BR112015027381A8 - pirimidinas substituídas por heterocicloalquila ligadas ao c e seus usos - Google Patents

pirimidinas substituídas por heterocicloalquila ligadas ao c e seus usos

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Publication number
BR112015027381A8
BR112015027381A8 BR112015027381A BR112015027381A BR112015027381A8 BR 112015027381 A8 BR112015027381 A8 BR 112015027381A8 BR 112015027381 A BR112015027381 A BR 112015027381A BR 112015027381 A BR112015027381 A BR 112015027381A BR 112015027381 A8 BR112015027381 A8 BR 112015027381A8
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BR
Brazil
Prior art keywords
substituted pyrimidines
heterocycloalkyl substituted
linked heterocycloalkyl
compounds
formula
Prior art date
Application number
BR112015027381A
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English (en)
Other versions
BR112015027381A2 (pt
Inventor
Cohen Frederick
Patel Snahel
Original Assignee
Hoffmann La Roche
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Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112015027381A2 publication Critical patent/BR112015027381A2/pt
Publication of BR112015027381A8 publication Critical patent/BR112015027381A8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

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Abstract

resumo patente de invenção: "pirimidinas substituídas por heterocicloalquila ligadas ao c e seus usos". a presente invenção fornece compostos de pirimidina de fórmula i-i e modalidades da mesma (i-i). na fórmula i-i em que r1, r2, r3, r4, r5, r6, m, n e o anel "het" são como descrito aqui. da mesma forma fornecido são as composições farmacêuticas compreendendo os compostos de fórmula i e métodos de usar tais compostos e composições.
BR112015027381A 2013-05-01 2014-04-29 pirimidinas substituídas por heterocicloalquila ligadas ao c e seus usos BR112015027381A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361818046P 2013-05-01 2013-05-01
PCT/EP2014/058635 WO2014177524A1 (en) 2013-05-01 2014-04-29 C-linked heterocycloalkyl substituted pyrimidines and their uses

Publications (2)

Publication Number Publication Date
BR112015027381A2 BR112015027381A2 (pt) 2017-07-25
BR112015027381A8 true BR112015027381A8 (pt) 2018-01-30

Family

ID=50630792

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BR112015027381A BR112015027381A8 (pt) 2013-05-01 2014-04-29 pirimidinas substituídas por heterocicloalquila ligadas ao c e seus usos

Country Status (11)

Country Link
US (1) US9868720B2 (pt)
EP (1) EP2991977B1 (pt)
JP (2) JP6523251B2 (pt)
KR (1) KR20160002850A (pt)
CN (1) CN105164114B (pt)
BR (1) BR112015027381A8 (pt)
CA (1) CA2907912A1 (pt)
HK (1) HK1213560A1 (pt)
MX (1) MX2015014861A (pt)
RU (1) RU2015147601A (pt)
WO (1) WO2014177524A1 (pt)

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EP2991977A1 (en) 2016-03-09
JP6523251B2 (ja) 2019-05-29
BR112015027381A2 (pt) 2017-07-25
RU2015147601A (ru) 2017-06-05
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WO2014177524A1 (en) 2014-11-06
CA2907912A1 (en) 2014-11-06
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