BR112015009849A2 - vanilina sintase - Google Patents

vanilina sintase

Info

Publication number
BR112015009849A2
BR112015009849A2 BR112015009849A BR112015009849A BR112015009849A2 BR 112015009849 A2 BR112015009849 A2 BR 112015009849A2 BR 112015009849 A BR112015009849 A BR 112015009849A BR 112015009849 A BR112015009849 A BR 112015009849A BR 112015009849 A2 BR112015009849 A2 BR 112015009849A2
Authority
BR
Brazil
Prior art keywords
vanillin synthase
vanillin
synthase
Prior art date
Application number
BR112015009849A
Other languages
English (en)
Inventor
Lindberg Møller Birger
Halkjær Hansen Esben
Hansen Jørgen
Janeshawari Gallage Nethaji
Original Assignee
Evolva Sa
Univ Copenhagen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evolva Sa, Univ Copenhagen filed Critical Evolva Sa
Publication of BR112015009849A2 publication Critical patent/BR112015009849A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/20—Synthetic spices, flavouring agents or condiments
    • A23L27/24—Synthetic spices, flavouring agents or condiments prepared by fermentation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
    • C12Y101/03038—Vanillyl-alcohol oxidase (1.1.3.38)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01126—Hydroxycinnamate 4-beta-glucosyltransferase (2.4.1.126)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/02—Aldehyde-lyases (4.1.2)
    • C12Y401/02041—Vanillin synthase (4.1.2.41)
BR112015009849A 2012-11-05 2013-11-05 vanilina sintase BR112015009849A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261722513P 2012-11-05 2012-11-05
PCT/DK2013/050357 WO2014067534A1 (en) 2012-11-05 2013-11-05 Vanillin synthase

Publications (1)

Publication Number Publication Date
BR112015009849A2 true BR112015009849A2 (pt) 2017-12-05

Family

ID=49585248

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015009849A BR112015009849A2 (pt) 2012-11-05 2013-11-05 vanilina sintase

Country Status (9)

Country Link
US (1) US10689672B2 (pt)
EP (1) EP2914733A1 (pt)
JP (1) JP6594205B2 (pt)
CN (1) CN104769121B (pt)
AU (2) AU2013339881B2 (pt)
BR (1) BR112015009849A2 (pt)
CA (1) CA2888636C (pt)
HK (1) HK1213943A1 (pt)
WO (1) WO2014067534A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105283547B (zh) * 2012-12-27 2022-10-04 罗地亚经营管理公司 用于生物合成生产的重组宿主细胞
EP3330374B1 (en) 2013-12-18 2022-02-02 Københavns Universitet Glycosyltransferase glycosylating flavokermesic acid and/or kermesic acid
US10704070B2 (en) 2015-03-03 2020-07-07 The Regents Of The University Of California Protecting group chemistry for clean, reductant-free dyeing
EP3532631A1 (en) 2016-10-26 2019-09-04 Ajinomoto Co., Inc. Method for producing l-methionine or metabolites requiring s-adenosylmethionine for synthesis
CN109890970B (zh) 2016-10-26 2023-04-04 味之素株式会社 生产目标物质的方法
WO2018079687A1 (en) 2016-10-26 2018-05-03 Ajinomoto Co., Inc. Method for producing objective substance
CN109890972B (zh) 2016-10-26 2022-11-08 味之素株式会社 生产目标物质的方法
EP3532628B1 (en) 2016-10-26 2024-02-28 Ajinomoto Co., Inc. Method for producing objective substance
EP3532610B1 (en) 2016-10-27 2023-09-27 Ajinomoto Co., Inc. Method for producing aldehyde
US10858676B2 (en) 2017-05-22 2020-12-08 Ajinomoto Co., Inc. Method for producing objective substance
US11680279B2 (en) 2017-11-29 2023-06-20 Ajinomoto Co., Inc. Method for producing objective substance
WO2020027251A1 (en) 2018-08-03 2020-02-06 Ajinomoto Co., Inc. Method for producing objective substance
CN110241146B (zh) * 2019-06-27 2021-04-06 杭州唯铂莱生物科技有限公司 一种组合酶法制备3,4-二羟基肉桂酸的方法及通过该方法生产的3,4-二羟基肉桂酸
CN111019995B (zh) 2019-12-31 2021-04-27 厦门欧米克生物科技有限公司 一种以丁香酚为底物发酵生成香兰素的方法
CR20230175A (es) * 2020-10-23 2023-07-26 Elo Life Systems Inc Métodos para producir plantas de vainilla con mejor sabor y producción agronómica
WO2023159017A1 (en) * 2022-02-15 2023-08-24 Evolva Sa Process for recovering and purifying vanillin

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484956A (en) 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
US6946587B1 (en) 1990-01-22 2005-09-20 Dekalb Genetics Corporation Method for preparing fertile transgenic corn plants
US5204253A (en) 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
US5128253A (en) 1991-05-31 1992-07-07 Kraft General Foods, Inc. Bioconversion process for the production of vanillin
AU5698794A (en) 1992-12-10 1994-07-04 Quest International B.V. Production of vanillin
DE19532317A1 (de) * 1995-09-01 1997-03-06 Haarmann & Reimer Gmbh Verfahren zur Herstellung von Vanillin und dafür geeignete Mikroorganismen
JPH10117776A (ja) 1996-10-22 1998-05-12 Japan Tobacco Inc インディカイネの形質転換方法
DE19649655A1 (de) * 1996-11-29 1998-06-04 Haarmann & Reimer Gmbh Syntheseenzyme für die Herstellung von Coniferylalkohol, Coniferylaldehyd, Ferulasäure, Vanillin und Vanillinsäure und deren Verwendung
CA2238215A1 (en) * 1997-06-19 1998-12-19 Markus Wetli Process for the production of vanillin
US20030070188A1 (en) 1997-07-15 2003-04-10 Daphna Havkin-Frenkel Vanillin biosynthetic pathway enzyme from Vanilla planifolia
GB9904251D0 (en) * 1999-02-24 1999-04-21 Zylepsis Ltd Flavour/aroma materials and their preparation
FR2792334B1 (fr) * 1999-04-14 2003-03-07 Agronomique Inst Nat Rech Procede d'obtention de cultures d'a. niger et leurs utilisations pour la production d'acide ferulique et d'acide vanillique
DE60040802D1 (de) 1999-12-01 2008-12-24 Adelaide Res & Innovation Pty Udp-glukose:aglycon-glukosyltransferase
DE19960106A1 (de) * 1999-12-14 2001-06-21 Haarmann & Reimer Gmbh Enzyme und Gene für die Herstellung von Vanillin
CN101165168B (zh) 2006-10-20 2010-05-12 上海爱普香料有限公司 一株链霉菌及利用其生物转化阿魏酸生产香兰素的方法
MX2008012689A (es) * 2007-04-19 2009-04-17 Biokab S A De C V Proceso para producir vainilla a partir de microorganismos inmovilizados por cultivo de superficies.
WO2013022881A1 (en) 2011-08-08 2013-02-14 International Flavors & Fragrances Inc. Compositions and methods for the biosynthesis of vanillin or vanillin beta-d-glucoside

Also Published As

Publication number Publication date
JP6594205B2 (ja) 2019-10-23
EP2914733A1 (en) 2015-09-09
CN104769121A (zh) 2015-07-08
CA2888636A1 (en) 2014-05-08
WO2014067534A1 (en) 2014-05-08
JP2015535181A (ja) 2015-12-10
CN104769121B (zh) 2021-06-01
AU2013339881B2 (en) 2017-08-24
AU2017265117B2 (en) 2019-10-17
US10689672B2 (en) 2020-06-23
US20150267227A1 (en) 2015-09-24
CA2888636C (en) 2022-11-29
AU2017265117A1 (en) 2017-12-14
AU2013339881A1 (en) 2015-04-16
HK1213943A1 (zh) 2016-07-15

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements