BR112018011096A2 - novos peptídeos que têm atividade antimicrobiana e nova enzima capaz de converter resíduo de configuração l em aminoácido de configuração d em um peptídeo - Google Patents

novos peptídeos que têm atividade antimicrobiana e nova enzima capaz de converter resíduo de configuração l em aminoácido de configuração d em um peptídeo

Info

Publication number
BR112018011096A2
BR112018011096A2 BR112018011096A BR112018011096A BR112018011096A2 BR 112018011096 A2 BR112018011096 A2 BR 112018011096A2 BR 112018011096 A BR112018011096 A BR 112018011096A BR 112018011096 A BR112018011096 A BR 112018011096A BR 112018011096 A2 BR112018011096 A2 BR 112018011096A2
Authority
BR
Brazil
Prior art keywords
configuration
amino acid
peptide
converting
antimicrobial activity
Prior art date
Application number
BR112018011096A
Other languages
English (en)
Inventor
Guillot Alain
Benjdia Alhosna
Berteau Olivier
Original Assignee
Inst Nat De La Rech Agronomique Inra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat De La Rech Agronomique Inra filed Critical Inst Nat De La Rech Agronomique Inra
Publication of BR112018011096A2 publication Critical patent/BR112018011096A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

a presente invenção se refere a uma nova classe de peptídeos que tem atividade antibacteriana e está presente em d-aminoácidos e seus usos. a mesma também se refere a uma nova enzima que apresenta uma atividade de epimerase de peptídeo in vitro e in vivo, sendo assim útil para modificar peptídeos a fim de alterar a configuração de aminoácido de l para d.
BR112018011096A 2015-12-02 2016-12-01 novos peptídeos que têm atividade antimicrobiana e nova enzima capaz de converter resíduo de configuração l em aminoácido de configuração d em um peptídeo BR112018011096A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15306909 2015-12-02
EP16183955 2016-08-12
PCT/EP2016/079362 WO2017093366A1 (en) 2015-12-02 2016-12-01 New peptides having antimicrobial activity and new enzyme capable of converting l-configured residue in d-configured amino acid in a peptide

Publications (1)

Publication Number Publication Date
BR112018011096A2 true BR112018011096A2 (pt) 2018-12-04

Family

ID=57482394

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018011096A BR112018011096A2 (pt) 2015-12-02 2016-12-01 novos peptídeos que têm atividade antimicrobiana e nova enzima capaz de converter resíduo de configuração l em aminoácido de configuração d em um peptídeo

Country Status (7)

Country Link
US (1) US10981957B2 (pt)
JP (1) JP2019500338A (pt)
CN (1) CN108368158A (pt)
BR (1) BR112018011096A2 (pt)
CA (1) CA3006403A1 (pt)
MX (1) MX2018006610A (pt)
WO (1) WO2017093366A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11174288B2 (en) 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL71691A (en) 1984-04-27 1991-04-15 Yeda Res & Dev Production of interferon-ypsilon
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
US5047335A (en) 1988-12-21 1991-09-10 The Regents Of The University Of Calif. Process for controlling intracellular glycosylation of proteins
FR2704860B1 (fr) 1993-05-05 1995-07-13 Pasteur Institut Sequences de nucleotides du locus cryiiia pour le controle de l'expression de sequences d'adn dans un hote cellulaire.
ATE294871T1 (de) 1994-06-30 2005-05-15 Novozymes Biotech Inc Nicht-toxisches, nicht-toxigenes, nicht- pathogenes fusarium expressionssystem und darin zu verwendende promotoren und terminatoren
US5955310A (en) 1998-02-26 1999-09-21 Novo Nordisk Biotech, Inc. Methods for producing a polypeptide in a bacillus cell
AU6188599A (en) 1998-10-26 2000-05-15 Novozymes A/S Constructing and screening a dna library of interest in filamentous fungal cells
EP2278016B1 (en) 1999-03-22 2012-09-26 Novozymes Inc. Promoter sequences derived from Fusarium Venenatum and uses thereof
US20060121083A1 (en) 2003-07-18 2006-06-08 Technion Research & Development Foundation Ltd. Anti-microbial medical implants and uses thereof
US7148404B2 (en) * 2004-05-04 2006-12-12 Novozymes A/S Antimicrobial polypeptides
US20070184015A1 (en) 2006-02-03 2007-08-09 Soonkap Hahn Novel PEGylation agent
EP3248985B1 (en) * 2007-01-19 2019-10-23 Kai Pharmaceuticals, Inc. Modifications of peptide compositions to increase stability and delivery efficiency

Also Published As

Publication number Publication date
JP2019500338A (ja) 2019-01-10
CN108368158A (zh) 2018-08-03
WO2017093366A1 (en) 2017-06-08
CA3006403A1 (en) 2017-06-08
US20180346526A1 (en) 2018-12-06
MX2018006610A (es) 2019-05-27
US10981957B2 (en) 2021-04-20

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired