AU2015336862B2 - Novel composition and solution with controlled calcium ion level, and related method and use for reperfusion - Google Patents

Novel composition and solution with controlled calcium ion level, and related method and use for reperfusion Download PDF

Info

Publication number
AU2015336862B2
AU2015336862B2 AU2015336862A AU2015336862A AU2015336862B2 AU 2015336862 B2 AU2015336862 B2 AU 2015336862B2 AU 2015336862 A AU2015336862 A AU 2015336862A AU 2015336862 A AU2015336862 A AU 2015336862A AU 2015336862 B2 AU2015336862 B2 AU 2015336862B2
Authority
AU
Australia
Prior art keywords
mmol
heart
pct
solution
reperfusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2015336862A
Other languages
English (en)
Other versions
AU2015336862A1 (en
Inventor
Darren FREED
Larry Hryshko
Christopher White
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transmedics Inc
Original Assignee
Transmedics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CA2015/050297 external-priority patent/WO2015154193A1/en
Application filed by Transmedics Inc filed Critical Transmedics Inc
Publication of AU2015336862A1 publication Critical patent/AU2015336862A1/en
Application granted granted Critical
Publication of AU2015336862B2 publication Critical patent/AU2015336862B2/en
Assigned to Tevosol, Inc. reassignment Tevosol, Inc. Request for Assignment Assignors: FREED, Darren
Assigned to TRANSMEDICS, INC. reassignment TRANSMEDICS, INC. Request for Assignment Assignors: Tevosol, Inc.
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02Preservation of living parts
    • A01N1/0205Chemical aspects
    • A01N1/021Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physiology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2015336862A 2014-10-24 2015-10-23 Novel composition and solution with controlled calcium ion level, and related method and use for reperfusion Active AU2015336862B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462068524P 2014-10-24 2014-10-24
US62/068,524 2014-10-24
AUPCT/CA2015/050297 2015-04-10
PCT/CA2015/050297 WO2015154193A1 (en) 2014-04-10 2015-04-10 Modulation of calcium ion homeostasis in harvested transplantable hearts
PCT/CA2015/051084 WO2016061700A1 (en) 2014-10-24 2015-10-23 Novel composition and solution with controlled calcium ion level, and related method and use for reperfusion

Publications (2)

Publication Number Publication Date
AU2015336862A1 AU2015336862A1 (en) 2017-06-01
AU2015336862B2 true AU2015336862B2 (en) 2018-08-09

Family

ID=55760003

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015336862A Active AU2015336862B2 (en) 2014-10-24 2015-10-23 Novel composition and solution with controlled calcium ion level, and related method and use for reperfusion

Country Status (6)

Country Link
EP (1) EP3209128A4 (zh)
CN (2) CN107105640B (zh)
AU (1) AU2015336862B2 (zh)
BR (1) BR112017008076B1 (zh)
CA (1) CA2965400C (zh)
WO (1) WO2016061700A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201600120839A1 (it) * 2016-12-01 2018-06-01 Valentina Valenti Soluzione cardioplegica con attivatori dell'autofagia per l'arresto diastolico del cuore in corso di interventi cardiochirurgici
CN113303325A (zh) * 2021-05-27 2021-08-27 南方医科大学南方医院 一种灌注液和适用于大鼠供体心脏的常温血液机械灌注系统

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5407793A (en) * 1991-10-18 1995-04-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education An aqueous heart preservation and cardioplegia solution
FR2785501B1 (fr) * 1998-11-10 2001-01-05 Centre Nat Rech Scient Solution de perfusion et/ou de conservation et/ou de reperfusion lors de la transplantation d'organes
WO2001001774A1 (en) * 1999-06-17 2001-01-11 Regents Of The University Of California Continuous cardiac perfusion preservation with peg-hb for improved hypothermic storage
US20030124503A1 (en) * 2001-12-28 2003-07-03 Olivencia-Yurvati Albert H. Pyruvate cardioplegia solutions for administration to the heart during cardiopulmonary surgery and methods of use thereof
AUPS312602A0 (en) * 2002-06-21 2002-07-18 James Cook University Organ arrest, protection, preservation and recovery
FR2975869B1 (fr) * 2011-05-31 2017-03-03 Hemarina Composition de preservation d'organe et utilisations
EP3128836B1 (en) * 2014-04-10 2020-09-09 Tevosol, Inc. Modulation of calcium ion homeostasis in harvested transplantable hearts
CN103893205B (zh) * 2014-04-15 2016-03-09 青岛大学附属医院 一种包含利多卡因和腺苷的心脏停搏液及其制备方法

Also Published As

Publication number Publication date
WO2016061700A1 (en) 2016-04-28
BR112017008076B1 (pt) 2021-06-29
BR112017008076A2 (pt) 2017-12-26
CN107105640B (zh) 2021-10-12
EP3209128A1 (en) 2017-08-30
CN113841687A (zh) 2021-12-28
CN107105640A (zh) 2017-08-29
CA2965400C (en) 2023-03-14
CA2965400A1 (en) 2016-04-28
AU2015336862A1 (en) 2017-06-01
EP3209128A4 (en) 2018-04-11

Similar Documents

Publication Publication Date Title
US11033021B2 (en) Composition and solution with controlled calcium ion level, and related method and use for reperfusion
US10327441B2 (en) Modulation of calcium ion homeostasis in harvested transplantable hearts
EP2611291B1 (en) Perfusion composition
EP3122180B1 (en) Apparatus for maintenance of harvested hearts for transplanting
AU2015336862B2 (en) Novel composition and solution with controlled calcium ion level, and related method and use for reperfusion
US20240090494A1 (en) Perfusion solution
Rudd et al. Toward a new cold and warm nondepolarizing, normokalemic arrest paradigm for orthotopic heart transplantation
Finger Organ preservation
Buchko et al. Continuous Hemodialysis during Ex Vivo Lung Perfusion Allows for Improved Maintenance of Perfusate Composition, without Compromising Functional Performance
Sugawara et al. A heat shock protein 70 inducer, geranylgeranylacetone, suppresses ischemia-reperfusion injury after lung transplantation in rats

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: TEVOSOL, INC.

Free format text: FORMER OWNER(S): FREED, DARREN

PC Assignment registered

Owner name: TRANSMEDICS, INC.

Free format text: FORMER OWNER(S): TEVOSOL, INC.