BR112015016189A2 - método para tratamento ou prevenção de desmielinização em um sujeito com necessidade do mesmo; composição farmacêutica; método para prevenção do progresso de uma doença desmielinizante em um paciente; método para tratamento de esclerose multipla progressiva em um paciente; e método da prevenção ou da redução na severidade da fase da iniciação da resposta autoimune em um paciente que tem uma doença desmielinizante - Google Patents

método para tratamento ou prevenção de desmielinização em um sujeito com necessidade do mesmo; composição farmacêutica; método para prevenção do progresso de uma doença desmielinizante em um paciente; método para tratamento de esclerose multipla progressiva em um paciente; e método da prevenção ou da redução na severidade da fase da iniciação da resposta autoimune em um paciente que tem uma doença desmielinizante

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Publication number
BR112015016189A2
BR112015016189A2 BR112015016189A BR112015016189A BR112015016189A2 BR 112015016189 A2 BR112015016189 A2 BR 112015016189A2 BR 112015016189 A BR112015016189 A BR 112015016189A BR 112015016189 A BR112015016189 A BR 112015016189A BR 112015016189 A2 BR112015016189 A2 BR 112015016189A2
Authority
BR
Brazil
Prior art keywords
patient
preventing
demyelinating disease
treating
severity
Prior art date
Application number
BR112015016189A
Other languages
English (en)
Other versions
BR112015016189A8 (pt
Inventor
Blitzer Jeremy
Mckearn John
Original Assignee
Pathologica Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pathologica Llc filed Critical Pathologica Llc
Publication of BR112015016189A2 publication Critical patent/BR112015016189A2/pt
Publication of BR112015016189A8 publication Critical patent/BR112015016189A8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

resumo método para tratamento ou prevenção de desmielinização em um sujeito com necessidade do mesmo; composição farmacêutica; método para prevenção do progresso de uma doença desmielinizante em um paciente; método para tratamento de esclerose multipla progressiva em um paciente; e método da prevenção ou da redução na severidade da fase da iniciação da resposta autoimune em um paciente que tem uma doença desmielinizante são divulgadas neste documento novas composições farmacêuticas orais de inibidores da samdc, análogos de poliamina e inibidores de biossíntese de poliamina, e suas aplicações para tratamento das condições, incluindo doenças desmielinizantes, doenças autoimunes afetando o sistema nervoso e outras condições neurodegenerativas. 1/1
BR112015016189A 2013-01-08 2014-01-08 usos de metilglioxal bis (guanilhidrazona) (“mgbg”), uso de metilglioxal bis (guanilhidrazona) (“mgbg”) e um agente e composição farmacêutica BR112015016189A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361750336P 2013-01-08 2013-01-08
US201361823276P 2013-05-14 2013-05-14
PCT/US2014/010714 WO2014110154A1 (en) 2013-01-08 2014-01-08 Methods and comp0stions for treatment of demyelinating diseases

Publications (2)

Publication Number Publication Date
BR112015016189A2 true BR112015016189A2 (pt) 2017-07-11
BR112015016189A8 BR112015016189A8 (pt) 2019-10-22

Family

ID=51167347

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015016189A BR112015016189A8 (pt) 2013-01-08 2014-01-08 usos de metilglioxal bis (guanilhidrazona) (“mgbg”), uso de metilglioxal bis (guanilhidrazona) (“mgbg”) e um agente e composição farmacêutica

Country Status (12)

Country Link
US (2) US10085955B2 (pt)
EP (2) EP2943189B1 (pt)
JP (2) JP6370804B2 (pt)
CN (2) CN109432073A (pt)
AU (2) AU2014205529B2 (pt)
BR (1) BR112015016189A8 (pt)
CA (1) CA2896977C (pt)
DK (1) DK2943189T3 (pt)
ES (1) ES2859553T3 (pt)
HK (1) HK1217451A1 (pt)
IL (1) IL239851B (pt)
WO (1) WO2014110154A1 (pt)

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WO2014110154A1 (en) 2014-07-17
EP2943189A4 (en) 2016-07-06
AU2018247351B2 (en) 2020-04-09
HK1217451A1 (zh) 2017-01-13
IL239851A0 (en) 2015-08-31
US20180360783A1 (en) 2018-12-20
CA2896977A1 (en) 2014-07-17
IL239851B (en) 2020-07-30
CN105163730A (zh) 2015-12-16
US20150359761A1 (en) 2015-12-17
ES2859553T3 (es) 2021-10-04
CN105163730B (zh) 2018-10-30
EP2943189B1 (en) 2021-03-10
US10350178B2 (en) 2019-07-16
BR112015016189A8 (pt) 2019-10-22
JP6370804B2 (ja) 2018-08-08
EP2943189A1 (en) 2015-11-18
JP2016504389A (ja) 2016-02-12
NZ749754A (en) 2020-09-25
EP3831372A1 (en) 2021-06-09
CA2896977C (en) 2021-12-07
US10085955B2 (en) 2018-10-02
AU2018247351A1 (en) 2018-11-08
AU2014205529A1 (en) 2015-07-09
DK2943189T3 (da) 2021-04-06
CN109432073A (zh) 2019-03-08
JP2018172427A (ja) 2018-11-08
AU2014205529B2 (en) 2018-08-09
NZ709157A (en) 2020-09-25

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