BR112017027378A2 - linhagem atenuada de salmonella e composição farmacêutica - Google Patents
linhagem atenuada de salmonella e composição farmacêuticaInfo
- Publication number
- BR112017027378A2 BR112017027378A2 BR112017027378-0A BR112017027378A BR112017027378A2 BR 112017027378 A2 BR112017027378 A2 BR 112017027378A2 BR 112017027378 A BR112017027378 A BR 112017027378A BR 112017027378 A2 BR112017027378 A2 BR 112017027378A2
- Authority
- BR
- Brazil
- Prior art keywords
- attenuated salmonella
- pharmaceutical composition
- additional
- salmonella strain
- copy
- Prior art date
Links
- 241000607142 Salmonella Species 0.000 title abstract 4
- 230000002238 attenuated effect Effects 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 108020004414 DNA Proteins 0.000 abstract 3
- 102000053602 DNA Human genes 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 108091008605 VEGF receptors Proteins 0.000 abstract 2
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
- A61K39/001109—Vascular endothelial growth factor receptors [VEGFR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001152—Transcription factors, e.g. SOX or c-MYC
- A61K39/001153—Wilms tumor 1 [WT1]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001166—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
- A61K39/001168—Mesothelin [MSLN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00118—Cancer antigens from embryonic or fetal origin
- A61K39/001182—Carcinoembryonic antigen [CEA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0275—Salmonella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Vascular Medicine (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15001803 | 2015-06-18 | ||
| EP15001803.4 | 2015-06-18 | ||
| PCT/EP2016/001004 WO2016202459A1 (en) | 2015-06-18 | 2016-06-16 | Vegfr-2 targeting dna vaccine for combination therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017027378A2 true BR112017027378A2 (pt) | 2018-08-28 |
Family
ID=53476620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017027378-0A BR112017027378A2 (pt) | 2015-06-18 | 2016-06-16 | linhagem atenuada de salmonella e composição farmacêutica |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10905752B2 (enExample) |
| EP (2) | EP3310379B1 (enExample) |
| JP (1) | JP6947649B2 (enExample) |
| KR (2) | KR20250024816A (enExample) |
| CN (1) | CN107995868B (enExample) |
| AU (1) | AU2016278588B2 (enExample) |
| BR (1) | BR112017027378A2 (enExample) |
| CA (1) | CA2989247C (enExample) |
| DK (1) | DK3310379T3 (enExample) |
| ES (2) | ES2760699T3 (enExample) |
| HU (1) | HUE046631T2 (enExample) |
| IL (1) | IL256076A (enExample) |
| LT (1) | LT3310379T (enExample) |
| MX (1) | MX2017016183A (enExample) |
| PL (2) | PL3310379T3 (enExample) |
| RU (1) | RU2018101722A (enExample) |
| SI (1) | SI3310379T1 (enExample) |
| WO (1) | WO2016202459A1 (enExample) |
| ZA (1) | ZA201708439B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2019112977A (ru) * | 2016-11-04 | 2020-12-04 | Факсимм Аг | Днк-вакцина, нацеленная на wt1, для комбинированной терапии |
| JP7712060B2 (ja) * | 2017-02-17 | 2025-07-23 | バクシム アクチェンゲゼルシャフト | 新規ｖｅｇｆｒ－２ターゲット免疫療法アプローチ |
| KR20190125481A (ko) * | 2017-03-17 | 2019-11-06 | 백심 아게 | 암의 면역요법을 위한 신규 pd-l1 표적화 dna 백신 |
| CN112638408A (zh) * | 2018-09-05 | 2021-04-09 | 万科斯蒙股份有限公司 | 用于联合疗法的靶向新抗原的dna疫苗 |
| KR20220128638A (ko) * | 2020-01-13 | 2022-09-21 | 백심 아게 | 항생제와 조합되는 살모넬라-기반의 dna 백신 |
| EP3922255A1 (en) * | 2020-06-10 | 2021-12-15 | Prokarium Limited | Cancer therapy |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7094410B2 (en) | 2002-03-02 | 2006-08-22 | The Scripps Research Institute | DNA vaccine against proliferating endothelial cells and methods of use thereof |
| NO337687B1 (no) | 2011-07-08 | 2016-06-06 | Norsk Elektro Optikk As | Hyperspektralt kamera og metode for å ta opp hyperspektrale data |
| HUE035438T2 (en) * | 2011-12-22 | 2018-05-02 | Vaximm Ag | A method for producing high yields of attenuated Salmonella strains |
| MX359315B (es) * | 2012-07-05 | 2018-09-25 | Vaximm Ag | Vacuna de adn para usarse en pacientes con cancer pancreatico. |
| JP6374388B2 (ja) * | 2012-09-21 | 2018-08-15 | インテンシティ セラピューティクス, インク.Intensity Therapeutics, Inc. | 癌の治療方法 |
| SG10201710473VA (en) * | 2013-02-22 | 2018-02-27 | Curevac Ag | Combination of vaccination and inhibition of the pd-1 pathway |
| MX364922B (es) * | 2013-04-25 | 2019-05-14 | Vaximm Ag | Vacuna de adn que dirige wt-1 novedosa para inmunoterapia contra cáncer. |
| KR20160130979A (ko) * | 2013-12-18 | 2016-11-15 | 백심 게엠베하 | 암 면역요법을 위한 신규한 msln 표적화 dna 백신 |
| JP7712060B2 (ja) * | 2017-02-17 | 2025-07-23 | バクシム アクチェンゲゼルシャフト | 新規ｖｅｇｆｒ－２ターゲット免疫療法アプローチ |
| KR20190125481A (ko) * | 2017-03-17 | 2019-11-06 | 백심 아게 | 암의 면역요법을 위한 신규 pd-l1 표적화 dna 백신 |
-
2016
- 2016-06-16 PL PL16736381T patent/PL3310379T3/pl unknown
- 2016-06-16 KR KR1020257001040A patent/KR20250024816A/ko active Pending
- 2016-06-16 KR KR1020187001398A patent/KR20180037948A/ko not_active Ceased
- 2016-06-16 ES ES16736381T patent/ES2760699T3/es active Active
- 2016-06-16 BR BR112017027378-0A patent/BR112017027378A2/pt not_active Application Discontinuation
- 2016-06-16 MX MX2017016183A patent/MX2017016183A/es unknown
- 2016-06-16 EP EP16736381.1A patent/EP3310379B1/en active Active
- 2016-06-16 CA CA2989247A patent/CA2989247C/en active Active
- 2016-06-16 LT LTEP16736381.1T patent/LT3310379T/lt unknown
- 2016-06-16 ES ES19205420T patent/ES2994561T3/es active Active
- 2016-06-16 AU AU2016278588A patent/AU2016278588B2/en active Active
- 2016-06-16 PL PL19205420.3T patent/PL3626262T3/pl unknown
- 2016-06-16 US US15/737,659 patent/US10905752B2/en active Active
- 2016-06-16 CN CN201680035593.2A patent/CN107995868B/zh active Active
- 2016-06-16 EP EP19205420.3A patent/EP3626262B1/en active Active
- 2016-06-16 SI SI201630549T patent/SI3310379T1/sl unknown
- 2016-06-16 RU RU2018101722A patent/RU2018101722A/ru not_active Application Discontinuation
- 2016-06-16 WO PCT/EP2016/001004 patent/WO2016202459A1/en not_active Ceased
- 2016-06-16 JP JP2017565248A patent/JP6947649B2/ja active Active
- 2016-06-16 HU HUE16736381A patent/HUE046631T2/hu unknown
- 2016-06-16 DK DK16736381.1T patent/DK3310379T3/da active
-
2017
- 2017-12-04 IL IL256076A patent/IL256076A/en unknown
- 2017-12-12 ZA ZA2017/08439A patent/ZA201708439B/en unknown
-
2020
- 2020-11-30 US US17/107,203 patent/US20210077605A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK3310379T3 (da) | 2019-12-16 |
| EP3310379A1 (en) | 2018-04-25 |
| KR20180037948A (ko) | 2018-04-13 |
| MX2017016183A (es) | 2018-06-19 |
| EP3626262C0 (en) | 2024-10-23 |
| ES2760699T3 (es) | 2020-05-14 |
| KR20250024816A (ko) | 2025-02-19 |
| JP6947649B2 (ja) | 2021-10-13 |
| US20180250345A1 (en) | 2018-09-06 |
| JP2018517419A (ja) | 2018-07-05 |
| IL256076A (en) | 2018-01-31 |
| CN107995868A (zh) | 2018-05-04 |
| AU2016278588A1 (en) | 2017-12-21 |
| PL3310379T3 (pl) | 2020-03-31 |
| WO2016202459A1 (en) | 2016-12-22 |
| US20210077605A1 (en) | 2021-03-18 |
| HUE046631T2 (hu) | 2020-03-30 |
| ES2994561T3 (en) | 2025-01-27 |
| ZA201708439B (en) | 2021-05-26 |
| LT3310379T (lt) | 2019-12-27 |
| EP3310379B1 (en) | 2019-11-06 |
| EP3626262A1 (en) | 2020-03-25 |
| HK1252435A1 (en) | 2019-05-24 |
| PL3626262T3 (pl) | 2025-02-17 |
| CN107995868B (zh) | 2021-07-13 |
| EP3626262B1 (en) | 2024-10-23 |
| CA2989247A1 (en) | 2016-12-22 |
| SI3310379T1 (sl) | 2020-02-28 |
| AU2016278588B2 (en) | 2022-03-31 |
| US10905752B2 (en) | 2021-02-02 |
| CA2989247C (en) | 2023-10-17 |
| RU2018101722A (ru) | 2019-07-18 |
| RU2018101722A3 (enExample) | 2019-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A ANUIDADE. |
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| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |