BR112018000331A2 - método para a síntese de pentostatina - Google Patents

método para a síntese de pentostatina

Info

Publication number
BR112018000331A2
BR112018000331A2 BR112018000331-0A BR112018000331A BR112018000331A2 BR 112018000331 A2 BR112018000331 A2 BR 112018000331A2 BR 112018000331 A BR112018000331 A BR 112018000331A BR 112018000331 A2 BR112018000331 A2 BR 112018000331A2
Authority
BR
Brazil
Prior art keywords
pentostatin
synthesis
dihydroimidazo
diazepin
deoxyribonucleoside
Prior art date
Application number
BR112018000331-0A
Other languages
English (en)
Inventor
Zabudkin Oleksandr
Schickaneder Christian
Matviienko Iaroslav
Sypchenko Volodymyr
Original Assignee
Synbias Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synbias Pharma Ag filed Critical Synbias Pharma Ag
Publication of BR112018000331A2 publication Critical patent/BR112018000331A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/02—Pentosyltransferases (2.4.2)
    • C12Y204/02006—Nucleoside deoxyribosyltransferase (2.4.2.6)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

a presente invenção refere-se a um método para a produção estéreo-seletiva de pentostatina compreendendo uma reação de transglicosilação enzimática entre 6,7-dihidroimidazo-[4,5-d]-[1,3]diazepin-8(3h)-ona e uma 2'-desoxirribonucleósido, seguido de uma hidrogenação de transferência assimétrica catalisada por ruténio.
BR112018000331-0A 2015-07-07 2016-07-06 método para a síntese de pentostatina BR112018000331A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15175659.0A EP3115461A1 (en) 2015-07-07 2015-07-07 Method for the synthesis of pentostatin
EP15175659.0 2015-07-07
PCT/EP2016/065958 WO2017005784A1 (en) 2015-07-07 2016-07-06 Method for the synthesis of pentostatin

Publications (1)

Publication Number Publication Date
BR112018000331A2 true BR112018000331A2 (pt) 2018-09-11

Family

ID=53524658

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018000331-0A BR112018000331A2 (pt) 2015-07-07 2016-07-06 método para a síntese de pentostatina

Country Status (19)

Country Link
US (1) US20180201966A1 (pt)
EP (2) EP3115461A1 (pt)
JP (1) JP2018522884A (pt)
KR (1) KR20180026738A (pt)
CN (1) CN107849593A (pt)
AR (1) AR105264A1 (pt)
AU (1) AU2016289854A1 (pt)
BR (1) BR112018000331A2 (pt)
DK (1) DK3320102T3 (pt)
ES (1) ES2764136T3 (pt)
HU (1) HUE046553T2 (pt)
MX (1) MX366715B (pt)
PL (1) PL3320102T3 (pt)
PT (1) PT3320102T (pt)
RU (1) RU2017145984A (pt)
SI (1) SI3320102T1 (pt)
TW (1) TWI648287B (pt)
UY (1) UY36775A (pt)
WO (1) WO2017005784A1 (pt)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2538857C (en) * 2003-09-15 2013-06-11 Supergen, Inc. Synthesis and manufacture of pentostatin and its precursors, analogs and derivatives
US20090012288A1 (en) 2007-07-03 2009-01-08 Hai-Ren Zhang Process for preparation of pentostatin (R)-3-(2-Deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidaz[4,5-d][1,3] diazepin-8-ol
WO2014177585A2 (en) * 2013-04-29 2014-11-06 Plasmia Biotech, S.L Biocatalytic production of nucleoside analogues as active pharmaceutical ingredients

Also Published As

Publication number Publication date
PT3320102T (pt) 2019-12-06
AR105264A1 (es) 2017-09-20
AU2016289854A1 (en) 2018-01-18
HUE046553T2 (hu) 2020-03-30
PL3320102T3 (pl) 2020-04-30
JP2018522884A (ja) 2018-08-16
DK3320102T3 (da) 2019-12-02
EP3320102B1 (en) 2019-09-04
US20180201966A1 (en) 2018-07-19
WO2017005784A1 (en) 2017-01-12
TW201706283A (zh) 2017-02-16
CN107849593A (zh) 2018-03-27
RU2017145984A3 (pt) 2019-09-09
EP3115461A1 (en) 2017-01-11
MX366715B (es) 2019-07-18
EP3320102A1 (en) 2018-05-16
MX2017017021A (es) 2018-08-15
SI3320102T1 (sl) 2020-02-28
RU2017145984A (ru) 2019-08-07
UY36775A (es) 2016-12-30
ES2764136T3 (es) 2020-06-02
TWI648287B (zh) 2019-01-21
KR20180026738A (ko) 2018-03-13

Similar Documents

Publication Publication Date Title
MX2021011351A (es) Tecnologias utiles para la preparacion de oligonucleotidos.
MX2018016331A (es) Formas cristalinas de compuesto de triazolopirimidina.
BR112017013382A2 (pt) método para preparar um composto, composto, e, ácido.
CO2019007313A2 (es) Producción enzimática de d-alulosa
CO2017001884A2 (es) Polimorfos de selinexor
BR112017023950A2 (pt) processo para a preparação de limonen-4-ol
EP3596212A4 (en) ENZYMATIC PRODUCTION OF HEXOSES
GT201300099A (es) Produccion de alquenos mediante conversion enzimatica combinada de acidos 3-hidroxialcanoicos
BR112018075667A2 (pt) cromatografia de interação hidrofóbica para purificação de oligonucleotídeos
BR112015020904A2 (pt) microrganismos e métodos para produção de butadieno e compostos relacionados por assimilação de formiato
IL274549A (en) Ligand-drug conjugates as substrates for selective cleavage by the exopeptidase activity of cathepsin B
ZA202102826B (en) Enzymatic production of hexoses
AR116790A1 (es) PROCEDIMIENTO PARA LA PREPARACIÓN DE 3a-HIDROXI-5a-PREGNAN-20-ONA (BREXANOLONA)
PH12019501224A1 (en) Compositions for treatment of polycystic kidney disease
MY185442A (en) Production of fatty acid alkyl esters with caustic treatment
BR112019020338A8 (pt) Composição para produção de tagatose, e, método de produção de tagatose
BR112016011899A2 (pt) Processo para preparação de 5-fluoro-1h-pirazóis
MX2022012236A (es) Composiciones que comprenden colina y su uso.
EA201791645A1 (ru) Новые соли и полиморфы scy-078
MX2018002354A (es) Métodos para el tratamiento de una enfermedad poliquística renal.
AR111036A1 (es) Procedimiento de preparación monotópica de compuestos organo-yodados
ECSP10010721A (es) Nifurtimox para el tratamiento de enfermedades causadas por trichomonadida
BR112018000331A2 (pt) método para a síntese de pentostatina
EP3662075A4 (en) IMPROVED PRODUCTION OF RHAMNOLIPIDS USING AT LEAST TWO SOURCES OF CARBON
BR112017021401A2 (pt) produção de compostos fragrantes

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements