BR112015026193B8 - Composição farmacêutica, método para formular uma composição farmacêutica, uso da composição farmacêutica, método para inibir a formação de biofilme em uma superfície, e, artigo fabricado para curativo - Google Patents

Composição farmacêutica, método para formular uma composição farmacêutica, uso da composição farmacêutica, método para inibir a formação de biofilme em uma superfície, e, artigo fabricado para curativo

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Publication number
BR112015026193B8
BR112015026193B8 BR112015026193A BR112015026193A BR112015026193B8 BR 112015026193 B8 BR112015026193 B8 BR 112015026193B8 BR 112015026193 A BR112015026193 A BR 112015026193A BR 112015026193 A BR112015026193 A BR 112015026193A BR 112015026193 B8 BR112015026193 B8 BR 112015026193B8
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
biofilm formation
formulating
dressing
manufactured article
Prior art date
Application number
BR112015026193A
Other languages
English (en)
Other versions
BR112015026193A2 (pt
BR112015026193B1 (pt
Inventor
B Herr Andrew
Young Gary
Original Assignee
Univ Cincinnati
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cincinnati filed Critical Univ Cincinnati
Publication of BR112015026193A2 publication Critical patent/BR112015026193A2/pt
Publication of BR112015026193B1 publication Critical patent/BR112015026193B1/pt
Publication of BR112015026193B8 publication Critical patent/BR112015026193B8/pt

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/16Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44Guanidine; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/46Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015Drug-containing film-forming compositions, e.g. spray-on
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406Antibiotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45Mixtures of two or more drugs, e.g. synergistic mixtures

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Toxicology (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

COMPOSIÇÃO FARMACÊUTICA, MÉTODO PARA FORMULAR UMA COMPOSIÇÃO FARMACÊUTICA, USO DA COMPOSIÇÃO FARMACÊUTICA, MÉTODO PARA INIBIR A FORMAÇÃO DE BIOFILME EM UMA SUPERFÍCIE, ARTIGO FABRICADO PARA CURATIVO, E, MÉTODO PARA AUMENTAR A EFICÁCIA ANTIBACTERIANA DE GENTAMICINA. Composições farmacêuticas que compreendem um antibiótico aminoglicosídico e pelo menos um agente quelante de zinco em uma concentração especificada e métodos de inibir a colonização bacteriana, formação de biofilme e tratamento de infecções bacterianas que utilizam as composições são fornecidas. As formulações tópicas adequadas para cuidado com o ferimento e formulações aplicáveis na superfície adequadas para necessidades de desinfecção médica, industrial e doméstica também são descritas.
BR112015026193A 2013-04-16 2014-04-16 Composição farmacêutica, método para formular uma composição farmacêutica, uso da composição farmacêutica, método para inibir a formação de biofilme em uma superfície, e, artigo fabricado para curativo BR112015026193B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361812701P 2013-04-16 2013-04-16
US61/812,701 2013-04-16
PCT/US2014/034320 WO2014172435A1 (en) 2013-04-16 2014-04-16 Antimicrobial compositions of aminoglycosidic antibiotics and zinc ion chelators

Publications (3)

Publication Number Publication Date
BR112015026193A2 BR112015026193A2 (pt) 2020-07-14
BR112015026193B1 BR112015026193B1 (pt) 2021-11-16
BR112015026193B8 true BR112015026193B8 (pt) 2022-07-19

Family

ID=51686955

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015026193A BR112015026193B8 (pt) 2013-04-16 2014-04-16 Composição farmacêutica, método para formular uma composição farmacêutica, uso da composição farmacêutica, método para inibir a formação de biofilme em uma superfície, e, artigo fabricado para curativo

Country Status (7)

Country Link
US (2) US9821063B2 (pt)
EP (1) EP2986119B1 (pt)
AU (1) AU2014253977B2 (pt)
BR (1) BR112015026193B8 (pt)
CA (1) CA2909283C (pt)
ES (1) ES2749223T3 (pt)
WO (1) WO2014172435A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201607814D0 (en) 2016-05-04 2016-06-15 5D Health Prot Group Ltd Anti-microbial compositions
CN107865966A (zh) * 2016-09-23 2018-04-03 刘力 局部给药的复方氨基糖苷类药物组合物
US11413300B2 (en) * 2017-01-30 2022-08-16 Smith & Nephew, Inc. Synergistic combination of thermolysin and an antibacterial agent to reduce or eliminate bacterial biofilms from surfaces
WO2019071325A1 (en) * 2017-10-13 2019-04-18 The University Of Queensland ZINC IONOPHORES AND USES THEREOF
IL258467A (en) * 2018-03-29 2018-07-04 Ilana Kolodkin Gal Methods of disrupting a biofilm and/or preventing formation of same
CN109750054B (zh) * 2019-02-21 2021-07-02 华中农业大学 一种牛支原体蛋白基因MbovGdpP及其应用
US11850233B2 (en) 2019-10-28 2023-12-26 Matibur Rahaman Zamadar Reduced adaptive microbial resistance treatment for flesh eating disease (necrotizing fasciitis)

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Publication number Priority date Publication date Assignee Title
US5133965A (en) 1988-06-08 1992-07-28 Fountain Pharmaceuticals, Inc. Dressing material having adsorbed thereon a solvent dilution microcarrier precursor solution
US5688516A (en) * 1992-11-12 1997-11-18 Board Of Regents, The University Of Texas System Non-glycopeptide antimicrobial agents in combination with an anticoagulant, an antithrombotic or a chelating agent, and their uses in, for example, the preparation of medical devices
US5362754A (en) * 1992-11-12 1994-11-08 Univ. Of Tx Md Anderson Cancer Center M-EDTA pharmaceutical preparations and uses thereof
ES2264211T3 (es) 1997-08-26 2006-12-16 Board Of Regents, The University Of Texas System Uso de una composicion que comprende un agente quelante y un compuesto antimicrobiano para el tratamiento de biopeliculas.
DE19753176C2 (de) 1997-11-20 2000-04-27 Gerlach Gerald F Nicht rekombinante Subunitvakzine
US20020091074A1 (en) 2000-09-20 2002-07-11 Wooley Richard E. Medical compositions, dressings and methods for treating microbial infections of skin lesions
US20040151765A1 (en) * 2001-09-18 2004-08-05 Ritchie Branson W. Methods and compositions for wound management
US6896809B2 (en) * 2002-12-20 2005-05-24 Providence Health System - Oregon Methods for purifying chitosan
CN101129383B (zh) * 2006-08-25 2014-04-02 天津和美生物技术有限公司 含氨基糖苷类抗生素的抗生素复方
CN101129381B (zh) 2006-08-25 2012-02-01 天津和美生物技术有限公司 含β-内酰胺类抗生素和离子螯合剂的抗生素复方
US8305331B2 (en) 2007-07-13 2012-11-06 Tte Indianapolis LCD device power saving system and method of reducing power consumption of LCD device
GB0714338D0 (en) * 2007-07-23 2007-09-05 Sinclair Pharmaceuticals Ltd method
CA2726529A1 (en) * 2008-05-30 2009-12-23 University Of Cincinnati Use of zinc chelators to inhibit biofilm formation
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CA2840965C (en) 2011-07-06 2021-03-02 Novartis Ag Cationic oil-in-water emulsions

Also Published As

Publication number Publication date
CA2909283A1 (en) 2014-10-23
US20180036410A1 (en) 2018-02-08
AU2014253977B2 (en) 2017-06-01
ES2749223T3 (es) 2020-03-19
WO2014172435A1 (en) 2014-10-23
US10124064B2 (en) 2018-11-13
CA2909283C (en) 2022-08-30
BR112015026193A2 (pt) 2020-07-14
BR112015026193B1 (pt) 2021-11-16
US20140308326A1 (en) 2014-10-16
EP2986119A1 (en) 2016-02-24
AU2014253977A1 (en) 2015-11-05
EP2986119B1 (en) 2019-08-14
EP2986119A4 (en) 2016-09-28
US9821063B2 (en) 2017-11-21

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