BR112017016721A2 - sistemas e métodos para geração de imagem de alta resolução - Google Patents

sistemas e métodos para geração de imagem de alta resolução

Info

Publication number
BR112017016721A2
BR112017016721A2 BR112017016721A BR112017016721A BR112017016721A2 BR 112017016721 A2 BR112017016721 A2 BR 112017016721A2 BR 112017016721 A BR112017016721 A BR 112017016721A BR 112017016721 A BR112017016721 A BR 112017016721A BR 112017016721 A2 BR112017016721 A2 BR 112017016721A2
Authority
BR
Brazil
Prior art keywords
environment
signal
location
fluorophore
photoluminescence
Prior art date
Application number
BR112017016721A
Other languages
English (en)
Other versions
BR112017016721B1 (pt
Inventor
Yuan Baohong
Cheng Bingbing
Wei Mingyuan
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/615,993 external-priority patent/US10379109B2/en
Application filed by Univ Texas filed Critical Univ Texas
Publication of BR112017016721A2 publication Critical patent/BR112017016721A2/pt
Publication of BR112017016721B1 publication Critical patent/BR112017016721B1/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels

Abstract

num aspecto, métodos de geração de imagem são descritos aqui. em algumas modalidades, um método de geração de imagem aqui descrito compreende a disposição de um fluoróforo comutável por ultrassom num ambiente; a exposição do ambiente a um feixe de ultrassom para criar uma região de ativação dentro do ambiente; a disposição do fluoróforo dentro da região de ativação para alternar o fluóroforo de um estado desligado para um estado ligado; a exposição do ambiente a um feixe de radiação eletromagnética, excitando assim o fluoróforo; a detecção de um sinal de fotoluminescência numa primeira localização dentro do ambiente, o sinal de fotoluminescência compreendendo pelo menos um sinal de fluorescência de ultrassom emitido pelo fluoróforo e um sinal de fundo; a correlação do sinal de fotoluminescência com um sinal de referência para gerar um coeficiente de correlação para a primeira localização; e multiplicação do sinal de fotoluminescência pelo coeficiente de correlação para a primeira localização para gerar um sinal de fotoluminescência modificado para a primeira localização.
BR112017016721-2A 2015-02-06 2016-02-08 Método de geração de imagem de alta resolução BR112017016721B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/615,993 US10379109B2 (en) 2013-01-24 2015-02-06 Systems and methods for high-resolution imaging
US14/615,993 2015-02-06
PCT/US2016/016941 WO2016127158A1 (en) 2015-02-06 2016-02-08 Systems and methods for high-resolution imaging

Publications (2)

Publication Number Publication Date
BR112017016721A2 true BR112017016721A2 (pt) 2018-04-10
BR112017016721B1 BR112017016721B1 (pt) 2021-07-20

Family

ID=56564807

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017016721-2A BR112017016721B1 (pt) 2015-02-06 2016-02-08 Método de geração de imagem de alta resolução

Country Status (10)

Country Link
EP (1) EP3254087B1 (pt)
JP (1) JP6767377B2 (pt)
CN (1) CN107430074B (pt)
AU (1) AU2016215058B2 (pt)
BR (1) BR112017016721B1 (pt)
CA (1) CA2975193C (pt)
DK (1) DK3254087T3 (pt)
MX (1) MX2017010091A (pt)
WO (1) WO2016127158A1 (pt)
ZA (1) ZA201705951B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016196691A2 (en) 2015-06-01 2016-12-08 California Institute Of Technology Compositions and methods for screening t cells with antigens for specific populations
WO2019059379A1 (ja) * 2017-09-21 2019-03-28 国立大学法人北海道大学 生体検査装置及び生体検査方法
CN107802239B (zh) * 2017-11-16 2020-07-31 重庆医科大学 一种在生物体组织内成像的系统
CN110068548B (zh) * 2019-05-08 2021-10-12 中国科学院合肥物质科学研究院 用于离轴积分腔系统中激光器的波长锁定装置及其锁定方法
WO2021030694A1 (en) 2019-08-15 2021-02-18 Cybersonics, Inc. Ultrasound transducer and housing for same
US20210060609A1 (en) * 2019-08-30 2021-03-04 Cybersonics, Inc. Ultrasonic generator and controller for ultrasonic generator
EP3795982B1 (en) 2019-09-18 2022-10-26 Centre National de la Recherche Scientifique Method and apparatus for detecting a photochemically active chemical species in a sample
CN113625286B (zh) * 2021-08-03 2023-11-14 重庆大学 基于相干特征的强稳健性截断相干系数超声波束形成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4619803B2 (ja) * 2005-01-26 2011-01-26 富士フイルム株式会社 蛍光断層画像取得装置
WO2008005554A2 (en) * 2006-07-06 2008-01-10 University Of Connecticut Method and apparatus for medical imaging using near-infrared optical tomography, fluorence tomography combined with ultrasound
US9192303B2 (en) * 2011-12-19 2015-11-24 The Regents Of The University Of California Temperature-modulated fluorescence tomography
US10267786B2 (en) * 2013-01-24 2019-04-23 Board Of Regents, The University Of Texas System Systems and methods for high-resolution imaging

Also Published As

Publication number Publication date
JP6767377B2 (ja) 2020-10-14
DK3254087T3 (da) 2020-09-07
BR112017016721B1 (pt) 2021-07-20
EP3254087A1 (en) 2017-12-13
CA2975193C (en) 2023-11-14
EP3254087A4 (en) 2018-08-01
EP3254087B1 (en) 2020-06-17
CN107430074B (zh) 2020-10-09
MX2017010091A (es) 2018-11-12
AU2016215058A1 (en) 2017-08-03
JP2018513352A (ja) 2018-05-24
AU2016215058B2 (en) 2021-06-24
WO2016127158A1 (en) 2016-08-11
ZA201705951B (en) 2018-09-26
CN107430074A (zh) 2017-12-01
CA2975193A1 (en) 2016-08-11

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Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/02/2016, OBSERVADAS AS CONDICOES LEGAIS.