BR112018008075A2 - treatment methods using anti-il-17a / f antibodies - Google Patents
treatment methods using anti-il-17a / f antibodiesInfo
- Publication number
- BR112018008075A2 BR112018008075A2 BR112018008075-6A BR112018008075A BR112018008075A2 BR 112018008075 A2 BR112018008075 A2 BR 112018008075A2 BR 112018008075 A BR112018008075 A BR 112018008075A BR 112018008075 A2 BR112018008075 A2 BR 112018008075A2
- Authority
- BR
- Brazil
- Prior art keywords
- human
- antibody
- seq
- week
- weeks
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562246989P | 2015-10-27 | 2015-10-27 | |
| US62/246,989 | 2015-10-27 | ||
| US201662303230P | 2016-03-03 | 2016-03-03 | |
| US62/303,230 | 2016-03-03 | ||
| US201662346826P | 2016-06-07 | 2016-06-07 | |
| US62/346,826 | 2016-06-07 | ||
| US201662405546P | 2016-10-07 | 2016-10-07 | |
| US62/405,546 | 2016-10-07 | ||
| PCT/EP2016/075821 WO2017072183A1 (en) | 2015-10-27 | 2016-10-26 | Methods of treatment using anti-il-17a/f antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018008075A2 true BR112018008075A2 (en) | 2018-12-04 |
Family
ID=57223670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018008075-6A BR112018008075A2 (en) | 2015-10-27 | 2016-10-26 | treatment methods using anti-il-17a / f antibodies |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US11492396B2 (https=) |
| EP (1) | EP3368570A1 (https=) |
| JP (5) | JP6931648B2 (https=) |
| KR (2) | KR20240156437A (https=) |
| CN (2) | CN116059350A (https=) |
| AU (2) | AU2016347471B2 (https=) |
| BR (1) | BR112018008075A2 (https=) |
| CA (1) | CA3001260A1 (https=) |
| CL (3) | CL2018001135A1 (https=) |
| CO (1) | CO2018004493A2 (https=) |
| IL (2) | IL258515B1 (https=) |
| MX (4) | MX2018005031A (https=) |
| MY (3) | MY206805A (https=) |
| RU (1) | RU2754683C2 (https=) |
| SG (2) | SG11201802887PA (https=) |
| WO (1) | WO2017072183A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018119142A1 (en) | 2016-12-21 | 2018-06-28 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| US20200277369A1 (en) * | 2017-11-20 | 2020-09-03 | Novartis Ag | Method of treating hidradentitis suppurativa with il-17 antagonists |
| GB201719447D0 (en) * | 2017-11-23 | 2018-01-10 | Ucb Biopharma Sprl | Pharmaceutical composition |
| WO2021050563A1 (en) * | 2019-09-09 | 2021-03-18 | The Rockefeller University | Antibody treatment for lesional tissue of hidradenitis suppurativa |
| US20230167497A1 (en) * | 2020-04-30 | 2023-06-01 | Xiaohua Xue | Methods of identifying modulators of the il-17 pathway |
| WO2022127842A1 (zh) * | 2020-12-17 | 2022-06-23 | 上海华奥泰生物药业股份有限公司 | 靶向il-17a和il-36r的双特异性抗体及其应用 |
| EP4471427A1 (en) * | 2023-05-31 | 2024-12-04 | Centre Hospitalier Universitaire De Nice | Biomarker for spondyloarthitis diagnostic and response to treatment |
| CN117866905B (zh) * | 2024-03-12 | 2024-06-04 | 北京贝来药业有限公司 | 基于纳米抗体基因修饰的干细胞及其制备方法和产品 |
| US20260070969A1 (en) * | 2024-09-11 | 2026-03-12 | Paragon Therapeutics, Inc. | Il-17 binding proteins, compositions, and methods of use thereof |
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| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| DK336987D0 (da) | 1987-07-01 | 1987-07-01 | Novo Industri As | Immobiliseringsmetode |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| GB8719042D0 (en) | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
| GB8720833D0 (en) | 1987-09-04 | 1987-10-14 | Celltech Ltd | Recombinant dna product |
| EP0436597B1 (en) | 1988-09-02 | 1997-04-02 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GB8907617D0 (en) | 1989-04-05 | 1989-05-17 | Celltech Ltd | Drug delivery system |
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| US5780225A (en) | 1990-01-12 | 1998-07-14 | Stratagene | Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules |
| AU7247191A (en) | 1990-01-11 | 1991-08-05 | Molecular Affinities Corporation | Production of antibodies using gene libraries |
| DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| CA2090126C (en) | 1990-08-02 | 2002-10-22 | John W. Schrader | Methods for the production of proteins with a desired function |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
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| CA2737241C (en) | 2008-09-26 | 2017-08-29 | Ucb Pharma S.A. | Multivalent antibody fusion proteins |
| RU2394575C1 (ru) * | 2009-04-13 | 2010-07-20 | Федеральное государственное учреждение "Уральский научно-исследовательский институт дерматовенерологии и иммунопатологии Федерального агентства по высокотехнологичной медицинской помощи" (ФГУ "УрНИИДВиИ Росмедтехнологий") | Способ лечения псориаза |
| CN102458437B (zh) | 2009-05-05 | 2015-06-10 | 诺维莫尼公司 | 抗il-17f抗体及其使用方法 |
| WO2011030107A1 (en) | 2009-09-10 | 2011-03-17 | Ucb Pharma S.A. | Multivalent antibodies |
| GB0920127D0 (en) | 2009-11-17 | 2009-12-30 | Ucb Pharma Sa | Antibodies |
| GB201000467D0 (en) | 2010-01-12 | 2010-02-24 | Ucb Pharma Sa | Antibodies |
| CN103154031A (zh) | 2010-10-08 | 2013-06-12 | 诺华有限公司 | 利用il-17拮抗剂治疗牛皮癣的方法 |
| ME02734B (me) * | 2011-01-14 | 2017-10-20 | Ucb Biopharma Sprl | Antitelo koje vezuje il-17a i il-17f |
| UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
| EP2783014A1 (en) | 2011-11-21 | 2014-10-01 | Novartis AG | Methods of treating psoriatic arthritis (psa) using il-17 antagonists and psa response or non- response alleles |
| WO2013158821A2 (en) | 2012-04-20 | 2013-10-24 | Novartis Ag | Methods of treating ankylosing spondylitis using il-17 antagonists |
| GB201213571D0 (en) | 2012-07-31 | 2012-09-12 | Univ Leuven Kath | Growth factor cocktail to enhnce osteogenic differentiayion of mesenchymal |
| LT2953969T (lt) * | 2013-02-08 | 2019-12-10 | Novartis Ag | Anti-il-17a antikūnai ir jų panaudojimas autoimuninių ir uždegiminių ligų gydymui |
| WO2014155278A2 (en) | 2013-03-26 | 2014-10-02 | Novartis Ag | Methods of treating autoimmune diseases using il-17 antagonists |
| CN115957326A (zh) | 2014-09-10 | 2023-04-14 | 诺华股份有限公司 | 使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展 |
| CA3002622A1 (en) | 2015-10-19 | 2017-04-27 | Novartis Ag | Methods of treating non-radiographic axial spondyloarthritis using interleukin-17 (il-17) antagonists |
| GB201522391D0 (en) | 2015-12-18 | 2016-02-03 | Ucb Biopharma Sprl | Antibody molecules |
| RU2680011C2 (ru) | 2016-04-29 | 2019-02-14 | Закрытое Акционерное Общество "Биокад" | Триспецифические антитела против il-17a, il-17f и другой провоспалительной молекулы |
-
2016
- 2016-10-26 CN CN202211252125.4A patent/CN116059350A/zh active Pending
- 2016-10-26 MY MYPI2022000672A patent/MY206805A/en unknown
- 2016-10-26 SG SG11201802887PA patent/SG11201802887PA/en unknown
- 2016-10-26 CA CA3001260A patent/CA3001260A1/en active Pending
- 2016-10-26 BR BR112018008075-6A patent/BR112018008075A2/en not_active Application Discontinuation
- 2016-10-26 AU AU2016347471A patent/AU2016347471B2/en active Active
- 2016-10-26 WO PCT/EP2016/075821 patent/WO2017072183A1/en not_active Ceased
- 2016-10-26 MY MYPI2022000687A patent/MY207225A/en unknown
- 2016-10-26 SG SG10202112586WA patent/SG10202112586WA/en unknown
- 2016-10-26 MY MYPI2018701559A patent/MY196489A/en unknown
- 2016-10-26 RU RU2018118029A patent/RU2754683C2/ru active
- 2016-10-26 KR KR1020247035487A patent/KR20240156437A/ko active Pending
- 2016-10-26 EP EP16790313.7A patent/EP3368570A1/en active Pending
- 2016-10-26 KR KR1020187014392A patent/KR20180067676A/ko not_active Ceased
- 2016-10-26 JP JP2018521530A patent/JP6931648B2/ja active Active
- 2016-10-26 US US15/771,310 patent/US11492396B2/en active Active
- 2016-10-26 MX MX2018005031A patent/MX2018005031A/es unknown
- 2016-10-26 CN CN201680062741.XA patent/CN108350068A/zh active Pending
-
2018
- 2018-04-05 IL IL258515A patent/IL258515B1/en unknown
- 2018-04-24 MX MX2022009380A patent/MX2022009380A/es unknown
- 2018-04-24 MX MX2022009379A patent/MX2022009379A/es unknown
- 2018-04-24 MX MX2023004315A patent/MX2023004315A/es unknown
- 2018-04-26 CO CONC2018/0004493A patent/CO2018004493A2/es unknown
- 2018-04-27 CL CL2018001135A patent/CL2018001135A1/es unknown
-
2021
- 2021-04-27 JP JP2021074962A patent/JP6931750B2/ja active Active
- 2021-06-01 JP JP2021092630A patent/JP7176044B2/ja active Active
- 2021-10-26 CL CL2021002816A patent/CL2021002816A1/es unknown
- 2021-10-26 CL CL2021002815A patent/CL2021002815A1/es unknown
-
2022
- 2022-10-11 US US18/045,623 patent/US20230287100A1/en active Pending
- 2022-10-11 US US18/045,597 patent/US20230279093A1/en active Pending
- 2022-11-09 JP JP2022179423A patent/JP2023025019A/ja active Pending
-
2023
- 2023-10-27 AU AU2023255037A patent/AU2023255037A1/en active Pending
-
2024
- 2024-11-22 JP JP2024203901A patent/JP2025037926A/ja active Pending
-
2025
- 2025-12-23 IL IL325567A patent/IL325567A/en unknown
Also Published As
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| US20230279093A1 (en) | Methods of Treatment Using Anti-IL-17A/F Antibodies | |
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