BR112018008250A2 - sequência de meio filtrante para purificação de biomateriais - Google Patents
sequência de meio filtrante para purificação de biomateriaisInfo
- Publication number
- BR112018008250A2 BR112018008250A2 BR112018008250A BR112018008250A BR112018008250A2 BR 112018008250 A2 BR112018008250 A2 BR 112018008250A2 BR 112018008250 A BR112018008250 A BR 112018008250A BR 112018008250 A BR112018008250 A BR 112018008250A BR 112018008250 A2 BR112018008250 A2 BR 112018008250A2
- Authority
- BR
- Brazil
- Prior art keywords
- filter medium
- biomaterials
- purification
- sequence
- filter media
- Prior art date
Links
- 239000012620 biological material Substances 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 238000005349 anion exchange Methods 0.000 abstract 2
- 239000012982 microporous membrane Substances 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract 1
- 238000011144 upstream manufacturing Methods 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/14—Pleat-type membrane modules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/10—Spiral-wound membrane modules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0081—After-treatment of organic or inorganic membranes
- B01D67/009—After-treatment of organic or inorganic membranes with wave-energy, particle-radiation or plasma
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0081—After-treatment of organic or inorganic membranes
- B01D67/0093—Chemical modification
- B01D67/00931—Chemical modification by introduction of specific groups after membrane formation, e.g. by grafting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0081—After-treatment of organic or inorganic membranes
- B01D67/0093—Chemical modification
- B01D67/00933—Chemical modification by addition of a layer chemically bonded to the membrane
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/10—Supported membranes; Membrane supports
- B01D69/107—Organic support material
- B01D69/1071—Woven, non-woven or net mesh
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/06—Organic material
- B01D71/40—Polymers of unsaturated acids or derivatives thereof, e.g. salts, amides, imides, nitriles, anhydrides, esters
- B01D71/401—Polymers based on the polymerisation of acrylic acid, e.g. polyacrylate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/06—Organic material
- B01D71/76—Macromolecular material not specifically provided for in a single one of groups B01D71/08 - B01D71/74
- B01D71/78—Graft polymers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2323/00—Details relating to membrane preparation
- B01D2323/15—Use of additives
- B01D2323/16—Swelling agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2323/00—Details relating to membrane preparation
- B01D2323/15—Use of additives
- B01D2323/218—Additive materials
- B01D2323/2182—Organic additives
- B01D2323/21827—Salts
- B01D2323/21828—Ammonium Salts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2323/00—Details relating to membrane preparation
- B01D2323/34—Use of radiation
- B01D2323/345—UV-treatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2323/00—Details relating to membrane preparation
- B01D2323/38—Graft polymerization
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2323/00—Details relating to membrane preparation
- B01D2323/38—Graft polymerization
- B01D2323/385—Graft polymerization involving radiation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2323/00—Details relating to membrane preparation
- B01D2323/42—Details of membrane preparation apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2325/00—Details relating to properties of membranes
- B01D2325/16—Membrane materials having positively charged functional groups
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2325/00—Details relating to properties of membranes
- B01D2325/42—Ion-exchange membranes
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Transplantation (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Water Supply & Treatment (AREA)
- Plasma & Fusion (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Filtering Materials (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
Abstract
a presente invenção refere-se a um meio filtrante que compreende: (i) um primeiro meio filtrante compreendendo um substrato não tecido de troca aniônica, sendo que o substrato não tecido de troca aniônica compreende uma pluralidade de grupos amônio quaternário; e (ii) um segundo meio filtrante compreendendo uma membrana microporosa funcionalizada, sendo que a membrana microporosa funcionalizada compreende uma pluralidade de grupos guanidila; sendo que o primeiro meio filtrante está posicionado a montante do segun-do meio filtrante.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562245403P | 2015-10-23 | 2015-10-23 | |
US62/245,403 | 2015-10-23 | ||
PCT/US2016/056326 WO2017069965A1 (en) | 2015-10-23 | 2016-10-11 | Filtration medium sequence for biomaterial purification |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112018008250A2 true BR112018008250A2 (pt) | 2018-10-23 |
BR112018008250B1 BR112018008250B1 (pt) | 2022-10-04 |
Family
ID=57218993
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018008250-3A BR112018008250B1 (pt) | 2015-10-23 | 2016-10-11 | Sequência de meio filtrante, dispositivo filtrante e método de fabricação de um fluido biológico |
Country Status (7)
Country | Link |
---|---|
US (1) | US10722848B2 (pt) |
EP (1) | EP3365095B1 (pt) |
JP (1) | JP6924750B2 (pt) |
CN (1) | CN108136338B (pt) |
BR (1) | BR112018008250B1 (pt) |
RU (1) | RU2698822C1 (pt) |
WO (1) | WO2017069965A1 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US9725710B2 (en) | 2014-01-08 | 2017-08-08 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
TWI675696B (zh) * | 2017-06-01 | 2019-11-01 | 美商Emd密理博公司 | 用於灌注應用之切向流過濾裝置 |
KR102439221B1 (ko) | 2017-12-14 | 2022-09-01 | 프로디자인 소닉스, 인크. | 음향 트랜스듀서 구동기 및 제어기 |
US11045773B2 (en) * | 2018-08-31 | 2021-06-29 | Pall Corporation | Salt tolerant porous medium |
US10737259B2 (en) * | 2018-08-31 | 2020-08-11 | Pall Corporation | Salt tolerant anion exchange medium |
US20200171442A1 (en) * | 2018-11-30 | 2020-06-04 | Entegris, Inc. | Hydrophilic filter membrane with pendant hydrophilic groups, and related methods of preparation and use |
WO2020128797A1 (en) | 2018-12-21 | 2020-06-25 | 3M Innovative Properties Company | Method for testing a chromatography device used for ion exchange |
CN111471101A (zh) * | 2020-04-13 | 2020-07-31 | 国药集团武汉血液制品有限公司 | 一种去除人免疫球蛋白类制品中残留的IgA的方法 |
WO2022015714A1 (en) * | 2020-07-14 | 2022-01-20 | Donaldson Company, Inc. | System and method for deaeration |
CN116615434A (zh) | 2020-12-04 | 2023-08-18 | 3M创新有限公司 | 用于生物材料纯化的过滤单元和方法 |
WO2022136968A1 (en) * | 2020-12-23 | 2022-06-30 | 3M Innovative Properties Company | Method of separating a virus from a composition using copolymer-grafted nonwoven substrates |
WO2023089412A1 (en) | 2021-11-19 | 2023-05-25 | 3M Innovative Properties Company | Method for biomaterial purification |
WO2024038338A1 (en) * | 2022-08-15 | 2024-02-22 | Solventum Intellectual Properties Company | Functionalized porous substrates and their use for detecting analytes |
CN220723675U (zh) * | 2023-02-17 | 2024-04-05 | 纳诺多克斯科技有限公司 | 液体过滤器 |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4740913Y1 (pt) | 1970-06-23 | 1972-12-11 | ||
US3876738A (en) | 1973-07-18 | 1975-04-08 | Amf Inc | Process for producing microporous films and products |
US3928517A (en) | 1973-12-26 | 1975-12-23 | Amf Inc | Quench bath regeneration system for microporous film production |
CA1073648A (en) | 1976-08-02 | 1980-03-18 | Edward R. Hauser | Web of blended microfibers and crimped bulking fibers |
DE3146913C2 (de) | 1981-11-26 | 1983-10-06 | C.A. Weidmueller Gmbh & Co, 4930 Detmold | Querverbinder |
US4707265A (en) | 1981-12-18 | 1987-11-17 | Cuno Incorporated | Reinforced microporous membrane |
US4726989A (en) | 1986-12-11 | 1988-02-23 | Minnesota Mining And Manufacturing | Microporous materials incorporating a nucleating agent and methods for making same |
US4867881A (en) | 1987-09-14 | 1989-09-19 | Minnesota Minning And Manufacturing Company | Orientied microporous film |
US5120594A (en) | 1989-11-20 | 1992-06-09 | Minnesota Mining And Manufacturing Company | Microporous polyolefin shaped articles with patterned surface areas of different porosity |
US5260360A (en) | 1991-10-18 | 1993-11-09 | Minnesota Mining And Manufacturing Company | Oil, water and sweat repellent microporous membrane materials |
US5522997A (en) * | 1993-03-16 | 1996-06-04 | Cognis, Inc. | Process for the removal of toxic cyanide and heavy metal species from alkaline solutions |
CA2127605A1 (en) | 1993-12-23 | 1995-06-24 | Peter J. Degen | Affinity separation method |
US5458782A (en) | 1994-01-07 | 1995-10-17 | Cuno Incorporated | Hydrolytically stable nylon membrane |
US5962544A (en) | 1995-12-07 | 1999-10-05 | 3M | Microporous materials of ethylene-vinyl alcohol copolymer and methods for making same |
US6056529A (en) | 1998-02-11 | 2000-05-02 | Cuno, Inc. | Systems for producing a plurality of different microporous phase inversion membrane each having any one of a plurality of different pore sizes from a single master dope batch |
US6413070B1 (en) | 1997-04-11 | 2002-07-02 | Cuno Incorporated | System for manufacturing reinforced three-zone microporous membrane |
AU758994B2 (en) | 1998-08-17 | 2003-04-03 | 3M Innovative Properties Company | Edge seal for filter cartridge |
US6712966B1 (en) | 1999-02-04 | 2004-03-30 | Cuno Incorporated | Graded particle-size retention filter medium for cell-type filter unit |
US6939466B2 (en) | 1998-08-17 | 2005-09-06 | Cuno Incorporated | Graded particle-size retention filter medium for fluid filtration unit with improved edge seal |
AU765826B2 (en) | 1999-01-07 | 2003-10-02 | 3M Innovative Properties Company | Pleated filter element and method of forming a pleated filter element |
US6780327B1 (en) | 1999-02-25 | 2004-08-24 | Pall Corporation | Positively charged membrane |
US6521011B1 (en) | 1999-07-15 | 2003-02-18 | 3M Innovative Properties Company | Self-supporting pleated filter and method of making same |
RU2170136C1 (ru) * | 2000-06-06 | 2001-07-10 | Государственный научный центр Российской Федерации Физико-энергетический институт им. акад. А.И. Лейпунского | Многослойный фильтрующий материал для ультра- и микрофильтрации и способ его изготовления |
ITTO20030039A1 (it) * | 2003-01-24 | 2004-07-25 | Fresenius Hemocare Italia Srl | Filtro per separare leucociti da sangue intero e/o da preparati derivati dal sangue, procedimento per la fabbricazione del filtro, dispositivo e utilizzazione. |
US7338692B2 (en) | 2003-09-12 | 2008-03-04 | 3M Innovative Properties Company | Microporous PVDF films |
JP5182793B2 (ja) * | 2007-10-12 | 2013-04-17 | 独立行政法人日本原子力研究開発機構 | 液体濾過用カートリッジフィルタ |
EP2522692B1 (en) | 2008-05-30 | 2014-06-18 | 3M Innovative Properties Company | Ligand monomers and copolymers made therewith |
EP2313183B1 (en) | 2008-05-30 | 2015-11-04 | 3M Innovative Properties Company | Ligand functionalized substrates |
DE102008037678A1 (de) | 2008-08-14 | 2010-02-25 | Sartorius Stedim Biotech Gmbh | Tiefenfilterschicht mit anorganischem Schichtdoppelhydroxid |
WO2010033807A1 (en) | 2008-09-19 | 2010-03-25 | 3M Innovative Properties Company | Ligand graft functionalized substrates |
CN102227246B (zh) | 2008-11-04 | 2015-06-17 | 3M创新有限公司 | 过滤器元件及其密封部 |
BRPI0916060A2 (pt) | 2008-11-04 | 2015-11-10 | 3M Innovative Properties Co | "interconector para fluidos" |
WO2010074773A1 (en) | 2008-12-23 | 2010-07-01 | 3M Innovative Properties Company | Functionalized nonwoven article |
US20100210160A1 (en) | 2009-02-18 | 2010-08-19 | 3M Innovative Properties Company | Hydrophilic porous substrates |
WO2010151447A1 (en) * | 2009-06-23 | 2010-12-29 | 3M Innovative Properties Company | Functionalized nonwoven article |
US9272246B2 (en) | 2011-03-28 | 2016-03-01 | 3M Innovative Properties Company | Ligand functional substrates |
EP2841640B1 (en) * | 2012-04-24 | 2018-10-10 | 3M Innovative Properties Company | Nonwoven article grafted with copolymer |
CN104736235B (zh) * | 2012-06-05 | 2017-10-13 | 3M创新有限公司 | 接枝共聚物官能化制品 |
WO2014052215A1 (en) | 2012-09-27 | 2014-04-03 | 3M Innovative Properties Company | Ligand grafted substrates |
AU2016243036B2 (en) * | 2015-04-03 | 2022-02-17 | Abbott Laboratories | Devices and methods for sample analysis |
-
2016
- 2016-10-11 WO PCT/US2016/056326 patent/WO2017069965A1/en active Application Filing
- 2016-10-11 EP EP16788850.2A patent/EP3365095B1/en active Active
- 2016-10-11 JP JP2018520105A patent/JP6924750B2/ja active Active
- 2016-10-11 RU RU2018112487A patent/RU2698822C1/ru active
- 2016-10-11 US US15/755,584 patent/US10722848B2/en active Active
- 2016-10-11 CN CN201680061591.0A patent/CN108136338B/zh active Active
- 2016-10-11 BR BR112018008250-3A patent/BR112018008250B1/pt active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
JP2018538127A (ja) | 2018-12-27 |
CN108136338A (zh) | 2018-06-08 |
EP3365095B1 (en) | 2024-07-24 |
WO2017069965A1 (en) | 2017-04-27 |
US10722848B2 (en) | 2020-07-28 |
BR112018008250B1 (pt) | 2022-10-04 |
JP6924750B2 (ja) | 2021-08-25 |
US20180257042A1 (en) | 2018-09-13 |
CN108136338B (zh) | 2021-09-03 |
RU2698822C1 (ru) | 2019-08-30 |
EP3365095A1 (en) | 2018-08-29 |
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Legal Events
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B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 11/10/2016, OBSERVADAS AS CONDICOES LEGAIS |