EP3209128A4 - Novel composition and solution with controlled calcium ion level, and related method and use for reperfusion - Google Patents

Novel composition and solution with controlled calcium ion level, and related method and use for reperfusion Download PDF

Info

Publication number
EP3209128A4
EP3209128A4 EP15853016.2A EP15853016A EP3209128A4 EP 3209128 A4 EP3209128 A4 EP 3209128A4 EP 15853016 A EP15853016 A EP 15853016A EP 3209128 A4 EP3209128 A4 EP 3209128A4
Authority
EP
European Patent Office
Prior art keywords
reperfusion
solution
calcium ion
related method
novel composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15853016.2A
Other languages
German (de)
French (fr)
Other versions
EP3209128A1 (en
Inventor
Christopher White
Darren FREED
Larry Hryshko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tevosol Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CA2015/050297 external-priority patent/WO2015154193A1/en
Application filed by Individual filed Critical Individual
Publication of EP3209128A1 publication Critical patent/EP3209128A1/en
Publication of EP3209128A4 publication Critical patent/EP3209128A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physiology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP15853016.2A 2014-10-24 2015-10-23 Novel composition and solution with controlled calcium ion level, and related method and use for reperfusion Withdrawn EP3209128A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462068524P 2014-10-24 2014-10-24
PCT/CA2015/050297 WO2015154193A1 (en) 2014-04-10 2015-04-10 Modulation of calcium ion homeostasis in harvested transplantable hearts
PCT/CA2015/051084 WO2016061700A1 (en) 2014-10-24 2015-10-23 Novel composition and solution with controlled calcium ion level, and related method and use for reperfusion

Publications (2)

Publication Number Publication Date
EP3209128A1 EP3209128A1 (en) 2017-08-30
EP3209128A4 true EP3209128A4 (en) 2018-04-11

Family

ID=55760003

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15853016.2A Withdrawn EP3209128A4 (en) 2014-10-24 2015-10-23 Novel composition and solution with controlled calcium ion level, and related method and use for reperfusion

Country Status (6)

Country Link
EP (1) EP3209128A4 (en)
CN (2) CN107105640B (en)
AU (1) AU2015336862B2 (en)
BR (1) BR112017008076B1 (en)
CA (1) CA2965400C (en)
WO (1) WO2016061700A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201600120839A1 (en) * 2016-12-01 2018-06-01 Valentina Valenti Cardioplegic solution with autophagy activators for the diastolic arrest of the heart during cardiac surgery
CN113303325A (en) * 2021-05-27 2021-08-27 南方医科大学南方医院 Perfusate and normal-temperature blood mechanical perfusion system suitable for rat donor heart

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5407793A (en) * 1991-10-18 1995-04-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education An aqueous heart preservation and cardioplegia solution
WO2001001774A1 (en) * 1999-06-17 2001-01-11 Regents Of The University Of California Continuous cardiac perfusion preservation with peg-hb for improved hypothermic storage
US20030124503A1 (en) * 2001-12-28 2003-07-03 Olivencia-Yurvati Albert H. Pyruvate cardioplegia solutions for administration to the heart during cardiopulmonary surgery and methods of use thereof
US20050202394A1 (en) * 2002-06-21 2005-09-15 Global Cardiac Solutions Pty. Ltd. Organ arrest, protection, preservation and recovery

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2785501B1 (en) * 1998-11-10 2001-01-05 Centre Nat Rech Scient PERFUSION AND / OR PRESERVATION AND / OR REPERFUSION SOLUTION DURING ORGAN TRANSPLANTATION
FR2975869B1 (en) * 2011-05-31 2017-03-03 Hemarina ORGAN PRESERVATION COMPOSITION AND USES
BR112016023394B1 (en) * 2014-04-10 2021-09-21 Darren Freed CARDIOPLEGAL COMPOSITION AND ITS USE
CN103893205B (en) * 2014-04-15 2016-03-09 青岛大学附属医院 A kind ofly comprise cardioplegic solution of lignocaine and adenosine and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5407793A (en) * 1991-10-18 1995-04-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education An aqueous heart preservation and cardioplegia solution
WO2001001774A1 (en) * 1999-06-17 2001-01-11 Regents Of The University Of California Continuous cardiac perfusion preservation with peg-hb for improved hypothermic storage
US20030124503A1 (en) * 2001-12-28 2003-07-03 Olivencia-Yurvati Albert H. Pyruvate cardioplegia solutions for administration to the heart during cardiopulmonary surgery and methods of use thereof
US20050202394A1 (en) * 2002-06-21 2005-09-15 Global Cardiac Solutions Pty. Ltd. Organ arrest, protection, preservation and recovery

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
D J HEARSE ET AL: "Protection of the myocardium during ischemic arrest. Dose response curves for procaine and lignocaine in cardioplegic solutions", MEDLINE, 1 June 1981 (1981-06-01), U.S.A., pages 1 - 2, XP055454788, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pubmed/7230856> [retrieved on 20180227] *
DOBSON G P ET AL: "Adenosine and lidocaine: a new concept in nondepolarizing surgical myocardial arrest, protection, and preservation", JOURNAL OF THORACIC AND CARDIOVASCULAR SURG, MOSBY-YEAR BOOK, INC., ST. LOUIS, MO, US, vol. 127, no. 3, 1 March 2004 (2004-03-01), pages 794 - 805, XP008092313, ISSN: 0022-5223, DOI: 10.1016/S0022-5223(03)01192-9 *
DONNA M RUDD ET AL: "Eight hours of cold static storage with adenosine and lidocaine (Adenocaine) heart preservation solutions: Toward therapeutic suspended animation", JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, MOSBY-YEAR BOOK, INC., ST. LOUIS, MO, US, vol. 142, no. 6, 5 May 2011 (2011-05-05), pages 1552 - 1561, XP028111611, ISSN: 0022-5223, [retrieved on 20110528], DOI: 10.1016/J.JTCVS.2011.05.023 *
N TAKEMOTO, H KURODA, T MORI: "THE RECIPROCAL PROTECTIVE EFFECTS OF MAGNESIUM AND CALCIUM IN HYPERKALEMIC CARDIOPLEGIC SOLUTIONS ON ISCHEMIC MYOCARDIUM", BASIC RESEARCH IN CARDIOLOGY, vol. 87, 1 September 1992 (1992-09-01), pages 559 - 569, XP009503749 *
See also references of WO2016061700A1 *
STACY B O BLENES ET AL: "Protecting the aged heart during cardiac surgery: The potential benefits of del Nido cardioplegia", JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, MOSBY-YEAR BOOK, INC., ST. LOUIS, MO, US, vol. 141, no. 3, 2 June 2010 (2010-06-02), pages 762 - 770, XP028144755, ISSN: 0022-5223, [retrieved on 20100607], DOI: 10.1016/J.JTCVS.2010.06.004 *

Also Published As

Publication number Publication date
WO2016061700A1 (en) 2016-04-28
BR112017008076B1 (en) 2021-06-29
CN107105640B (en) 2021-10-12
CN113841687A (en) 2021-12-28
AU2015336862A1 (en) 2017-06-01
CA2965400A1 (en) 2016-04-28
CA2965400C (en) 2023-03-14
EP3209128A1 (en) 2017-08-30
AU2015336862B2 (en) 2018-08-09
BR112017008076A2 (en) 2017-12-26
CN107105640A (en) 2017-08-29

Similar Documents

Publication Publication Date Title
EP3110988A4 (en) Methods for treating lithium-containing materials
EP3145875A4 (en) Electrochemical treatment methods
EP3341330A4 (en) Methods for treating lithium-containing materials
EP3154586A4 (en) Treating lymphomas
EP3118251A4 (en) Rubber composition
EP3196287A4 (en) Cell culture apparatus
EP3167113A4 (en) Methods for treating lignocellulosic material
EP3303475A4 (en) Microporous polymeric composition
EP3102232A4 (en) Methods and compositions for treating abnormal cell growth
EP3142497A4 (en) Hydrogen-containing composition
EP3118252A4 (en) Rubber composition
EP3238692A4 (en) Hydrogel composition
EP3213752A4 (en) Composition for treating cancer stem cells
EP3174676A4 (en) Wood treatment for dimensional stabilization
EP3154546A4 (en) Methods for treating pruritus
EP3287010A4 (en) Composition for improving food-texture
EP3235900A4 (en) Cell culture apparatus
EP3196272A4 (en) Polishing material, composition for polishing, and polishing method
EP3194025A4 (en) Methods for preventing or treating osteoarthritis
EP3269686A4 (en) Fresh water-generating apparatus
ZA201608406B (en) Enzyme treatment composition
EP3209128A4 (en) Novel composition and solution with controlled calcium ion level, and related method and use for reperfusion
EP3239162A4 (en) Crystallization water-free calcium dibutyryladenosine cyclophosphate crystal form, and preparation method and use thereof
EP3369419A4 (en) Composition for treating diabetes
EP3197438A4 (en) Pharmaceutical composition having improved content uniformity

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20170522

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20180309

RIC1 Information provided on ipc code assigned before grant

Ipc: A01N 1/02 20060101AFI20180306BHEP

17Q First examination report despatched

Effective date: 20181127

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: TEVOSOL, INC.

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20200109