BR112015021000A2 - composição de uma distribuição liberação prolongada e método de estabilizar proteínas durante o processo de fabricação - Google Patents
composição de uma distribuição liberação prolongada e método de estabilizar proteínas durante o processo de fabricaçãoInfo
- Publication number
- BR112015021000A2 BR112015021000A2 BR112015021000A BR112015021000A BR112015021000A2 BR 112015021000 A2 BR112015021000 A2 BR 112015021000A2 BR 112015021000 A BR112015021000 A BR 112015021000A BR 112015021000 A BR112015021000 A BR 112015021000A BR 112015021000 A2 BR112015021000 A2 BR 112015021000A2
- Authority
- BR
- Brazil
- Prior art keywords
- composition
- manufacturing process
- proteins during
- protein
- prolonged release
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 6
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000002035 prolonged effect Effects 0.000 title abstract 2
- 230000000087 stabilizing effect Effects 0.000 title abstract 2
- 239000004005 microsphere Substances 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000011859 microparticle Substances 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Gastroenterology & Hepatology (AREA)
- Ophthalmology & Optometry (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361786035P | 2013-03-14 | 2013-03-14 | |
| PCT/US2014/026320 WO2014151725A1 (en) | 2013-03-14 | 2014-03-13 | Composition of a sustained-release delivery and method of stabilizing proteins during fabrication process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015021000A2 true BR112015021000A2 (pt) | 2017-07-18 |
Family
ID=50483567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015021000A BR112015021000A2 (pt) | 2013-03-14 | 2014-03-13 | composição de uma distribuição liberação prolongada e método de estabilizar proteínas durante o processo de fabricação |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20140274873A1 (https=) |
| EP (2) | EP2968574A1 (https=) |
| JP (2) | JP6649246B2 (https=) |
| KR (1) | KR20150128857A (https=) |
| CN (1) | CN105188759A (https=) |
| AU (2) | AU2014236938B2 (https=) |
| BR (1) | BR112015021000A2 (https=) |
| CA (1) | CA2902547A1 (https=) |
| RU (1) | RU2720412C2 (https=) |
| WO (1) | WO2014151725A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106076214B (zh) * | 2016-07-15 | 2019-12-17 | 沈阳化工大学 | 一种具有核壳结构的海藻酸钙微球制备方法 |
| GB201906835D0 (en) * | 2019-05-15 | 2019-06-26 | Ucb Biopharma Sprl | Dry microparticles |
| WO2022163966A1 (ko) * | 2021-01-29 | 2022-08-04 | 주식회사 티온랩테라퓨틱스 | 초기 방출 제어된 데포 조성물 및 이의 제조방법 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4777043A (en) * | 1985-12-17 | 1988-10-11 | Genentech, Inc. | Stabilized human tissue plasminogen activator compositions |
| US5997856A (en) * | 1988-10-05 | 1999-12-07 | Chiron Corporation | Method and compositions for solubilization and stabilization of polypeptides, especially proteins |
| KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US6448077B1 (en) | 1994-02-10 | 2002-09-10 | Imclone Systems, Inc. | Chimeric and humanized monoclonal antibodies specific to VEGF receptors |
| ATE201983T1 (de) * | 1995-03-10 | 2001-06-15 | Roche Diagnostics Gmbh | Polypeptid-enthaltende pharmazeutische darreichungsformen in form von mikropartikeln und verfahren zu deren herstellung |
| GB9514285D0 (en) * | 1995-07-13 | 1995-09-13 | Univ Nottingham | Polymeric lamellar substrate particles for drug delivery |
| US5665428A (en) * | 1995-10-25 | 1997-09-09 | Macromed, Inc. | Preparation of peptide containing biodegradable microspheres by melt process |
| US6884879B1 (en) | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
| JP4360758B2 (ja) * | 1999-04-08 | 2009-11-11 | ジェネンテック・インコーポレーテッド | 逆の電荷のポリペプチド類をベースにした組成物 |
| DE60127175T2 (de) * | 2000-12-21 | 2007-11-08 | Nektar Therapeutics, San Carlos | Lagerstabile pulverzusammensetzungen mit interleukin-4 rezeptor |
| EP1436329A4 (en) | 2001-09-20 | 2005-04-27 | Alexion Pharma Inc | ANTI-PDGF ANTIBODIES AND METHODS FOR PRODUCING FOCUSED ANTIBODIES |
| US7265084B2 (en) * | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| US9415102B2 (en) * | 2002-09-06 | 2016-08-16 | Alexion Pharmaceuticals, Inc. | High concentration formulations of anti-C5 antibodies |
| KR100466637B1 (ko) * | 2003-06-26 | 2005-01-13 | 주식회사 펩트론 | 서방성 미립구의 혼합 제형을 연속한 단일 공정으로제조하는 방법 |
| US20060182783A1 (en) * | 2004-04-30 | 2006-08-17 | Allergan, Inc. | Sustained release intraocular drug delivery systems |
| US7993634B2 (en) * | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
| US8591885B2 (en) * | 2004-04-30 | 2013-11-26 | Allergan, Inc. | Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems |
| WO2005110374A1 (en) * | 2004-04-30 | 2005-11-24 | Allergan, Inc. | Intraocular drug delivery systems containing a therapeutic component, a cyclodextrin, and a polymeric component |
| CA2593112A1 (en) * | 2005-01-21 | 2006-07-27 | Alza Corporation | Therapeutic peptide formulations for coating microneedles with improved stability containing at least one counterion |
| MX2007013213A (es) * | 2005-04-25 | 2007-12-12 | Amgen Inc | Composiciones de liberacion prolongada de peptidos biodegradables que contienen porogenos. |
| JP5074750B2 (ja) * | 2005-12-07 | 2012-11-14 | 一般財団法人化学及血清療法研究所 | シクロデキストリン類を含有する液状フィブリノゲン製剤 |
| US8642067B2 (en) * | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
| WO2009031011A2 (en) * | 2007-09-05 | 2009-03-12 | Pfizer Limited | Xinafoate salt of n4-(2, 2-difluoro-4h-benz0 [1,4] 0xazin-3-one) -6-yl] -5-fluoro-n2- [3- (methylaminocar bonylmethyleneoxy) phenyl] 2, 4-pyrimidinediamine |
| WO2009099132A1 (ja) * | 2008-02-05 | 2009-08-13 | Kyowa Hakko Bio Co., Ltd. | グルタチオンの保存安定性向上方法 |
| EP3785735A1 (en) * | 2008-11-03 | 2021-03-03 | Molecular Partners AG | Binding proteins inhibiting the vegf-a receptor interaction |
| CA2776472A1 (en) | 2009-10-01 | 2011-04-07 | Evonik Degussa Corporation | Microparticle compositions and methods for treating age-related macular degeneration |
| US9668915B2 (en) * | 2010-11-24 | 2017-06-06 | Dose Medical Corporation | Drug eluting ocular implant |
-
2014
- 2014-03-13 AU AU2014236938A patent/AU2014236938B2/en not_active Ceased
- 2014-03-13 BR BR112015021000A patent/BR112015021000A2/pt not_active IP Right Cessation
- 2014-03-13 EP EP14717337.1A patent/EP2968574A1/en not_active Withdrawn
- 2014-03-13 CA CA2902547A patent/CA2902547A1/en not_active Abandoned
- 2014-03-13 US US14/209,683 patent/US20140274873A1/en not_active Abandoned
- 2014-03-13 EP EP20167724.2A patent/EP3693021A1/en not_active Withdrawn
- 2014-03-13 RU RU2015135147A patent/RU2720412C2/ru active
- 2014-03-13 JP JP2016502103A patent/JP6649246B2/ja not_active Expired - Fee Related
- 2014-03-13 KR KR1020157027832A patent/KR20150128857A/ko not_active Ceased
- 2014-03-13 CN CN201480015377.2A patent/CN105188759A/zh active Pending
- 2014-03-13 WO PCT/US2014/026320 patent/WO2014151725A1/en not_active Ceased
-
2019
- 2019-03-19 AU AU2019201884A patent/AU2019201884B2/en not_active Ceased
- 2019-12-02 JP JP2019217753A patent/JP2020029466A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014236938B2 (en) | 2018-12-20 |
| JP6649246B2 (ja) | 2020-02-19 |
| KR20150128857A (ko) | 2015-11-18 |
| AU2019201884A1 (en) | 2019-04-11 |
| RU2720412C2 (ru) | 2020-04-29 |
| EP3693021A1 (en) | 2020-08-12 |
| JP2016517418A (ja) | 2016-06-16 |
| US20140274873A1 (en) | 2014-09-18 |
| CA2902547A1 (en) | 2014-09-25 |
| RU2015135147A (ru) | 2017-04-18 |
| JP2020029466A (ja) | 2020-02-27 |
| EP2968574A1 (en) | 2016-01-20 |
| AU2019201884B2 (en) | 2020-08-27 |
| CN105188759A (zh) | 2015-12-23 |
| AU2014236938A1 (en) | 2015-09-03 |
| WO2014151725A1 (en) | 2014-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Ipc: A61K 47/18 (2006.01), A61K 38/00 (2006.01), A61K 4 |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2662 DE 11-01-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |