BR112017008076B1 - Solução com nível de íon cálcio controlado, composição para preparação da solução e processo e uso relacionados para reperfusão - Google Patents

Solução com nível de íon cálcio controlado, composição para preparação da solução e processo e uso relacionados para reperfusão Download PDF

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Publication number
BR112017008076B1
BR112017008076B1 BR112017008076-1A BR112017008076A BR112017008076B1 BR 112017008076 B1 BR112017008076 B1 BR 112017008076B1 BR 112017008076 A BR112017008076 A BR 112017008076A BR 112017008076 B1 BR112017008076 B1 BR 112017008076B1
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BR
Brazil
Prior art keywords
heart
reperfusion
solution
mmoles
mmol
Prior art date
Application number
BR112017008076-1A
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English (en)
Portuguese (pt)
Other versions
BR112017008076A2 (pt
Inventor
Darren Freed
Christopher White
Larry Hryshko
Original Assignee
Darren Freed
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CA2015/050297 external-priority patent/WO2015154193A1/en
Application filed by Darren Freed filed Critical Darren Freed
Publication of BR112017008076A2 publication Critical patent/BR112017008076A2/pt
Publication of BR112017008076B1 publication Critical patent/BR112017008076B1/pt

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Dentistry (AREA)
  • Physiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Biophysics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR112017008076-1A 2014-10-24 2015-10-23 Solução com nível de íon cálcio controlado, composição para preparação da solução e processo e uso relacionados para reperfusão BR112017008076B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462068524P 2014-10-24 2014-10-24
US62/068,524 2014-10-24
PCT/CA2015/050297 WO2015154193A1 (en) 2014-04-10 2015-04-10 Modulation of calcium ion homeostasis in harvested transplantable hearts
CAPCT/CA2015/050297 2015-04-10
PCT/CA2015/051084 WO2016061700A1 (en) 2014-10-24 2015-10-23 Novel composition and solution with controlled calcium ion level, and related method and use for reperfusion

Publications (2)

Publication Number Publication Date
BR112017008076A2 BR112017008076A2 (pt) 2017-12-26
BR112017008076B1 true BR112017008076B1 (pt) 2021-06-29

Family

ID=55760003

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017008076-1A BR112017008076B1 (pt) 2014-10-24 2015-10-23 Solução com nível de íon cálcio controlado, composição para preparação da solução e processo e uso relacionados para reperfusão

Country Status (6)

Country Link
EP (1) EP3209128A4 (zh)
CN (2) CN107105640B (zh)
AU (1) AU2015336862B2 (zh)
BR (1) BR112017008076B1 (zh)
CA (1) CA2965400C (zh)
WO (1) WO2016061700A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201600120839A1 (it) * 2016-12-01 2018-06-01 Valentina Valenti Soluzione cardioplegica con attivatori dell'autofagia per l'arresto diastolico del cuore in corso di interventi cardiochirurgici
CN113303325A (zh) * 2021-05-27 2021-08-27 南方医科大学南方医院 一种灌注液和适用于大鼠供体心脏的常温血液机械灌注系统

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5407793A (en) * 1991-10-18 1995-04-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education An aqueous heart preservation and cardioplegia solution
FR2785501B1 (fr) * 1998-11-10 2001-01-05 Centre Nat Rech Scient Solution de perfusion et/ou de conservation et/ou de reperfusion lors de la transplantation d'organes
KR20020059255A (ko) * 1999-06-17 2002-07-12 린다 에스. 스티븐슨 저온 저장을 개선하기 위한 ＰＥＧ-Ｈｂ를 사용하는 연속심장 관류 보존
US20030124503A1 (en) * 2001-12-28 2003-07-03 Olivencia-Yurvati Albert H. Pyruvate cardioplegia solutions for administration to the heart during cardiopulmonary surgery and methods of use thereof
AUPS312602A0 (en) * 2002-06-21 2002-07-18 James Cook University Organ arrest, protection, preservation and recovery
FR2975869B1 (fr) * 2011-05-31 2017-03-03 Hemarina Composition de preservation d'organe et utilisations
EP3128836B1 (en) * 2014-04-10 2020-09-09 Tevosol, Inc. Modulation of calcium ion homeostasis in harvested transplantable hearts
CN103893205B (zh) * 2014-04-15 2016-03-09 青岛大学附属医院 一种包含利多卡因和腺苷的心脏停搏液及其制备方法

Also Published As

Publication number Publication date
CA2965400C (en) 2023-03-14
WO2016061700A1 (en) 2016-04-28
CN113841687A (zh) 2021-12-28
CA2965400A1 (en) 2016-04-28
CN107105640A (zh) 2017-08-29
EP3209128A1 (en) 2017-08-30
BR112017008076A2 (pt) 2017-12-26
CN107105640B (zh) 2021-10-12
AU2015336862B2 (en) 2018-08-09
EP3209128A4 (en) 2018-04-11
AU2015336862A1 (en) 2017-06-01

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Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/10/2015, OBSERVADAS AS CONDICOES LEGAIS.

B25A Requested transfer of rights approved

Owner name: TEVOSOL, INC. (CA)