BR112017021271A2 - formulação e processo para modular a cura de ferimentos - Google Patents

formulação e processo para modular a cura de ferimentos

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Publication number
BR112017021271A2
BR112017021271A2 BR112017021271A BR112017021271A BR112017021271A2 BR 112017021271 A2 BR112017021271 A2 BR 112017021271A2 BR 112017021271 A BR112017021271 A BR 112017021271A BR 112017021271 A BR112017021271 A BR 112017021271A BR 112017021271 A2 BR112017021271 A2 BR 112017021271A2
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BR
Brazil
Prior art keywords
formulation
compounds
independently
autophagy
wound healing
Prior art date
Application number
BR112017021271A
Other languages
English (en)
Inventor
Tsai Chun-Che
L Summers Jack
M Jamison James
M Mcguire Karen
Original Assignee
Biomendics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomendics Llc filed Critical Biomendics Llc
Publication of BR112017021271A2 publication Critical patent/BR112017021271A2/pt

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Abstract

trata-se de métodos e compostos para a cura de ferimentos através da modulação de autofagia. uma formulação para modular a autofagia compreende um primeiro composto modulador (fam) selecionado dentre os compostos que têm a estrutura geral (i), em que: l representa um ligante selecionado dentre -c=c-, (um tolano), -ch=ch- (um estilbeno, de preferência, trans); ou -cra=crb- um derivado de estilbeno; em que ra e rb são, independentemente, h ou fenila opcionalmente substituída por -(r3)p ou -(r4)q; r1 a r4 são substituintes independentes em qualquer posição disponível dos anéis de fenila, de preferência, em 3, 3?, 4, 4? e/ou 5, 5?; e m, n, p e q são, independentemente, 0, 1, 2 ou 3 representando o número de substituintes dos anéis, respectivamente, mas pelo menos um dentre m ou n deve ser =1. cada r1 a r2 é independentemente selecionado dentre os substituintes descritos no presente documento, incluindo, porém, sem limitação, hidroxila, alcóxi, halo, halometila e glicosídeos. a formulação pode também incluir um composto modulador de autofagia auxiliar (aam) conforme descrito no presente documento. a formulação pode incluir um hidrogel formado pelos próprios compostos, ou de outro modo, e pode incluir sais e/ou complexos.
BR112017021271A 2015-04-08 2016-04-07 formulação e processo para modular a cura de ferimentos BR112017021271A2 (pt)

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