BR112015018355A8 - novos compostos de pirimidina condensados substituídos - Google Patents

novos compostos de pirimidina condensados substituídos

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Publication number
BR112015018355A8
BR112015018355A8 BR112015018355A BR112015018355A BR112015018355A8 BR 112015018355 A8 BR112015018355 A8 BR 112015018355A8 BR 112015018355 A BR112015018355 A BR 112015018355A BR 112015018355 A BR112015018355 A BR 112015018355A BR 112015018355 A8 BR112015018355 A8 BR 112015018355A8
Authority
BR
Brazil
Prior art keywords
pyrimidine compounds
substituted condensed
condensed pyrimidine
new substituted
medicaments
Prior art date
Application number
BR112015018355A
Other languages
English (en)
Other versions
BR112015018355A2 (pt
Inventor
Hesslinger Christian
Jakob Florian
Konetzki Ingo
J Shiers Jason
Ratcliffe Paul
Craan Tobias
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of BR112015018355A2 publication Critical patent/BR112015018355A2/pt
Publication of BR112015018355A8 publication Critical patent/BR112015018355A8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
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  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)

Abstract

resumo novos compostos de pirimidina condensados substituídos. a invenção está relacionada a novos compostos de pirimidina condensados substituídos de fórmula geral (i) (i) na qual os agrupamentos químicos, substituintes e índices são como definido na descrição, e a seu uso como medicamentos, em particular como medicamentos para o tratamento de condições e doenças que podem ser tratadas pela inibição da enzima pde4. 1/1
BR112015018355A 2013-02-04 2014-02-03 novos compostos de pirimidina condensados substituídos BR112015018355A8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361760197P 2013-02-04 2013-02-04
EP13000550 2013-02-04
EP13002373 2013-05-03
PCT/EP2014/000274 WO2014117948A1 (en) 2013-02-04 2014-02-03 Novel substituted condensed pyrimidine compounds

Publications (2)

Publication Number Publication Date
BR112015018355A2 BR112015018355A2 (pt) 2017-07-18
BR112015018355A8 true BR112015018355A8 (pt) 2018-01-23

Family

ID=51261480

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015018355A BR112015018355A8 (pt) 2013-02-04 2014-02-03 novos compostos de pirimidina condensados substituídos

Country Status (9)

Country Link
US (1) US9670189B2 (pt)
EP (1) EP2951173B1 (pt)
JP (1) JP6307525B2 (pt)
AU (1) AU2014211756B2 (pt)
BR (1) BR112015018355A8 (pt)
CA (1) CA2899963A1 (pt)
ES (1) ES2637716T3 (pt)
MX (1) MX2015009677A (pt)
WO (1) WO2014117948A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014066659A1 (en) * 2012-10-25 2014-05-01 Tetra Discovery Partners, Llc. Heteroaryl inhibitors of pde4
TW201512189A (zh) * 2013-04-16 2015-04-01 Gruenenthal Chemie 新型被取代之嘧啶縮合化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1046939C (zh) 1993-07-02 1999-12-01 比克·古尔顿·劳姆贝尔格化学公司 氟烷氧基取代的苯甲酰胺类及其制备方法和应用
US20060293343A1 (en) * 2005-05-18 2006-12-28 Asahi Kasei Pharma Corporation Pyrimidine derivatives
DK2215092T3 (da) 2007-10-19 2012-05-07 Boehringer Ingelheim Int Substitueret piperidino-dihydrothienopyrimidin
WO2012054874A1 (en) 2010-10-22 2012-04-26 Intermune, Inc. Novel macrocyclic inhibitors of hepatitis c virus replication
WO2014066659A1 (en) * 2012-10-25 2014-05-01 Tetra Discovery Partners, Llc. Heteroaryl inhibitors of pde4

Also Published As

Publication number Publication date
ES2637716T3 (es) 2017-10-16
AU2014211756A1 (en) 2015-09-24
JP2016510333A (ja) 2016-04-07
EP2951173A1 (en) 2015-12-09
US20150344496A1 (en) 2015-12-03
US9670189B2 (en) 2017-06-06
WO2014117948A1 (en) 2014-08-07
AU2014211756B2 (en) 2017-04-13
BR112015018355A2 (pt) 2017-07-18
CA2899963A1 (en) 2014-08-07
MX2015009677A (es) 2015-11-25
JP6307525B2 (ja) 2018-04-04
EP2951173B1 (en) 2017-05-17

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B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

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