BR112018007958A2 - composições e métodos que usam um polifenol para a saúde musculoesquelética - Google Patents

composições e métodos que usam um polifenol para a saúde musculoesquelética

Info

Publication number
BR112018007958A2
BR112018007958A2 BR112018007958-8A BR112018007958A BR112018007958A2 BR 112018007958 A2 BR112018007958 A2 BR 112018007958A2 BR 112018007958 A BR112018007958 A BR 112018007958A BR 112018007958 A2 BR112018007958 A2 BR 112018007958A2
Authority
BR
Brazil
Prior art keywords
muscle
polyphenol
compositions
methods
functionality
Prior art date
Application number
BR112018007958-8A
Other languages
English (en)
Other versions
BR112018007958B1 (pt
Inventor
Noëlle Horcajada Marie
Membrez Fanny
Breuille Denis
Boutry Claire
Original Assignee
Nestec S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nestec S.A. filed Critical Nestec S.A.
Publication of BR112018007958A2 publication Critical patent/BR112018007958A2/pt
Publication of BR112018007958B1 publication Critical patent/BR112018007958B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/185—Vegetable proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A61K38/011—Hydrolysed proteins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

a presente invenção refere-se a uma composição que compreende um ou mais polifenóis, como oleuropeína, rutina, quercetina ou curcumina, que pode tratar ou evitar a sarcopenia, reduzir a perda da funcionalidade muscular (por exemplo, força muscular, velocidade de marcha, etc.), aumentar a funcionalidade muscular e/ou melhorar a recuperação da funcionalidade muscular após atrofia muscular. a composição pode ser administrada a um indivíduo que é idoso e/ou frágil.
BR112018007958-8A 2015-11-17 2016-11-17 Composições compreendendo polifenol, e uso não-terapêutico de oleuropeína. BR112018007958B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562256401P 2015-11-17 2015-11-17
US62/256,401 2015-11-17
PCT/EP2016/078014 WO2017085190A1 (en) 2015-11-17 2016-11-17 Compositions and methods using a polyphenol for musculoskeletal health

Publications (2)

Publication Number Publication Date
BR112018007958A2 true BR112018007958A2 (pt) 2018-10-30
BR112018007958B1 BR112018007958B1 (pt) 2022-04-19

Family

ID=57354360

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018007958-8A BR112018007958B1 (pt) 2015-11-17 2016-11-17 Composições compreendendo polifenol, e uso não-terapêutico de oleuropeína.

Country Status (10)

Country Link
US (3) US10751357B2 (pt)
EP (3) EP3376881B1 (pt)
JP (1) JP6859336B2 (pt)
CN (2) CN116617196A (pt)
AU (1) AU2016358236B2 (pt)
BR (1) BR112018007958B1 (pt)
CA (2) CA3224027A1 (pt)
ES (1) ES2788166T3 (pt)
MX (1) MX2018005779A (pt)
WO (1) WO2017085190A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116617196A (zh) 2015-11-17 2023-08-22 雀巢产品有限公司 将多酚用于肌肉骨骼健康的组合物和方法
US10744100B2 (en) * 2015-11-17 2020-08-18 Societe Des Produits Nestle S.A. Compositions and methods using a polyphenol for musculoskeletal health
WO2018178029A1 (en) * 2017-03-27 2018-10-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treating degenerative muscular and/or neurological conditions or diseases
JP2021503878A (ja) * 2017-11-21 2021-02-15 ソシエテ・デ・プロデュイ・ネスレ・エス・アー 筋肉の質及び／又は筋量のためのオレウロペイン又はクルクミンを使用する組成物及び方法
CN112888320A (zh) * 2018-11-05 2021-06-01 雀巢产品有限公司 使用姜黄素和ω-3脂肪酸的组合用于细胞能量的组合物和方法
US20220202842A1 (en) * 2019-05-13 2022-06-30 Societe Des Produits Nestle S.A. Compositions and methods to treat or prevent metabolic fatigue using at the compound oleuropein or a metabolite thereof
JP2022532323A (ja) * 2019-05-13 2022-07-14 ソシエテ・デ・プロデュイ・ネスレ・エス・アー カルシウムと、オレウロペイン又はその代謝産物のうちの少なくとも１つとの組み合わせを使用する組成物及び方法
US20230190846A1 (en) * 2020-09-11 2023-06-22 Tzung-Yan LEE Pharmaceutical compositions and uses thereof in treating muscle atrophy
CN116437908A (zh) * 2020-11-18 2023-07-14 雀巢产品有限公司 用于细胞能量的使用橄榄苦苷和槲皮素的组合的组合物和方法
KR102366919B1 (ko) * 2021-05-28 2022-02-24 농업회사법인 주식회사 이비채 상지, 두충, 오가피 및 흑두 혼합 추출물을 포함하는 근감소 억제 기능성 건강식품 조성물

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6592863B2 (en) * 2000-08-22 2003-07-15 Nestec S.A. Nutritional composition
EP1811866B1 (en) 2004-11-16 2018-09-26 DSM IP Assets B.V. The use of anti-oxidant compounds for muscle damage
JP2006328031A (ja) * 2005-05-30 2006-12-07 Asahi Breweries Ltd 筋繊維タイプ移行抑制剤
EP1982707A1 (en) * 2007-04-18 2008-10-22 DSMIP Assets B.V. Use of hydroxytyrosol as anti-aging agent
JP2009161459A (ja) * 2007-12-28 2009-07-23 Kao Corp 持久力向上剤
PL2418965T3 (pl) * 2009-04-17 2016-12-30 Połączenia hydroksytyrozolu do zwiększania czynności mitochondrium i wytwarzania energii
EP2501371A4 (en) * 2009-10-07 2013-07-31 Dsm Ip Assets Bv USE OF HYDROXYTYROSOL FOR IMPROVED MUSCLE DIFFERENTIATION
US20130059920A1 (en) * 2009-10-07 2013-03-07 Dsm Ip Assets, B.V. Hydroxytyrosol benefits muscle differentiation and muscle contraction and relaxation
WO2012097061A1 (en) * 2011-01-13 2012-07-19 Abbott Laboratories Nutritional compositions and methods for improving skeletal muscle protein metabolism
EP2580967A1 (en) * 2011-10-11 2013-04-17 Nestec S.A. Accelerating muscle recovery after immobilization-induced muscle atrophy
EP2583563A1 (en) 2011-10-21 2013-04-24 Nestec S.A. Whey protein micelles against muscle atrophy and sarcopenia
WO2013144267A2 (en) * 2012-03-29 2013-10-03 Nestec S.A. Improvement of musculoskeletal health by nutrition and exercise
BR112015024846B1 (pt) * 2013-04-05 2023-10-31 Société des Produits Nestlé S.A. Composições para utilização no estímulo do crescimento ósseo
JP6753775B2 (ja) * 2013-04-15 2020-09-09 ソシエテ・デ・プロデュイ・ネスレ・エス・アー 電気筋肉刺激と組み合わせられるホエータンパク質の使用
EP3091859A1 (en) * 2013-12-18 2016-11-16 Abbott Laboratories Methods for increasing skeletal muscle protein synthesis using green tea extract
KR20170002443A (ko) * 2014-04-18 2017-01-06 옴니액티브 헬스 테크놀로지스 리미티드 커큐민 조성물 및 이의 용도
JP6849433B2 (ja) * 2014-04-28 2021-03-24 サントリーホールディングス株式会社 ケルセチン配糖体を含有する筋萎縮抑制剤
JP6434763B2 (ja) * 2014-09-29 2018-12-05 ルネサスエレクトロニクス株式会社 半導体装置
BR112017005762B1 (pt) * 2014-10-14 2021-10-05 Société des Produits Nestlé S.A. Composição compreendendo uma fonte de proteína, e um antioxidante e seu uso
JP2016199536A (ja) * 2015-04-07 2016-12-01 株式会社ニュートリション・アクト 筋肉増強およびメタボリックシンドローム改善ならびにｑｏｌ改善のための組成物
US10744100B2 (en) * 2015-11-17 2020-08-18 Societe Des Produits Nestle S.A. Compositions and methods using a polyphenol for musculoskeletal health
CN116617196A (zh) 2015-11-17 2023-08-22 雀巢产品有限公司 将多酚用于肌肉骨骼健康的组合物和方法
AU2017270131B2 (en) * 2016-05-27 2023-03-09 Société des Produits Nestlé S.A. Nutritional composition for treating or preventing impaired mobility

Also Published As

Publication number Publication date
JP2018534278A (ja) 2018-11-22
MX2018005779A (es) 2018-09-06
BR112018007958B1 (pt) 2022-04-19
EP3376881A1 (en) 2018-09-26
CA3224027A1 (en) 2017-05-26
ES2788166T3 (es) 2020-10-20
CN108347987A (zh) 2018-07-31
US11364254B2 (en) 2022-06-21
US20200368266A1 (en) 2020-11-26
US20180353527A1 (en) 2018-12-13
WO2017085190A1 (en) 2017-05-26
US20200061094A1 (en) 2020-02-27
EP3685680A1 (en) 2020-07-29
AU2016358236A1 (en) 2018-04-12
JP6859336B2 (ja) 2021-04-14
EP3868219A1 (en) 2021-08-25
CN116617196A (zh) 2023-08-22
CA3001078A1 (en) 2017-05-26
EP3376881B1 (en) 2020-03-11
AU2016358236B2 (en) 2020-09-10
US10751357B2 (en) 2020-08-25
US11813273B2 (en) 2023-11-14

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