BR112015005047B1 - dispositivo e conjunto para misturar e dispensar em gotículas dois componentes biológicos reativos na forma de selante de tecidos e/ou agente hemostático - Google Patents
dispositivo e conjunto para misturar e dispensar em gotículas dois componentes biológicos reativos na forma de selante de tecidos e/ou agente hemostático Download PDFInfo
- Publication number
- BR112015005047B1 BR112015005047B1 BR112015005047-6A BR112015005047A BR112015005047B1 BR 112015005047 B1 BR112015005047 B1 BR 112015005047B1 BR 112015005047 A BR112015005047 A BR 112015005047A BR 112015005047 B1 BR112015005047 B1 BR 112015005047B1
- Authority
- BR
- Brazil
- Prior art keywords
- volume
- dispensing
- nozzle
- biological components
- mixing
- Prior art date
Links
- 238000002156 mixing Methods 0.000 title claims abstract description 29
- 239000000565 sealant Substances 0.000 title claims abstract description 9
- 229940030225 antihemorrhagics Drugs 0.000 title claims abstract description 6
- 239000002874 hemostatic agent Substances 0.000 title claims abstract description 6
- 239000012530 fluid Substances 0.000 claims abstract description 35
- 238000004891 communication Methods 0.000 claims abstract description 4
- 229920000052 poly(p-xylylene) Polymers 0.000 claims description 10
- 229920000642 polymer Polymers 0.000 claims description 6
- 239000013047 polymeric layer Substances 0.000 claims description 6
- 229920002545 silicone oil Polymers 0.000 claims description 5
- 108010049003 Fibrinogen Proteins 0.000 claims description 3
- 102000008946 Fibrinogen Human genes 0.000 claims description 3
- 108090000190 Thrombin Proteins 0.000 claims description 3
- 229940012952 fibrinogen Drugs 0.000 claims description 3
- 229960004072 thrombin Drugs 0.000 claims description 3
- 229960000074 biopharmaceutical Drugs 0.000 claims description 2
- 108091006146 Channels Proteins 0.000 claims 4
- 230000007704 transition Effects 0.000 claims 4
- 239000010410 layer Substances 0.000 claims 2
- 238000000034 method Methods 0.000 abstract description 5
- 238000007789 sealing Methods 0.000 abstract description 3
- 230000023597 hemostasis Effects 0.000 abstract description 2
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 238000000203 droplet dispensing Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 239000000463 material Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000007921 spray Substances 0.000 description 4
- 239000000227 bioadhesive Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 125000001309 chloro group Chemical group Cl* 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 239000003106 tissue adhesive Substances 0.000 description 2
- VRBFTYUMFJWSJY-UHFFFAOYSA-N 28804-46-8 Chemical compound ClC1CC(C=C2)=CC=C2C(Cl)CC2=CC=C1C=C2 VRBFTYUMFJWSJY-UHFFFAOYSA-N 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000002178 crystalline material Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000001471 fibrinogenolytic effect Effects 0.000 description 1
- 239000003527 fibrinolytic agent Substances 0.000 description 1
- 230000003480 fibrinolytic effect Effects 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 238000001771 vacuum deposition Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00491—Surgical glue applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
- B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
- B01F25/452—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces
- B01F25/4521—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces the components being pressed through orifices in elements, e.g. flat plates or cylinders, which obstruct the whole diameter of the tube
- B01F25/45212—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces the components being pressed through orifices in elements, e.g. flat plates or cylinders, which obstruct the whole diameter of the tube the elements comprising means for adjusting the orifices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/50—Movable or transportable mixing devices or plants
- B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
- B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
- B01F33/50112—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held of the syringe or cartridge type
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
- B05B1/30—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages
- B05B1/32—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages in which a valve member forms part of the outlet opening
- B05B1/323—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages in which a valve member forms part of the outlet opening the valve member being actuated by the pressure of the fluid to be sprayed
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B15/00—Details of spraying plant or spraying apparatus not otherwise provided for; Accessories
- B05B15/50—Arrangements for cleaning; Arrangements for preventing deposits, drying-out or blockage; Arrangements for detecting improper discharge caused by the presence of foreign matter
- B05B15/52—Arrangements for cleaning; Arrangements for preventing deposits, drying-out or blockage; Arrangements for detecting improper discharge caused by the presence of foreign matter for removal of clogging particles
- B05B15/528—Arrangements for cleaning; Arrangements for preventing deposits, drying-out or blockage; Arrangements for detecting improper discharge caused by the presence of foreign matter for removal of clogging particles by resilient deformation of the nozzle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00491—Surgical glue applicators
- A61B2017/00495—Surgical glue applicators for two-component glue
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/2305—Mixers of the two-component package type, i.e. where at least two components are separately stored, and are mixed in the moment of application
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Surgical Instruments (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/611,511 US9022975B2 (en) | 2012-09-12 | 2012-09-12 | Airless, non-clogging tip assembly and device |
| US13/611,511 | 2012-09-12 | ||
| PCT/US2013/059119 WO2014043154A1 (en) | 2012-09-12 | 2013-09-11 | Airless, non-clogging tip assembly and device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015005047A2 BR112015005047A2 (pt) | 2017-07-04 |
| BR112015005047B1 true BR112015005047B1 (pt) | 2021-05-04 |
Family
ID=49213171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015005047-6A BR112015005047B1 (pt) | 2012-09-12 | 2013-09-11 | dispositivo e conjunto para misturar e dispensar em gotículas dois componentes biológicos reativos na forma de selante de tecidos e/ou agente hemostático |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9022975B2 (https=) |
| EP (1) | EP2895259B1 (https=) |
| JP (1) | JP6211617B2 (https=) |
| KR (1) | KR102075883B1 (https=) |
| CN (1) | CN104619404B (https=) |
| AU (1) | AU2013315649B2 (https=) |
| BR (1) | BR112015005047B1 (https=) |
| CA (1) | CA2884662C (https=) |
| ES (1) | ES2701802T3 (https=) |
| IL (1) | IL237174B (https=) |
| IN (1) | IN2015DN01146A (https=) |
| MX (1) | MX356595B (https=) |
| RU (1) | RU2648228C2 (https=) |
| WO (1) | WO2014043154A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2734122B1 (en) * | 2011-07-20 | 2018-05-30 | Stryker Corporation | Manifold for filling plural cannulae |
| US10792044B2 (en) * | 2013-03-13 | 2020-10-06 | Applied Cardiovascular Solutions, LLC | Methods, compositions, and devices for the occlusion of cavities and passageways |
| ES2713958T3 (es) * | 2014-09-04 | 2019-05-24 | Ethicon Inc | Dispositivo de obstrucción mínima para el suministro de fluidos |
| USD877891S1 (en) | 2015-12-22 | 2020-03-10 | Guangzhou Bioseal Biotech Co., Ltd. | Reconstitution and delivery device |
| USD877890S1 (en) | 2015-12-22 | 2020-03-10 | Guangzhou Bioseal Biotech Co., Ltd. | Reconstitution device |
| US10918790B2 (en) * | 2015-12-22 | 2021-02-16 | Guangzhou Bioseal Biotech Co., Ltd. | Dual syringe with funnel feeding kit |
| US10737058B2 (en) | 2016-12-28 | 2020-08-11 | Ethicon Llc | Rigid and flexible laparoscopic multiple component material dispensing devices and methods |
| US20180235839A1 (en) * | 2017-02-17 | 2018-08-23 | Leonidas A. Johnson | Dual Container for Sterile Fabrication and Filling |
| USD893714S1 (en) | 2018-02-14 | 2020-08-18 | Ethicon Llc | Laparoscopic adaptor |
| CN110115945A (zh) * | 2019-04-28 | 2019-08-13 | 沪东中华造船(集团)有限公司 | 一种用于混合两种流体的装置 |
| US12539374B2 (en) * | 2021-02-19 | 2026-02-03 | Ethicon, Inc. | Systems, devices and methods for dispensing biocompatible reactive formulations and controlling cross-linking of the reactive components of the biocompatible reactive formulations |
| CN113042274B (zh) * | 2021-04-29 | 2024-09-06 | 广州市极动焊接机械有限公司 | 一种机器人胶枪清除器 |
| KR102385837B1 (ko) | 2022-01-25 | 2022-04-14 | (주)두원메디텍 | 믹스 스프레이 약액 주입기 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2112160A (en) * | 1933-04-04 | 1938-03-22 | Kenneth Fredericks | Method of and apparatus for effecting medicinal treatment |
| US3395344A (en) * | 1964-11-25 | 1968-07-30 | Coulter Electronics | Particle studying apparatus with selfclearing scanner element |
| US3581940A (en) * | 1968-11-12 | 1971-06-01 | Alberto Culver Co | Multiple compartment dispenser container with check valves |
| US3818907A (en) * | 1973-04-23 | 1974-06-25 | M Walton | Double cylinder lavage syringe |
| US5116315A (en) | 1989-10-03 | 1992-05-26 | Hemaedics, Inc. | Biological syringe system |
| PT689874E (pt) | 1994-06-28 | 2002-03-28 | Aventis Behring Gmbh | Dispositivo para a pulverizacao de uma mistura de dois componentes |
| US6063055A (en) | 1997-04-14 | 2000-05-16 | Biosurgical Corporation | Turbulence mixing head for a tissue sealant applicator and spray head for same |
| FR2793222B1 (fr) | 1999-05-05 | 2001-07-06 | Oreal | Tete de distribution et recipient ainsi equipe |
| JP3063935U (ja) * | 1999-05-17 | 1999-12-10 | 川澄化学工業株式会社 | 二液同時混合注出器及びプランジャ結合部材 |
| WO2003080461A1 (de) * | 2002-03-21 | 2003-10-02 | Beiersdorf Ag | Mehrkammerbehälter mit substanzausgabevorrichtung |
| US6972005B2 (en) * | 2002-05-10 | 2005-12-06 | Boehm Jr Frank H | Dual chamber syringe and dual lumen needle |
| CN2560364Y (zh) * | 2002-07-29 | 2003-07-16 | 李国平 | 医用清洗器 |
| US6884232B1 (en) * | 2003-10-31 | 2005-04-26 | Baxter International Inc. | Laparoscopic spray device and method of use |
| US8789725B2 (en) | 2004-03-29 | 2014-07-29 | P G United States Israel Ltd. | Foam dispenser nozzle |
| EP2018885B1 (en) * | 2007-07-25 | 2011-02-09 | Schott forma vitrum ag | Application device |
| US8408480B2 (en) * | 2008-04-25 | 2013-04-02 | Confluent Surgical, Inc. | Self-cleaning spray tip |
| CN201959347U (zh) * | 2011-01-25 | 2011-09-07 | 上海振浦医疗设备有限公司 | 一次性使用精密过滤注射器 |
-
2012
- 2012-09-12 US US13/611,511 patent/US9022975B2/en active Active
-
2013
- 2013-09-11 RU RU2015113361A patent/RU2648228C2/ru active
- 2013-09-11 CA CA2884662A patent/CA2884662C/en active Active
- 2013-09-11 MX MX2015003158A patent/MX356595B/es active IP Right Grant
- 2013-09-11 WO PCT/US2013/059119 patent/WO2014043154A1/en not_active Ceased
- 2013-09-11 BR BR112015005047-6A patent/BR112015005047B1/pt active IP Right Grant
- 2013-09-11 JP JP2015532008A patent/JP6211617B2/ja active Active
- 2013-09-11 ES ES13763437T patent/ES2701802T3/es active Active
- 2013-09-11 AU AU2013315649A patent/AU2013315649B2/en active Active
- 2013-09-11 KR KR1020157008643A patent/KR102075883B1/ko active Active
- 2013-09-11 CN CN201380047539.6A patent/CN104619404B/zh active Active
- 2013-09-11 EP EP13763437.4A patent/EP2895259B1/en active Active
-
2015
- 2015-02-10 IL IL237174A patent/IL237174B/en active IP Right Grant
- 2015-02-12 IN IN1146DEN2015 patent/IN2015DN01146A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN104619404A (zh) | 2015-05-13 |
| CN104619404B (zh) | 2017-03-08 |
| MX356595B (es) | 2018-06-05 |
| JP2015529532A (ja) | 2015-10-08 |
| JP6211617B2 (ja) | 2017-10-11 |
| BR112015005047A2 (pt) | 2017-07-04 |
| IN2015DN01146A (https=) | 2015-06-26 |
| KR20150056570A (ko) | 2015-05-26 |
| EP2895259A1 (en) | 2015-07-22 |
| AU2013315649B2 (en) | 2018-02-01 |
| IL237174B (en) | 2019-01-31 |
| EP2895259B1 (en) | 2018-10-31 |
| US9022975B2 (en) | 2015-05-05 |
| CA2884662C (en) | 2020-06-23 |
| ES2701802T3 (es) | 2019-02-26 |
| AU2013315649A1 (en) | 2015-03-19 |
| KR102075883B1 (ko) | 2020-02-11 |
| CA2884662A1 (en) | 2014-03-20 |
| IL237174A0 (en) | 2015-04-30 |
| MX2015003158A (es) | 2015-07-14 |
| RU2015113361A (ru) | 2016-11-10 |
| US20140074154A1 (en) | 2014-03-13 |
| RU2648228C2 (ru) | 2018-03-22 |
| WO2014043154A1 (en) | 2014-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |
|
| B15K | Others concerning applications: alteration of classification |
Ipc: B01F 5/06 (2006.01), B01F 13/00 (2006.01), A61B 17 |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 11/09/2013, OBSERVADAS AS CONDICOES LEGAIS. |