BR112017013176A2 - chimeric antigen receptors and methods for using them - Google Patents

chimeric antigen receptors and methods for using them

Info

Publication number
BR112017013176A2
BR112017013176A2 BR112017013176-5A BR112017013176A BR112017013176A2 BR 112017013176 A2 BR112017013176 A2 BR 112017013176A2 BR 112017013176 A BR112017013176 A BR 112017013176A BR 112017013176 A2 BR112017013176 A2 BR 112017013176A2
Authority
BR
Brazil
Prior art keywords
amino acid
cells
seq
cell
cdrs
Prior art date
Application number
BR112017013176-5A
Other languages
English (en)
Portuguese (pt)
Inventor
A.Marasco Wayne
Original Assignee
Dana-Farber Cancer Institute Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana-Farber Cancer Institute Inc. filed Critical Dana-Farber Cancer Institute Inc.
Publication of BR112017013176A2 publication Critical patent/BR112017013176A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
BR112017013176-5A 2014-12-19 2015-12-21 chimeric antigen receptors and methods for using them BR112017013176A2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462094625P 2014-12-19 2014-12-19
US62/094,625 2014-12-19
US201562252083P 2015-11-06 2015-11-06
US62/252,083 2015-11-06
PCT/US2015/067225 WO2016100985A2 (en) 2014-12-19 2015-12-21 Chimeric antigen receptors and methods of use thereof

Publications (1)

Publication Number Publication Date
BR112017013176A2 true BR112017013176A2 (en) 2018-05-15

Family

ID=55229842

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017013176-5A BR112017013176A2 (en) 2014-12-19 2015-12-21 chimeric antigen receptors and methods for using them

Country Status (11)

Country Link
US (3) US20170362297A1 (https=)
EP (1) EP3233900A2 (https=)
JP (3) JP2018504894A (https=)
KR (2) KR102923234B1 (https=)
CN (1) CN108064252A (https=)
AU (4) AU2015364245B2 (https=)
BR (1) BR112017013176A2 (https=)
CA (1) CA2968412A1 (https=)
IL (3) IL320860A (https=)
RU (1) RU2017125531A (https=)
WO (1) WO2016100985A2 (https=)

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Also Published As

Publication number Publication date
JP7833003B2 (ja) 2026-03-18
US20250243259A1 (en) 2025-07-31
AU2024200592B2 (en) 2026-03-12
AU2022200257B2 (en) 2023-11-16
JP2024163140A (ja) 2024-11-21
US12195514B2 (en) 2025-01-14
IL302660B2 (en) 2025-10-01
CA2968412A1 (en) 2016-06-23
IL252295B2 (en) 2023-10-01
IL302660B1 (en) 2025-06-01
RU2017125531A (ru) 2019-01-21
IL302660A (en) 2023-07-01
JP2022064952A (ja) 2022-04-26
EP3233900A2 (en) 2017-10-25
AU2024200592A1 (en) 2024-02-22
US20210061877A1 (en) 2021-03-04
AU2015364245A1 (en) 2017-06-08
IL252295A0 (en) 2017-07-31
US20170362297A1 (en) 2017-12-21
AU2022200257A1 (en) 2022-02-10
AU2015364245B2 (en) 2020-04-02
IL320860A (en) 2025-07-01
IL252295B1 (en) 2023-06-01
AU2020204373B2 (en) 2021-10-21
CN108064252A (zh) 2018-05-22
KR20260038272A (ko) 2026-03-18
AU2020204373A1 (en) 2020-07-23
WO2016100985A3 (en) 2016-08-18
KR102923234B1 (ko) 2026-02-04
JP2018504894A (ja) 2018-02-22
JP7548950B2 (ja) 2024-09-10
WO2016100985A2 (en) 2016-06-23
KR20170090506A (ko) 2017-08-07

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