08-26 | 2019-01-18 | 前进制药知识产权有限公司 | 用于以低的日剂量施用的含富马酸二甲酯的药物组合物 |
DK3079666T3 (da) | 2013-12-12 | 2021-03-22 | Almirall Sa | Farmaceutiske sammensætninger omfattende dimethylfumarat |
CN104288774B (zh) | 2014-04-21 | 2018-10-09 | 河南省健康伟业生物医药研究股份有限公司 | 一种肠溶包衣、富马酸二甲酯肠溶制剂及其制备方法 |
CN104352441B (zh) * | 2014-10-16 | 2017-06-09 | 山东百诺医药股份有限公司 | 一种富马酸二甲酯肠溶微丸及其制备方法 |
CN104490849A (zh) * | 2014-11-24 | 2015-04-08 | 广东东阳光药业有限公司 | 一种高密度的富马酸二甲酯肠溶颗粒及其制备方法 |
-
2016
- 2016-12-23 WO PCT/EP2016/002175 patent/WO2017114593A1/en active Application Filing
- 2016-12-23 US US16/067,335 patent/US11013693B2/en active Active
- 2016-12-23 EP EP16825700.4A patent/EP3397247B1/en active Active
- 2016-12-23 AU AU2016382661A patent/AU2016382661B2/en active Active
- 2016-12-23 ES ES16825700T patent/ES2953440T3/es active Active
- 2016-12-23 BR BR112018013184-9A patent/BR112018013184A2/pt not_active IP Right Cessation
- 2016-12-23 EA EA201800403A patent/EA201800403A1/ru unknown
- 2016-12-23 PL PL16825700.4T patent/PL3397247T3/pl unknown
- 2016-12-23 CN CN201680076777.3A patent/CN108472260B/zh active Active
- 2016-12-23 UA UAA201808101A patent/UA124456C2/uk unknown
- 2016-12-23 CA CA3007483A patent/CA3007483C/en active Active
Also Published As
Publication number | Publication date |
---|---|
ES2953440T3 (es) | 2023-11-13 |
AU2016382661B2 (en) | 2022-05-19 |
EP3397247C0 (en) | 2023-06-07 |
CA3007483A1 (en) | 2017-07-06 |
PL3397247T3 (pl) | 2023-09-18 |
AU2016382661A1 (en) | 2018-06-28 |
EP3397247B1 (en) | 2023-06-07 |
UA124456C2 (uk) | 2021-09-22 |
WO2017114593A1 (en) | 2017-07-06 |
CN108472260A (zh) | 2018-08-31 |
US11013693B2 (en) | 2021-05-25 |
CN108472260B (zh) | 2021-08-10 |
EA201800403A1 (ru) | 2018-12-28 |
EP3397247A1 (en) | 2018-11-07 |
CA3007483C (en) | 2021-12-07 |
US20200163887A1 (en) | 2020-05-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2018007704A (es) | Composicion farmaceutica que comprende lenalidomida amorfa y un antioxidante. | |
CL2014002077A1 (es) | Composicion farmaceutica que comprende fumarato de dimetilo; metodo de preparacion; capsula que comprende microtabletas de fumarato de dimetilo; metodo para el tratamiento, profilaxis o mejora de la esclerosis multiple. | |
EP3096763A4 (en) | Novel process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof | |
BR112015031417A8 (pt) | forma de dosagem farmacêutica, composição farmacêutica, métodos para tratamento de um paciente com necessidade de cisteamina e para preparo de uma forma de dosagem | |
SG11202001161YA (en) | Method of producing pharmaceutical compositions comprising immunogenic chikungunya virus chikv-delta5nsp3 | |
IL252296B (en) | A pharmaceutical preparation containing dimethyl fumarate for the treatment of multiple sclerosis | |
BR112017014085A2 (pt) | processos para a preparação de hemifumarato de tenofovir alafenamida amorfo e uma pré-mistura do mesmo | |
IL285899A (en) | Pharmaceutical dosage form for application to mucous membranes and methods for its production | |
HU231045B1 (en) | Novel process for the preparation of carboprost tromethamine | |
EP3308783A4 (en) | USE OF A COMPOSITION FOR PREPARING A MEDICAMENT FOR THE TREATMENT OF AMYOTROPHER LATERAL SCLEROSIS | |
BR112016028316A2 (pt) | composição farmacêutica oral de isotretinoina, seu processo de preparação e método de tratamento | |
PH12016502243A1 (en) | Pharmaceutical compositions for treating infectious diseases | |
MX2017015137A (es) | Composicion farmaceutica oral de dosis diaria de isotretinoin. | |
EA201890944A1 (ru) | Фармацевтические композиции нилотиниба гидрохлорида | |
IL282845A (en) | A process for the preparation of optically enriched isoxazolines | |
BR112016028083A2 (pt) | Composição oral farmacêutica de isotretinoina e seu processo de preparação | |
MX2017015322A (es) | Composicion farmaceutica oral de isotretinoin. | |
BR112019005426A2 (pt) | composições de éster de colina de ácido lipoico e métodos para estabilizar em produtos de fármaco farmaceuticamente relevantes | |
IN2013MU01111A (pt) | ||
BR112016007031A8 (pt) | composição farmacêutica oral sólida, processo para preparar a composição farmacêutica oral sólida, e uso de uma composição farcêutica oral sólida | |
BR112018013184A2 (pt) | processo para preparação de um granulado revestido entérico compreendendo dimetilfumarato | |
EP3381467A4 (en) | PHARMACEUTICAL VACCINE COMPOSITION FOR ORAL ADMINISTRATION AND METHOD FOR PREPARING A PHARMACEUTICAL VACCINE COMPOSITION FOR ORAL ADMINISTRATION | |
PH12020500045A1 (en) | Novel composition of enzalutamide oral dosage form and method of manufacturing thereof | |
GB201718483D0 (en) | Pharmaceutical composition for treatment of meopausal syndrome and preparation method thereof | |
IN2013MU03428A (pt) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2755 DE 24-10-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |