EA201890944A1 - Фармацевтические композиции нилотиниба гидрохлорида - Google Patents

Фармацевтические композиции нилотиниба гидрохлорида

Info

Publication number
EA201890944A1
EA201890944A1 EA201890944A EA201890944A EA201890944A1 EA 201890944 A1 EA201890944 A1 EA 201890944A1 EA 201890944 A EA201890944 A EA 201890944A EA 201890944 A EA201890944 A EA 201890944A EA 201890944 A1 EA201890944 A1 EA 201890944A1
Authority
EA
Eurasian Patent Office
Prior art keywords
nilotiniba
hydrochloride
pharmaceutical compositions
crospovidone
excipient
Prior art date
Application number
EA201890944A
Other languages
English (en)
Other versions
EA036204B1 (ru
Inventor
Абдуллах Услу
Мустафа Коктурк
Сейхан Турккан
Джумхур Окчелик
Омер Хулки Оджак
Original Assignee
Нобел Илач Санайи Ве Тиджарет А.Ш.
Ао "Нобел Алматинская Фармацевтическая Фабрика"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Нобел Илач Санайи Ве Тиджарет А.Ш., Ао "Нобел Алматинская Фармацевтическая Фабрика" filed Critical Нобел Илач Санайи Ве Тиджарет А.Ш.
Publication of EA201890944A1 publication Critical patent/EA201890944A1/ru
Publication of EA036204B1 publication Critical patent/EA036204B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение предоставляет композицию, содержащую форму T17 безводного нилотиниба гидрохлорида, в которой кросповидон применяют в качестве наполнителя в лекарственной форме вместо наполнителей предшествующего уровня техники, таких как микрокристаллическая целлюлоза и лактоза.
EA201890944A 2015-10-16 2015-10-16 Фармацевтические композиции нилотиниба гидрохлорида EA036204B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2015/057962 WO2017064538A1 (en) 2015-10-16 2015-10-16 Pharmaceutical compositions of nilotinib hydrochloride

Publications (2)

Publication Number Publication Date
EA201890944A1 true EA201890944A1 (ru) 2018-09-28
EA036204B1 EA036204B1 (ru) 2020-10-14

Family

ID=58517905

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201890944A EA036204B1 (ru) 2015-10-16 2015-10-16 Фармацевтические композиции нилотиниба гидрохлорида

Country Status (2)

Country Link
EA (1) EA036204B1 (ru)
WO (1) WO2017064538A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2017821A3 (cs) 2017-12-20 2019-07-03 Zentiva, K.S. Léková forma obsahující krystalický nilotinib
WO2020101597A2 (en) * 2018-08-27 2020-05-22 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Capsule compositions comprising tyrosine-kinase inhibitors
IL295007A (en) 2020-01-31 2022-09-01 Nanocopoeia Llc Amorphous nilotinib microparticles and uses thereof
EP4142699A1 (en) 2020-04-30 2023-03-08 Nanocopoeia LLC Orally disintegrating tablet comprising amorphous solid dispersion of nilotinib
EP4355306A1 (en) 2021-06-19 2024-04-24 Helm AG Granulate composition comprising nilotinib

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7049283B2 (en) * 2000-12-06 2006-05-23 Novartis Ag Pharmaceutical compositions for the oral delivery of pharmacologically active agents
EP1321142A1 (en) * 2001-12-21 2003-06-25 Novartis AG Solid pharmaceutical composition for oral administration of Tegaserod
RU2375048C2 (ru) * 2003-07-17 2009-12-10 Д-Р Редди'С Лабораторис Инк. Фармацевтическая композиция с набухающим покрытием
TW201022240A (en) * 2008-11-05 2010-06-16 Teva Pharma Nilotinib HCl crystalline forms

Also Published As

Publication number Publication date
EA036204B1 (ru) 2020-10-14
WO2017064538A1 (en) 2017-04-20

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