EP3209128A4 - Neuartige zusammensetzung und lösung mit kontrolliertem calciumionengehalt und zugehöriges verfahren und verwendung zur reperfusion - Google Patents

Neuartige zusammensetzung und lösung mit kontrolliertem calciumionengehalt und zugehöriges verfahren und verwendung zur reperfusion Download PDF

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Publication number
EP3209128A4
EP3209128A4 EP15853016.2A EP15853016A EP3209128A4 EP 3209128 A4 EP3209128 A4 EP 3209128A4 EP 15853016 A EP15853016 A EP 15853016A EP 3209128 A4 EP3209128 A4 EP 3209128A4
Authority
EP
European Patent Office
Prior art keywords
reperfusion
solution
calcium ion
related method
novel composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15853016.2A
Other languages
English (en)
French (fr)
Other versions
EP3209128A1 (de
Inventor
Christopher White
Darren FREED
Larry Hryshko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tevosol Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CA2015/050297 external-priority patent/WO2015154193A1/en
Application filed by Individual filed Critical Individual
Publication of EP3209128A1 publication Critical patent/EP3209128A1/de
Publication of EP3209128A4 publication Critical patent/EP3209128A4/de
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Dentistry (AREA)
  • Physiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Biophysics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP15853016.2A 2014-10-24 2015-10-23 Neuartige zusammensetzung und lösung mit kontrolliertem calciumionengehalt und zugehöriges verfahren und verwendung zur reperfusion Withdrawn EP3209128A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462068524P 2014-10-24 2014-10-24
PCT/CA2015/050297 WO2015154193A1 (en) 2014-04-10 2015-04-10 Modulation of calcium ion homeostasis in harvested transplantable hearts
PCT/CA2015/051084 WO2016061700A1 (en) 2014-10-24 2015-10-23 Novel composition and solution with controlled calcium ion level, and related method and use for reperfusion

Publications (2)

Publication Number Publication Date
EP3209128A1 EP3209128A1 (de) 2017-08-30
EP3209128A4 true EP3209128A4 (de) 2018-04-11

Family

ID=55760003

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15853016.2A Withdrawn EP3209128A4 (de) 2014-10-24 2015-10-23 Neuartige zusammensetzung und lösung mit kontrolliertem calciumionengehalt und zugehöriges verfahren und verwendung zur reperfusion

Country Status (6)

Country Link
EP (1) EP3209128A4 (de)
CN (2) CN113841687A (de)
AU (1) AU2015336862B2 (de)
BR (1) BR112017008076B1 (de)
CA (1) CA2965400C (de)
WO (1) WO2016061700A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201600120839A1 (it) * 2016-12-01 2018-06-01 Valentina Valenti Soluzione cardioplegica con attivatori dell'autofagia per l'arresto diastolico del cuore in corso di interventi cardiochirurgici
CN113303325A (zh) * 2021-05-27 2021-08-27 南方医科大学南方医院 一种灌注液和适用于大鼠供体心脏的常温血液机械灌注系统

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5407793A (en) * 1991-10-18 1995-04-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education An aqueous heart preservation and cardioplegia solution
WO2001001774A1 (en) * 1999-06-17 2001-01-11 Regents Of The University Of California Continuous cardiac perfusion preservation with peg-hb for improved hypothermic storage
US20030124503A1 (en) * 2001-12-28 2003-07-03 Olivencia-Yurvati Albert H. Pyruvate cardioplegia solutions for administration to the heart during cardiopulmonary surgery and methods of use thereof
US20050202394A1 (en) * 2002-06-21 2005-09-15 Global Cardiac Solutions Pty. Ltd. Organ arrest, protection, preservation and recovery

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2785501B1 (fr) * 1998-11-10 2001-01-05 Centre Nat Rech Scient Solution de perfusion et/ou de conservation et/ou de reperfusion lors de la transplantation d'organes
FR2975869B1 (fr) * 2011-05-31 2017-03-03 Hemarina Composition de preservation d'organe et utilisations
ES2834388T3 (es) * 2014-04-10 2021-06-17 Tevosol Inc Modulación de la homeostasis de iones calcio en corazones trasplantables recogidos
CN103893205B (zh) * 2014-04-15 2016-03-09 青岛大学附属医院 一种包含利多卡因和腺苷的心脏停搏液及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5407793A (en) * 1991-10-18 1995-04-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education An aqueous heart preservation and cardioplegia solution
WO2001001774A1 (en) * 1999-06-17 2001-01-11 Regents Of The University Of California Continuous cardiac perfusion preservation with peg-hb for improved hypothermic storage
US20030124503A1 (en) * 2001-12-28 2003-07-03 Olivencia-Yurvati Albert H. Pyruvate cardioplegia solutions for administration to the heart during cardiopulmonary surgery and methods of use thereof
US20050202394A1 (en) * 2002-06-21 2005-09-15 Global Cardiac Solutions Pty. Ltd. Organ arrest, protection, preservation and recovery

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
D J HEARSE ET AL: "Protection of the myocardium during ischemic arrest. Dose response curves for procaine and lignocaine in cardioplegic solutions", MEDLINE, 1 June 1981 (1981-06-01), U.S.A., pages 1 - 2, XP055454788, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pubmed/7230856> [retrieved on 20180227] *
DOBSON G P ET AL: "Adenosine and lidocaine: a new concept in nondepolarizing surgical myocardial arrest, protection, and preservation", JOURNAL OF THORACIC AND CARDIOVASCULAR SURG, MOSBY-YEAR BOOK, INC., ST. LOUIS, MO, US, vol. 127, no. 3, 1 March 2004 (2004-03-01), pages 794 - 805, XP008092313, ISSN: 0022-5223, DOI: 10.1016/S0022-5223(03)01192-9 *
DONNA M RUDD ET AL: "Eight hours of cold static storage with adenosine and lidocaine (Adenocaine) heart preservation solutions: Toward therapeutic suspended animation", JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, MOSBY-YEAR BOOK, INC., ST. LOUIS, MO, US, vol. 142, no. 6, 5 May 2011 (2011-05-05), pages 1552 - 1561, XP028111611, ISSN: 0022-5223, [retrieved on 20110528], DOI: 10.1016/J.JTCVS.2011.05.023 *
N TAKEMOTO, H KURODA, T MORI: "THE RECIPROCAL PROTECTIVE EFFECTS OF MAGNESIUM AND CALCIUM IN HYPERKALEMIC CARDIOPLEGIC SOLUTIONS ON ISCHEMIC MYOCARDIUM", BASIC RESEARCH IN CARDIOLOGY, vol. 87, 1 September 1992 (1992-09-01), pages 559 - 569, XP009503749 *
See also references of WO2016061700A1 *
STACY B O BLENES ET AL: "Protecting the aged heart during cardiac surgery: The potential benefits of del Nido cardioplegia", JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, MOSBY-YEAR BOOK, INC., ST. LOUIS, MO, US, vol. 141, no. 3, 2 June 2010 (2010-06-02), pages 762 - 770, XP028144755, ISSN: 0022-5223, [retrieved on 20100607], DOI: 10.1016/J.JTCVS.2010.06.004 *

Also Published As

Publication number Publication date
BR112017008076B1 (pt) 2021-06-29
AU2015336862B2 (en) 2018-08-09
CN107105640B (zh) 2021-10-12
CN113841687A (zh) 2021-12-28
BR112017008076A2 (pt) 2017-12-26
AU2015336862A1 (en) 2017-06-01
CA2965400C (en) 2023-03-14
EP3209128A1 (de) 2017-08-30
CN107105640A (zh) 2017-08-29
CA2965400A1 (en) 2016-04-28
WO2016061700A1 (en) 2016-04-28

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