BR112014030509A2 - métodos para aumentar o progresso genético em uma linhagem ou raça de suíno usando células de esperma de sexo selecionado - Google Patents
métodos para aumentar o progresso genético em uma linhagem ou raça de suíno usando células de esperma de sexo selecionadoInfo
- Publication number
- BR112014030509A2 BR112014030509A2 BR112014030509A BR112014030509A BR112014030509A2 BR 112014030509 A2 BR112014030509 A2 BR 112014030509A2 BR 112014030509 A BR112014030509 A BR 112014030509A BR 112014030509 A BR112014030509 A BR 112014030509A BR 112014030509 A2 BR112014030509 A2 BR 112014030509A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- sperm cells
- sex
- lineage
- genetic progress
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 230000002068 genetic effect Effects 0.000 title abstract 3
- 241000282898 Sus scrofa Species 0.000 abstract 3
- 230000002708 enhancing effect Effects 0.000 abstract 2
- 244000144980 herd Species 0.000 abstract 1
- 230000009027 insemination Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D19/00—Instruments or methods for reproduction or fertilisation
- A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
- A61D19/027—Devices for injecting semen into animals, e.g. syringes, guns, probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D19/00—Instruments or methods for reproduction or fertilisation
- A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/02—Breeding vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/012—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor characterised by internal passages or accessories therefor
- A61B1/015—Control of fluid supply or evacuation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/303—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the vagina, i.e. vaginoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/313—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for introducing through surgical openings, e.g. laparoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0012—Ovulation-period determination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D19/00—Instruments or methods for reproduction or fertilisation
- A61D19/04—Instruments or methods for reproduction or fertilisation for embryo transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/40—Population genetics; Linkage disequilibrium
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
- A61B2034/2046—Tracking techniques
- A61B2034/2055—Optical tracking systems
- A61B2034/2057—Details of tracking cameras
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Reproductive Health (AREA)
- Environmental Sciences (AREA)
- Animal Husbandry (AREA)
- Optics & Photonics (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Physiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Computational Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biotechnology (AREA)
- Evolutionary Biology (AREA)
- Theoretical Computer Science (AREA)
- Ecology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Robotics (AREA)
- Transplantation (AREA)
- Gynecology & Obstetrics (AREA)
- Hematology (AREA)
Abstract
resumo patente de invenção: "métodos para aumentar o progresso genético em uma linhagem ou raça de suíno usando células de esperma de sexo selecionado". a presente invenção refere-se a métodos para aumentar o progresso genético de uma linhagem, raça ou manada de suíno através do uso de células de esperma de sexo selecionado em técnicas de inseminação artificial. a invenção também abrange métodos de inseminar artificialmente um suíno via cateter intrauterino profundo ou através de um procedimento laparoscópico, que permitem o uso de doses reduzidas de células de esperma de sexo selecionado.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261656446P | 2012-06-06 | 2012-06-06 | |
US13/840,598 US9433195B2 (en) | 2012-06-06 | 2013-03-15 | Methods for increasing genetic progress in a line or breed of swine using sex-selected sperm cells |
PCT/US2013/044521 WO2013184922A2 (en) | 2012-06-06 | 2013-06-06 | Methods for increasing genetic progress in a line or breed of swine using sex-selected sperm cells |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014030509A2 true BR112014030509A2 (pt) | 2017-06-27 |
Family
ID=49712848
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014030509A BR112014030509A2 (pt) | 2012-06-06 | 2013-06-06 | métodos para aumentar o progresso genético em uma linhagem ou raça de suíno usando células de esperma de sexo selecionado |
Country Status (10)
Country | Link |
---|---|
US (5) | US9433195B2 (pt) |
EP (1) | EP2858488A4 (pt) |
KR (1) | KR101708105B1 (pt) |
CN (1) | CN104519828A (pt) |
BR (1) | BR112014030509A2 (pt) |
CA (1) | CA2875058C (pt) |
HK (1) | HK1208596A1 (pt) |
MX (2) | MX358748B (pt) |
NZ (1) | NZ630356A (pt) |
WO (1) | WO2013184922A2 (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9433195B2 (en) | 2012-06-06 | 2016-09-06 | Inguran, Llc | Methods for increasing genetic progress in a line or breed of swine using sex-selected sperm cells |
US9888990B2 (en) | 2012-06-06 | 2018-02-13 | Inguran, Llc | Methods for use of sex sorted semen to improve genetic management in swine |
MX2020011408A (es) * | 2013-03-15 | 2021-09-15 | Inguran Llc | Metodos para uso de semen sexado para mejorar la gestion genetica en cerdos. |
US10379041B2 (en) * | 2015-10-21 | 2019-08-13 | Union Evolution | Method for determining the quality of a semen of a vertebrate animal |
WO2019100018A1 (en) * | 2017-11-20 | 2019-05-23 | Inguran, Llc | Methods for increasing the rate of genetic progress and generating inbred lines in non-human mammals using gametes derived from embryos |
CN108742492A (zh) * | 2018-06-29 | 2018-11-06 | 辛琰琰 | 无孔穹窿镜 |
CN112773318B (zh) * | 2021-01-29 | 2022-06-24 | 四川省畜牧科学研究院 | 一种雏禽性别鉴定肛笔 |
CN113311176A (zh) * | 2021-04-14 | 2021-08-27 | 昆明天沃生物科技有限公司 | 一种检测母猪妊娠及怀胎数量的方法 |
Family Cites Families (42)
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CA2142161A1 (en) | 1995-02-09 | 1996-08-10 | Larry Hayward Jewett | Shipping container for shipping livestock |
JP4323571B2 (ja) | 1997-01-31 | 2009-09-02 | エックスワイ, インコーポレイテッド | 光学装置 |
US6071689A (en) | 1997-12-31 | 2000-06-06 | Xy, Inc. | System for improving yield of sexed embryos in mammals |
US6149867A (en) | 1997-12-31 | 2000-11-21 | Xy, Inc. | Sheath fluids and collection systems for sex-specific cytometer sorting of sperm |
WO1999038883A1 (en) | 1998-02-03 | 1999-08-05 | Xy, Inc. | Specific oligonucleotide primers for detection of bovine male chromosome presence by polymerase chain reaction and method |
US6746873B1 (en) | 1998-02-20 | 2004-06-08 | Xy, Inc. | Vibratory system for a sorting flow cytometer |
BR9912539A (pt) * | 1998-07-30 | 2001-05-02 | Xy Inc | Sistema equino para inseminação artificial não-cirúrgica |
US6071680A (en) | 1998-12-21 | 2000-06-06 | Eastman Kodak Company | Reflective photographic display material with voided polyester layer |
US7208265B1 (en) | 1999-11-24 | 2007-04-24 | Xy, Inc. | Method of cryopreserving selected sperm cells |
US6263745B1 (en) | 1999-12-03 | 2001-07-24 | Xy, Inc. | Flow cytometer nozzle and flow cytometer sample handling methods |
ES2156579B1 (es) | 2000-01-20 | 2002-01-16 | Univ Murcia | Dispositivo y metodo para introducir y/o recoger fluidos en el interior del utero de un animal. |
GB2360360B (en) * | 2000-03-14 | 2002-03-20 | Univ Bristol | A method of sorting cells |
EP2258172B1 (en) | 2000-05-09 | 2017-04-19 | Xy, Llc | Flow cytometer for diffentiating x-chromosome bearing and y-chromosome bearing populations of spermatozoa |
HUP0303158A2 (hu) * | 2000-06-12 | 2003-12-29 | Colorado State University | Izolált X-, illetve Y-kromoszómákat hordozó spermium-populációk alkalmazásán alapuló integrált állattenyésztési rendszer |
NZ525667A (en) * | 2000-10-05 | 2005-07-29 | Xy Inc | System of hysteroscopic insemination of mammals especially mares |
CA2822983C (en) | 2000-11-29 | 2017-05-09 | Xy, Llc | System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations |
US7713687B2 (en) | 2000-11-29 | 2010-05-11 | Xy, Inc. | System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations |
NZ517094A (en) | 2002-02-08 | 2005-03-24 | Advanced Animal Technology Ltd | Improvements in and relating to substance delivery device |
AU2003237840A1 (en) | 2002-05-14 | 2003-12-02 | Monsanto Technology Llc | Multiple closed nucleus breeding for swine production |
CN100570360C (zh) | 2002-08-15 | 2009-12-16 | Xy公司 | 一种流式细胞仪及流式细胞计数方法 |
US7169548B2 (en) | 2002-09-13 | 2007-01-30 | Xy, Inc. | Sperm cell processing and preservation systems |
FR2845973B1 (fr) | 2002-10-22 | 2005-03-04 | Eric Cognard | Dispositif de transport d'un recipient en position verticale comportant un emballage a l'interieur duquel est agence un systeme gyroscopique |
BRPI0408852A (pt) | 2003-03-28 | 2006-04-04 | Monsanto Technology Llc | processo para a coloração de espermatozóide |
DK2305171T3 (da) | 2003-03-28 | 2022-03-21 | Inguran Llc | Apparat og fremgangsmåder til tilvejebringelse af kønssorteret dyresæd |
ES2541121T3 (es) | 2003-05-15 | 2015-07-16 | Xy, Llc | Clasificación eficiente de células haploides por sistemas de citometría de flujo |
AU2004264882A1 (en) | 2003-08-04 | 2005-02-24 | Monsanto Technology Llc | Method for genetic improvement of terminal boars |
US7892725B2 (en) | 2004-03-29 | 2011-02-22 | Inguran, Llc | Process for storing a sperm dispersion |
AU2005228046B2 (en) | 2004-03-29 | 2011-01-20 | Inguran, Llc | Use of a composition which regulates regulates oxidation/reduction reactions intracellularly and/or extracellularly in a staining or sorting process of spermatozoa |
AU2005266930B2 (en) | 2004-07-22 | 2010-09-16 | Inguran, Llc | Process for enriching a population of sperm cells |
US7893315B2 (en) | 2004-11-04 | 2011-02-22 | Advanced Cell Technology, Inc. | Derivation of embryonic stem cells and embryo-derived cells |
US20060118167A1 (en) | 2004-12-03 | 2006-06-08 | Xy, Inc. | Pressure regulated continuously variable volume container for fluid delivery |
US7618770B2 (en) | 2005-07-29 | 2009-11-17 | Xy, Inc. | Methods and apparatus for reducing protein content in sperm cell extenders |
CA2705261A1 (en) | 2007-11-07 | 2009-05-14 | Wisconsin Alumni Research Foundation | Methods and compositions for improved cattle longevity and milk production |
US8060353B2 (en) | 2008-05-02 | 2011-11-15 | Iguran LLC | Flow cytometer remote monitoring system |
JP2012501187A (ja) | 2008-08-29 | 2012-01-19 | ザ・キュレーターズ・オブ・ザ・ユニバーシティ・オブ・ミズーリ | ブタ胚をガラス化する高スループットおよび非侵襲的方法 |
ES2348528B1 (es) | 2008-09-26 | 2011-09-28 | Universidad De Murcia | Dispositivo y procedimiento de introduccion u obtencion de un fluido con gametos, embriones o cualquier otro tipo de solucion del interior del oviducto de una cerda. |
PL2421545T3 (pl) | 2009-04-23 | 2018-05-30 | Jbs United Animal Health Ii Llc | Sposób i kompozycja do synchronizacji czasu inseminacji |
FR2953724B1 (fr) | 2009-12-14 | 2012-01-13 | Genes Diffusion | Composition de materiel seminal porcin pour l'insemination artificielle de truies |
WO2012002823A2 (en) | 2010-06-09 | 2012-01-05 | Androgenix Ltd | Materials and methods for sperm sex selection in pigs |
ES2399933B1 (es) | 2011-05-24 | 2014-03-26 | Javier Gil Pascual | Diluyente para suspension seminal |
US9433195B2 (en) | 2012-06-06 | 2016-09-06 | Inguran, Llc | Methods for increasing genetic progress in a line or breed of swine using sex-selected sperm cells |
MX2020011408A (es) * | 2013-03-15 | 2021-09-15 | Inguran Llc | Metodos para uso de semen sexado para mejorar la gestion genetica en cerdos. |
-
2013
- 2013-03-15 US US13/840,598 patent/US9433195B2/en active Active
- 2013-06-06 MX MX2014015000A patent/MX358748B/es active IP Right Grant
- 2013-06-06 EP EP13800545.9A patent/EP2858488A4/en active Pending
- 2013-06-06 MX MX2020011406A patent/MX2020011406A/es unknown
- 2013-06-06 BR BR112014030509A patent/BR112014030509A2/pt not_active Application Discontinuation
- 2013-06-06 KR KR1020147034384A patent/KR101708105B1/ko active IP Right Grant
- 2013-06-06 CN CN201380029461.5A patent/CN104519828A/zh active Pending
- 2013-06-06 US US14/406,186 patent/US9743645B2/en active Active
- 2013-06-06 NZ NZ630356A patent/NZ630356A/en not_active IP Right Cessation
- 2013-06-06 WO PCT/US2013/044521 patent/WO2013184922A2/en active Application Filing
- 2013-06-06 CA CA2875058A patent/CA2875058C/en active Active
-
2015
- 2015-09-22 HK HK15109280.3A patent/HK1208596A1/xx unknown
-
2017
- 2017-07-20 US US15/655,663 patent/US10188082B2/en active Active
-
2019
- 2019-01-15 US US16/248,569 patent/US10542734B2/en active Active
- 2019-12-09 US US16/708,007 patent/US11653635B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
MX2020011406A (es) | 2021-09-15 |
US9433195B2 (en) | 2016-09-06 |
EP2858488A2 (en) | 2015-04-15 |
WO2013184922A2 (en) | 2013-12-12 |
US10542734B2 (en) | 2020-01-28 |
US20150148666A1 (en) | 2015-05-28 |
US20200146268A1 (en) | 2020-05-14 |
WO2013184922A3 (en) | 2015-01-29 |
US20170311577A1 (en) | 2017-11-02 |
MX358748B (es) | 2018-08-31 |
US20190141965A1 (en) | 2019-05-16 |
CN104519828A (zh) | 2015-04-15 |
NZ630356A (en) | 2016-09-30 |
KR20150006061A (ko) | 2015-01-15 |
US11653635B2 (en) | 2023-05-23 |
CA2875058A1 (en) | 2013-12-12 |
HK1208596A1 (en) | 2016-03-11 |
KR101708105B1 (ko) | 2017-02-17 |
US10188082B2 (en) | 2019-01-29 |
US20130331693A1 (en) | 2013-12-12 |
US9743645B2 (en) | 2017-08-29 |
MX2014015000A (es) | 2015-03-05 |
EP2858488A4 (en) | 2016-02-24 |
CA2875058C (en) | 2023-04-04 |
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