BR112015024181A2 - uso de uma composição compreendendo silibina - Google Patents
uso de uma composição compreendendo silibinaInfo
- Publication number
- BR112015024181A2 BR112015024181A2 BR112015024181A BR112015024181A BR112015024181A2 BR 112015024181 A2 BR112015024181 A2 BR 112015024181A2 BR 112015024181 A BR112015024181 A BR 112015024181A BR 112015024181 A BR112015024181 A BR 112015024181A BR 112015024181 A2 BR112015024181 A2 BR 112015024181A2
- Authority
- BR
- Brazil
- Prior art keywords
- composition
- treatment
- sratb
- nash
- patients
- Prior art date
Links
- FDQAOULAVFHKBX-UHFFFAOYSA-N Isosilybin A Natural products C1=C(O)C(OC)=CC(C2C(OC3=CC(=CC=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 FDQAOULAVFHKBX-UHFFFAOYSA-N 0.000 title abstract 2
- SEBFKMXJBCUCAI-UHFFFAOYSA-N NSC 227190 Natural products C1=C(O)C(OC)=CC(C2C(OC3=CC=C(C=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-UHFFFAOYSA-N 0.000 title abstract 2
- VLGROHBNWZUINI-UHFFFAOYSA-N Silybin Natural products COc1cc(ccc1O)C2OC3C=C(C=CC3OC2CO)C4Oc5cc(O)cc(O)c5C(=O)C4O VLGROHBNWZUINI-UHFFFAOYSA-N 0.000 title abstract 2
- SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 title abstract 2
- 229940043175 silybin Drugs 0.000 title abstract 2
- 235000014899 silybin Nutrition 0.000 title abstract 2
- 150000002632 lipids Chemical class 0.000 abstract 2
- 230000002503 metabolic effect Effects 0.000 abstract 2
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 abstract 2
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 abstract 2
- 230000001590 oxidative effect Effects 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 1
- 230000003859 lipid peroxidation Effects 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02K—DYNAMO-ELECTRIC MACHINES
- H02K41/00—Propulsion systems in which a rigid body is moved along a path due to dynamo-electric interaction between the body and a magnetic field travelling along the path
- H02K41/02—Linear motors; Sectional motors
- H02K41/03—Synchronous motors; Motors moving step by step; Reluctance motors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Combustion & Propulsion (AREA)
- Electromagnetism (AREA)
- Power Engineering (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicinal Preparation (AREA)
Abstract
resumo composição para uso no tratamento de tratamento de alterações oxidativas metabólicas em esteato-hepatite não alcoólica (nash) a presente invenção refere-se a uma composição para uso no tratamento de alterações oxidativas metabólicas em esteato-hepatite não alcoólica (nash), em que a referida composição compreende silibina e em que o tratamento é administrado a pacientes com um perfil lipidômico alterado. pacientes com perfil lipidômico alterado exibem um alto valor de sratb no ensaio de sratb (marcador de peroxidação lipídica) em relação a indivíduos saudáveis.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000425A ITMI20130425A1 (it) | 2013-03-20 | 2013-03-20 | Composizione per il trattamento della sindrome metabolica e delle alterazioni metabolico-ossidative nei pazienti con steatoepatite non alcolica (nash) |
| PCT/EP2014/055499 WO2014147119A1 (en) | 2013-03-20 | 2014-03-19 | Silybin for the treatment of metabolic oxidative alterations in patients with non-alcoholic steatohepatitis (nash) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015024181A2 true BR112015024181A2 (pt) | 2017-07-18 |
Family
ID=48444504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015024181A BR112015024181A2 (pt) | 2013-03-20 | 2014-03-19 | uso de uma composição compreendendo silibina |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2976075B1 (pt) |
| JP (1) | JP2016515540A (pt) |
| BR (1) | BR112015024181A2 (pt) |
| DK (1) | DK2976075T3 (pt) |
| ES (1) | ES2749192T3 (pt) |
| HU (1) | HUE045695T2 (pt) |
| IT (1) | ITMI20130425A1 (pt) |
| MX (1) | MX370252B (pt) |
| PL (1) | PL2976075T3 (pt) |
| PT (1) | PT2976075T (pt) |
| RU (1) | RU2694896C2 (pt) |
| WO (1) | WO2014147119A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105983016B (zh) | 2015-03-23 | 2023-08-11 | 天士力医药集团股份有限公司 | 一种含有水飞蓟宾的药物组合 |
| CN105983018B (zh) * | 2015-03-23 | 2022-06-03 | 天士力医药集团股份有限公司 | 一种含有水飞蓟宾的药物组合物 |
| CN108685899A (zh) * | 2017-04-07 | 2018-10-23 | 澳门科技大学 | 黄酮木脂素在制备用于治疗自身免疫炎症疾病的药物的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1215291B (it) * | 1985-07-17 | 1990-01-31 | Inverni Della Beffa Spa | Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche. |
| CN1513444A (zh) * | 2003-07-11 | 2004-07-21 | 辽宁医联新药研究所 | 治疗代谢综合征的药物 |
| CZ20033042A3 (cs) * | 2003-11-10 | 2005-06-15 | Naturprodukt Cz Spol. S R. O. | Potravinový doplněk na bázi silymarinu |
| WO2009066712A1 (ja) * | 2007-11-21 | 2009-05-28 | Kracie Pharma, Ltd. | アロマターゼ阻害剤 |
| US20100239552A1 (en) * | 2009-03-16 | 2010-09-23 | Genmedica Therapeutics Sl | Combination Therapies for Treating Metabolic Disorders |
| US20140335061A1 (en) * | 2011-12-08 | 2014-11-13 | Metaproteomics, Llc | Supplemented oil compositions and methods for improved health |
-
2013
- 2013-03-20 IT IT000425A patent/ITMI20130425A1/it unknown
-
2014
- 2014-03-19 BR BR112015024181A patent/BR112015024181A2/pt not_active Application Discontinuation
- 2014-03-19 MX MX2015013409A patent/MX370252B/es active IP Right Grant
- 2014-03-19 HU HUE14718921A patent/HUE045695T2/hu unknown
- 2014-03-19 PT PT147189211T patent/PT2976075T/pt unknown
- 2014-03-19 RU RU2015144870A patent/RU2694896C2/ru active
- 2014-03-19 JP JP2016503648A patent/JP2016515540A/ja active Pending
- 2014-03-19 PL PL14718921T patent/PL2976075T3/pl unknown
- 2014-03-19 WO PCT/EP2014/055499 patent/WO2014147119A1/en active Application Filing
- 2014-03-19 EP EP14718921.1A patent/EP2976075B1/en active Active
- 2014-03-19 ES ES14718921T patent/ES2749192T3/es active Active
- 2014-03-19 DK DK14718921.1T patent/DK2976075T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2749192T3 (es) | 2020-03-19 |
| HUE045695T2 (hu) | 2020-01-28 |
| MX2015013409A (es) | 2016-06-24 |
| PL2976075T3 (pl) | 2020-03-31 |
| WO2014147119A1 (en) | 2014-09-25 |
| EP2976075A1 (en) | 2016-01-27 |
| DK2976075T3 (da) | 2019-10-14 |
| EP2976075B1 (en) | 2019-07-17 |
| RU2015144870A (ru) | 2017-04-25 |
| RU2694896C2 (ru) | 2019-07-18 |
| JP2016515540A (ja) | 2016-05-30 |
| PT2976075T (pt) | 2019-10-14 |
| ITMI20130425A1 (it) | 2014-09-21 |
| MX370252B (es) | 2019-12-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |