BR112016008080A8 - sal de composto heterocíclico contendo nitrogênio ou cristal do mesmo, composição farmacêutica e inibidor de flt3 - Google Patents

sal de composto heterocíclico contendo nitrogênio ou cristal do mesmo, composição farmacêutica e inibidor de flt3 Download PDF

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Publication number
BR112016008080A8
BR112016008080A8 BR112016008080A BR112016008080A BR112016008080A8 BR 112016008080 A8 BR112016008080 A8 BR 112016008080A8 BR 112016008080 A BR112016008080 A BR 112016008080A BR 112016008080 A BR112016008080 A BR 112016008080A BR 112016008080 A8 BR112016008080 A8 BR 112016008080A8
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BR
Brazil
Prior art keywords
crystal
pharmaceutical composition
flt3
salt
heterocyclic compound
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BR112016008080A
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English (en)
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BR112016008080B1 (pt
Inventor
Mizumoto Shinsuke
Matsumoto Takuya
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Fujifilm Corp
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Publication date
Application filed by Fujifilm Corp filed Critical Fujifilm Corp
Publication of BR112016008080A8 publication Critical patent/BR112016008080A8/pt
Publication of BR112016008080B1 publication Critical patent/BR112016008080B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/10—Succinic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
    • C07C65/11—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic with carboxyl groups on a condensed ring system containing two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

resumo “sal de composto heterocíclico contendo nitrogênio ou cristal do mesmo, composição farmacêutica e inibidor de flt3” a presente invenção refere-se a um composto e composição farmacêutica que mostram estabilidade e/ou solubilidade superior, etc. e têm atividade inibitória de flt3 superior. a presente invenção provê um sal de (s,e)-n-(1-((5-(2-((4-cianofenil)amino)-4-(propilamino)pirimidin-5-il)pent-4-in-1-il)amino)-1-oxopropan-2-il)-4-(dimetilamino)-n-metilbut-2-enamida ou um cristal do mesmo. uma vez que o sal ou um cristal do mesmo tenha atividade inibitória de flt3 superior e mostre pro-priedades físico-químicas superiores como fármacos, tais como estabilidade de ar-mazenamento, solubilidade e assim por diante, ele é útil para tratamentos de doen-ças ou condições relacionadas à flt3. a presente invenção também provê uma composição farmacêutica e inibidor de flt3 contendo o sal ou um cristal do mesmo.
BR112016008080-7A 2013-10-16 2014-10-15 sal de ácido carboxílico ou um sal de ácido mineral, cristal de succinato, cristal de fumarato e composição farmacêutica BR112016008080B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013215755 2013-10-16
JP2013-215755 2013-10-16
PCT/JP2014/077368 WO2015056683A1 (ja) 2013-10-16 2014-10-15 含窒素複素環化合物の塩またはその結晶、医薬組成物およびｆｌｔ３阻害剤

Publications (2)

Publication Number Publication Date
BR112016008080A8 true BR112016008080A8 (pt) 2020-03-17
BR112016008080B1 BR112016008080B1 (pt) 2021-02-23

Family

ID=52828126

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016008080-7A BR112016008080B1 (pt) 2013-10-16 2014-10-15 sal de ácido carboxílico ou um sal de ácido mineral, cristal de succinato, cristal de fumarato e composição farmacêutica

Country Status (14)

Country Link
US (1) US9701644B2 (pt)
EP (1) EP3059227B1 (pt)
JP (1) JP5887028B2 (pt)
KR (1) KR101744033B1 (pt)
CN (1) CN105683167B (pt)
AU (1) AU2014335312B9 (pt)
BR (1) BR112016008080B1 (pt)
CA (1) CA2927079C (pt)
DK (1) DK3059227T3 (pt)
ES (1) ES2738573T3 (pt)
HK (1) HK1219946A1 (pt)
PL (1) PL3059227T3 (pt)
RU (1) RU2641106C2 (pt)
WO (1) WO2015056683A1 (pt)

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RU2727195C2 (ru) 2014-08-22 2020-07-21 Фуджифилм Корпорэйшн Фармацевтическая композиция для лечения злокачественной опухоли, положительной по мутации flt3, ингибитор мутантного flt3 и их применение
US11286670B2 (en) 2015-02-06 2022-03-29 Roofguard Manufacturing, Llc Roof drain cover
JP6412471B2 (ja) * 2015-07-15 2018-10-24 富士フイルム株式会社 含窒素複素環化合物の製造方法およびその中間体
TW202027749A (zh) * 2018-10-12 2020-08-01 日商富士軟片股份有限公司 急性骨髓性白血病用抗腫瘤劑
CN112996514A (zh) * 2018-10-31 2021-06-18 富士胶片株式会社 包含抗肿瘤剂的片剂
WO2020090969A1 (ja) 2018-10-31 2020-05-07 富士フイルム株式会社 抗腫瘍剤を含む医薬組成物の包装体
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TW202045174A (zh) 2019-02-28 2020-12-16 日商富士軟片股份有限公司 組合醫藥
BR112021018168B1 (pt) 2019-03-21 2023-11-28 Onxeo Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2023027966A1 (en) 2021-08-24 2023-03-02 Biomea Fusion, Inc. Pyrazine compounds as irreversible inhibitors of flt3
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WO2023225005A1 (en) 2022-05-17 2023-11-23 Biomea Fusion, Inc. Flt3 combination therapy for cancer and compositions therefor

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Also Published As

Publication number Publication date
DK3059227T3 (da) 2019-08-26
AU2014335312B9 (en) 2017-05-25
WO2015056683A1 (ja) 2015-04-23
EP3059227A4 (en) 2016-09-07
BR112016008080B1 (pt) 2021-02-23
CA2927079C (en) 2017-05-23
CN105683167A (zh) 2016-06-15
ES2738573T3 (es) 2020-01-23
HK1219946A1 (zh) 2017-04-21
CN105683167B (zh) 2018-10-23
CA2927079A1 (en) 2015-04-23
JPWO2015056683A1 (ja) 2017-03-09
EP3059227A1 (en) 2016-08-24
KR101744033B1 (ko) 2017-06-07
KR20160049009A (ko) 2016-05-04
RU2016114540A (ru) 2017-11-21
US20160229812A1 (en) 2016-08-11
PL3059227T3 (pl) 2019-11-29
US9701644B2 (en) 2017-07-11
EP3059227B1 (en) 2019-06-26
RU2641106C2 (ru) 2018-01-16
AU2014335312B2 (en) 2017-01-05
AU2014335312A1 (en) 2016-05-05
JP5887028B2 (ja) 2016-03-16

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