BR112015004653A2 - método diagnóstico e terapêutico de câncer de moléculas alvo expressas em células-tronco cancerígenas - Google Patents

método diagnóstico e terapêutico de câncer de moléculas alvo expressas em células-tronco cancerígenas

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Publication number
BR112015004653A2
BR112015004653A2 BR112015004653A BR112015004653A BR112015004653A2 BR 112015004653 A2 BR112015004653 A2 BR 112015004653A2 BR 112015004653 A BR112015004653 A BR 112015004653A BR 112015004653 A BR112015004653 A BR 112015004653A BR 112015004653 A2 BR112015004653 A2 BR 112015004653A2
Authority
BR
Brazil
Prior art keywords
cancer
stem cells
target molecules
molecules expressed
therapeutic method
Prior art date
Application number
BR112015004653A
Other languages
English (en)
Portuguese (pt)
Inventor
Kagamu Hiroshi
Narita Ichiei
Hayashi Takashi
Goto Yoshihiro
Original Assignee
Univ Niigata
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Niigata, Otsuka Pharma Co Ltd filed Critical Univ Niigata
Publication of BR112015004653A2 publication Critical patent/BR112015004653A2/pt

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C12Y—ENZYMES
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BR112015004653A 2012-09-04 2013-09-03 método diagnóstico e terapêutico de câncer de moléculas alvo expressas em células-tronco cancerígenas BR112015004653A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012193757 2012-09-04
PCT/JP2013/074172 WO2014038682A2 (en) 2012-09-04 2013-09-03 Cancer diagnostic and therapeutic method targeting molecules expressed in cancer stem cells

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BR112015004653A2 true BR112015004653A2 (pt) 2017-07-04

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US (1) US20150297694A1 (enExample)
EP (1) EP2893352A2 (enExample)
JP (1) JP2015529825A (enExample)
KR (1) KR20150046787A (enExample)
CN (1) CN104769431A (enExample)
AR (1) AR092423A1 (enExample)
AU (1) AU2013313974A1 (enExample)
BR (1) BR112015004653A2 (enExample)
CA (1) CA2883577A1 (enExample)
EA (1) EA201590495A1 (enExample)
IL (1) IL237411A0 (enExample)
IN (1) IN2015DN01646A (enExample)
MX (1) MX2015002749A (enExample)
PH (1) PH12015500388A1 (enExample)
SG (1) SG11201501394SA (enExample)
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WO2017153952A1 (en) * 2016-03-10 2017-09-14 Glaxosmithkline Intellectual Property Development Limited 5-sulfamoyl-2-hydroxybenzamide derivatives
ITUA20161994A1 (it) * 2016-03-24 2017-09-24 Azienda Ospedaliera Univ Senese Uso degli inibitori ddx3 come agenti anti-iperproliferativi
US10738363B2 (en) 2016-08-31 2020-08-11 National Central University Analyzer and analytical method for predicting prognosis of cancer radiotherapy
TWI614629B (zh) * 2016-08-31 2018-02-11 National Central University 預測癌症放射線治療之預後的分析器及方法
EP4039260B1 (en) * 2017-02-07 2024-04-17 Saitama Medical University Cd62llow cd4+ t-cells for treating or preventing cancer
WO2020171138A1 (ja) 2019-02-20 2020-08-27 学校法人 埼玉医科大学 放射線治療による抗腫瘍免疫効果を評価する末梢血バイオマーカー
CN118649238B (zh) * 2024-08-20 2024-12-10 中山大学孙逸仙纪念医院深汕中心医院 Ddx3x抑制剂在制备治疗人工关节无菌性松动的药物中的应用

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CN1852974A (zh) * 2003-06-09 2006-10-25 密歇根大学董事会 用于治疗和诊断癌症的组合物和方法
EP2003196A3 (en) * 2003-06-09 2009-01-07 The Regents of the University of Michigan Compositions and methods for treating and diagnosing cancer
US8518901B2 (en) * 2008-09-23 2013-08-27 The Johns Hopkins University Fused diimidazodiazepine compounds and methods of use and manufacture thereof
US20120202814A1 (en) 2009-10-02 2012-08-09 Università Degli Studi Di Siena Compounds with ddx3 inhibitory activity and uses thereof

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IL237411A0 (en) 2015-04-30
MX2015002749A (es) 2015-09-25
EA201590495A1 (ru) 2015-07-30
WO2014038682A3 (en) 2014-05-15
AU2013313974A1 (en) 2015-03-12
CA2883577A1 (en) 2014-03-13
JP2015529825A (ja) 2015-10-08
KR20150046787A (ko) 2015-04-30
US20150297694A1 (en) 2015-10-22
IN2015DN01646A (enExample) 2015-07-03
AR092423A1 (es) 2015-04-22
CN104769431A (zh) 2015-07-08
SG11201501394SA (en) 2015-03-30
PH12015500388A1 (en) 2015-04-27
TW201413245A (zh) 2014-04-01
WO2014038682A2 (en) 2014-03-13
EP2893352A2 (en) 2015-07-15

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