BR112017026580A2 - microrganismo com produtividade de ácido lático melhorada e um processo para a produção de ácido lático usando o mesmo - Google Patents

microrganismo com produtividade de ácido lático melhorada e um processo para a produção de ácido lático usando o mesmo

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Publication number
BR112017026580A2
BR112017026580A2 BR112017026580-0A BR112017026580A BR112017026580A2 BR 112017026580 A2 BR112017026580 A2 BR 112017026580A2 BR 112017026580 A BR112017026580 A BR 112017026580A BR 112017026580 A2 BR112017026580 A2 BR 112017026580A2
Authority
BR
Brazil
Prior art keywords
lactic acid
microorganisms
methods
same
improved
Prior art date
Application number
BR112017026580-0A
Other languages
English (en)
Korean (ko)
Inventor
Bin Yang Eun
Hee Lee Tae
Hye Kim Seon
Song Gyuhyeon
Woong Ha Cheol
Na Kyungsu
Lyeol Yang Young
Sun Kang Min
Hyoung Lee Hyo
Original Assignee
Cj Cheiljedang Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cj Cheiljedang Corporation filed Critical Cj Cheiljedang Corporation
Publication of BR112017026580A2 publication Critical patent/BR112017026580A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/56—Lactic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01003—Aldehyde dehydrogenase (NAD+) (1.2.1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01001—Pyruvate decarboxylase (4.1.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01—Acid-Thiol Ligases (6.2.1)
    • C12Y602/01001—Acetate-CoA ligase (6.2.1.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

a presente invenção refere-se ao saccharomyces sp. capaz de produzir ácido lático com uma diminuição da atividade de piruvato descarboxilase (pdc) e aumento das atividades de aldeído desidrogenase (ald) e acetil-coa sintetase (acs), e um método de produção de ácido lático a partir do meio de cultura obtido pela cultura do microrganismo.
BR112017026580-0A 2015-06-12 2015-06-12 microrganismo com produtividade de ácido lático melhorada e um processo para a produção de ácido lático usando o mesmo BR112017026580A2 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/KR2015/005963 WO2016199966A1 (ko) 2015-06-12 2015-06-12 젖산 생산이 향상된 미생물 및 이를 이용하여 젖산을 생산하는 방법

Publications (1)

Publication Number Publication Date
BR112017026580A2 true BR112017026580A2 (pt) 2018-08-14

Family

ID=57504112

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017026580-0A BR112017026580A2 (pt) 2015-06-12 2015-06-12 microrganismo com produtividade de ácido lático melhorada e um processo para a produção de ácido lático usando o mesmo

Country Status (5)

Country Link
US (1) US10155967B2 (pt)
EP (1) EP3309247A4 (pt)
CN (1) CN107922917A (pt)
BR (1) BR112017026580A2 (pt)
WO (1) WO2016199966A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI20195716A1 (en) * 2019-08-30 2021-03-01 Finnfoam Oy Genetically modified fungi and related methods and uses

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1294728B1 (it) 1997-09-12 1999-04-12 Biopolo S C A R L Ceppi di lievito per la riproduzione di acido lattico
WO2009013159A2 (en) 2007-07-23 2009-01-29 Dsm Ip Assets B.V. Acetyl-coa producing enzymes in yeast
JP4963488B2 (ja) * 2008-04-23 2012-06-27 トヨタ自動車株式会社 変異体酵母及びこれを用いた物質生産方法
KR101114912B1 (ko) * 2008-06-24 2012-02-14 한국과학기술원 폴리락테이트와 그 공중합체 생성능이 개선된 변이 미생물을 이용한 폴리락테이트와 그 공중합체의 제조방법
US20120021421A1 (en) 2009-02-13 2012-01-26 Jacques Amar Bacterial DNA as Markers of Cardiovascular and/or Metabolic Disease
IN2012DN02396A (pt) * 2009-09-29 2015-08-21 Butamax Tm Advanced Biofuels
JP2011254747A (ja) * 2010-06-08 2011-12-22 Toyota Central R&D Labs Inc 高級アルコール生産微生物及びその利用
EP3312284A3 (en) * 2010-07-26 2018-05-30 Genomatica, Inc. Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene
KR101438882B1 (ko) 2012-04-24 2014-09-05 씨제이제일제당 (주) 신규한 ｄ형 젖산 생산균주
KR101576186B1 (ko) * 2012-06-26 2015-12-10 한국생명공학연구원 에탄올 생산 경로가 봉쇄된 클루이베로마이세스 막시아누스 균주 및 이의 용도
KR102255306B1 (ko) 2013-11-15 2021-05-25 삼성전자주식회사 아세트알데히드 데히드로게나제를 포함하는 락테이트 생산능을 갖는 유전적으로 조작된 효모 세포, 그를 제조하는 방법 및 그를 사용하여 락테이트를 생산하는 방법
KR101577134B1 (ko) * 2014-05-09 2015-12-14 씨제이제일제당 (주) 젖산 생산이 향상된 미생물 및 이를 이용하여 젖산을 생산하는 방법
CN104099258A (zh) 2014-07-16 2014-10-15 江南大学 一种乙醇积累减少的酿酒酵母基因工程菌及其应用

Also Published As

Publication number Publication date
US20180171370A1 (en) 2018-06-21
EP3309247A1 (en) 2018-04-18
US10155967B2 (en) 2018-12-18
WO2016199966A1 (ko) 2016-12-15
CN107922917A (zh) 2018-04-17
EP3309247A4 (en) 2019-01-09

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B09B Patent application refused [chapter 9.2 patent gazette]
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