BR112017020615A2 - análogos de indol como antagonistas receptores de 5-oxo-ete e métodos de uso dos mesmos - Google Patents
análogos de indol como antagonistas receptores de 5-oxo-ete e métodos de uso dos mesmosInfo
- Publication number
- BR112017020615A2 BR112017020615A2 BR112017020615A BR112017020615A BR112017020615A2 BR 112017020615 A2 BR112017020615 A2 BR 112017020615A2 BR 112017020615 A BR112017020615 A BR 112017020615A BR 112017020615 A BR112017020615 A BR 112017020615A BR 112017020615 A2 BR112017020615 A2 BR 112017020615A2
- Authority
- BR
- Brazil
- Prior art keywords
- oxo
- methods
- compounds
- receptor antagonists
- indole analogues
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000002874 Acne Vulgaris Diseases 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 208000019693 Lung disease Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 206010000496 acne Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000414 obstructive effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
a presente revelação se refere a análogos de indol da fórmula i como antagonistas de 5-oxo-ete em que r1, r2, ra, rb, l, x, m e n são como definidos aqui. os métodos para a preparação de compostos da fórmula i, composições farmacêuticas compreendendo tais compostos e seu uso para o tratamento de condições relacionadas a receptores de 5-oxo-ete são também revelados. os compostos são úteis para o tratamento ou profilaxia de uma doença ou condição selecionada entre asma, rinite alérgica, distúrbio pulmonar obstrutivo crônico, dermatite atópica, psoríase e acne.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562140732P | 2015-03-31 | 2015-03-31 | |
US62/140,732 | 2015-03-31 | ||
PCT/CA2016/050363 WO2016154749A1 (en) | 2015-03-31 | 2016-03-29 | Indole analogs as 5-oxo-ete receptor antagonists and method of use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112017020615A2 true BR112017020615A2 (pt) | 2018-06-26 |
BR112017020615B1 BR112017020615B1 (pt) | 2024-02-20 |
Family
ID=57003771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017020615-3A BR112017020615B1 (pt) | 2015-03-31 | 2016-03-29 | Compostos análogos de indol, composição farmacêutica e combinação que compreende os mesmos e usos terapêuticos dos ditos compostos |
Country Status (10)
Country | Link |
---|---|
US (1) | US10501414B2 (pt) |
EP (1) | EP3277665B1 (pt) |
JP (1) | JP6824898B2 (pt) |
KR (1) | KR20170137077A (pt) |
CN (1) | CN107635961B (pt) |
AU (1) | AU2016240069B2 (pt) |
BR (1) | BR112017020615B1 (pt) |
CA (1) | CA2980221C (pt) |
HK (1) | HK1250163A1 (pt) |
WO (1) | WO2016154749A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111650380A (zh) * | 2020-06-02 | 2020-09-11 | 中国药科大学 | 5-oxo-ETE及其氧桥二十烷类受体在急性心肌梗塞中的应用 |
TW202340187A (zh) * | 2021-12-20 | 2023-10-16 | 加拿大商費爾哈芬製藥公司 | Oxer1拮抗劑及其用途 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2007000150A (es) * | 2004-07-01 | 2007-03-30 | Univ California | Inhibicion de moleculas pequenas de la interaccion del domini pdz. |
WO2006046683A1 (en) * | 2004-10-25 | 2006-05-04 | Astellas Pharma Inc. | Thiazolylbenzofuran derivatives as leukotriene and prostaglandin d2 receptor antagonists |
AU2006216170B2 (en) * | 2005-02-25 | 2012-02-09 | Ono Pharmaceutical Co., Ltd. | Indole compound and use thereof |
US7496182B2 (en) | 2005-04-15 | 2009-02-24 | Verizon Business Global Llc | Handling emergency service calls originating from internet telephony |
WO2007025254A2 (en) | 2005-08-26 | 2007-03-01 | Henry Ford Health System | Investigation and treatment of cancer using a g-protien coupled eicosnoid receptor |
WO2010127452A1 (en) | 2009-05-04 | 2010-11-11 | The Royal Institution For The Advancement Of Learning/Mcgill University | 5-oxo-ete receptor antagonist compounds |
-
2016
- 2016-03-29 WO PCT/CA2016/050363 patent/WO2016154749A1/en active Application Filing
- 2016-03-29 AU AU2016240069A patent/AU2016240069B2/en active Active
- 2016-03-29 US US15/562,677 patent/US10501414B2/en active Active
- 2016-03-29 JP JP2017551031A patent/JP6824898B2/ja active Active
- 2016-03-29 CA CA2980221A patent/CA2980221C/en active Active
- 2016-03-29 EP EP16771139.9A patent/EP3277665B1/en active Active
- 2016-03-29 BR BR112017020615-3A patent/BR112017020615B1/pt active IP Right Grant
- 2016-03-29 KR KR1020177027986A patent/KR20170137077A/ko active IP Right Grant
- 2016-03-29 CN CN201680017873.0A patent/CN107635961B/zh active Active
-
2018
- 2018-07-24 HK HK18109603.0A patent/HK1250163A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP3277665A4 (en) | 2018-12-05 |
WO2016154749A1 (en) | 2016-10-06 |
EP3277665A1 (en) | 2018-02-07 |
US20180086702A1 (en) | 2018-03-29 |
CN107635961B (zh) | 2021-07-20 |
US10501414B2 (en) | 2019-12-10 |
CA2980221A1 (en) | 2016-10-06 |
JP2018510177A (ja) | 2018-04-12 |
KR20170137077A (ko) | 2017-12-12 |
AU2016240069A1 (en) | 2017-10-26 |
CA2980221C (en) | 2024-03-12 |
EP3277665B1 (en) | 2020-03-04 |
AU2016240069B2 (en) | 2020-05-21 |
HK1250163A1 (zh) | 2018-11-30 |
CN107635961A (zh) | 2018-01-26 |
JP6824898B2 (ja) | 2021-02-03 |
BR112017020615B1 (pt) | 2024-02-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2019001744A1 (es) | Derivados de benzoxazol como inmunomoduladores. | |
BR112018069612A2 (pt) | compostos de pirroltriazina como inibidores de tam | |
CU20160167A7 (es) | Compuestos de pirazolopiridinas y pirazolopirimidinas útiles en el tratamiento de condiciones alérgicas y respiratorias | |
CL2019002103A1 (es) | Derivados de tirosinamida como inhibidores de rho-quinasa. | |
BR112015028879A8 (pt) | compostos derivados heterocíclicos, composição farmacêutica compreendendo os referidos compostos e usos dos mesmos | |
BR112015022545A2 (pt) | compostos de pirazolo e os usos disso | |
BR112018015273A2 (pt) | derivados de benzimidazol como moduladores de ror-gama | |
CL2015002301A1 (es) | Acido 2-aza-biciclo[2.2.1]heptano-3-carboxílico (bencil-ciano-metil)-amidas sustituidas inhibidores de catepsina c. | |
CO7131357A2 (es) | Compuestos de n-ariltriazol como antagonistas de lpar | |
CL2016001543A1 (es) | Derivados del isocromeno como inhibidores de las fosfoinositido-3 quinasas. | |
BR112013028430A2 (pt) | composto, composição farmacêutica, método para tratar uma doença ou condição mediada por tirosina quinase do baço (syk), e, uso de uma quantidade terapeuticamente eficiente do composto | |
BR112016029612A2 (pt) | compostos de di-hidroisoquinolinona substituídos | |
BR112016018555A8 (pt) | Ciclopropilaminas como inibidores de lsd1, seu uso, composição farmacêutica que os compreende e método de inibição de lsd1 | |
EA201890086A1 (ru) | 1,4-замещенные производные пиперидина | |
BR112015025260A2 (pt) | compostos heterocíclicos fundidos como inibidores da proteína quinase | |
BR112013025387A2 (pt) | análogos substituídos da n-fenilpirimidin-2-amina como inibidores da quinase axl | |
BR112015021999A8 (pt) | inibidores de indoleamina 2,3-dioxigenase (ido), seus usos, composição farmacêutica, e método para inibir a atiavidade de indoleamina 2,3-dioxigenase | |
TR201901886T4 (tr) | DNA-PK inhibitörleri. | |
BR112016022069A2 (pt) | Composto, composição farmacêutica, e, uso de um composto | |
BR112015032595A8 (pt) | inibidores de ido | |
BR112017004173A2 (pt) | composto, composição farmacêutica, e, método para tratar uma doença ou condição patológica. | |
BR112017009647A2 (pt) | 2-amino-3,5-difluoro-3,6-dimetil-6-fenil-3,4,5,6-tetraidropiridinas como inibidoras da bace1 para tratar a doença de alzheimer | |
BR112015020350A2 (pt) | derivados de 6-(5-hidroxi-1h-pirazol-1-il)nicotinamida e seu uso como inibidores de phd | |
BR112017012402A2 (pt) | derivados de 2,4-dioxo-quinazolina-6-sulfonamida como inibidores de parg | |
BR112017005997A2 (pt) | método |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 29/03/2016, OBSERVADAS AS CONDICOES LEGAIS |