BR112016020987A2 - método de identificação de receptores de aloenxerto renal, kit, conjunto de assinatura gênica, método de seleção de paciente e uso de um agente imunossupressivo - Google Patents
método de identificação de receptores de aloenxerto renal, kit, conjunto de assinatura gênica, método de seleção de paciente e uso de um agente imunossupressivoInfo
- Publication number
- BR112016020987A2 BR112016020987A2 BR112016020987A BR112016020987A BR112016020987A2 BR 112016020987 A2 BR112016020987 A2 BR 112016020987A2 BR 112016020987 A BR112016020987 A BR 112016020987A BR 112016020987 A BR112016020987 A BR 112016020987A BR 112016020987 A2 BR112016020987 A2 BR 112016020987A2
- Authority
- BR
- Brazil
- Prior art keywords
- kit
- immunosuppressive agent
- gene signature
- patient selection
- signature set
- Prior art date
Links
- 230000004547 gene signature Effects 0.000 title 1
- 229940125721 immunosuppressive agent Drugs 0.000 title 1
- 239000003018 immunosuppressive agent Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000010187 selection method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461951651P | 2014-03-12 | 2014-03-12 | |
| US61/951,651 | 2014-03-12 | ||
| PCT/US2015/020291 WO2015138803A1 (en) | 2014-03-12 | 2015-03-12 | Method for identifying kidney allograft recipients at risk for chronic injury |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112016020987A2 true BR112016020987A2 (pt) | 2017-08-15 |
| BR112016020987A8 BR112016020987A8 (pt) | 2021-07-06 |
| BR112016020987B1 BR112016020987B1 (pt) | 2023-11-14 |
Family
ID=54072426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016020987-7A BR112016020987B1 (pt) | 2014-03-12 | 2015-03-12 | Método de identificação de receptores de aloenxerto renal e método de seleção de receptor do aloenxerto renal |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10941446B2 (pt) |
| EP (1) | EP3117220B1 (pt) |
| CN (2) | CN109207580B (pt) |
| AU (1) | AU2015229270B2 (pt) |
| BR (1) | BR112016020987B1 (pt) |
| CA (1) | CA2942384C (pt) |
| ES (1) | ES2824108T3 (pt) |
| WO (1) | WO2015138803A1 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015229270B2 (en) * | 2014-03-12 | 2020-12-24 | Icahn School Of Medicine At Mount Sinai | Method for identifying kidney allograft recipients at risk for chronic injury |
| ES2850281T3 (es) | 2014-06-26 | 2021-08-26 | Icahn School Med Mount Sinai | Método para diagnosticar el rechazo agudo subclínico y clínico mediante el análisis de conjuntos de genes predictivos, un agente terapéutico para usar en el tratamiento y kits para determinar la expresión |
| WO2017070441A1 (en) * | 2015-10-23 | 2017-04-27 | Icahn School Of Medicine At Mount Sinai | Identifying and treating cancer patients who are suitable for a targeted therapy using an hdac6 inhibitor |
| WO2017100259A1 (en) * | 2015-12-08 | 2017-06-15 | Icahn School Of Medicine At Mount Sinai | Pretransplant prediction of post-transplant acute rejection |
| CN110573629A (zh) * | 2017-03-30 | 2019-12-13 | 伊利诺伊大学理事会 | 用于诊断早期胰腺癌的方法和试剂盒 |
| WO2019122303A1 (en) | 2017-12-22 | 2019-06-27 | Vib Vzw | Predicting chronic allograft injury through ischemia-induced dna methylation |
| EP3781153A4 (en) | 2018-04-16 | 2022-04-06 | Icahn School of Medicine at Mount Sinai | METHOD AND KITS FOR PREDICTING ACUTE REJECTION AND RENAL ALLOGraft LOSS USING PRE-TRANSPLANTATION TRANSCRIPTOMIC SIGNATURES IN RECIPIENT BLOOD |
| EP3983562A1 (en) | 2019-06-17 | 2022-04-20 | Vib Vzw | Predicting chronic allograft injury through age-related dna methylation |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582908B2 (en) | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| WO1996039154A1 (en) | 1995-06-06 | 1996-12-12 | Isis Pharmaceuticals, Inc. | Oligonucleotides having phosphorothioate linkages of high chiral purity |
| US5985662A (en) | 1995-07-13 | 1999-11-16 | Isis Pharmaceuticals Inc. | Antisense inhibition of hepatitis B virus replication |
| US20030104371A1 (en) * | 1997-09-24 | 2003-06-05 | Strom Terry B. | Methods of evaluating transplant rejection |
| JP4212278B2 (ja) | 2001-03-01 | 2009-01-21 | 日本たばこ産業株式会社 | 移植片拒絶反応抑制剤 |
| US7955800B2 (en) | 2002-06-25 | 2011-06-07 | Advpharma Inc. | Metastasis-associated gene profiling for identification of tumor tissue, subtyping, and prediction of prognosis of patients |
| AU2004213839B2 (en) * | 2003-02-14 | 2010-08-12 | Beth Israel Deaconess Medical Center, Inc. | Predicting graft rejection |
| HN2004000285A (es) | 2003-08-04 | 2006-04-27 | Pfizer Prod Inc | ANTICUERPOS DIRIGIDOS A c-MET |
| CN101039951A (zh) | 2003-11-03 | 2007-09-19 | 基因信息公司 | 肝癌生物标志物 |
| CN1846699A (zh) | 2005-04-13 | 2006-10-18 | 中南大学湘雅医院 | 1－(取代苯基)－5－甲基－2－(1h) 吡啶酮(i)化合物用于制备抗除肾间质纤维化外其他器官纤维化或组织纤维化药物的应用 |
| RS53599B1 (en) | 2005-05-10 | 2015-02-27 | Intermune, Inc. | PIRIDON DERIVATIVES FOR STRESS MODULATION OF ACTIVATED PROTEIN KINASE SYSTEMS |
| EP1731620A1 (en) | 2005-06-07 | 2006-12-13 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method for the diagnosis of immune graft tolerance |
| EP2298932A1 (en) | 2005-09-29 | 2011-03-23 | Epigenomics AG | Methods and nucleic acids for the analysis of gene expression, in particular methylation of KAAG1, associated with tissue classification |
| GB0524110D0 (en) | 2005-11-28 | 2006-01-04 | Univ Cambridge Tech | Biomarkers and methods for identification of agents useful in the treatment of affective disorders |
| GB0605217D0 (en) | 2006-03-15 | 2006-04-26 | Novartis Ag | Method and compositions for assessing acute rejection |
| MX2008014110A (es) | 2006-05-02 | 2008-11-14 | Therakos Inc | Metodos y reactivos para detectar la susceptibilidad a la enfermedad del injerto versus el hospedero o mortalidad relacionada con el transplante. |
| US20070269827A1 (en) * | 2006-05-18 | 2007-11-22 | Oklahoma Medical Research Foundation | Predicting and Diagnosing Patients With Autoimmune Disease |
| US20080274911A1 (en) | 2006-11-07 | 2008-11-06 | Burington Bart E | Gene expression profiling based identification of genomic signature of high-risk multiple myeloma and uses thereof |
| EP2104737B1 (en) | 2006-12-08 | 2013-04-10 | Asuragen, INC. | Functions and targets of let-7 micro rnas |
| KR101007926B1 (ko) | 2006-12-27 | 2011-01-12 | (주)레퍼런스바이오랩 | 표준 발현 유전자를 발굴하기 위한 유전자 발현 데이터처리, 분석 방법 |
| CA2713909C (en) | 2008-02-01 | 2023-12-12 | The General Hospital Corporation | Use of microvesicles in diagnosis, prognosis and treatment of medical diseases and conditions |
| JP2011521630A (ja) | 2008-05-30 | 2011-07-28 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | ゲノミクスまたはプロテオミクス発現プロファイリングを用いて腎同種移植の拒絶反応を診断する方法 |
| WO2010009735A2 (en) * | 2008-07-23 | 2010-01-28 | Dako Denmark A/S | Combinatorial analysis and repair |
| ES2492498T3 (es) | 2009-01-15 | 2014-09-09 | The Board Of Trustees Of The Leland Stanford Junior University | Panel de biomarcadores para el diagnóstico y la predicción de rechazo de injerto |
| EP2389582B1 (en) | 2009-01-20 | 2016-04-06 | Cambridge Enterprise Limited | Methods for predicting autoimmune disease risk |
| US9005616B2 (en) | 2009-08-31 | 2015-04-14 | Amplimmune, Inc. | Methods and compositions for the inhibition of transplant rejection |
| MX353186B (es) | 2009-09-03 | 2018-01-05 | Genentech Inc | Metodos para el tratamiento, diagnosis y monitoreo de artritis reumatoide. |
| WO2011044511A2 (en) | 2009-10-08 | 2011-04-14 | The Trustees Of Columbia University In The City Of New York | Rage regulates rock activity in cardiovascular disease |
| PL2496720T3 (pl) * | 2009-11-06 | 2021-01-11 | The Board Of Trustees Of The Leland Stanford Junior University | Nieinwazyjna diagnoza odrzucenia przeszczepu u pacjentów z przeszczepem narządu |
| EP2510116A2 (en) | 2009-12-09 | 2012-10-17 | Aviir, Inc. | Biomarker assay for diagnosis and classification of cardiovascular disease |
| ES2798114T3 (es) * | 2010-03-25 | 2020-12-09 | Univ Leland Stanford Junior | Biomarcadores de proteínas y de genes para el rechazo de trasplantes de órganos |
| KR20130043104A (ko) * | 2010-04-06 | 2013-04-29 | 카리스 라이프 사이언스 룩셈부르크 홀딩스 | 질병용 순환 생물학적 지표들 |
| TWI542690B (zh) | 2010-05-12 | 2016-07-21 | 再生醫學Ｔｘ有限責任公司 | 生物活性腎細胞 |
| WO2012031008A2 (en) | 2010-08-31 | 2012-03-08 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
| US20120107825A1 (en) | 2010-11-01 | 2012-05-03 | Winger Edward E | Methods and compositions for assessing patients with reproductive failure using immune cell-derived microrna |
| CA2827894A1 (en) | 2011-02-22 | 2012-08-30 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers |
| BR112013032232A2 (pt) * | 2011-06-16 | 2016-09-20 | Caris Life Sciences Switzerland Holdings S A R L | método de caracterização de câncer através do uso de biomarcador de ácido nucleico |
| US20130078633A1 (en) | 2011-09-22 | 2013-03-28 | ImmuMetrix, LLC | Detection of Isotype Profiles as Signatures for Disease |
| EP2771487A1 (en) | 2011-10-27 | 2014-09-03 | Asuragen, INC. | Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors |
| FI123683B (en) | 2011-11-28 | 2013-09-13 | Teknologian Tutkimuskeskus Vtt | Process for catalytic oxidation of a natural composition comprising unsaturated fatty acids and / or esters thereof and use of a mixture obtained therefrom to produce mono-, oligo- and / or polyesters |
| EP4349343A2 (en) | 2011-11-30 | 2024-04-10 | Jörn Bullerdiek | Expression of mirnas in placental tissue |
| AU2013207778B2 (en) | 2012-01-13 | 2017-10-12 | Genentech, Inc. | Biological markers for identifying patients for treatment with VEGF antagonists |
| US20150242701A1 (en) | 2012-09-20 | 2015-08-27 | Sharp Kabushiki Kaisha | Image processing device, image display device, image capture device, image printing device, gradation conversion method, and computer readable medium |
| WO2014055117A1 (en) | 2012-10-04 | 2014-04-10 | Asuragen, Inc. | Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions |
| WO2014071205A1 (en) | 2012-11-02 | 2014-05-08 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for diagnosis, prognosis and treatment of hematological malignancies |
| US20140329704A1 (en) | 2013-03-28 | 2014-11-06 | President And Fellows Of Harvard College | Markers for mature beta-cells and methods of using the same |
| CN103421905A (zh) | 2013-08-20 | 2013-12-04 | 张飚 | 从血液中检测用于诊断脑卒中的microRNA的方法 |
| EP3044333A4 (en) | 2013-09-09 | 2017-08-09 | The Scripps Research Institute | Methods and systems for analysis of organ transplantation |
| AU2015229270B2 (en) * | 2014-03-12 | 2020-12-24 | Icahn School Of Medicine At Mount Sinai | Method for identifying kidney allograft recipients at risk for chronic injury |
| ES2897004T3 (es) | 2014-06-26 | 2022-02-28 | Icahn School Med Mount Sinai | Métodos para diagnosticar el riesgo de fibrosis y rechazo de aloinjerto renal |
| ES2850281T3 (es) | 2014-06-26 | 2021-08-26 | Icahn School Med Mount Sinai | Método para diagnosticar el rechazo agudo subclínico y clínico mediante el análisis de conjuntos de genes predictivos, un agente terapéutico para usar en el tratamiento y kits para determinar la expresión |
| WO2017100259A1 (en) | 2015-12-08 | 2017-06-15 | Icahn School Of Medicine At Mount Sinai | Pretransplant prediction of post-transplant acute rejection |
| WO2017147196A1 (en) | 2016-02-22 | 2017-08-31 | Massachusetts Institute Of Technology | Methods for identifying and modulating immune phenotypes |
| WO2017203008A1 (en) | 2016-05-25 | 2017-11-30 | Curevac Ag | Novel biomarkers |
| US20180356402A1 (en) | 2017-06-08 | 2018-12-13 | The Cleveland Clinic Foundation | Urine biomarkers for detecting graft rejection |
| EP3781153A4 (en) | 2018-04-16 | 2022-04-06 | Icahn School of Medicine at Mount Sinai | METHOD AND KITS FOR PREDICTING ACUTE REJECTION AND RENAL ALLOGraft LOSS USING PRE-TRANSPLANTATION TRANSCRIPTOMIC SIGNATURES IN RECIPIENT BLOOD |
-
2015
- 2015-03-12 AU AU2015229270A patent/AU2015229270B2/en active Active
- 2015-03-12 CN CN201811063221.8A patent/CN109207580B/zh active Active
- 2015-03-12 US US15/125,009 patent/US10941446B2/en active Active
- 2015-03-12 EP EP15761612.9A patent/EP3117220B1/en active Active
- 2015-03-12 CN CN201580024911.0A patent/CN106461679B/zh active Active
- 2015-03-12 ES ES15761612T patent/ES2824108T3/es active Active
- 2015-03-12 BR BR112016020987-7A patent/BR112016020987B1/pt active IP Right Grant
- 2015-03-12 CA CA2942384A patent/CA2942384C/en active Active
- 2015-03-12 WO PCT/US2015/020291 patent/WO2015138803A1/en active Application Filing
-
2021
- 2021-02-01 US US17/164,607 patent/US11674181B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN106461679A (zh) | 2017-02-22 |
| EP3117220B1 (en) | 2020-07-08 |
| CN109207580B (zh) | 2022-03-11 |
| WO2015138803A1 (en) | 2015-09-17 |
| BR112016020987A8 (pt) | 2021-07-06 |
| CA2942384A1 (en) | 2015-09-17 |
| US11674181B2 (en) | 2023-06-13 |
| AU2015229270A1 (en) | 2016-10-20 |
| CA2942384C (en) | 2024-01-23 |
| BR112016020987B1 (pt) | 2023-11-14 |
| US20170114407A1 (en) | 2017-04-27 |
| EP3117220A1 (en) | 2017-01-18 |
| EP3117220A4 (en) | 2017-08-30 |
| AU2015229270B2 (en) | 2020-12-24 |
| CN109207580A (zh) | 2019-01-15 |
| ES2824108T3 (es) | 2021-05-11 |
| US10941446B2 (en) | 2021-03-09 |
| US20210230700A1 (en) | 2021-07-29 |
| CN106461679B (zh) | 2018-10-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112016020987A2 (pt) | método de identificação de receptores de aloenxerto renal, kit, conjunto de assinatura gênica, método de seleção de paciente e uso de um agente imunossupressivo | |
| CL2018000813A1 (es) | Conjugados de anticuerpo-fármaco de pirrolobenzodiazepina y métodos de uso. | |
| BR112017025828A2 (pt) | dispositivo de nó hospedeiro e métodos de uso com o mesmo. | |
| HK1223660A1 (zh) | 種測序文庫的構建方法及試劑盒和應用 | |
| CL2016002364A1 (es) | Indazol-3-carboxamidas 5-sustituidas y preparación y uso de las mismas | |
| BR112017024899A2 (pt) | proteínas de ligação trispecíficas e métodos de uso. | |
| EP3001196B8 (en) | Blood testing system and method | |
| BR112016024034A2 (pt) | ativadores de canal iônico e métodos de uso | |
| BR112016018521A2 (pt) | composição, e, kit. | |
| EP3509907A4 (en) | SYSTEMS AND METHODS FOR ANALYZING A CORE BY MEANS OF X-RAY FLUORESCENCE | |
| EP3347695A4 (en) | ANALYZE INSTRUMENT, APPROPRIATE SYSTEMS AND METHOD | |
| BR112016030968A2 (pt) | análogos de pridopidina, preparação e uso destes | |
| EP3113698A4 (en) | Single incision specimen retrieval assembly, method of use, and kit | |
| CR20160362A (es) | Anticuerpos anti-jagged1 y metodos de uso | |
| CL2018001139A1 (es) | Anticuerpos anti-htra1 y métodos de uso de los mismos. | |
| EP3368502A4 (en) | ELECTROCHEMICAL HALOGENIZATION AND OXYHALOGENIZATION SYSTEMS AND METHOD | |
| EP3179913A4 (en) | System for defining and executing audiometric tests | |
| EP3341021A4 (en) | ANTI-ALK ANTIBODIES AND METHOD OF USE THEREOF | |
| EP3353354A4 (en) | MEANS FOR COLLECTING, SAMPLING, AND DIAGNOSING SEASON SAMPLES AND ASSOCIATED METHODS | |
| EP3139163A4 (en) | Immunochromotographic analysis kit, immunochromotographic analysis device, and immunochromotographic analysis method | |
| EP3220342A4 (en) | Itinerary determination method, itinerary determination program and itinerary determination device | |
| BR112016024806A2 (pt) | aplicativo de mensagem privada e métodos associados. | |
| GB201617572D0 (en) | Use, method, kit, composition and antibodies | |
| GB201620377D0 (en) | Systems, methods, and kits for cleansing an ocular region | |
| EP3254297A4 (en) | Probes, systems, cartridges, and methods of use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 12/03/2015, OBSERVADAS AS CONDICOES LEGAIS |