BR112015014556A2 - caroteno hidroxilase e seu uso para produzir carotenoides - Google Patents

caroteno hidroxilase e seu uso para produzir carotenoides

Info

Publication number
BR112015014556A2
BR112015014556A2 BR112015014556A BR112015014556A BR112015014556A2 BR 112015014556 A2 BR112015014556 A2 BR 112015014556A2 BR 112015014556 A BR112015014556 A BR 112015014556A BR 112015014556 A BR112015014556 A BR 112015014556A BR 112015014556 A2 BR112015014556 A2 BR 112015014556A2
Authority
BR
Brazil
Prior art keywords
produce carotenoids
hydroxylase
carotene
carotene hydroxylase
beta
Prior art date
Application number
BR112015014556A
Other languages
English (en)
Inventor
Chevreux Bastien
Farrell Christopher
Mayorga Maria
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of BR112015014556A2 publication Critical patent/BR112015014556A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/13129—Beta-carotene 3-hydroxylase (1.14.13.129)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

resumo caroteno hidroxilase e seu uso para produzir carotenoides a presente invenção refere-se a uma hidroxilase inovadora, codificação de sequência de ácidos nucleicos, portanto, construções e vetores de expressão que compreendem essa sequência, microrganismos transformados com a mesma, processos para a hidroxilação microbiológica de isoprenoides, por exemplo, processos para converter betacaroteno em beta-criptoxantina e zeaxantina, cantaxantina em astaxantina.
BR112015014556A 2012-12-20 2013-08-27 caroteno hidroxilase e seu uso para produzir carotenoides BR112015014556A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12198352 2012-12-20
US201361830273P 2013-06-03 2013-06-03
PCT/IB2013/056583 WO2014096990A1 (en) 2012-12-20 2013-08-27 Carotene hydroxylase and its use for producing carotenoids

Publications (1)

Publication Number Publication Date
BR112015014556A2 true BR112015014556A2 (pt) 2017-10-10

Family

ID=47458725

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015014556A BR112015014556A2 (pt) 2012-12-20 2013-08-27 caroteno hidroxilase e seu uso para produzir carotenoides

Country Status (9)

Country Link
US (1) US10081797B2 (pt)
EP (1) EP2935570B1 (pt)
JP (1) JP6319697B2 (pt)
KR (1) KR102113368B1 (pt)
CN (2) CN113774034A (pt)
BR (1) BR112015014556A2 (pt)
CA (1) CA2895298A1 (pt)
EA (1) EA201500663A1 (pt)
WO (1) WO2014096990A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201400836A8 (ru) * 2012-01-23 2016-03-31 ДСМ АйПи АССЕТС Б.В. Получение дитерпена
EP3400295A4 (en) * 2016-01-08 2019-09-04 DSM IP Assets B.V. PERMUTATION OF THE SEXUAL TYPE IN YARROWIA LIPOLYTICA
CN109536518A (zh) * 2018-10-31 2019-03-29 昆明理工大学 一种八氢番茄红素脱氢酶基因RKcrtI及其应用
CN111454854B (zh) * 2020-05-02 2022-05-06 昆明理工大学 一株产虾青素的红冬孢酵母基因工程菌株
CN113413377B (zh) * 2021-06-23 2023-06-09 陕西中医药大学 3-羟基-β-紫罗兰酮在制备血管相关性疾病的药物中的用途
CN114317307B (zh) * 2021-12-30 2024-05-10 广州智特奇生物科技股份有限公司 一种可提高虾青素生物合成产量的基因工程菌及其构建方法与应用
WO2023148187A1 (en) 2022-02-02 2023-08-10 Dsm Ip Assets B.V. Yarrowia production process
KR20230138333A (ko) * 2022-03-23 2023-10-05 씨제이제일제당 (주) 헤마토코쿠스 플루비알리스 유래의 제라닐제라닐 피로포스페이트 신타아제를 포함하는 카로티노이드 또는 이를 전구체로 하는 물질 생산 미생물 및 이를 이용한 카로티노이드 또는 레티노이드 생산방법
CN115074410A (zh) * 2022-06-30 2022-09-20 武汉合生科技有限公司 一种生物合成虾青素的方法及载体
CN115895922B (zh) * 2022-12-19 2024-04-02 云南大学 一株高产类胡萝卜素的禾本红酵母及其应用
CN118126851A (zh) * 2024-03-27 2024-06-04 黄石曼菲特生物科技有限公司 一株高产虾青素、角黄素及β-胡萝卜素的解脂亚罗酵母及其培养方法与应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2073475T3 (es) 1989-04-21 1995-08-16 Kirin Brewery Secuencias de dna utilizables en la sintesis de carotenoides.
DE69132769T2 (de) 1990-03-02 2002-04-18 Bp Corp. North America Inc., Chicago Biosynthese von carotinoiden in genetisch hergestellten wirtszellen
KR100231454B1 (ko) 1993-12-27 1999-12-01 무라세 쇼우이치 크산토필의 합성에 유용한 dna 사슬 및 크산토필의 제조법
EP0747483B1 (en) 1995-06-09 2004-03-24 DSM IP Assets B.V. Fermentative carotenoid production
US5744341A (en) 1996-03-29 1998-04-28 University Of Maryland College Park Genes of carotenoid biosynthesis and metabolism and a system for screening for such genes
DE19801120A1 (de) 1998-01-15 1999-07-22 Basf Ag Orotidin-5'-Phosphatdecarboxylase-Gen, Genkonstrukt enthaltend dieses Gen und seine Verwendung
DE19916140A1 (de) * 1999-04-09 2000-10-12 Basf Ag Carotinhydroxylase und Verfahren zur Herstellung von Xanthophyllderivaten
EP1592783A2 (de) * 2003-01-09 2005-11-09 Basf Aktiengesellschaft Verfahren zur herstellung von carotinoiden oder deren vorstufen mittels gentechnisch veränderter organismen der gattung blakeslea, mit dem verfahren hergestellte carotinoide oder deren vorstufen und deren verwendung
DE10300649A1 (de) * 2003-01-09 2004-07-22 Basf Ag Verfahren zur Herstellung von Ketocarotinoiden durch Kultivierung von genetisch veränderten Organismen
WO2004063358A1 (de) * 2003-01-09 2004-07-29 Basf Aktiengesellschaft Verfahren zur gentechnischen veränderung von organismen der gattung blakeslea, entsprechende organismen und deren verwendung
DE102004007624A1 (de) 2004-02-17 2005-09-15 Sungene Gmbh & Co. Kgaa Neue Ketolasen und Verfahren zur Herstellung von Ketocarotinoiden
DE102004007622A1 (de) * 2004-02-17 2005-08-25 Sungene Gmbh & Co. Kgaa Verfahren zur Herstellung von Ketocarotinoiden in genetisch veränderten, nicht-humanen Organismen
JP2006075097A (ja) * 2004-09-10 2006-03-23 Tadashi Matsunaga カロテノイド生産能を有する形質転換体及びカロテノイドの生産方法
AU2006227165B2 (en) 2005-03-18 2011-11-10 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
JP2007254459A (ja) * 2006-02-21 2007-10-04 Yamaha Motor Co Ltd アスタキサンチンの保存安定性が高い緑藻抽出物
KR20090046376A (ko) * 2007-11-06 2009-05-11 부경대학교 산학협력단 카로티노이드 생합성 유전자로 형질 전환된 효모 및 이를이용한 아스타잔틴의 대량 생산 방법
WO2010079032A1 (en) 2008-12-17 2010-07-15 Basf Plant Science Gmbh Production of ketocarotenoids in plants
CN102021197A (zh) * 2009-09-11 2011-04-20 中国科学院海洋研究所 一种植物双价表达载体及其构建方法

Also Published As

Publication number Publication date
EP2935570B1 (en) 2018-09-19
WO2014096990A8 (en) 2015-12-23
WO2014096990A1 (en) 2014-06-26
US10081797B2 (en) 2018-09-25
EA201500663A1 (ru) 2015-12-30
EP2935570A1 (en) 2015-10-28
KR102113368B1 (ko) 2020-05-22
CN105308180A (zh) 2016-02-03
CA2895298A1 (en) 2014-06-26
JP2016505259A (ja) 2016-02-25
KR20150099787A (ko) 2015-09-01
CN113774034A (zh) 2021-12-10
JP6319697B2 (ja) 2018-05-09
US20150315550A1 (en) 2015-11-05

Similar Documents

Publication Publication Date Title
BR112015014556A2 (pt) caroteno hidroxilase e seu uso para produzir carotenoides
CR20150658A (es) Montajes de mezcla que incluyen impulsores magnéticos
NI201700142A (es) Anticuerpos anti-cd38 para el tratamiento de amiloidosis de cadena ligera y otr
AR113177A2 (es) Polipéptidos que tienen actividad de lisozima y polinucleótidos que los codifican
GT201700048A (es) Terapias de combinación con anticuerpos anti-cd38
UY35456A (es) Moléculas de unión para bcma y cd3
CL2017002820A1 (es) Variantes de alfa-amilasa y polinucleótidos que codifican las mismas
GT201600187A (es) Codificación de transformación inversa de espacio de color universal
UY36245A (es) Constructos de anticuerpos para cdh19 y cd3
BR112018001042A2 (pt) construtos de anticorpo para flt3 e cd3
BR112015023472A2 (pt) método de produção de um produto químico, método de bioprodução de um produto químico, organismo geneticamente modificado e produto
BR112013029885A2 (pt) desacoplador isolador
EA201500659A1 (ru) Ацетилтрансферазы и их применение для получения каротиноидов
UY34332A (es) Composiciones y métodos para controlar malezas co mprendiendo un polinucleótido y agente de transfe rencia, y que modulan la fitoeno desaturasa?.
BR112015000994A2 (pt) processo e sistema de reação para a preparação de metanol
MX353055B (es) Procedimiento para la preparación de óxidos mixtos multimetálicos y su uso como catalizadores de alto desempeño en la deshidrogenación oxidativa de etano para la producción de etileno, sin formación de ácido acético u otros hidrocarburos oxigenados.
AU2015213170A1 (en) Dilution of the reactants of an oxidative dehydrogenation of alkanes with carbon dioxide
PE20200461A1 (es) Catalizadores aglomerados de deshidrogenacion oxidativa
BR112016002105A2 (pt) Microrganismo modificado, método para produzir alanina e uso de um microrganismo modificado
BR112016028527A2 (pt) micro-organismo produtor de o-acetil-homoserina e método para produção de o-acetil homoserina usando o mesmo
CL2014003565A1 (es) Uso de 2-metileno-19-nor-(20s)-1alpha,25-dihidroxivitamina d3 para tratar el hiperparatiroidismo secundario.
GB2535662A (en) Gate valve with pneumatic system for shearing application
BR112016014413A8 (pt) Glicosiltransferase que glicosila o ácido flavoquermésico e/ou ácido quermésico
BR112015033057A2 (pt) Elemento de torção transmissivo com resposta elástica
BR112015008539A2 (pt) micro-esferas compreendendo carotenóides

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2529 DE 25-06-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.