BR112018011765B1 - EMULSIONS COMPRISING A SUN PROTECTION FACTOR UV AND A CARNOSINE COMPOUND, PROCESS FOR PRODUCTION OF SUNSCREEN IN EMULSION FORM, AND USE OF CARNOSINE COMPOUNDS - Google Patents

Abstract

emulsions with uv sun protection factors and carnosines. The present invention relates to emulsions containing (a) at least one UV sun protection factor, (b) at least one compound of formula (i), (i) wherein r1 represents h or ch3 and r2 represents h or cooh or its salts; (c) at least one emulsifier, as well as optionally (d1) vehicle and/or (d) oily body with the condition that the emulsions have a droplet size, in which the d50 value lies in the range of 0, 1 to 100 µm.

Description

FIELD OF THE INVENTION

[001] The invention is in the field of cosmetics and refers especially to sunscreen agents in emulsion form with better storage stability.

STATUS OF THE TECHNIQUE

[002] According to a 2015 statistic, the number of people over 14 years old in Germany, who apply sun protection products for more than 20 days a year, is around 20 million and during the last few years it is constantly increasing. Thus, sunscreens are included in the most sought after cosmetic products, since according to current studies, the number of skin cancers caused by UV radiation since 2003 has more than doubled.

[003] Sunscreens are very varied with respect to composition, quality and, with that, also, finally, the price. Simple recipes, which are mainly offered by discount stores, are made very simply and contain only a few sun protection factors in small amounts which, at best, leads to short-term protection on previously tanned skin. Other products present a “cocktail” of sun protection factors, that is, here it is used that the sun protection factors have their maximum absorption in different wavelength ranges and, with an intelligent choice, uniform protection is obtained. through a broad spectrum of white sunlight. It is obvious, that these products are not only qualitatively of high value, but they are also more expensive for the consumer.

[004] There is an unbroken tendency to improve cosmetic agents in their effect by adding other active substances. In the field of sun protection products, there is, for example, great interest in identifying active substances that extend the area of protection, i.e., they do not only provide protection against skin damage or light-induced skin aging ( UV influence), but also in relation to other influences such as, for example, environmental toxins. The fact is, namely, that sun protection factors are largely or even completely useless against environmentally induced skin damage, as these follow completely different reaction pathways in the cell.

[005] With the introduction of new or additional active substances, however, it is not only associated with an increase in quality, the problems also grow. Not every active substance can be incorporated into every desired formulation, the complexity in production and storage increases and under certain circumstances it must also be taken into account that the additive itself is again sensitive to the influence of air or light.

[006] Particularly interesting are the corresponding preparations in the form of an emulsion, in which the droplets have a particularly small diameter, since they can not only be atomized easily, but also have a high scattering power, that is, they quickly penetrate the surface. skin. Such emulsions are characterized by the fact that the droplets are so small that they do not scatter light. The solutions therefore appear to be transparent. The disadvantage of such formulations is, however, that in the case of a longer storage, and in particular at elevated temperatures, they do not show sufficient stability and, likewise, they unmix as easily as they were formed. However, these are precisely the conditions to which sunscreens are regularly subject.

[007] In principle, this is harmless to the product, as it can be homogenized again through multiple vigorous shaking. For a consumer, who has just decided on a high-quality and correspondingly expensive product, however, this is unsatisfactory and will optionally lead to the fact that the next purchase decision will be different.

[008] The objective of the present one was, therefore, to make available emulsion-based sunscreens, which, also in a prolonged temperature storage, are sufficiently stable. Part of this objective was to find corresponding stabilizers, which as possible fulfill not only a functional objective, but, in addition, also present an active substance character, which is advantageous for the field of application of sun protection.

DESCRIPTION OF THE INVENTION

[009] A first object of the invention relates to emulsions containing (a) at least one UV sun protection factor, (b) at least one compound of formula (I)

[0010] in which R1 represents H or CH2 and R2 represents H or COOH or salts thereof; (c) at least one emulsifier and optionally (d1) vehicle and/or (d2) oily substance

[0011] with the proviso that the emulsions have a droplet size in which the D50 value is in the range of 0.1 to 100 μm, in particular in the range of 0.5 to 70 μm and particularly preferably , in the range of 1 to 50 μm.

[0012] Indication means that at least 50% of all droplets in the emulsion are in the indicated value range. Furthermore, it is preferable that the D90 value is in the range of in the range of 1 to 150 μm and particularly preferably in the range of 10 to 100 μm. It is particularly preferable that both the D50 value and the D90 value lie in the range from 0.1 to 100 μm and, in particular, in the range from 1 to 40 μm.

[0013] The emulsions may be present as O/W or W/O emulsions or as multiple W/O/W or O/W/O emulsions.

[0014] Surprisingly, with carnosines a group of substances was discovered, which not only have properties of active substances partly known and partly not yet known in connection with the protection of the skin against damage induced by light and the environment, but they are also still capable of keeping emulsions based on UV-A and/or UV-B sun protection factors stable for storage also at elevated temperatures and for longer periods of time. With this, carnosines perfectly fulfill the profile of requirements described at the beginning, in which they give the formulations an action effect and, at the same time, still a functional objective, namely, they act as a stabilizer.

UV SUN PROTECTION FACTORS

[0015] UV sun protection factors (component a) must be understood, for example, organic substances (sun protection filters) present in liquid or crystalline form at room temperature, which are capable of absorbing ultraviolet rays and releasing again the energy absorbed in the form of long-wave radiation, eg heat. In general, UV sun protection factors considered on their own, are available in amounts of 0.1 to 5 and preferably 0.2 to 1% by weight. The total amount of sun protection factors in a preparation can however be significantly higher and according to the SPF (“sun protection factor”) can amount to up to 25% by weight, preferably about 10 to about 15% by weight. .

[0016] UVB filters can be oil soluble or water soluble. As oil-soluble substances, for example: • 3-benzylidene camphor or 3-benzylidenenor camphor and its derivatives, for example 3-(4-methylbenzylidene)camphor, are mentioned; • 4-aminobenzoic derivatives, preferably 4-(dimethylamino)benzoic acid 2-ethylhexyl ester, 4-(dimethylamino)benzoic acid 2-octyl ester and 4-(dimethylamino)-benzoic acid amyl ester; • cinnamic acid ester, preferably 4-methoxycinnamic acid 2-ethylhexyl ester, 4-methoxycinnamic acid propyl ester, 4-methoxycinnamic acid isoamyl ester, 2-cyano-3,3 2-ethylhexyl ester -phenylcinnamic (octocrylene); • salicylic acid ester, preferably salicylic acid 2-ethylhexyl ester, salicylic acid 4-isopropylbenzyl ester, salicylic acid homomenthyl ester; • benzophenone derivatives, preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone; • benzalmalonic acid ester, preferably 4-methoxybenzomalonic acid di-2-ethylhexyl ester; • triazine derivatives, such as, for example, 2,4,6-trianilino-(p-carbo-2'-ethyl-1'-hexyloxy)-1,3,5-triazine and octyl triazone or dioctyl butamido triazone ( Uvasorb® HEB); • propan-1,3-diones, such as, for example, 1-(4-tert.butylphenyl)-3-(4'-methoxyphenyl)propan-1,3-dione; • ketotricyclo(5.2.1.0)decane derivatives.

[0017] As water-soluble substances are included: • 2-phenylbenzimidazole-5-sulfonic acid and salts thereof of alkali metals, alkaline earth metals, ammonium, alkylammonium, alkanolammonium and glucammonium; • 1H-benzimidazole-4,6-disulfonic acid, 2,2'-(1,4-phenylene)bis-disodium salt (Neo Heliopan® AP) • sulfonic acid derivatives of benzophenones, preferably 2-hydroxy-4- methoxybenzophenon-5-sulfonic and salts thereof; • sulfonic acid derivatives of 3-benzylidene camphor, such as, for example, 4-(2-oxo-3-bornylidene-methyl)benzenesulfonic acid and 2-methyl-5-(2-oxo-3-bornylidene)sulfonic acid and salts of the same.

[0018] Typical UV-A filters include, in particular, benzoylmethane derivatives, such as, for example, 1-(4'-tert.butylphenyl)-3-(4'-methoxyphenyl)propan-1,3- dona, 4-tert.-butyl-4'-methoxy-dibenzoylmethane (Parsol® 1789), 2-(4-diethylamino-2-hydroxybenzoyl)-benzoic acid hexyl ester (Uvinul® A Plus), 1-phenyl-3 -(4'-isopropylphenyl)-propan-1,3-dione and enamine compounds. Of course, UV-A and UV-B filters can also be used in blends. Particularly favorable combinations are benzoylmethane derivatives, for example 4-tert-butyl-4'-methoxydibenzoylmethane (Parsol® 1789) and 2-cyano-3,3-phenylcinnamic acid 2-ethylhexyl ester (octocrylene) in combination with cinnamic acid esters, preferably 4-methoxycinnamic acid 2-ethylhexyl ester and/or 4-methoxycinnamic acid propyl ester and/or 4-methoxycinnamic acid isoamyl ester. Advantageously, such combinations are combined with water-soluble filters, such as, for example, 2-phenylbenzimidazole-5-sulfonic acid and alkali metal, alkaline earth, ammonium, alkylammonium, alkanolammonium and glucammonium salts thereof.

CARNOSINES

[0019] In the case of carnosines, which make up formula (I) and which form component (b), these are fundamentally known compounds, which are accessible by the usual processes of organic chemistry. Preferably, this is the group of substances which is formed by carnosine, L-carnosine, D-carnosine, D/L-carnosine, carnicine, carnicine*HCl, anserine, D-anserine, L-anserine and L -anserine*HNO3 and mixtures thereof.

[0020] By salts of the compounds of the formula (I) are understood, according to the invention, salts of the compounds of the formula (I) with mineral acids and particularly preferably salts of the formula (II):

[0021] in which n represents 1, 2 or 3 and A represents HCl or HNO3 and R1 represents H or CH3 and R2 represents H or COOH.

[0022] The advantageous use of carnosines in the field of prophylaxis against skin aging or light-induced skin damage is sufficiently known from the prior art.

[0023] Thus, from research carried out by Aruoma and collaborators in 1989, it is known, for example, that carnosine is capable of intercepting ROS (“reactive oxygen species”) [Biochem. J. 264(3), page 863-869 (1989)]. According to a report by Babizhayev et al., carnosine can additionally intercept alpha-beta-unsaturated aldehydes, which are released in the peroxidation of cell membrane fatty acids in oxidative stress [Membran & Cell Biol. 12(1), page 89-99 (1998)].

[0024] The document EP 1310238 A2 (BASF) publishes cosmetic or dermatological preparations of sunscreens, which contain at least one cholesteric liquid crystalline component that reflects in the infrared wavelength range from 750 nm to 2500 nm, at least one substance of filter that protects against the ultraviolet radiation range from 280 nm to 449 nm and at least one cosmetically acceptable carrier and its use. In addition, other antioxidants may be added, such as, for example, carnosine.

[0025] EP 1388339 A1 (VISA) publishes the use of carnosine for the control of the aging process, whereby the formation of skin wrinkles is reversed, prevented and reduced. Carnosine is designated as an anti-wrinkle active substance, which protects, among others, also against glycosylation and chronic inflammation.

[0026] The purpose of document EP 2181697 A2 (SHISEIDO) is sunscreens in the form of O/W, which are distinguished by a special cocktail of emulsifiers and sunscreen filters. Table 3-3 publishes two compositions (Examples 22 and 23), which contain the combination of carnosine with UV filters.

[0027] Furthermore, from EP 1591105 A1 (STADA) cosmetic and pharmaceutical preparations are known, which contain an antioxidant, which protect the skin against infrared radiation. Among the numerous possible antioxidants, carnosine and arnesine are also mentioned. Furthermore, the compositions to be applied topically comprise one or more inorganic and/or organic UV filters. This report does not contain a concrete publication for blends of carnosines and UV filters.

[0028] EP 2545898 A1 (COTY) publishes preparations, which protect the skin from damage due to infrared rays and, in this case, contain plant extracts, vitamins, rubin powder, mica and titanium dioxide. In paragraph [0026] carnosine is also mentioned as another suitable auxiliary substance, however as a radical scavenger. This report also does not contain a concrete publication for blends of carnosines and UV filters.

[0029] International patent application WO 1990 006102 A1 (PEPTIDE TECHNOLOGY) likewise relates to the antioxidative property of carnosine compounds. It is mainly reported that the compounds found reduce or prevent cross-linking of collagen in the skin and/or damage to skin DNA cells, in particular, caused by aging or UV radiation. Application occurs topically or by injection. A reference to mixing with UV filters is not found in the report.

[0030] WO 2010 124817 A2 (KPSS) refers to conditioning agents based on, among others, dipeptides, such as, for example, carnosine, for hair. In the embodiment examples there is a publication for the combination of carnosine with a UV filter, namely benzophenone-3 in examples 4, 8, 9 and 16, wherein the weight ratio between carnosine and benzophenone-3 is in the range of 1:03 to 1:2.

[0031] Furthermore, reference is made to the international patent application WO 2014 128228 A2 (SYMRISE), which shows the ability of these substances to protect against infrared radiation based on the inhibition of MMP expression. Specifically, equal weight mixtures of carnosine with Uvinul A and octocrylene are published here.

[0032] The purpose of document US 2006/216251 A1 (TRACIE MARTIN) is topical compositions, containing carnosine, carnitine and a liponic acid, for the treatment and protection of the skin, in particular, with respect to the indication of skin aging in relation to to chronological aging (chrono-ageing) or photo-aging (photo-aging), which is aimed at wrinkles, skin weakening and loss of elasticity. Treatment aimed at hyperpigmentation is published in the same way. Reference is also made in the report to the influence of carnosines on MMP-1 inhibition. Examples 1 to 8 publish a use amount of carnosine in the range of 1% by weight and 2% by weight.

[0033] According to the English abstract of document KR 2004 0074795 A (A E KYUNG), 0.1 to 2% by weight of carnosine in cosmetic compositions has an antioxidant effect on the skin and increases collagen synthesis. An example is a formulation containing 0.1% by weight of carcinine (carnosine), 0.5% by weight of salicylic acid, 5.0% by weight of 1,3-butylene glycol, 1.3% by weight , polyethylene sorbitan monolaurate, 0.7% by weight, polyethylene lauric ether, 15% by weight, ethanol, 0.2% flavorings, preservatives and water.

[0034] However, the Applicant has further found that carnosines in particular increase the activity of G6PDH production and react to apoptosis. The use of substances as protective and restorative medicines or hygiene products is possible, in principle, for all preparations, which are used for the prevention of damage or damage to the skin and, therefore, in skin care and prophylaxis. Another use in this field is the application on sensitive skin, damaged due to allergy or other origins. The skin damage, in this case, can have the most varied origins.

[0035] The usual application amount of carnosines amounts, based on the emulsion, typically to about 0.001 to about 2.5% by weight, preferably about 0.005 to 2% by weight, and in particular about 0.005 to about 2.5% by weight. 01 to about 1.5% by weight.

EMULSIFIERS

[0036] As emulsifiers for emulsions, for example, non-ionogenic surfactants from at least one of the following groups are included: • addition products of 2 to 30 mol of ethylene oxide and/or 0 to 5 mol of propylene oxide with linear fatty alcohols of 8 to 22 carbon atoms, with fatty acids of 12 to 22 carbon atoms, with alkylphenols of 8 to 15 carbon atoms in the alkyl group, and alkylamines with 8 to 22 carbon atoms in the alkyl radical ; • alkyl and/or alkenyl oligoglycosides with 8 to 22 carbon atoms in the alk(en)yl radical and their ethoxylated analogues; • addition products of 1 to 15 mol of ethylene oxide with castor oil and/or solidified castor oil; • addition products of 15 to 60 mol of ethylene oxide with castor oil and/or solidified castor oil; • partial esters of glycerin and/or sorbitan with unsaturated, linear or saturated branched fatty acids with 12 to 22 carbon atoms and/or hydroxycarboxylic acids with 3 to 18 carbon atoms and their adducts with 1 to 30 mol of ethylene oxide; • partial esters of polyglycerin (average degree of condensation 2 to 8), polyethylene glycol (molecular weight 400 to 5000), trimethylolpropane, pentaerythritol, sugar alcohols (eg sorbitol), alkyl glycosides (eg methyl glycoside, butyl glycoside, lauryl glycoside) and polyglycosides (e.g. cellulose) with linear or branched, saturated and/or unsaturated fatty acids of 12 to 22 carbon atoms and/or hydroxycarboxylic acids of 3 to 18 carbon atoms and their adducts with 1 to 30 mol of ethylene oxide; • mixed esters of pentaerythritol, fatty acids, citric acid and fatty alcohol and/or mixed esters of fatty acids with 6 to 22 carbon atoms, methyl glucose and polyols, preferably glycerin or polyglycerin. • Mono-, di- and trialkyl phosphates and mono-, di- and/or tri-PEG-alkyl phosphates and salts thereof; • wool wax alcohols; • polysiloxane-polyalkyl-polyether copolymers or corresponding derivatives; • block copolymers, for example polyethylene glycol-30 dipolyhydroxystearates; • polymer emulsifiers, eg Pemulen types (TR-1 TR-2) from Goodrich or Cosmedia® SP from Cognis; • polyalkylene glycols and • glycerin carbonate.

[0037] The following particularly suitable emulsifiers are clarified in detail:

[0038] Alkoxylates: The products of ethylene oxide and/or propylene oxide additions with fatty alcohols, fatty acids, alkyl phenols or with castor oil represent known products for sale in the market. In this case, they are homologous mixtures, whose average degree of alkoxylation corresponds to the ratio of the amounts of ethylene oxide and/or propylene oxide substances and substrate, with which the addition reaction is carried out. C12/18-fatty acid mono- and diesters of ethylene oxide addition products with glycerin are known as moisturizers for cosmetic preparations.

[0039] Alkyl and/or alkenyl oligoglycoside. Alkyl and/or alkenyl oligoglycosides, their production and their use are known from the state of the art. Its production occurs, in particular, through the reaction of glucose or oligosaccharides with primary alcohols with 8 to 18 carbon atoms. With respect to the glycoside moiety, it is noted that both monoglycosides, in which a cyclic sugar moiety is glycosidicly linked to the fatty alcohol, and also oligomeric glycosides with a degree of oligomerization up to preferably about 8, are suitable. The degree of oligomerization in this case is an average statistical value, which is based on a distribution of homologs for such technical products.

[0040] Partial glycerides. Typical examples for suitable partial glycerides are hydroxystearic acid monoglyceride, hydroxystearic acid diglyceride, isostearic acid monoglyceride, isostearic acid diglyceride, oleic acid monoglyceride, oleic acid diglyceride, ricinolic acid monoglyceride, ricinolic acid diglyceride, linolenic acid monoglyceride, linolic acid diglyceride, linolenic acid monoglyceride, linolenic acid diglyceride, erucic acid monoglyceride, erucic acid diglyceride, tartaric acid monoglyceride, tartaric acid diglyceride, citric acid monoglyceride, diglyceride of citric acid, monoglyceride of malic acid, diglyceride of malic acid and their technical mixtures which, subordinate to the production process, may still contain small amounts of triglyceride. Likewise, addition products of 1 to 30, preferably 5 to 10 mol of ethylene oxide with the mentioned partial glycerides are suitable.

[0041] Sorbitan esters. As sorbitan esters are included sorbitan monoisostearate, sorbitan sesquiostearate, sorbitan diisostearate, sorbitan triisostearate, sorbitan monooleate, sorbitan sesquioleate, sorbitan dioleate, sorbitan trioleate, sorbitan monoerucate, sesquierucate Sorbitan Dierucate, Sorbitan Dierucate, Sorbitan Trierucate, Sorbitan Monoricinoleate, Sorbitan Sesquirinoleate, Sorbitan Diricinoleate, Sorbitan Triricinoleate, Sorbitan Monohydroxystearate, Sorbitan Sesquihydroxystearate, Sorbitan Dihydroxystearate, Sorbitan Trihydroxystearate , sorbitan monotartrate, sorbitan sesquitartrate, sorbitan ditartrate, sorbitan tritartrate, sorbitan monocitrate, sorbitan sesquicitrate, sorbitan dicitrate, sorbitan tricitrate, sorbitan monomaleate, sorbitan sesquimaleate, sorbitan dimaleate, trimaleate of sorbitan and its technical mixtures. Likewise, addition products of 1 to 30, preferably 5 to 10 mol of ethylene oxide with the mentioned sorbitan esters are suitable.

[0042] Polyglyceric esters. Typical examples of suitable polyglyceric esters are polyglycerol-2-dipolyhydroxystearate (Dehymuls® PGPH), polyglycerin-3-di-isostearate (Lameform® TGI), polyglycerol-4-isostearate (Isolan® GI 34), polyglycerol-3 oleate, di - isostearoyl polyglycerol-3 di-isostearate (Isolan® PDI), polyglycerol-3 methylglucose distearate (Tego Care® 450), polyglycerol-3 beeswax (Cera Bellina®), polyglycerol-4 caprate (polyglycerol caprate T2010/90) , polyglycerol-3 cetyl ether (Chimexane® NL), polyglycerol-3 distearate (Cremophor® GS 32) and polyglycerol polyrinoleate (Admul® WOL 1403), polyglycerol isostearate dimerate and mixtures thereof. Examples of other suitable polyol esters are the mono-, di- and triesters of trimethylolpropane reacted with 1 to 30 mol of ethylene oxide or pentaerythritol with lauric acid, coconut fatty acid, stearic fatty acid, palmitic acid, stearic acid, oleic acid, behenic acid and the like.

[0043] Anionic emulsifiers. Typical anionic emulsifiers are aliphatic fatty acids of 12 to 22 carbon atoms, such as, for example, palmitic acid, stearic acid or behenic acid, and dicarboxylic acids of 12 to 22 carbon atoms, such as, for example, azelaic acid or sebacic.

[0044] Amphoteric and cationic emulsifiers. In addition, bipolar surfactants can be used as emulsifiers. Bipolar surfactants are designated as surfactant compounds which bear in the molecule at least one quaternary ammonium group and at least one carboxylate group and one sulfonate group. Particularly suitable bipolar surfactants are so-called betaines, such as N-alkyl-N,N-dimethylammonium glycinates, e.g. coco-alkyldimethylammonium glycinate, N-acylaminopropyl-N,N-dimethylammonium glycinates, e.g. coco-acylaminopropyldimethylammonium glycinate and 2-alkyl-3-carboxylmethyl-3-hydroxyethylimidazoline with 8 to 18 carbon atoms each in the alkyl or acyl group; and coco-acylaminoethylhydroxyethylcarboxymethyl glycinate. Particularly preferred is the fatty acid amide derivative known by the designation CTFA such as cocamido-propyl betaine. Suitable emulsifiers, likewise, are ampholytic surfactants. Ampholytic surface-active agents are understood to be those surface-active compounds which, in addition to a C8/18-alkyl or acyl group, contain in the molecule at least one free amino group and at least one COOH or SO3H group and are capable of forming internal salts. Examples of suitable ampholytic surfactants are N-alkylglycines, N-alkylpropionic acids, N-alkylaminobutyric acids, N-alkyliminodipropionic acids, N-hydroxyethyl-N-alkylamidopropylglycines, N-alkyltaurines, N-alkylsarcosines, 2-alkylaminopropionic acids and alkylaminoacetic acids with about 8 to 18 carbon atoms each in the alkyl group. Particularly preferred ampholytic surfactants are N-coco-alkylaminopropionate, coco-acylaminoethylaminopropionate and C12/18-acylsarcosine. Finally, cationic surfactants are also included as emulsifiers, with those of the esterquat type, preferably digra-xo acid triethanolamine ester salts being particularly preferred.

[0045] In many cases, it has proved advantageous to use combinations of different emulsifiers, namely binary mixtures (e.g. alkyl polyglycoside/fatty alcohol ethoxylate) or ternary mixtures (e.g. alkyl polyglycoside/alkyl benzenesulfonate). /esterquat or monoglyceride/fatty alcohol ethoxylate/fatty alcohol).

[0046] The amount of application of the emulsifiers can be between about 1 and about 30% by weight. Ranges of about 2 to 20 and in particular about 5 to 10% by weight are preferred. Correspondingly preferred combinations are taken from the embodiment examples.

VEHICLES

[0047] Both emulsions may contain vehicles or solvents as an optional component (d1), which are selected from the group formed by water, alcohols, esters, butylene glycol, dipropylene glycol, ethanol, ethoxydiglycol, ethyl acetate, glycerin, propanol, isopropanol , macrogols, propylene glycol methyl ether (2), propylene glycol methyl ether (3), propylene carbonate, propylene glycol, triethylene glycol, isoparaffin, amyl acetate, amyl benzoate, benzyl acetate, butyl acetate, butylene glycol, butyl lactate , buto-octyl benzoate, buto-octyl salicylate, C10-C13 alkanes, C14-C17 alkanes, C11-C15 cycloalkanes, caprylyl butyrate, isoparaffins, diacetin, dicaprylyl triacetin ether, dicaprylyl maleate and mixtures thereof.

[0048] The proportion of the vehicles in the emulsion can be up to 50% by weight and is generally in the range of about 25% by weight, and in particular about 10 to about 15% by weight.

OIL SUBSTANCE

[0049] In addition, emulsions may contain oily substances (component d2). For this purpose, for example, Guerbet alcohols based on fatty alcohols with 6 to 18, preferably 8 to 10 carbon atoms, esters of linear C6-C22-fatty acids with linear or branched C6-C22-fatty alcohols are included. or esters of branched C6-C13-carboxylic acids with linear or branched C6-C22-fatty alcohols, such as, for example, myristyl myristate, myristyl palmitate, myristyl stearate, myristyl isostearate, myristyl oleate, myristyl behenate , myristyl erucate, cetyl myristate, cetyl palmitate, cetyl stearate, cetyl isostearate, cetyl oleate, cetyl behenate, cetyl erucate, stearyl myristate, stearyl palmitate, stearyl stearate, stearyl isostearate , stearyl oleate, stearyl behanate, stearyl erucate, isostearyl myristate, isostearyl palmitate, isostearyl stearate, isostearyl isostearate, isostearyl oleate, isostearyl behenate, isostearyl oleate, oleyl myristate, oleyl palmitate, oleyl stearate, oleyl isostearate, oleyl oleate, oleyl behenate, oleyl erucate, behenyl myristate, behenyl palmitate, behenyl stearate, behenyl isostearate, behenyl oleate, behenyl behenate, behenyl erucate, erucill myristate, erucill palmitate, erucill stearate, erucill isostearate, erucill oleate, erucill behenate and erucyl erucate. In addition, esters of linear C6-C22-fatty acids with branched alcohols, in particular 2-ethyl-hexanol, esters of C18-C38-alkyl-hydroxycarboxylic acids with linear or branched C6-C22-fatty alcohols, in in particular, diocyl malates, esters of linear and/or branched fatty acids with polyvalent alcohols (such as, for example, propylene glycol, dimerodiol or trimerotriol) and/or Guerbet alcohols, triglycerides based on C6-C10-fatty acids , liquid mixtures of mono-/di-/triglycerides based on C6-C18-fatty acids, esters of C6-C22-fatty alcohols and/or Guerbet alcohols with aromatic carboxylic acids, in particular benzoic acid, esters of C2-C12-dicarboxylic acids with linear or branched alcohols of 1 to 22 carbon atoms or polyols of 2 to 10 carbon atoms and 2 to 6 hydroxyl groups, vegetable oils, branched primary alcohols, substituted cyclohexanes, carbonates of C6 alcohols -C22-linear or branched fats, t such as, for example, dicaprylyl carbonates (Cetiol® CC), Guerbet carbonates based on fatty alcohols with 6 to 18, preferably 8 to 10 carbon atoms, benzoic acid esters with linear and/or branched C6-C22 alcohols (e.g. Finsolv® TN), symmetrical or asymmetrical, linear or branched dialkyl ethers with 6 to 22 carbon atoms per alkyl group, such as, for example, dicapryl ether (Cetiol® OE), ring-opening products of esters of fatty acids epoxidized with polyols, silicone oils (cyclomethicone, methicone silicon types and others) and/or aliphatic or naphthenic hydrocarbons, such as, for example, squalane, squalene or dialkylcyclohexanes.

[0050] The proportion of the oily substances in the emulsion can be up to 50% by weight and is generally in the range of about 5 to about 25% by weight and in particular about 10 to about 15% by weight .

OTHER AUXILIARY AND ADDITIVE SUBSTANCES

[0051] The emulsions according to the invention may have other typical auxiliary substances and additives, such as, for example, mild surface-active agents, pearl luster waxes, consistency-giving agents, thickeners, re-greasing agents, stabilizers, polymers , silicone compounds, greases, waxes, lecithins, phospholipids, UV sun protection factors, humectants, biogenic active substances, antioxidants, deodorants, antiperspirants, insect repellents, self-tanning products, tyrosine inhibitors (depigmentation agents), hydrotropics, solubilizers, preservatives, perfume oils, dyes and the like.

SURFACTANT AGENTS

[0052] Anionic, nonionic, cationic and/or amphoteric or bipolar surfactants may be contained as surfactants; the description of these substances overlaps with that for emulsifiers, since both have surface-active properties.

[0053] Typical examples of anionic surfactants are soaps, alkyl benzenesulfonates, alkanesulfonates, olefin sulfonates, alkyl ether sulfonates, glyceric ether sulfonates, a-methyl ester sulfonates, sulfofatty acids, alkyl sulfates, alkyl ether sulfates , glyceric ether sulfates, fatty acid ether sulfates, hydroxy mixed ether sulfates, monoglyceride (ether) sulfates, fatty acid amide (ether) sulfates, mono- and dialkyl sulfosuccinates, mono- and dialkyl, sulfo-triglycerides, amide soaps, ether carboxylic acids and salts thereof, fatty acid isethionates, fatty acid sarcosinates, fatty acid taurides, N-acylamino acids such as, for example, lactylates of acyl, acyl tartrates, acyl glutamates and acyl aspartates, alkyl oligoglycoside sulfates, fatty acid condensates from protein (in particular, wheat-based plant products) and phosphate those of alkyl (ether). Unless the anionic surfactants contain polyglycolic ether chains, they may have a conventional homolog distribution, preferably, however, a narrow one. Typical examples of non-ionic surfactants are fatty alcohol polyglycolic ether, alkylphenol polyglycolic ether, fatty acid polyglycolic ester, fatty acid amide polyglycolic ether, fatty amine polyglycolic ether, alkoxylated triglycerides, mixed or mixed formal ethers, oligoglycosides of alkyl(en)yl optionally partially oxidized or derivatives of glucuronic acid, fatty acid N-alkyl glucamides, protein hydrolysates (in particular wheat-based plant products), polyol fatty acid esters, sugar ester, ester of sorbitan, polysorbates and amine oxides. Unless the surfactants contain polyglycol ether chains, they may have a conventional, preferably, however, a narrow homolog distribution. Typical examples of cationic surfactants are quaternary ammonium compounds, such as, for example, dimethyldistearyl ammonium chloride and esterquats, in particular, quaternary fatty acid trialkanolamine ester salts. Typical examples of amphoteric or bi-polar surfactants are alkylbetaines, alkylamidobetains, aminopropionates, aminoglycinates, imidazolinium betaines and sulfobetaines. In the case of the surfactants mentioned, these are exclusively known compounds. Typical examples of particularly suitable mild surfactants, i.e. particularly skin-friendly surfactants, are fatty alcohol polyglycolic ether sulfates, monoglyceride sulfates, mono- and/or dialkyl sulfosuccinates, fatty acid isethionates, acid sarcosinates fatty acids, fatty acid taurides, fatty acid glutamates, α-olefin sulfonates, ether carboxylic acids, alkyl oligoglycosides, fatty acid glucamides, alkylamidobetaines, amphoacetals and/or protein fatty acid condensates, the latter preferably based on of wheat proteins.

GREASES AND WAXES

[0054] Typical examples of greases are glycerides, i.e. vegetable or animal products, solid or liquid, which consist essentially of mixed glyceric esters of higher fatty acids, as waxes are included, among others, natural waxes, such as, for example, , candelilla wax, carnauba wax, japanese wax, esparto wax, cork wax, guarum wax, rice germ oil wax, sugar cane wax, ouricuri wax, montane wax, beeswax , shellac wax, spermaceti, lanolin (wool wax), rump fat, ceresin, ozokerite (mineral wax), petrolatum, paraffin wax, microwaxes; chemically modified waxes (solid waxes), such as, for example, montane ester waxes, sasol waxes, hydrogenated jojoba waxes, and synthetic waxes, such as, for example, polyalkylene waxes and polyethylene glycol waxes. In addition to greases, substances similar to grease, such as lecithins and phospholipids, are also included as additives. By the designation lecithins, the expert understands those glycero-phospholipids, which are formed from fatty acids, glycerin, phosphoric acid and choline through esterification. In the scientific world, lecithins, therefore, are also frequent as phosphatidylcholines (PC). As examples of natural lecithins, mention should be made of cephalins, which are also called phosphatidic acids and represent derivatives of 1,2-diacyl-sn-glycerin-3-phosphoric acids. On the other hand, phospholipids are usually understood to mean the mono- and preferably diesters of phosphoric acid with glycerin (glycerin phosphates), which are generally added to greases. In addition, sphingosines or sphingolipids are also included.

pearl shine waxes

[0055] As pearl luster waxes are included, for example: alkylene glycol ester, especially ethylene glycol distearate; fatty acid alkanolamides, especially coconut fatty acid diethanolamide; partial glycerides, especially stearic acid monoglyceride; esters of polyvalent carboxylic acids, optionally substituted by hydroxy with fatty alcohols of 6 to 22 carbon atoms, especially long-chain tartaric acid esters; derivatives of greases and oils, such as, for example, fatty alcohols, fatty ketones, fatty aldehydes, fatty ethers and fatty carbonates, which in sum have at least 24 carbon atoms, especially laurone and distearyl ether; fatty acids such as stearic acid, hydroxystearic acid or behenic acid, ring-opening products of olefin peroxides of 12 to 22 carbon atoms with fatty alcohols of 12 to 22 carbon atoms and/or polyols of 2 to 15 carbon atoms carbon and 2 to 10 hydroxyl groups and mixtures thereof.

coolants

[0056] Cooling agents are compounds, which produce a cold sensation on the skin. As a rule, these are menthol compounds, which - in addition to the base body, menthol itself - for example, selected from the group formed by menthol methyl ether, menthone glycerol acetal (FEMA GRAS1 3807) , menthone glycerol ketal (FEMA GRAS 3808), menthyl lactate (FEMA GRAS 3748), menthol ethylene glycol carbonate (FEMA GRAS 3805), menthol propylene glycol carbonate (FEMA GRAS 3806), menthyl-N-ethyloxamate, monomethyl succinate (FEMA GRAS 3810), monomenthyl glutamate (FEMA GRAS 4006), menthoxy-1,2-propanediol (FEMA GRAS 3784), menthoxy-2-methyl-1,2-propanedioll (FEMA GRAS 3849) and the esters and Menthanecarboxylic acid amides WS-3, WS-4, WS-5, WS-12, WS-14 and WS-30 and mixtures thereof.

[0057] A first important representative of these substances is represented by monomenthyl succinate (FEMA GRAS 3810). Both succinate and analogous monomentyl glutarate (FEMA GRAS 4006) represent important representatives of monomentyl esters based on di- and polycarboxylic acids (formula III): 1 FEMA stands for "Flavor and Extracts Manufacturers Association" and GRAS is defined as "Generally Regarded As Safe". A FEMA GRAS designation means that the substance so characterized is tested according to the standard method and is considered to be toxicologically harmless.

[0058] Examples of applications of these substances are found, for example, in WO 2003 043431 (Unilever) or EP 1332772 A1 (IFF).

[0059] The next important group of preferred menthol compounds in the sense of the invention comprises menthol carbonate esters and polyols, such as, for example, glycols, glycerin or carbohydrates, such as, for example, menthol ethylene glycol carbonates ( FEMA GRAS 3805 = Frescolat® MGC), menthol propylene glycol carbonates (FEMA GRAS 3784 = Frescolat® MPC), menthol 2-methyl-1,2-propanediol carbonates (FEMA GRAS 3849) or the corresponding sugar derivatives. Likewise, methyl lactate menthol compounds (FEMA GRAS 3748 = Frescolat® ML) and, in particular, menthone glycerol acetal (FEMA GRAS 3807) or menthone glycerol ketal (FEMA GRAS 3808), which is commercially by the name Frescolat® MGA. As particularly advantageous among these substances, menthone glycerol acetal/ketal and menthyl lactate and ethylene glycol menthol carbonate or propylene glycol menthol carbonate, which the applicant sells under the names Frescolat® MGA, Frescolat® ML, Frescolat® MGC and Frescolat® MPC.

[0060] In the 70s of the last century, menthol compounds were first developed, which in the 3 position have a C-C bond and of which, in the same way, a series of representatives can be used. These substances are generally designated as WS types. The base body is a menthol derivative, in which the hydroxyl group is sub-substituted by a carboxyl group (WS-1). From this structure all other WS types are derived, such as, for example, the preferred species WS-3, WS-4, WS-5, WS-12, WS-14 and WS-30.

Thickening agents and thickeners

[0061] As consistency-giving agents, fatty alcohols or hydroxy fatty alcohols with 12 to 22 and preferably 16 to 18 carbon atoms are included, in the first place, and, in addition, partial glycerides, fatty acids or hydroxy fatty acids. A combination of these substances with alkyl oligoglycosides and/or fatty acid N-methylglucamides of the same chain length and/or polyglycerinpoly-12-hydroxystearates is preferred. Suitable thickeners are, for example, aerosyl types (hydrophilic silicic acids), polysaccharides, in particular xanthan gum, guar-guar, agar-agar, alginates and tyloses, carboxymethyl cellulose and hydroxyethyl- and hydroxypropyl cellulose, moreover, mono- and higher molecular weight polyethylene glycol diesters of fatty acids, polyacrylates (e.g. Carbopole® and pemulen grades from Goodrich; Synthalene® from Signa; keltrol grades from Kelco; sepigel grades from Seppic; salcare grades from Allied Col -loids), polyacrylamides, polymers, polyvinyl alcohol and polyvinylpyrrolidone. Bentonites, such as, for example, Bentone® Gel VS-rPC (Rheox), have also been proved to be particularly effective, in which case it is a mixture of cyclopentasiloxane, disteardimonium hectorite and propylene carbonate. Other surfactants included, such as, for example, glycerides of ethoxylated fatty acids, esters of fatty acids with polyols, such as, for example, pentaerythritol or trimethylolpropane, ethoxylates of fatty alcohols with narrow homolog distribution or alkyl oligoglycosides, and electrolytes such as sodium chloride and ammonium chloride.

Regreasing agents and stabilizers

[0062] As re-greasing agents, substances such as, for example, lanolin and lecithin and polyethoxylated or acylated lanolin and lecithin derivatives, polyol-fatty acid esters, monoglycerides and fatty acid alkanolamides can be used, the the latter serve at the same time as foam stabilizers.

[0063] As foam stabilizers, metallic salts of fatty acids can be used, such as, for example, magnesium, aluminum and/or zinc stearate or ricinoleate.

polymers

[0064] Suitable cationic polymers are, for example, cationic cellulose derivatives, such as, for example, a quaternary hydroxyethyl cellulose, which is sold under the name Polymer JR 400® by Amerchol, cationic starch, copolymers of dialkylammonium salts and acrylamides , quaternary vinylpyrrolidone/vinylimidazole polymers such as, for example, Luviquat® (BASF), condensation products of polyglycols and amines, quaternary collagen polypeptides, such as, for example, hydroxypropyl lauryldimonium hydrolyzed collagen (Lamequat®L/Grünau ), quaternary wheat polypeptides, polyethyleneimine, cationic silicone polymers such as, for example, amodimethicone, copolymers of adipic acid and dimethylaminohydroxypropyldiethylenetriamine (Cartaretine®/Sandoz), copolymers of acrylic acid with dimethyldiallylammonium chloride ( Merquat® 550/Chemviron), polyaminopolyamides and their cross-linked water-soluble polymers derived from cationic chitin, such as, for example, lo, quaternary chitosan, optionally distributed in microcrystalline form, condensation products of dihaloalkylene, such as, for example, dibromobutane with bisdialkylamines, such as, for example, bis-dimethylamino-1,3-propane, cationic guar gum, such as such as Jaguar® CBS, Jaguar® C-17, Jaguar® C-16 from the company Celanese, quaternary ammonium salt polymers, such as, for example, Mirapol® A-15, Mirapol® AD-1 , Mirapol® AZ-1 from the company Miranol.

[0065] As anionic, bipolar, amphoteric and nonionic polymers are included, for example, vinyl acetate/crotonic acid copolymers, vinylpyrrolidone/vinyl acrylate copolymers, vinyl acetate/butyl maleate/vinyl acrylate copolymers. isobornyl, methyl vinyl ether/maleic acid anhydride copolymers and esters thereof, uncrosslinked and crosslinked polyacrylic acids such as polyols, acrylamidopropyltrimethylammonium chloride/acrylate copolymers, octylacrylamide/methyl methacrylate/tert.butylaminoethyl methacrylate/ 2-hydroxypropyl methacrylate, polyvinylpyrrolidone, vinylpyrrolidone/vinyl acetate copolymers, vinylpyrrolidone/dimethylaminoethyl methacrylate/vinylcaprolactam terpolymers and optionally derivatized cellulose ethers and silicones.

silicone compounds

[0066] Suitable silicone compounds are, for example, dimethylpolysiloxane, methylphenylpolysiloxane, cyclic silicones and silicone compounds modified with amino, fatty acid, alcohol, polyether, epoxy, fluorine, glycoside and/or alkyl, which at room temperature can be present both in liquid form and in resin form. Furthermore, simethicones are suitable, in which case they are mixtures of dimethicones with an average chain length of 200 to 300 dimethylsiloxane units and hydrogenated silicates.

Humectants

[0067] Humectants serve to further optimize the sensory properties of the composition and to regulate skin moisture. At the same time, the cold stability of the preparations according to the invention, in particular in the case of emulsions, increases. The humectants are generally contained in an amount of 0.1 to 15% by weight, preferably 1 to 10% by weight, and in particular 5 to 10% by weight.

[0068] According to the invention, among others, amino acids, pyrrolidonecarboxylic acid, lactic acid and salts thereof, lactitol, urea and urea derivatives, uric acid, glucosamine, creatinine, collagen dissociation products, chitosan or salts are suitable. /chitosan derivatives and in particular polyols and polyol derivatives (e.g. glycerin, diglycerin, triglycerin, ethylene glycol, propylene glycol, butylene glycol, erythritol, 1,2,6-hexanetriol, polyethylene glycols such as PEG-4, PEG-6, PEG-7, PEG-8, PEG-9, PEG-10, PEG-12, PEG-14, PEG-16, PEG-18, PEG-20), sugars and sugar derivatives (among others, fructose, glucose, maltose, maltitol, mannitol, inositol, sorbitol, sorbitylsilanediol, sucrose, trehalose, xylose, xylitol, glucuronic acid and salts thereof), ethoxylated sorbitol (Sorbeth-6, Sorbeth-20, Sorbeth-30 , Sorbeth-40), honey and solidified honey, solidified starch hydrolysates and mixtures of solidified wheat protein and PEG-acetate copolymer 20. According to the invention, glycerin, diglycerin, triglycerin and butylene glycol are preferably suitable as humectants.

Biogenic active substances and antioxidants

[0069] By biogenic active substances should be understood, for example, tocopherol, tocopheryl acetate, tocopheryl palmitate, ascorbic acid, (deoxy)ribonucleic acid and its fragmentation products, β-glucans, retinol, bisabolol, allantoin, phytanotriol, panthenol, AHA acids, amino acids, ceramides, pseudoceramides, essential oils, plant extracts such as, for example, Prunus extract, underground Vigna nut extract and vitamin complexes.

[0070] Antioxidants interrupt the photochemical reaction chain, which is caused when UV radiation penetrates the skin. Typical examples of these are amino acids (e.g. glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (e.g. urocanic acid) and their derivatives, peptides such as D,L-carnosine, D-carnosine, L- carnosine and its derivatives (e.g. anserine), carotinoids, carotins (e.g. α-carotene, β-carotene, lycopine) and its derivatives, chlorogenic acid and its derivatives, liponic acid and its derivatives (e.g. dihydroliponic), aurothioglucose, propylthiouracil and other thiols (e.g. thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauric esters of palmitoyl , oleyl, Y-linoleyl, cholesterol and glycerol) and salts thereof, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and its derivatives (ester, ether, peptides, lipids, nucleotides, nucleosides and salts) and sulfoximine compounds (eg example, sulfoximines of butionine, homocysteine sulfoximine, butionine sulfones, penta-, hexa-, heptathionine sulfoximine) in very low compatible dosages (e.g. pmol up to μmol/kg), in addition, (metal) chelators (e.g. , α-hydroxy fatty acids, palmitic acid, phytinic acid, lactoferrin), α-hydroxy acids (e.g. citric acid, lactic acid, malic acid), huminic acid, galenic acid, galene extracts, bilirubin, biliverdin, EDTA, EGTA and its derivatives, unsaturated fatty acids and their derivatives (e.g. Y-linolenic acid, linolic acid, oleic acid), folic acid and their derivatives, ubiquinone and ubiquinol and their derivatives, vitamin C and derivatives (e.g. e.g. ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (e.g. vitamin E acetate), vitamin A and derivatives (vitamin A palmitate) and benzoic resin coniferyl benzoate, rutinic acid and its derivatives, α-glycosylrutin, ferulic acid, f urfurylideneglucitol, carnosine, butylhydroxytoluene, butylhydroxyanisole, nordihydroguajac-resinoic acid, nordihydroguajarretic acid, trihydroxybutyrophenone, uric acid and its derivatives, mannose and its derivatives, superoxide dismutase, zinc and its derivatives (e.g. ZnO, ZnSO4), selenium and its derivatives (e.g. selenium-methionine), stilbenes and their derivatives (e.g. stilbene oxide, trans-stilbene oxide) and suitable derivatives according to invention (salts, esters, ethers, sugar, nucleotides, peptides and lipids) of these active substances mentioned.

Deodorants and germ-inhibiting agents

[0071] Cosmetic deodorants (deodorants) react against body odors, mask or remove them. Body odors result from the action of skin bacteria on apocrine sweat, forming unpleasant odor degradation products. Therefore, deodorants contain active substances, which act as germ-inhibiting agents, enzyme inhibitors, odor absorbers or odor masking agents.

germ-inhibiting agents

[0072] Essentially all substances effective against gram-positive bacteria are suitable as germ-inhibiting agents, such as, for example, 4-hydroxybenzoic acid and salts thereof and esters, N-(4-chlorophenyl)-N'-( 34-dichlorophenyl)urea, 2,4,4'-trichloro-2'-hydroxy-diphenyl ether (triclosan), 4-chloro-3,5-dimethyl-phenol, 2,2'-methylene-bis(6-bromo) -4-chlorophenol), 3-methyl-4-(1-methylethyl)-phenol, 2-benzyl-4-chlorophenol, 3-(4-chlorophenoxy)-1,2-propanediol, 3-iodo-2-propynylbutylcarbamate, chlorhexidine, 3,4,4'-trichlorocarbanilide (TTC), antibacterial fragrances, thymol, thyme oil, eugenol, clove oil, menthol, peppermint oil, farnesol, phenoxyethanol, glycerin monocaprinate, glycerin monocaprylate, glycerin monolaurate (GML), diglycerin monocaprinate (DMC), salicylic acid N-alkylamides such as, for example, salicylic acid n-octylamide or salicylic acid n-decylamide.

enzyme inhibitors

[0073] As enzyme inhibitors, for example, esterase inhibitors are suitable. Here, they are preferably trialkyl citrates, such as trimethyl citrate, tripropyl citrate, triisopropyl citrate, tributyl citrate and, in particular, triethyl citrate (Hydagen® CAT). The substances inhibit enzymatic activity and thus reduce odor formation. Other substances, which are included as esterase inhibitors, are sterol sulfates or phosphates, such as, for example, lanosterine sulfate or phosphate, cholesterine, campesterine, stigmasterine and sitosterin, dicarboxylic acids and their esters, such as, for example, glutaric acid, glutaric acid monoethyl ester, glutaric acid diethyl ester, adipic acid, adipic acid monoethyl ester, adipic acid diethyl ester, malonic acid and malonic acid diethyl ester, hydroxycarboxylic acids and their esters, such as such as, for example, citric acid, malic acid, tartaric acid or diethyl ester of tartaric acid and zinc glycinate.

odor absorbers

[0074] Substances which absorb the odor-forming compounds and which can retain them widely are suitable as odor absorbers. These decrease the partial pressure of the isolated components and thus also reduce their propagation speed. It is important, that in this case the perfumes must remain unchanged. Odor absorbers are not effective against bacteria. These contain, for example, as a main component a complex zinc salt of ricinoleic acid or special fragrances, with a largely neutral odor, which are known to the expert as “fixers”, such as, for example, extracts of Labdanum or Styrax or certain derivatives. of abietic acid. Odorants or perfume oils act as odor maskers, which, in addition to their function as odor maskers, give deodorants their respective olfactory note. As perfume oils, for example, mixtures of natural and synthetic odorants are mentioned. Natural odorants are extracts from flowers, stems and leaves, fruits, fruit peels, roots, woods, herbs and grasses, needles and branches and resins and balms. In addition, animal raw materials such as, for example, musk and castoreum are included. Typical synthetic odorant compounds are esters, ethers, aldehydes, ketones, alcohols and hydrocarbons. Flavor compounds of the ester type are, for example, benzyl acetate, p-tert-butylcyclohexyl acetate, linalyl acetate, phenylethyl acetate, linalyl benzoate, benzyl formate, allylcyclohexyl propionate, styralyl and benzyl salicylate. Ethers include, for example, benzylethyl ether, in aldehydes, for example, linear alkanals of 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamen aldehyde, hydroxycitronellal, lilyal and bourgeonal, in ketones, for example, jojonas and methylcedrylketone, in alcohols anethole, citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol and terpineol, hydrocarbons mainly include terpenes and balms. Preferably, however, mixtures of various odorants are used, which together produce an attractive olfactory note. Also relatively low volatility ethereal oils, which are used most often as aromatic components, are suitable as perfume oils, e.g. sage oil, chamomile oil, clove oil, lemon balm oil, peppermint oil, cinnamon leaf oil, linden oil, juniper berry oil, vetiver oil, frankincense oil, ferula gumosa oil, labdanum oil and lavandin oil. Preferably, bergamot oil, dihydromyrcenol, lilyl, lyral, citronellol, phenylethyl alcohol, α-hexyl cinnamic aldehyde, geraniol, benzylacetone, cyclamenaldehyde, linalool, Boisambrene Forte, ambroxane, indole, hedione, sandelice, oil of lemon, tangerine oil, orange oil, allylamyl glycolate, cyclovertal, lavandin oil, grape sage oil, β-apricot, geranium whiskey oil, cyclohexyl salicylate, vertofix coeur, iso-E-super , Fixolide NP, evernyl, iraldein gamma, phenylacetic acid, geranyl acetate, benzyl acetate, rose oxide, romilate, irotyl and floramate alone or in mixtures.

antiperspirants

[0075] Antiperspirants (antiperspirants) reduce, through the influence of the activity of the eccrine sweat glands, the formation of sweat and thus react against underarm dampness and body odor. Aqueous or anhydrous formulations of antiperspirants typically contain the following constituents: • astringent active substances, • oil components, • non-ionic emulsifiers, • co-emulsifiers, • consistency-giving agents, • auxiliary substances such as, for example, thickeners or complexing agents and/or • non-aqueous solvents, such as, for example, ethanol, propylene glycol and/or glycerin.

[0076] As astringent antiperspirant active substances, mainly aluminum, zirconium or zinc salts are suitable. Such suitable antiperspirant active substances are, for example, aluminum chloride, aluminum hydrochloride, aluminum dichlorohydrate, aluminum sesquihydrochloride and their complex compounds, for example with propylene glycol-1,2. Aluminum hydroxyalantoinate, aluminum chloride tartrate, aluminum zirconium trihydrochloride, aluminum zirconium tetrahydrochloride, aluminum zirconium pentahydrochloride and their complex compounds, eg with amino acids such as glycine. In addition, the usual oil-soluble and water-soluble auxiliary agents may be contained in the antiperspirants in smaller amounts. Such oil-soluble auxiliary agents may be, for example: • anti-inflammatory, skin-protective or scented ethereal oils, synthetic, skin-protective active substances and/or • oil-soluble perfume oils.

[0077] Usual water-soluble additives are, for example, preservatives, water-soluble odorants, pH-adjusting agents, for example, buffer mixtures, water-soluble thickeners, for example, water-soluble natural or synthetic polymers, such as, for example, gum xanthan, hydroxyethylcellulose, polyvinylpyrrolidone or high molecular weight polyethylene oxides.

insect repellents

[0078] As insect repellents are included N,N-diethyl-m-toluamide, 1,2-pentanediol or ethyl butylacetylaminopropionates.

Self-tanning and depigmentation agents

[0079] Dihydroxyacetone is suitable as self-tanning products. As tyrosine inhibitors which prevent melamine formation and find application in depigmentation agents, for example arbutin, ferulic acid, koji acid, coumaric acid and ascorbic acid (vitamin C) are included.

hydrotropes

[0080] Furthermore, to improve the flow behavior, hydrotropes can be used, such as, for example, ethanol, isopropyl alcohol or polyols; these substances largely correspond to the vehicles described at the beginning. The polyols, which are included herein, preferably have 2 to 15 carbon atoms and at least two hydroxyl groups. Polyols may contain further functional groups, in particular amino groups or be modified with nitrogen. Typical examples are • glycerin; • alkylene glycols, such as, for example, ethylene glycol, diethylene glycol, propylene glycol, butylene glycol, hexylene glycol and polyethylene glycols having an average molecular weight of 100 to 1000 Daltons; • technical oligoglycerin mixtures with a proper degree of condensation of 1.5 to 10, such as technical diglycerin mixtures with a diglycerin content of 40 to 50% by weight; • methylol compounds, such as, in particular, trimethylolethane, trimethylolpropane, trimethylolbutane, pentaerythritol and dipentaerythritol; • lower alkylglycosides, in particular those with 1 to 8 carbon atoms in the alkyl moiety, such as, for example, methyl- and butylglycoside; • sugar alcohols with 5 to 12 carbon atoms, such as, for example, sorbitol or mannitol; • sugar with 5 to 12 carbon atoms, such as, for example, glucose or sucrose; • amino sugar, such as, for example, glucamine; • dialcohol amines such as diethanolamine or 2-amino-1,3-propanediol.

preservatives

[0081] Suitable preservatives include, for example, phenoxy-ethanol, formaldehyde solution, parabens, pentanediol or sorbic acid and the silver complexes known by the name Surfacine® and the other classes of substances listed in Annex 6, part A and B of the cosmetics regulation.

Perfume and scent oils

[0082] As perfume oils, mixtures of odorants are mentioned. Natural fragrances are extracts of flowers (lily, lavender, roses, jasmine, neroli, ylang-ylang), stems and leaves (geranium, patchouli, petitgrain), fruits (anise, coriander, cumin, juniper), fruit peels (bergamot, lemon, oranges), roots (nutmeg, angelica, celery, cardamom, costus, iris, azorean), woods (pine wood, sandalwood, gaja, cedar, rose), herbs and grasses (tarragon, lemongrass, sage , thyme), needles and branches (fir, pine, maritime pine, mountain pine), resins and balms (galbanum, elemi, benzoin, myrrh, frankincense, opoponax). In addition, animal odorants such as, for example, civet and castoreum are included). Typical synthetic odorant compounds are products such as esters, ethers, aldehydes, ketones, alcohols and hydrocarbons. Flavor compounds of the ester type are, for example, benzyl acetate, phenoxyethylisobutyrate, p-tert-butylcyclohexyl acetate, linalyl acetate, dimethylbenzylcarbinyl acetate, phenylethyl acetate, linaline benzoate, benzyl formate, ethylmethylphenyl glycinate, allylcyclohexyl propionate, styralyl propionate and benzyl salicylate. Ethers include, for example, benzylethyl ether, aldehydes, for example, linear alkanals with 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamen aldehyde, hydroxycitronellal, lilyal and bourgeonal, and ketones, for example, jojonas, α-isomethylionone and methylcedrylketone, in alcohols anethole, citronellol, eugenol, isoeugenol, geraniol, linalool, fetylethyl alcohol and terpineol, the hydrocarbons mainly include terpenes and balms. Preferably, however, mixtures of various odorants are used, which together produce an attractive olfactory note. Also ethereal oils of lower volatility, which are most often used as aromatic components, are suitable as perfume oils, e.g. sage oil, chamomile oil, clove oil, lemon balm oil, peppermint oil, cinnamon leaves, linden blossom oil, juniper berry oil, vetiver oil, frankincense oil, ferula gumosa oil, labolanum oil and lavandim oil. Preferably, bergamot oil, dihydromyrcenol, lilyl, lyral, citronellol, phenylethyl alcohol, a-hexylcinnamic aldehyde, geraniol, benzylacetone, cyclamen aldehyde, linalool, Boisambrene Forte, ambroxan, indole, hedione, sandelice, lemon oil , tangerine oil, orange oil, allylamyl glycolate, cyclovertal, lavandin oil, grape sage oil, β-apricot, geranium whiskey oil, cyclohexyl salicylate, vertofix coeur, iso-E-Super, Fixolide NP, evernyl, gamma iraldehyde, phenylacetic acid, geranyl acetate, benzyl acetate, rose oxide, romilate, irotile and floramate alone or in mixtures.

[0083] As flavorings are included, for example, peppermint oil, curly spearmint oil, anise oil, star anise oil, cumin oil, eucalyptus oil, fennel oil, lemon oil, wintergreen, clove oil, menthol and the like.

dyes

[0084] As colorants, substances accessible and suitable for cosmetic purposes can be used, such as are compiled in the publication “Kosmetische Farbemitte” of the Farbstoffkommission der Deutschen Forschungsgemeinschaft, Verlag Chemie, Weinheim, 1984, page 81-106. Examples are cochineal red A (CI 16255), patent blue V (CI42051), indigotin (CI73015), chlorophyllin (CI75810), quinoline yellow (CI47005), titanium dioxide (CI77891), indanthrene blue RS (CI 69800) and red lacquer (CI58000). As a luminescence dye, luminol can also be contained. These dyes are generally used in concentrations of 0.001 to 0.1% by weight, based on the entire mixture.

[0085] The total proportion of auxiliary and additive substances can be from 1 to 50, preferably 5 to 40% by weight, based on the agents. The production of the agents can take place by the usual cold or hot processes; preferably it is worked according to the phase inversion temperature method.

EMULSIONS

[0086] In a preferred embodiment, the emulsions have the following composition: (a) about 0.1 to about 20% by weight, preferably about 1 to about 15% by weight, and in particular about from 2 to about 10% by weight of sun protection factors, (b) about 0.001 to about 2.5% by weight, preferably about 0.005 to about 2% by weight, and in particular about 0.01 to about 1.5% by weight of carnosine compounds, (c) about 1 to about 30% by weight, preferably about 2 to about 25, and in particular about 5 to about from 10% by weight of emulsifiers, (d) 0 to about 50% by weight, preferably from about 5 to about 40% by weight, and in particular from about 10 to about 20% by weight of carrier and (e) 0 to about 50% by weight, preferably about 5 to about 40% by weight, and in particular about 10 to about 20% by weight, of oily substance, provided that the indicated amounts are topped up with water and optionally with other ras auxiliary and additive substances to 100% by weight.

[0087] Particularly preferred are emulsions, which have the following composition: (a) about 1 to about 15% by weight and preferably about 2 to about 10% by weight of sun protection factors, (b) about from 0.005 to about 2% by weight, preferably from about 0.01 to about 1.5% by weight, and in particular from about 0.05 to about 0.1% by weight, of carnosine compounds, (c) about 2 to about 25, and preferably about 5 to about 10% by weight, of emulsifiers, (d) 5 to about 50% by weight, preferably about 5 to about 40% by weight, and , in particular, about 10 to about 20% by weight of carrier and (e) 5 to about 50% by weight, preferably about 5 to about 40% by weight, and in particular about 10 to about 10 to about 50% by weight. about 20% by weight of oily substance, provided that the indicated amounts are optionally supplemented with other auxiliary substances and additives to 100% by weight.

[0088] In the quantities indicated it must be considered, that these fit the specialist. This would not even consider compositions, which do not add up to 100% by weight or which exceed.

[0089] Finally, it should be noted, that the invention relates to those emulsions, which are thermodynamically stable and which form spontaneously or with low input of mechanical energy. This extends, however, in the same way, to emulsions, which have the same droplet size distribution and which have been produced by another means, for example, through high pressure homogenization. The measurement of droplet size diameter can occur by methods known to the skilled person. Examples to this end include laser supported processes, such as, for example, photon correlation spectroscopy, laser diffractometry, laser counting process or turbidimetry.

INDUSTRIAL APPLICABILITY

[0090] Another object of the invention relates to a process for producing sunscreens in emulsion form, comprising the following steps: (i) providing at least one UV sun protection factor; (ii) providing at least one carnosine compound; (iii) providing at least one emulsifier (iv) mixing components (a) and (b) optionally with the addition of vehicles, oily substances and/or other additive cosmetic substances forming an emulsion.

[0091] Finally, the invention also relates to the use of carnosine compounds of formula (I) as stabilizers for emulsions and, in particular, emulsions, these being used in amounts ranging from about 0.001 to about 0.001 2.5% by weight - based on emulsion -.

[0092] Unless expressly stated, the above-mentioned embodiments and preferred range specifications also refer to the claimed process and claimed use. A repetition is therefore unnecessary.

[0093] Next, the invention is explained in detail based on examples of embodiment, however, without being restricted thereto. In the first part, experimental research is found, which attests to the hitherto unknown character of carnosine compounds as active substances to protect the skin against environmental influences. In the second part, it is shown that carnosines are able to keep emulsions, which contain UV sun protection factors, stable for longer periods, also at elevated temperatures. In the last part, examples of formulations are finally given.

EXAMPLES CARNOSINES AS ACTIVE SUBSTANCES AGAINST ENVIRONMENTAL SKIN DAMAGE EXAMPLES 1 TO 6, COMPARATIVE EXAMPLES V1 AND V2 Efficacy against skin aging

[0094] Background: The enzyme glucose 6 phosphate dehydrogenase (G6PDH) catalyzes the first step of the “pentose pathway”, in which an essential constituent element of DNA, namely deoxyribose, is formed. In this case, glucose 6 phosphate (G6P) with the help of G6PDH is converted into gluconate 6-phosphate (6PG). At the same time, the coenzyme NADP required in this case is reduced to NADPH2 which, in turn, can catalyze a large number of other biological reactions, such as, for example, glutathione recycling or lipid synthesis. Reduced glutathione protects many enzymes, which dispose of SH groups and cells against oxidative stress, such as, for example, the action of UV. Thus, the G6PDH content is an important parameter for cell protection and skin renewal.

[0095] Method: The activity of G6PDH was determined in vitro in human fibroblasts according to the enzymatic method of Okada, the DNA content according to the process of Desaulniers. Results are compiled in Table 1. Results of 3 measurement series each with triple determination in % relative compared to a blank sample are shown.Table 1 Stimulation of G6PDH activity (indicated in % relative)

[0096] As the examples show, the addition of carnosine causes both the amount of cellular DNA and G6PDH to increase in a statistically significant way. This already unexpected effect in itself can be further enhanced by the combination with UV sun protection filters, although these alone do not show any effect.

EXAMPLES 7 AND 8 Inhibition of apoptosis induction

[0097] Background: Apoptosis, unlike necrosis, is a naturally targeted cell death of unwanted or damaged cells. It is an active process of cells (suicide on command). Especially in aging skin, due to a deficiency of growth factors in the skin, induced apoptosis of skin cells occurs. In the respective cells affected by apoptosis the nuclear DNA is degraded by the specific enzyme endonuclease and the DNA fragments are channeled to the cytoplasm.

[0098] Method: The ability of carnosines to prevent apoptosis induced by a deficiency of human fibroblasts in human skin cells is investigated. These tests were performed in vitro on human fibroblasts and human keratinocytes. Human cells were cultured in a nutrient medium (DMEM = Dulbecco Minimum Essential Medium by the company Life Technologie Sarl) with 10% fetal calf serum (from the Dutcher company). Bromodeoxyuridine BrdU was added to this nutrient medium, which was incorporated into the DNA and later served to detect DNA fragments in the cytoplasm. After a two-day incubation period, the nutrient medium was changed to nutrient medium (DMEM) without fetal calf serum. The active substance to be tested was added. To compare, a cell sample lacking the active substance to be tested was incubated.

[0099] After another incubation period of one or two days at 37oC, cells were recovered by trypsinization according to the Dunnebacke and Zitcer method described in: Cell and tissue culture, editor: J. Paul, Churchill Livingstone , 1975, page 226. After trypsinization the cells were centrifuged and counted. Then, the content of BrdU in DNA fragments from the cytoplasm was determined with the aid of the ELISA test (ELISA kit from Roche). The BrdU content is a measure for the DNA fragments, which from the nucleus, from the cell nucleus, have been channeled into the cytoplasm. Results were based on one million cells and reported in percent compared to control. The results are compiled in the following table 2. Table 2 Number of cells and content of DNA fragments

[00100] In vitro examples show that, through the use of carnosines, apoptosis in human cell cultures and the content of free DNA fragments in the cytoplasm and, therefore, the degree of DNA destroyed in the cell nucleus, decrease .

EXAMPLES 9 AND 10 Stimulation of the synthesis of dermal macromolecules (GAG)

[00101] Background: The aim of these investigations is to prove a stimulating activity of carnosines on the synthesis of dermal macromolecules in in vitro cultures of human fibroblasts. The dermis is made up of cells (fibroblasts and mast cells), tissue components (collagen and elastin) and so-called basic substances. These base substances include, for example, glycosaminoglycan (GAG), hyaluronic acid, chondroitin sulfate, dermatan sulfate and glycoproteins. Due to skin aging, the intermolecular bonding and elasticity of the dermis, and thus the skin's firmness, decreases. Likewise, the number of skin cells present, in particular fibroblasts, decreases as the skin ages. Collagen fibers are fragmented over time and the ratio of insoluble to soluble collagen increases. The thin dermal elastic fibers thicken and are destroyed. GAG (glycosaminoglycan) synthesis decreases. All these processes contribute to skin aging and its manifestations, such as wrinkles and lack of skin firmness.

[00102] Method: The measurement method is based on a staining of macromolecules in a culture of human fibroblasts, which with type I collagen form a collagen gel or collagen network fibers. Certain regions of these fibers are quantified with the aid of staining reagents in the part of the mentioned macromolecules.

[00103] For this purpose, a suspension of human fibroblasts is mixed with a solution of type I collagen (1-2 mg/ml). This mixture was incubated for 14 days in a defined nutrient medium (DMEM = Dulbecco Minimum Essential Medium, company Life Technologie Sarl) with 0.5 or 2% by weight of fetal calf serum (FCS) at 37oC in a CO2 atmosphere. at 5%, in Petri dishes (5 ml per dish) with the addition of different concentrations of plant extracts to be investigated.

[00104] The kinetics of collagen gel concentration was determined 2 to 3 times a week by measuring two perpendicular diameters on each collagen gel with a microscope with image analysis system. The size of the area is shown in table 8 in cm2. After an incubation of 14 days, the density of the collagen gel was determined through an image analysis with a light source from visible light, in which different shades of gray were comparatively investigated. This is a relative density determination (0=light or white and 1=black), which can be provided without any units.

[00105] After an incubation period of 7 and after 14 days, biopsies (tissue samples) were taken and histological sections of collagen gel were obtained with human fibroblasts. Macromolecule synthesis was investigated and quantified by staining glycosaminoglycan with PAS-Alcian blue, for example, from the company SIGMA, according to the periodic acid-Schiff (PAS) staining method, described in: Mowry RW, Anal . NY Adad. Sci. 106 Art 2, 402, 1963. The assessment of the stimulation of macromolecule synthesis was performed directly in the fibroblast environment. This zone is also called the “perifibroblast area”.

[00106] A quantification of the secretion of the “perifibroblasts” or the secretion of fibroblasts in the periphery, was performed by an image analyzer by means of a microscope. Reactive structures were detected in the “perifibroblast area” and the different shades of gray were comparatively determined. In this case, the grayscale values were divided from 0 = white to 255 = black. These parameters are directly proportional to the intensity of macromolecule synthesis and, thus, to the proportion of GAG in the fibroblasts.

* 5% em peso, de soro fetal de vi tela (FCS)[00107] In the following table 3 the results of the values of these parameters are shown and are seen directly as representative values for the synthesis activity of fibroblasts. The proportion of GAGs is described as the relative value of shades of gray.Table 3 Content of GAGs in human fibroblast tissue samples with collagen.

* 5% by weight of fetal calf serum (FCS)

[00108] From the results of determining the proportion of glycosaminoglycan in collagen gel tissue samples with fibroblasts, especially in the perifibroblast area, after an incubation period of 14 days, compared to the standard with addition of carnosines, a significant increase in the proportion of GAG can be recognized. This points in vitro to a regenerative and revitalizing activity of carnosines in human fibroblasts.

EXAMPLES 11 AND 12 Inhibition of elastase activity

[00109] Background: Elastase is a protease, which in inflammatory states is separated by fibroblasts and is co-responsible for the degradation of dermal macromolecules, such as, for example, collagen and elastic, and thus for skin aging.

[00110] Method: To investigate the efficacy of the plant extract to inhibit the release of elastase, pancreatic elastase (a serine protease) was researched and as a substrate, elastin was labeled with a synthetic chromogenic substrate. The system was incubated with the active substances for 30 minutes at room temperature and then, after centrifugation, the optical density of the dye was determined at 40 nm. The amount of application of the extracts was 0.3% by weight. The results are compiled in Table 4. The indication occurred relative to a control as standard (= 0%), as standard served α1-antitrypsin.Table 4 Inhibition of elastin

[00111] The results show that carnosine is able to inhibit elastase and especially pancreas elastase.

EXAMPLES 13 AND 14 Inhibition of collagen glycation.

[00112] To prove that carnosines inhibit non-enzymatic glycation of macromolecules, type I collagen was treated with glucose and extracts for a period of 21 days at 45oC. Then, the suspensions were centrifuged and the content of Schiff's bases in the supernatant liquid was determined by measuring fluorescence at 430 nm. The results are compiled in Table 5. Data refer again to the control as standard (no extract and no glucose).Table 5 Inhibition of collagen glycation

[00113] The in vitro results point to the fact that carnosines are able to inhibit collagen glycation and thus delay the aging process of the dermis through the glycation of collagen fibers.

CARNOSINES AS EMULSION STABILIZERS EXAMPLES 15 TO 17, COMPARATIVE EXAMPLES V3 TO V5 stability surveys

[00114] Several emulsions containing different UV sun protection factors were homogenized under high pressure, so that the D50 value was in the range of 0.1 to 100 μm. Then, the emulsions were transferred under air exclusion in 150 ml dark flasks and then, with and without addition of 0.2% by weight of carnosine, they were stored in a drying oven at 40oC for a period of 6 weeks. The evaluation takes place after 1 week each of storage according to the following scale: (++) = no change; (+) = small turbidity; (#) = clear turbidity; (-) = separated.

[00115] The results are compiled in table 6. Examples 15 to 17 are according to the invention, examples V3 to V5 are for comparison.Table 6 Stability surveys (quantitative data as % by weight)

Spray de proteção solar O/W, SPE 15-20 (quantidade em % em peso) (Tabela 8)

Creme de proteção solar (W/O), SPF 40 (quantidade em % em peso) (Tabela 9)

Leite de proteção solar (W/O) (quantidade em % em peso) (Tabela 10)

[00116] The emulsions according to the invention prove to be completely stable for more than 5 weeks when stored at 40oC; a first clouding occurs after 6 weeks. At this point, all comparative formulations without the addition of carnosine were already separated. EXAMPLES OF FORMULATIONS Sun protection spray (amount in % by weight) (Table 7)

O/W sunscreen spray, SPE 15-20 (amount in % by weight) (Table 8)

Sun protection cream (W/O), SPF 40 (amount in % by weight) (Table 9)

Sun protection milk (W/O) (amount in % by weight) (Table 10)

Claims (15)

1. Emulsions, characterized in that they comprise: (a) at least one UV sun protection factor, (b) at least one carnosine compound of formula (I)

wherein: R1 represents H or CH3, and R2 represents H or COOH or salts thereof; (c) at least one emulsifier and optionally: (d1) vehicle, and/or (d2) oily substances, provided that the emulsions have a droplet size in which the D50 value is in the range of 40 at 100 μm. 2. Emulsions, according to claim 1, characterized by the fact that the D90 value is in the range of 40 to 150 μm. 3. Emulsions, according to claims 1 or 2, characterized by the fact that both the D50 value and the D90 value are in the range of 40 to 100 μm. 4. Emulsions according to any one of claims 1 to 3, characterized in that the UV sun protection factors are selected from the group formed by UV-A and UV-B sun protection factors. 5. Emulsions, according to claim 4, characterized by the fact that the UV-A filters are selected from the group formed by benzoylmethane and enamine compounds and their mixtures. 6. Emulsions, according to claim 4, characterized by the fact that the UV-B filters are selected from the group formed by 3-benzylidene camphor, 3-benzylidenenor camphor and their derivatives, derivatives of 4-aminobenzoic acid , cinnamic acid esters, salicylic acid esters, benzophenone derivatives, benzalmalonic acid esters, triazine derivatives, propan-1,3-diones, ketotricyclo(5,2,1,0)decane derivatives, acid 2 -phenylbenzimidazole-5-sulfonic acid and salts thereof; sulfonic acid derivatives of benzophenones, sulfonic acid derivatives of 3-benzylidene camphor and mixtures thereof. 7. Emulsions according to any one of claims 1 to 6, characterized in that the compound of formula (I) is selected from the group formed by carnosine, L-carnosine, D-carnosine, D/L -carnosine, carnicine, carnicine*HCl, anserine, D-anserine, L-anserine and L-anserine*HNO3 and mixtures thereof. 8. Emulsions according to any one of claims 1 to 7, characterized in that the emulsifiers are selected from the group formed by alkoxylates, alkyl and/or alkenyl oligoglycosides, partial glycerides, sorbitan esters , polyglyceric esters, fatty acids, amphoteric and/or cationic surfactants and mixtures thereof. 9. Emulsions according to any one of claims 1 to 8, characterized in that the carriers are selected from the group formed by water, alcohols, esters, butylene glycol, dipropylene glycol, ethanol, ethoxydiglycol, ethyl acetate, glycerin, propanol, isopropanol, macrogols, propylpropylene glycol methyl ether (2), propylene glycol methyl ether (3), propylene carbonate, propylene glycol, triethylene glycol, isoparaffin, amyl acetate, amyl benzoate, benzyl acetate, butyl acetate, butylene glycol, butyl lactate, butooctyl benzoate, butooctyl salicylate, C10-C13 alkanes, C14C17 alkanes, C11-C15 cycloalkanes, caprylyl butyrate, isoparaffin, diacetin, triacetin, dicapryl ether and dicaprylyl maleate and mixtures thereof. 10. Emulsions according to any one of claims 1 to 9, characterized in that the oily substances are selected from the group formed by Guerbet alcohols based on fatty alcohols with 6 to 18 carbon atoms, esters of linear C6-C22-fatty acids with linear or branched C6-C22-fatty alcohols or esters of branched C6-C13-carboxylic acids with linear or branched C6-C22-fatty alcohols, linear or branched C6-C22-fatty acid esters with alcohols esters of C18-C38-alkyl-hydroxycarboxylic acids with linear or branched C6-C22-fatty alcohols, esters of linear and/or branched fatty acids with polyvalent alcohols and/or Guerbet alcohols, triglycerides based on C6-C10 acids -fats, mixtures of liquid mono-/di-/triglycerides based on C6-C18-fatty acids, esters of C6-C22-fatty alcohols and/or Guerbet alcohols with aromatic carboxylic acids, esters of C2-C12-dicarboxylic acids with linear or branched alcohols 1 to 22 carbon atoms or polyols having 2 to 10 carbon atoms and 2 to 6 hydroxyl groups, vegetable oils, branched primary alcohols, substituted cyclohexanes, carbonates of linear or branched C6-C22-fatty alcohols, Guerbet carbonates based on fatty alcohols with 6 to 18, benzoic acid esters with C6-C22-linear and/or branched alcohols, symmetrical or asymmetrical, linear or branched dialkyl ethers with 6 to 22 carbon atoms per alkyl group, products ring-opening of epoxidized fatty acid esters with polyols, silicone oils, aliphatic or naphthenic hydrocarbons and mixtures thereof. 11. Emulsions according to any one of claims 1 to 10, characterized in that they have the following composition: (a) from 0.1 to 20% by weight of UV sun protection factors, (b) of 0.001 to 2.5% by weight of carnosine compounds, (c) from 1 to 30% by weight of emulsifiers, provided that the indicated amounts, with water and optionally with other auxiliary and additive substances, are supplemented by up to 100 % by weight. 12. Emulsions, according to claim 11, characterized in that they have the following composition: (a) from 0.1 to 20% by weight of UV sun protection factors, (b) from 0.001 to 2, 5% by weight of carnosine compounds, (c) from 1 to 30% by weight of emulsifiers, (d) from 5 to 50% by weight of vehicles, and (e) from 5 to 50% by weight of oily substances, provided that the amounts indicated, optionally with other auxiliary substances and additives, complement each other up to 100% by weight. 13. Process for the production of sunscreens in emulsion form, characterized in that it comprises the following steps: (i) providing at least one UV sun protection factor; (ii) providing at least one carnosine compound; (iii) providing at least one emulsifier; (iv) mixing components (a) and (b), optionally with the addition of vehicles, oily substances and/or other additive cosmetic substances forming an emulsion. 14. Use of carnosine compounds of formula (I), characterized by the fact that they are used as stabilizers for emulsions and, in particular, emulsions. 15. Use according to claim 14, characterized in that the carnosine compounds are used in amounts ranging from 0.001 to 2.5% by weight based on the emulsion.