BR112017023478A2 - Melhoramento do efeito das células t car- concebidas por meio de vacinação de ácido nucleico - Google Patents

Melhoramento do efeito das células t car- concebidas por meio de vacinação de ácido nucleico

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Publication number
BR112017023478A2
BR112017023478A2 BR112017023478-5A BR112017023478A BR112017023478A2 BR 112017023478 A2 BR112017023478 A2 BR 112017023478A2 BR 112017023478 A BR112017023478 A BR 112017023478A BR 112017023478 A2 BR112017023478 A2 BR 112017023478A2
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Brazil
Prior art keywords
antigen
car
nucleic acid
improvement
effect
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BR112017023478-5A
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English (en)
Inventor
Sahin Ugur
Reinhard Katharina
Simon Petra
Anna Miroz Karolina
Hobohm Kathleen
Original Assignee
Biontech Cell & Gene Therapies Gmbh
TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gGmbH
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Application filed by Biontech Cell & Gene Therapies Gmbh, TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gGmbH filed Critical Biontech Cell & Gene Therapies Gmbh
Publication of BR112017023478A2 publication Critical patent/BR112017023478A2/pt

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Abstract

a presente invenção, de uma forma geral, engloba o tratamento de doenças por meio de células alvo que expressam um antígeno na superfície celular. em particular, a invenção se refere a um método para estimular, amortecer e / ou expandir células t in vivo geneticamente modificadas para expressar um receptor quimérico de antígeno (car) direcionado para um antígeno, compreendendo contatar as células t com o antígeno ou sua variante in vivo . em uma concretização, o antígeno ou a sua variante é proporcionado pela administração de um ácido nucleico que codifica o antigénio ou a sua variante.
BR112017023478-5A 2015-05-11 2016-05-09 Melhoramento do efeito das células t car- concebidas por meio de vacinação de ácido nucleico BR112017023478A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/EP2015/060356 WO2016180467A1 (en) 2015-05-11 2015-05-11 Enhancing the effect of car-engineered t cells by means of nucleic acid vaccination
EPPCT/EP2015/060356 2015-05-11
PCT/EP2016/060332 WO2016180778A1 (en) 2015-05-11 2016-05-09 Enhancing the effect of car-engineered t cells by means of nucleic acid vaccination

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BR112017023478A2 true BR112017023478A2 (pt) 2018-07-24

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BR112017023478-5A BR112017023478A2 (pt) 2015-05-11 2016-05-09 Melhoramento do efeito das células t car- concebidas por meio de vacinação de ácido nucleico

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US (2) US10799534B2 (pt)
EP (2) EP3294325B1 (pt)
JP (1) JP6914851B2 (pt)
KR (1) KR20180027414A (pt)
CN (2) CN114533865A (pt)
AU (3) AU2016259726B2 (pt)
BR (1) BR112017023478A2 (pt)
CA (1) CA2985156A1 (pt)
DK (1) DK3294325T3 (pt)
ES (1) ES2952421T3 (pt)
FI (1) FI3294325T3 (pt)
HK (2) HK1247098A1 (pt)
HR (1) HRP20230902T1 (pt)
HU (1) HUE062646T2 (pt)
LT (1) LT3294325T (pt)
MX (1) MX2017014346A (pt)
PL (1) PL3294325T3 (pt)
PT (1) PT3294325T (pt)
RS (1) RS64420B1 (pt)
SI (1) SI3294325T1 (pt)
WO (2) WO2016180467A1 (pt)

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