BR112017005660A2 - novos ativadores de guanilato ciclase solúvel e sua utilização - Google Patents
novos ativadores de guanilato ciclase solúvel e sua utilizaçãoInfo
- Publication number
- BR112017005660A2 BR112017005660A2 BR112017005660A BR112017005660A BR112017005660A2 BR 112017005660 A2 BR112017005660 A2 BR 112017005660A2 BR 112017005660 A BR112017005660 A BR 112017005660A BR 112017005660 A BR112017005660 A BR 112017005660A BR 112017005660 A2 BR112017005660 A2 BR 112017005660A2
- Authority
- BR
- Brazil
- Prior art keywords
- guanylate cyclase
- soluble guanylate
- cyclase activators
- new soluble
- pharmaceutical compositions
- Prior art date
Links
- 102000007637 Soluble Guanylyl Cyclase Human genes 0.000 title abstract 3
- 108010007205 Soluble Guanylyl Cyclase Proteins 0.000 title abstract 3
- 239000003119 guanylate cyclase activator Substances 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000004410 intraocular pressure Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462052537P | 2014-09-19 | 2014-09-19 | |
| PCT/IB2015/057219 WO2016042536A1 (en) | 2014-09-19 | 2015-09-18 | Novel soluble guanylate cyclase activators and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017005660A2 true BR112017005660A2 (pt) | 2017-12-19 |
Family
ID=54238488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017005660A BR112017005660A2 (pt) | 2014-09-19 | 2015-09-18 | novos ativadores de guanilato ciclase solúvel e sua utilização |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9938260B2 (https=) |
| EP (1) | EP3194384A1 (https=) |
| JP (3) | JP6678656B2 (https=) |
| KR (1) | KR20170054508A (https=) |
| CN (1) | CN106687456B (https=) |
| AU (1) | AU2015319724B2 (https=) |
| BR (1) | BR112017005660A2 (https=) |
| CA (1) | CA2961745A1 (https=) |
| CL (1) | CL2017000640A1 (https=) |
| CO (1) | CO2017002506A2 (https=) |
| CR (1) | CR20170102A (https=) |
| DO (1) | DOP2017000073A (https=) |
| EA (1) | EA033697B1 (https=) |
| IL (1) | IL251094A0 (https=) |
| MA (1) | MA40583A (https=) |
| MX (1) | MX2017003621A (https=) |
| PE (1) | PE20170937A1 (https=) |
| PH (1) | PH12017500481A1 (https=) |
| SG (1) | SG11201701915TA (https=) |
| WO (1) | WO2016042536A1 (https=) |
| ZA (1) | ZA201701835B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201606269WA (en) | 2014-02-06 | 2016-09-29 | Heptares Therapeutics Ltd | Bicyclic aza compounds as muscarinic m1 receptor and/or m4 receptor agonists |
| PE20170937A1 (es) * | 2014-09-19 | 2017-07-13 | Glaxosmithkline Ip Dev Ltd | Nuevos activadores de la guanilato ciclasa soluble y su uso |
| AU2015316796A1 (en) | 2014-09-19 | 2017-03-30 | Bayer Pharma Aktiengesellschaft | Benzyl substituted indazoles as Bub1 inhibitors |
| CN109890379A (zh) | 2016-10-11 | 2019-06-14 | 拜耳制药股份公司 | 包含sGC活化剂和盐皮质激素受体拮抗剂的组合产品 |
| WO2019081456A1 (en) | 2017-10-24 | 2019-05-02 | Bayer Aktiengesellschaft | USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT |
| EP3498298A1 (en) | 2017-12-15 | 2019-06-19 | Bayer AG | The use of sgc stimulators and sgc activators alone or in combination with pde5 inhibitors for the treatment of bone disorders including osteogenesis imperfecta (oi) |
| EP3787610A1 (en) | 2018-04-30 | 2021-03-10 | Bayer Aktiengesellschaft | The use of sgc activators and sgc stimulators for the treatment of cognitive impairment |
| EP3793553A1 (en) | 2018-05-15 | 2021-03-24 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization |
| EP3574905A1 (en) | 2018-05-30 | 2019-12-04 | Adverio Pharma GmbH | Method of identifying a subgroup of patients suffering from dcssc which benefits from a treatment with sgc stimulators and sgc activators in a higher degree than a control group |
| US20220128561A1 (en) | 2019-01-17 | 2022-04-28 | Bayer Aktiengesellschaft | Methods to determine whether a subject is suitable of being treated with an agonist of soluble gyanylyl cyclase (sgc) |
| EP4536205A1 (en) | 2022-06-09 | 2025-04-16 | Bayer Aktiengesellschaft | Soluble guanylate cyclase activators for use in the treatment of heart failure with preserved ejection fraction in women |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5602143A (en) | 1994-12-08 | 1997-02-11 | Allergan | Method for reducing intraocular pressure in the mammalian eye by administration of guanylate cyclase inhibitors |
| WO2008067127A2 (en) * | 2006-11-09 | 2008-06-05 | Alcon Research, Ltd. | Water insoluble polymer matrix for drug delivery |
| TW200938529A (en) * | 2007-12-03 | 2009-09-16 | Smithkline Beecham Corp | Compounds |
| WO2010015653A1 (en) * | 2008-08-07 | 2010-02-11 | Smithkline Beecham Corporation | Pyrimidine derivatives as activators of soluble guanylate cyclase |
| KR20110133034A (ko) * | 2009-02-26 | 2011-12-09 | 머크 샤프 앤드 돔 코포레이션 | 가용성 구아닐레이트 시클라제 활성화제 |
| DE102009012314A1 (de) | 2009-03-09 | 2010-09-16 | Bayer Schering Pharma Aktiengesellschaft | Oxo-heterocyclisch substituierte Alkylcarbonsäuren und ihre Verwendung |
| JP5636296B2 (ja) | 2011-01-20 | 2014-12-03 | 公益財団法人微生物化学研究会 | 塩分含有有機廃液処理剤、並びに、塩分濃度低下剤、塩分含有有機廃液の処理方法、及び包括固定担体 |
| PE20170937A1 (es) * | 2014-09-19 | 2017-07-13 | Glaxosmithkline Ip Dev Ltd | Nuevos activadores de la guanilato ciclasa soluble y su uso |
-
2015
- 2015-09-18 PE PE2017000478A patent/PE20170937A1/es unknown
- 2015-09-18 CA CA2961745A patent/CA2961745A1/en not_active Abandoned
- 2015-09-18 JP JP2017515074A patent/JP6678656B2/ja active Active
- 2015-09-18 MX MX2017003621A patent/MX2017003621A/es unknown
- 2015-09-18 CR CR20170102A patent/CR20170102A/es unknown
- 2015-09-18 KR KR1020177010181A patent/KR20170054508A/ko not_active Ceased
- 2015-09-18 EP EP15772026.9A patent/EP3194384A1/en not_active Withdrawn
- 2015-09-18 BR BR112017005660A patent/BR112017005660A2/pt not_active Application Discontinuation
- 2015-09-18 US US15/509,895 patent/US9938260B2/en active Active
- 2015-09-18 AU AU2015319724A patent/AU2015319724B2/en active Active
- 2015-09-18 CN CN201580050717.XA patent/CN106687456B/zh active Active
- 2015-09-18 EA EA201790655A patent/EA033697B1/ru not_active IP Right Cessation
- 2015-09-18 WO PCT/IB2015/057219 patent/WO2016042536A1/en not_active Ceased
- 2015-09-18 SG SG11201701915TA patent/SG11201701915TA/en unknown
- 2015-09-18 MA MA040583A patent/MA40583A/fr unknown
-
2017
- 2017-03-12 IL IL251094A patent/IL251094A0/en unknown
- 2017-03-14 ZA ZA2017/01835A patent/ZA201701835B/en unknown
- 2017-03-14 PH PH12017500481A patent/PH12017500481A1/en unknown
- 2017-03-16 CL CL2017000640A patent/CL2017000640A1/es unknown
- 2017-03-16 CO CONC2017/0002506A patent/CO2017002506A2/es unknown
- 2017-03-16 DO DO2017000073A patent/DOP2017000073A/es unknown
-
2018
- 2018-03-05 US US15/911,797 patent/US10472350B2/en active Active
-
2020
- 2020-03-02 JP JP2020035272A patent/JP6908747B2/ja active Active
-
2021
- 2021-06-30 JP JP2021109106A patent/JP2021155450A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016042536A1 (en) | 2016-03-24 |
| CN106687456B (zh) | 2019-12-03 |
| DOP2017000073A (es) | 2017-04-16 |
| JP2020105189A (ja) | 2020-07-09 |
| MA40583A (fr) | 2016-03-24 |
| IL251094A0 (en) | 2017-04-30 |
| CA2961745A1 (en) | 2016-03-24 |
| JP6908747B2 (ja) | 2021-07-28 |
| EA033697B1 (ru) | 2019-11-18 |
| US20170305888A1 (en) | 2017-10-26 |
| EP3194384A1 (en) | 2017-07-26 |
| JP2021155450A (ja) | 2021-10-07 |
| AU2015319724B2 (en) | 2018-05-10 |
| US9938260B2 (en) | 2018-04-10 |
| KR20170054508A (ko) | 2017-05-17 |
| AU2015319724A1 (en) | 2017-04-06 |
| SG11201701915TA (en) | 2017-04-27 |
| PH12017500481A1 (en) | 2017-08-07 |
| JP2017527602A (ja) | 2017-09-21 |
| CN106687456A (zh) | 2017-05-17 |
| CL2017000640A1 (es) | 2017-10-06 |
| US20180194756A1 (en) | 2018-07-12 |
| CO2017002506A2 (es) | 2017-07-28 |
| JP6678656B2 (ja) | 2020-04-08 |
| EA201790655A1 (ru) | 2017-08-31 |
| PE20170937A1 (es) | 2017-07-13 |
| US10472350B2 (en) | 2019-11-12 |
| MX2017003621A (es) | 2017-07-14 |
| ZA201701835B (en) | 2018-12-19 |
| CR20170102A (es) | 2017-07-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112017005660A2 (pt) | novos ativadores de guanilato ciclase solúvel e sua utilização | |
| MX2016016666A (es) | Derivados de acido boronico y usos terapeuticos de los mismos. | |
| MX2016015093A (es) | Derivados de acido boronico y sus usos terapeuticos. | |
| BR112018012707A2 (pt) | inibidores da interação de menin-mll | |
| SV2018005760A (es) | Derivados de aminotiazol utiles como agentes antiviricos | |
| MX2015012414A (es) | Sal de omecamtiv mecarbilo y proceso para preparar la sal. | |
| CL2016001918A1 (es) | Heteroaril amidas como inhibidores de agregación de proteína | |
| BR112019000693A2 (pt) | composições de muc1- car e métodos para uso | |
| BR112016006048A8 (pt) | composições antimicrobianas | |
| MX2020002123A (es) | Sales de ribociclib y formas en estado sólido de las mismas. | |
| MX376122B (es) | Composiciones de plinabulina. | |
| MX2017006953A (es) | Medicamentos para disminuir la evolucion de la enfermedad de parkinson. | |
| AR101414A1 (es) | Derivados de pirrolidinona como inhibidores de metap-2 | |
| EA201791716A1 (ru) | Фармацевтический состав | |
| CO2017001601A2 (es) | Derivados de 1-acetil-4-((pirazin-2-il) amino)-1,2,3,4-tetrahydroquinolina-6 carboxamida como inhibidores de bromodominio | |
| DOP2016000297A (es) | Composiciones farmacéuticas útiles para tratar enfermedades infecciosas | |
| MX389026B (es) | Una composicion farmaceutica y el uso de la misma. | |
| EA201691741A1 (ru) | Фармацевтическая композиция | |
| UY36150A (es) | Derivados de naftiridinadiona | |
| MX2018005987A (es) | Compuestos heterociclicos para el tratamiento de enfermedades. | |
| EA201692518A2 (ru) | Способы улучшения производительности миокарда у пациентов после операции фонтена с применением композиций уденафила | |
| CL2018002848A1 (es) | Formulaciones liquidas de fosfoplatino | |
| EA201991373A1 (ru) | МОДУЛЯТОРЫ ROR ГАММА (RORγ) | |
| BR112018004244A2 (pt) | formulações sólidas de pirofosfato férrico solúvel, kits e seus métodos de uso | |
| CO2017002963A2 (es) | Espiro-tiazolonas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |