BR112017002577A2 - vacina recombinante, semente-mãe de um vírus recombinante do adenovírus aviário e uso de um vetor de adenovírus aviário - Google Patents

vacina recombinante, semente-mãe de um vírus recombinante do adenovírus aviário e uso de um vetor de adenovírus aviário

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Publication number
BR112017002577A2
BR112017002577A2 BR112017002577-9A BR112017002577A BR112017002577A2 BR 112017002577 A2 BR112017002577 A2 BR 112017002577A2 BR 112017002577 A BR112017002577 A BR 112017002577A BR 112017002577 A2 BR112017002577 A2 BR 112017002577A2
Authority
BR
Brazil
Prior art keywords
vaccine
recombinant
avian adenovirus
vector
disease
Prior art date
Application number
BR112017002577-9A
Other languages
English (en)
Inventor
Lozano-Dubernard Bernardo
Soto- Priante Ernesto
Sarfati-Mizrahi David
Original Assignee
Grupo Industrial Pecuario, S.A. De C.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grupo Industrial Pecuario, S.A. De C.V. filed Critical Grupo Industrial Pecuario, S.A. De C.V.
Publication of BR112017002577A2 publication Critical patent/BR112017002577A2/pt

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
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    • C12N2710/10011—Adenoviridae
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10211—Aviadenovirus, e.g. fowl adenovirus A
    • C12N2710/10234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10211—Aviadenovirus, e.g. fowl adenovirus A
    • C12N2710/10241—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10211—Aviadenovirus, e.g. fowl adenovirus A
    • C12N2710/10271—Demonstrated in vivo effect
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2710/16011—Herpesviridae
    • C12N2710/16071—Demonstrated in vivo effect
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16171—Demonstrated in vivo effect

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Abstract

uma vacina recombinante que compreende um vetor de adenovírus aviário, sorotipo 9 (fadv-9), com pelo menos uma sequência de nucleotídeos exógena inserida que codifica pelo menos um antígeno de uma doença de interesse e que substitui a região não essencial do genoma do adenovírus, e um veículo, adjuvante e/ou excipiente farmaceuticamente aceitáveis, em que a pelo menos uma sequência de nucleotídeos exógena que codifica pelo menos um antígeno de uma doença de interesse e que substitui a região não essencial do genoma do adenovírus está localizada entre os nucleotídeos 491 e 2782. o vetor desta vacina é estável para produção em escala industrial. da mesma forma, mesmo quando esta vacina é administrada em combinação com uma vacina contra a doença de marek, ambas as vacinas produzem uma resposta imune adequada que não é afetada pela interferência entre elas. da mesma forma, a eficácia da vacina recombinante não é afetada pelos anticorpos maternos e é capaz de induzir uma resposta protetora precoce e duradoura, mesmo com uma única aplicação.
BR112017002577-9A 2014-08-08 2015-08-06 vacina recombinante, semente-mãe de um vírus recombinante do adenovírus aviário e uso de um vetor de adenovírus aviário BR112017002577A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IBPCT/IB2014/063809 2014-08-08
PCT/IB2014/063809 WO2016020730A1 (es) 2014-08-08 2014-08-08 Vacuna en vector recombinante de adenovirus aviar serotipo 9
PCT/IB2015/055994 WO2016020885A1 (es) 2014-08-08 2015-08-06 Vacuna en vector recombinante de adenovirus aviar serotipo 9

Publications (1)

Publication Number Publication Date
BR112017002577A2 true BR112017002577A2 (pt) 2018-02-27

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BR112017002577-9A BR112017002577A2 (pt) 2014-08-08 2015-08-06 vacina recombinante, semente-mãe de um vírus recombinante do adenovírus aviário e uso de um vetor de adenovírus aviário

Country Status (14)

Country Link
US (1) US10758608B2 (pt)
EP (1) EP3178938A4 (pt)
JP (1) JP2017526737A (pt)
KR (1) KR20170063552A (pt)
CN (1) CN106661592A (pt)
AR (1) AR101468A1 (pt)
BR (1) BR112017002577A2 (pt)
CA (1) CA2956997A1 (pt)
CO (1) CO2017001614A2 (pt)
EA (1) EA038951B1 (pt)
MX (3) MX2017001742A (pt)
PE (2) PE20170429A1 (pt)
PH (1) PH12017500216A1 (pt)
WO (2) WO2016020730A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110043732A (ko) 2008-08-08 2011-04-27 쓰리엠 이노베이티브 프로퍼티즈 컴파니 광을 처리하기 위한 점탄성층을 갖는 도광체
WO2016020730A1 (es) * 2014-08-08 2016-02-11 Laboratorio Avi-Mex, S.A. De C.V. Vacuna en vector recombinante de adenovirus aviar serotipo 9
CN108126191B (zh) * 2016-12-01 2021-04-06 普莱柯生物工程股份有限公司 一种疫苗组合物及其制备方法和应用
CN108653724B (zh) * 2017-04-01 2020-11-27 普莱柯生物工程股份有限公司 一种用于预防禽减蛋综合征的疫苗组合物、及其制备方法和应用
CN110680914B (zh) * 2019-09-23 2021-11-26 洛阳职业技术学院 一种三联灭活疫苗及其制备方法
CN111494617A (zh) * 2020-04-08 2020-08-07 扬州优邦生物药品有限公司 一种四联灭活疫苗及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL103939A (en) * 1992-12-01 1996-09-12 Abic Ltd An anti-DBI vaccine in birds containing attenuated live DBI virus
JP3606870B2 (ja) 1993-04-14 2005-01-05 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガニゼーション 組換えトリアデノウイルスベクター
US6296852B1 (en) 1993-04-14 2001-10-02 Commonwealth Scientific And Industrial Research Organisation Recombinant avian adenovirus vector
US6048535A (en) * 1997-06-12 2000-04-11 Regents Of The University Of Minnesota Multivalent in ovo avian vaccine
WO2007072916A1 (ja) * 2005-12-22 2007-06-28 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute 卵内接種用ワクチン
KR20110081222A (ko) * 2008-09-26 2011-07-13 어번 유니버시티 비복제성 벡터화된 백신의 점막 투여에 의한 조류의 면역화
EP2353610A4 (en) 2008-11-19 2013-12-11 Avi Mex S A De C V Lab RECOMBINANT INACTIVATED VIRUS VECTOR VACCINE
WO2016020730A1 (es) * 2014-08-08 2016-02-11 Laboratorio Avi-Mex, S.A. De C.V. Vacuna en vector recombinante de adenovirus aviar serotipo 9
BR112018000194A2 (pt) * 2015-07-10 2018-09-11 University Of Guelph sistema de vetor de adenovírus 9 de ave (fadv-9) e métodos associados

Also Published As

Publication number Publication date
CN106661592A (zh) 2017-05-10
EP3178938A4 (en) 2018-03-21
WO2016020885A1 (es) 2016-02-11
EA201790296A1 (ru) 2017-06-30
MX2022000718A (es) 2022-02-24
MX2022003590A (es) 2022-05-26
KR20170063552A (ko) 2017-06-08
CA2956997A1 (en) 2016-02-11
WO2016020730A1 (es) 2016-02-11
EA038951B1 (ru) 2021-11-15
MX2017001742A (es) 2017-05-15
PH12017500216B1 (en) 2017-07-03
CO2017001614A2 (es) 2017-07-28
EP3178938A1 (en) 2017-06-14
PE20221792A1 (es) 2022-11-25
AR101468A1 (es) 2016-12-21
JP2017526737A (ja) 2017-09-14
US10758608B2 (en) 2020-09-01
PH12017500216A1 (en) 2017-07-03
PE20170429A1 (es) 2017-05-11
US20170232096A1 (en) 2017-08-17

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