BR112016030560A8 - parceiros de ligação específicos para epímeros de vitamina d, anticorpo e método para separar uma vitamina d epimérica de uma amostra suspeita de conter uma vitamina d epimérica - Google Patents
parceiros de ligação específicos para epímeros de vitamina d, anticorpo e método para separar uma vitamina d epimérica de uma amostra suspeita de conter uma vitamina d epiméricaInfo
- Publication number
- BR112016030560A8 BR112016030560A8 BR112016030560A BR112016030560A BR112016030560A8 BR 112016030560 A8 BR112016030560 A8 BR 112016030560A8 BR 112016030560 A BR112016030560 A BR 112016030560A BR 112016030560 A BR112016030560 A BR 112016030560A BR 112016030560 A8 BR112016030560 A8 BR 112016030560A8
- Authority
- BR
- Brazil
- Prior art keywords
- vitamin
- epimeric
- epimers
- antibodies
- antibody
- Prior art date
Links
- 229940046008 vitamin d Drugs 0.000 title abstract 9
- 230000009870 specific binding Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000012491 analyte Substances 0.000 abstract 2
- 230000009260 cross reactivity Effects 0.000 abstract 2
- 230000002163 immunogen Effects 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 1
- 230000027455 binding Effects 0.000 abstract 1
- 239000002981 blocking agent Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
parceiros de ligação específicos para epímeros de vitamina d. a presente invenção refere-se a anticorpos que são aumentados contra compostos de fórmula (i), em que z é um carreador imunogênico. estes compostos são capazes de se ligar especificamente a anticorpos correspondentes. os anticorpos são específicos para epímeros de vitamina d. anticorpos de acordo com os princípios descritos no presente relatório descritivo, podem ser empregados para minimizar ou eliminar reatividade cruzada de 3-epímero em ensaios para formas não epiméricas de analitos de vitamina d. a sobrestimação de analito de vitamina d não epimérico total causada pela reatividade cruzada de vitamina d de 3-epímero com um anticorpo para analito de vitamina d pode ser substancialmente evitada empregando-se, como agentes de bloqueio, anticorpos preparados contra imunógenos, que são um composto da fórmula (i), em que z é um carreador imunogênico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462018012P | 2014-06-27 | 2014-06-27 | |
PCT/US2015/036907 WO2015200182A1 (en) | 2014-06-27 | 2015-06-22 | Binding partners specific for vitamin d epimers |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112016030560A2 BR112016030560A2 (pt) | 2017-08-15 |
BR112016030560A8 true BR112016030560A8 (pt) | 2021-07-13 |
Family
ID=54938700
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016030560A BR112016030560A8 (pt) | 2014-06-27 | 2015-06-22 | parceiros de ligação específicos para epímeros de vitamina d, anticorpo e método para separar uma vitamina d epimérica de uma amostra suspeita de conter uma vitamina d epimérica |
Country Status (8)
Country | Link |
---|---|
US (1) | US9815907B2 (pt) |
EP (1) | EP3172239A4 (pt) |
JP (1) | JP6681349B2 (pt) |
KR (2) | KR102309377B1 (pt) |
CN (2) | CN106661115A (pt) |
AU (1) | AU2015280292B2 (pt) |
BR (1) | BR112016030560A8 (pt) |
WO (1) | WO2015200182A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2015280290B2 (en) * | 2014-06-27 | 2019-09-19 | Siemens Healthcare Diagnostics Inc. | Compositions relating to vitamin D |
US10191069B2 (en) | 2014-12-17 | 2019-01-29 | Siemens Healthcare Diagnostics Inc. | Accurate assay measurement of hydrophobic haptenic analytes |
JPWO2021100841A1 (pt) * | 2019-11-22 | 2021-05-27 |
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JPH01503808A (ja) | 1987-07-16 | 1989-12-21 | イー・アイ・デユポン・ド・ネモアース・アンド・コンパニー(インコーポレイテツド) | 固定化された凝集剤を用いるアフイニテイ分離 |
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JPH09143154A (ja) | 1995-11-20 | 1997-06-03 | Kureha Chem Ind Co Ltd | ビタミンd3 誘導体の製造方法 |
EP0873126A4 (en) | 1995-12-29 | 2000-04-19 | A And D Assay Inc | BRANDED VITAMIN COMPOUNDS AND THEIR USE |
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US8133694B2 (en) * | 1998-06-25 | 2012-03-13 | Immundiagnostik Ag | Functional vitamin D derivatives and method of determining 25-hydroxy- and 1α, 25-dihydroxy vitamin D |
ATE256658T1 (de) * | 1998-06-25 | 2004-01-15 | Immundiagnostik Ges Fuer Produ | Funktionelle vitamin-d-derivate und verfahren zur bestimmung von 25-hydroxy- und 1alpha,25- dihydroxy-vitamin-d |
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-
2015
- 2015-06-22 CN CN201580034567.3A patent/CN106661115A/zh active Pending
- 2015-06-22 JP JP2016575396A patent/JP6681349B2/ja active Active
- 2015-06-22 US US15/319,221 patent/US9815907B2/en active Active
- 2015-06-22 AU AU2015280292A patent/AU2015280292B2/en active Active
- 2015-06-22 KR KR1020187005289A patent/KR102309377B1/ko active IP Right Grant
- 2015-06-22 EP EP15811774.7A patent/EP3172239A4/en active Pending
- 2015-06-22 WO PCT/US2015/036907 patent/WO2015200182A1/en active Application Filing
- 2015-06-22 BR BR112016030560A patent/BR112016030560A8/pt active Search and Examination
- 2015-06-22 KR KR1020177002253A patent/KR20170014013A/ko active Application Filing
- 2015-06-22 CN CN202110304614.9A patent/CN112979818A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2017526630A (ja) | 2017-09-14 |
KR20170014013A (ko) | 2017-02-07 |
BR112016030560A2 (pt) | 2017-08-15 |
EP3172239A1 (en) | 2017-05-31 |
WO2015200182A1 (en) | 2015-12-30 |
JP6681349B2 (ja) | 2020-04-15 |
KR20180021933A (ko) | 2018-03-05 |
EP3172239A4 (en) | 2017-06-21 |
AU2015280292A1 (en) | 2016-12-15 |
CN106661115A (zh) | 2017-05-10 |
KR102309377B1 (ko) | 2021-10-05 |
US20170121426A1 (en) | 2017-05-04 |
AU2015280292B2 (en) | 2019-08-01 |
CN112979818A (zh) | 2021-06-18 |
US9815907B2 (en) | 2017-11-14 |
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