BR112018011762A2 - método e aparelho para administração de gases inclu-indo óxido nítrico para combater fibrose - Google Patents

método e aparelho para administração de gases inclu-indo óxido nítrico para combater fibrose

Info

Publication number
BR112018011762A2
BR112018011762A2 BR112018011762A BR112018011762A BR112018011762A2 BR 112018011762 A2 BR112018011762 A2 BR 112018011762A2 BR 112018011762 A BR112018011762 A BR 112018011762A BR 112018011762 A BR112018011762 A BR 112018011762A BR 112018011762 A2 BR112018011762 A2 BR 112018011762A2
Authority
BR
Brazil
Prior art keywords
nitric oxide
gases including
including nitric
administering gases
administering
Prior art date
Application number
BR112018011762A
Other languages
English (en)
Inventor
H Fine David
A Dasse Kurt
K Wedel Mark
C Petit Priscilla
Original Assignee
Vero Biotech LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vero Biotech LLC filed Critical Vero Biotech LLC
Publication of BR112018011762A2 publication Critical patent/BR112018011762A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/104—Preparation of respiratory gases or vapours specially adapted for anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/14—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
    • A61M16/16—Devices to humidify the respiration air
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0027—Accessories therefor, e.g. sensors, vibrators, negative pressure pressure meter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
    • A61M2016/102—Measuring a parameter of the content of the delivered gas
    • A61M2016/1035—Measuring a parameter of the content of the delivered gas the anaesthetic agent concentration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0208—Oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0266—Nitrogen (N)
    • A61M2202/0275—Nitric oxide [NO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3368—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3546—Range
    • A61M2205/3561—Range local, e.g. within room or hospital
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/005—Parameter used as control input for the apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/205—Blood composition characteristics partial oxygen pressure (P-O2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/30—Blood pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2240/00—Specially adapted for neonatal use
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7052—Fibrosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

um método de modulação dos níveis de saturação de oxigê-nio pode incluir a medição dos níveis de saturação de oxigênio em um paciente, a administração de óxido nítrico inalado, o ajuste da dose de oxigênio em tempo real a uma segunda dose com base no óxido nítrico inalado.
BR112018011762A 2015-12-11 2016-12-11 método e aparelho para administração de gases inclu-indo óxido nítrico para combater fibrose BR112018011762A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562266466P 2015-12-11 2015-12-11
US201662336731P 2016-05-15 2016-05-15
PCT/US2016/066047 WO2017100731A1 (en) 2015-12-11 2016-12-11 Method and apparatus for administering gases including nitric oxide to address fibrosis

Publications (1)

Publication Number Publication Date
BR112018011762A2 true BR112018011762A2 (pt) 2018-12-04

Family

ID=59014314

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112018011803A BR112018011803A2 (pt) 2015-12-11 2016-12-11 método e mecanismo para a administração de gases incluindo óxido nítrico
BR112018011762A BR112018011762A2 (pt) 2015-12-11 2016-12-11 método e aparelho para administração de gases inclu-indo óxido nítrico para combater fibrose

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR112018011803A BR112018011803A2 (pt) 2015-12-11 2016-12-11 método e mecanismo para a administração de gases incluindo óxido nítrico

Country Status (7)

Country Link
US (3) US20170165447A1 (pt)
EP (2) EP3386577A4 (pt)
JP (2) JP2019501965A (pt)
AU (2) AU2016366697A1 (pt)
BR (2) BR112018011803A2 (pt)
CA (2) CA3008022A1 (pt)
WO (2) WO2017100731A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2019009934A (es) 2017-02-27 2020-01-30 Third Pole Inc Sistemas y metodos para generar oxido nitrico.
CA3151184A1 (en) 2017-02-27 2018-08-30 Third Pole, Inc. Systems and methods for ambulatory generation of nitric oxide
MX2020010523A (es) 2017-02-27 2021-02-09 Third Pole Inc Sistemas y metodos para generar oxido nitrico.
SG11202000893QA (en) * 2017-08-30 2020-02-27 Bellerophon Pulse Tech Llc Use of inhaled nitric oxide for the treatment of pulmonary hypertension associated with lung disease
JP7357213B2 (ja) * 2017-09-27 2023-10-06 パナソニックＩｐマネジメント株式会社 水素供給装置
MX2020006741A (es) * 2017-12-28 2020-11-24 Bellerophon Pulse Tech Llc Uso de oxigeno y oxido nitrico inhalado para el tratamiento de la hipertension pulmonar.
BR112020013109A2 (pt) * 2017-12-28 2020-11-24 Bellerophon Pulse Technologies Llc administração pulsada de óxido nítrico inalado para o tratamento da hipertensão pulmonar
US11754538B1 (en) * 2018-07-18 2023-09-12 Vero Biotech Inc. Method and apparatus for automatic calibration
US11672938B1 (en) 2018-07-18 2023-06-13 Vero Biotech LLC Start-up protocols for nitric oxide delivery device
TW202021637A (zh) * 2018-08-10 2020-06-16 美商貝勒羅豐治療公司 吸入性一氧化氮（ｉＮＯ）用於改善嚴重低血氧症之用途
WO2020232419A1 (en) 2019-05-15 2020-11-19 Third Pole, Inc. Systems and methods for generating nitric oxide
EP3969415A4 (en) 2019-05-15 2023-08-16 Third Pole, Inc. ELECTRODES FOR NITRIC OXIDE GENERATION
JP2023512444A (ja) 2020-01-11 2023-03-27 サード ポール，インコーポレイテッド 湿度制御を用いた酸化窒素生成のためのシステムおよび方法
CN113318123A (zh) * 2020-02-28 2021-08-31 ＭｉＺ株式会社 用于预防和/或改善肺炎的含分子态氢组合物
EP4167920A4 (en) 2020-06-18 2024-06-12 Third Pole, Inc. SYSTEMS AND METHODS FOR PREVENTING AND TREATING INFECTIONS WITH NITRIC OXIDE
CN113304373B (zh) * 2021-05-26 2023-01-20 新疆维吾尔自治区人民医院 一种麻醉科吸入式麻醉装置面罩及其控制方法
US11975139B2 (en) 2021-09-23 2024-05-07 Third Pole, Inc. Systems and methods for delivering nitric oxide

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5558083A (en) * 1993-11-22 1996-09-24 Ohmeda Inc. Nitric oxide delivery system
DK0973443T3 (da) * 1997-01-17 2006-07-24 Ino Therapeutics Gmbh Styret gasforsyningssystem
US5918596A (en) * 1997-04-22 1999-07-06 Instrumentarium Corp. Special gas dose delivery apparatus for respiration equipment
US20050217668A1 (en) * 2003-10-24 2005-10-06 Pulmonox Technologies Corporation System and elements for managing therapeutic gas administration to a spontaneously breathing non-ventilated patient
WO2008060783A2 (en) * 2006-10-05 2008-05-22 Centocor Ortho Biotech Inc. Ccr2 antagonists for treatment of fibrosis
US10780241B2 (en) * 2008-08-21 2020-09-22 Vero Biotech LLC Devices and methods for minimizing and treating high-altitude sickness
EP3578664A1 (en) * 2009-03-30 2019-12-11 Nordic Bioscience A/S Collagen iv neo-epitope fibrosis assay
US20120093948A1 (en) * 2009-11-20 2012-04-19 Fine David H Nitric Oxide Treatments
WO2011094684A1 (en) * 2010-02-01 2011-08-04 Geno Llc Nitric oxide delivery system
JP5581500B2 (ja) * 2010-03-10 2014-09-03 学校法人北里研究所 虚血再灌流障害軽減用治療剤および治療装置
EP2914324A4 (en) * 2012-11-05 2016-04-20 Geno Llc METHOD FOR MIXING GASES INCLUDING STAIN OXIDE
CA2905439A1 (en) * 2013-03-13 2014-10-02 Ino Therapeutics Llc Devices and methods for monitoring oxygenation during treatment with delivery of nitric oxide
US9629358B2 (en) * 2013-03-15 2017-04-25 Mallinckrodt Hospital Products IP Limited Administration and monitoring of nitric oxide in ex vivo fluids
US20160271056A1 (en) * 2013-12-23 2016-09-22 Nitric Solutions Inc. Cystic fibrosis treatment comprising nitric oxide
EP3209360B1 (en) * 2014-10-20 2022-12-07 VERO Biotech LLC Nitrogen dioxide storage cassette
EP3108920A1 (en) * 2015-06-22 2016-12-28 Linde AG Device for delivering nitric oxide and oxygen to a patient

Also Published As

Publication number Publication date
US20200368271A1 (en) 2020-11-26
JP2019501965A (ja) 2019-01-24
US20170165447A1 (en) 2017-06-15
EP3386577A1 (en) 2018-10-17
CA3008022A1 (en) 2017-06-15
EP3386574A4 (en) 2019-07-17
AU2016366697A1 (en) 2018-06-28
EP3386577A4 (en) 2019-09-25
JP2019506259A (ja) 2019-03-07
AU2016366699A1 (en) 2018-06-28
EP3386574A1 (en) 2018-10-17
WO2017100731A1 (en) 2017-06-15
WO2017100729A1 (en) 2017-06-15
US20170165294A1 (en) 2017-06-15
CA3008000A1 (en) 2017-06-15
BR112018011803A2 (pt) 2018-12-04

Similar Documents

Publication Publication Date Title
BR112018011762A2 (pt) método e aparelho para administração de gases inclu-indo óxido nítrico para combater fibrose
CY1121150T1 (el) Νευροδραστικα 19-αλκοξυ-17-υποκατεστημενα στεροειδη, χρησιμα σε μεθοδους θεραπειας
CY1124368T1 (el) Μεθοδοι αυξησης της τονικης αναστολης και θεραπειας του συνδρομου angelman
BR112019008930A2 (pt) métodos e sistemas para gerenciar conformidade de paciente
EP4252833A3 (en) Microstimulation sleep disordered breathing (sdb) therapy device
CY1123354T1 (el) Συνθεσεις τοπικης εφαρμογης που περιλαμβανουν ενα κορτικοστεροειδες και ενα ρετινοειδες για τη θεραπεια της ψωριασης
NZ746112A (en) Cyclic di-nucleotide compounds and methods of use
BR112016020618A8 (pt) oligômero antissentido, composição farmacêutica, e, uso de um oligômero antissentido
BR112015023203A8 (pt) métodos para tratamento de câncer, método para aumentar a eficiência de um tratamento de câncer, método para retardar e/ou prevenir o desenvolvimento de câncer, método para tratar um indivíduo com câncer, método para aumentar a sensibilidade para um agente de terapia para câncer, método para estender um período de sensibilidade e método para estender a duração da resposta para uma terapia para câncer.
BR112017005693A2 (pt) método para tratar e/ou prevenir uma doença hepática, e, composição farmacêutica.
NZ707064A (en) Method and systems for the delivery of oxygen enriched gas
NZ726256A (en) Methods for treating pulmonary non-tuberculous mycobacterial infections
BR112018013245A2 (pt) método e aparelho para administração óxido nítrico com drogas suplementares
WO2015117010A3 (en) Bag3 as a target for therapy of heart failure
EA201691155A1 (ru) Комбинации ингибиторов гистондеацетилазы и иммуномодулирующих лекарственных средств
WO2019006005A3 (en) METHODS AND COMPOSITIONS FOR THE TREATMENT OF MELANOMA
BR112015023020A2 (pt) combinação de inibidor de egfr t790m e inibidor de egfr para o tratamento de câncer pulmonar de células não-pequenas
CL2017003066A1 (es) Composiciones de carbonato de calcio amorfo para administración mediante inhalación, sublingual o bucal
CR20170259A (es) Terapias de envenenamiento y composiciones farmacéuticas, sistemas y equipos relacionados
MX2018011813A (es) Medicina obtenida mediante la combinacion de agonista fxr y arb.
CY1124734T1 (el) Μορφες δοσολογιας αυξητικης ορμονικης μακρας δρασης
BR112017014361A2 (pt) métodos para aperfeiçoamento de terapia celular
IN2014KN02583A (pt)
BR112014030404A2 (pt) proteína de fusão hgh-xten e seu uso no tratamento da deficiência de hormônio do crescimento
BR112017014994A2 (pt) formulação em pó nasal para o tratamento de hipoglicemia

Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2700 DE 04-10-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.