BR112014025206A2 - filme oral contendo pérolas de liberação entérica de opiato - Google Patents
filme oral contendo pérolas de liberação entérica de opiatoInfo
- Publication number
- BR112014025206A2 BR112014025206A2 BR112014025206A BR112014025206A BR112014025206A2 BR 112014025206 A2 BR112014025206 A2 BR 112014025206A2 BR 112014025206 A BR112014025206 A BR 112014025206A BR 112014025206 A BR112014025206 A BR 112014025206A BR 112014025206 A2 BR112014025206 A2 BR 112014025206A2
- Authority
- BR
- Brazil
- Prior art keywords
- oral
- release
- oral film
- enteric
- release beads
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Abstract
resumo patente de invenção: "filme oral contendo pérolas de liberação entérica de opiato". a presente invenção refere-se a uma dosagem de filme oral comestível ou wafer oral de liberação de droga opiato resistente a abuso e de liberação controlada para tratar dor e abuso de substância é provida. a dosagem de filme oral comestível ou wafer oral de liberação de droga inclui uma camada de liberação controlada contendo perolas de liberação entérica dispersas em uma matriz polímero. as pérolas de liberação entérica são formadas de uma quantidade terapêutica de um agonista de opióide e/ou seu sal farmaceuticamente aceitável e uma quantidade sub-terapêutica de antagonista de opióide e/ou seu sal farmaceuticamente aceitável revestida ou encapsulada em um polímero de liberação entérica. a matriz polímero de liberação controlada dissolve ou desintegra seguindo administração ou consumo do wafer oral ou filme oral comestível, liberando as pérolas de liberação entérica para serem engolidas, com subseqüente absorção dos ingredientes ativos dentro dos intestinos do paciente.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/445,716 US9687445B2 (en) | 2012-04-12 | 2012-04-12 | Oral film containing opiate enteric-release beads |
US13/445,716 | 2012-04-12 | ||
PCT/EP2013/057552 WO2013153145A1 (en) | 2012-04-12 | 2013-04-11 | Oral film containing opiate enteric-release beads |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014025206A2 true BR112014025206A2 (pt) | 2017-07-11 |
BR112014025206B1 BR112014025206B1 (pt) | 2022-04-19 |
Family
ID=48050757
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014025206-8A BR112014025206B1 (pt) | 2012-04-12 | 2013-04-11 | Método de fabricação de uma dosagem de filme oral compreendendo pérolas de liberação entérica |
Country Status (9)
Country | Link |
---|---|
US (2) | US9687445B2 (pt) |
EP (1) | EP2836197B1 (pt) |
JP (1) | JP6254148B2 (pt) |
CN (1) | CN104271114B (pt) |
BR (1) | BR112014025206B1 (pt) |
CA (1) | CA2869450C (pt) |
ES (1) | ES2745210T3 (pt) |
HK (1) | HK1201718A1 (pt) |
WO (1) | WO2013153145A1 (pt) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7927626B2 (en) | 2003-08-07 | 2011-04-19 | Ethicon, Inc. | Process of making flowable hemostatic compositions and devices containing such compositions |
WO2008148798A2 (en) | 2007-06-04 | 2008-12-11 | Egalet A/S | Controlled release pharmaceutical compositions for prolonged effect |
EP2393484A1 (en) | 2009-02-06 | 2011-12-14 | Egalet Ltd. | Immediate release composition resistant to abuse by intake of alcohol |
AU2010265213B2 (en) | 2009-06-24 | 2012-08-23 | Egalet Ltd. | Controlled release formulations |
JP6539274B2 (ja) | 2013-08-12 | 2019-07-03 | ファーマシューティカル マニュファクチュアリング リサーチ サービシズ,インコーポレーテッド | 押出成形された即放性乱用抑止性丸剤 |
US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
CA2845443A1 (en) * | 2014-03-04 | 2015-09-04 | Pharmascience Inc. | Orally disintegrating tablet of nabilone and method of manufacturing |
JP6371463B2 (ja) | 2014-07-17 | 2018-08-08 | ファーマシューティカル マニュファクチュアリング リサーチ サービシズ,インコーポレーテッド | 即時放出性乱用抑止性液体充填剤形 |
AU2015336065A1 (en) | 2014-10-20 | 2017-05-04 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
US20160175296A1 (en) * | 2014-12-23 | 2016-06-23 | Arx, Llc | Method of producing uniform buprenorphine-containing formulations |
EP3248595A4 (en) * | 2015-01-22 | 2018-07-11 | Nipro Corporation | Film preparation |
US10183018B2 (en) | 2015-05-28 | 2019-01-22 | Lumosa Therapeutics Co., Ltd. | Pharmaceutical formulations for sustained release of sebacoyl dinalbuphine ester |
US11234974B2 (en) | 2015-05-28 | 2022-02-01 | Lumosa Therapeutics Co., Ltd. | Pharmaceutical formulations for sustained release of sebacoyl dinalbuphine ester |
GB201511284D0 (en) * | 2015-06-26 | 2015-08-12 | Univ Witwatersrand Jhb | An oral pharmaceutical dosage form for the delivery of a peptide and/or protein |
US10662146B2 (en) | 2015-09-15 | 2020-05-26 | Praxis Bioresearch, LLC | Prodrugs of fencamfamine |
US9650338B1 (en) | 2016-07-29 | 2017-05-16 | VDM Biochemicals, Inc. | Opioid antagonist compounds and methods of making and using |
WO2019058172A1 (en) * | 2017-09-07 | 2019-03-28 | Nls-1 Pharma Ag | MAZINDOLE TREATMENT FOR HEROID DEPENDENCE AND DISORDER RELATED TO THE USE OF PSYCHOACTIVE SUBSTANCES |
FR3084837B1 (fr) * | 2018-08-10 | 2021-10-29 | Urgo Rech Innovation Et Developpement | Composition filmogene mucoadhesive et son utilisation pour le traitement des douleurs liees aux poussees dentaires |
DE102020112422A1 (de) | 2020-05-07 | 2021-11-11 | Lts Lohmann Therapie-Systeme Ag | Verfahren zur Herstellung eines oralen Dünnfilms umfassend Mikropartikel |
DE102021105268A1 (de) | 2021-03-04 | 2022-09-08 | Lts Lohmann Therapie-Systeme Ag. | Oraler Dünnfilm |
GB202214721D0 (en) | 2022-10-06 | 2022-11-23 | Rewire Therapeutics Ltd | A treatment for mental disorders |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6335029B1 (en) | 1998-08-28 | 2002-01-01 | Scimed Life Systems, Inc. | Polymeric coatings for controlled delivery of active agents |
US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US7029700B2 (en) * | 2000-01-14 | 2006-04-18 | Brown University Research Foundation | Micronized freeze-dried particles |
OA12215A (en) * | 2000-02-08 | 2006-05-09 | Euro Celtique Sa | Tamper-resistant oral opioid agonist formulations. |
US7067116B1 (en) | 2000-03-23 | 2006-06-27 | Warner-Lambert Company Llc | Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1 |
IL160222A0 (en) * | 2001-08-06 | 2004-07-25 | Euro Celtique Sa | Opioid agonist formulations with releasable and sequestered antagonist |
US8343546B2 (en) | 2005-09-13 | 2013-01-01 | Coating Place, Inc. | Ion exchange resin treated to control swelling |
DE102006027793A1 (de) | 2006-06-16 | 2007-12-20 | Lts Lohmann Therapie-Systeme Ag | Opioid-Kombinations-Wafer |
DE102006027795A1 (de) | 2006-06-16 | 2007-12-20 | Lts Lohmann Therapie-Systeme Ag | Raucherentwöhnungs-Kombinationswafer |
DE102006027792A1 (de) | 2006-06-16 | 2007-12-20 | Lts Lohmann Therapie-Systeme Ag | Antidepressiva-Kombinations-Wafer |
DE102006027791A1 (de) | 2006-06-16 | 2007-12-20 | Lts Lohmann Therapie-Systeme Ag | AchE-NMDA-Kombinationswafer |
DE102006027796A1 (de) | 2006-06-16 | 2007-12-20 | Lts Lohmann Therapie-Systeme Ag | Estrogen-Gestagen-Kombinationen |
DE102006027794A1 (de) | 2006-06-16 | 2007-12-20 | Lts Lohmann Therapie-Systeme Ag | Antihypertonie-Kombinationswafer |
DE102006027790A1 (de) | 2006-06-16 | 2007-12-20 | Lts Lohmann Therapie-Systeme Ag | Typ-2-Diabetes Kombinations-Wafer |
US20100285130A1 (en) * | 2009-05-06 | 2010-11-11 | Monosol Rx, Llc | Coating of complexed actives in film formulations |
US8475832B2 (en) * | 2009-08-07 | 2013-07-02 | Rb Pharmaceuticals Limited | Sublingual and buccal film compositions |
EP2467126A1 (en) * | 2009-08-19 | 2012-06-27 | Bayer Pharma Aktiengesellschaft | Drug delivery systems (wafer) for pediatric use |
US20110195989A1 (en) * | 2010-02-09 | 2011-08-11 | Rudnic Edward M | Controlled Release Formulations of Opioids |
-
2012
- 2012-04-12 US US13/445,716 patent/US9687445B2/en active Active
-
2013
- 2013-04-11 EP EP13714969.6A patent/EP2836197B1/en active Active
- 2013-04-11 US US14/390,322 patent/US9763879B2/en active Active
- 2013-04-11 BR BR112014025206-8A patent/BR112014025206B1/pt active IP Right Grant
- 2013-04-11 WO PCT/EP2013/057552 patent/WO2013153145A1/en active Application Filing
- 2013-04-11 CA CA2869450A patent/CA2869450C/en active Active
- 2013-04-11 ES ES13714969T patent/ES2745210T3/es active Active
- 2013-04-11 JP JP2015504952A patent/JP6254148B2/ja active Active
- 2013-04-11 CN CN201380024379.3A patent/CN104271114B/zh active Active
-
2015
- 2015-02-06 HK HK15101382.7A patent/HK1201718A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US9687445B2 (en) | 2017-06-27 |
ES2745210T3 (es) | 2020-02-28 |
CA2869450A1 (en) | 2013-10-17 |
CA2869450C (en) | 2020-06-02 |
BR112014025206B1 (pt) | 2022-04-19 |
JP2015512924A (ja) | 2015-04-30 |
EP2836197A1 (en) | 2015-02-18 |
US20130273162A1 (en) | 2013-10-17 |
US20150064231A1 (en) | 2015-03-05 |
HK1201718A1 (en) | 2015-09-11 |
JP6254148B2 (ja) | 2017-12-27 |
CN104271114A (zh) | 2015-01-07 |
EP2836197B1 (en) | 2019-06-19 |
US9763879B2 (en) | 2017-09-19 |
CN104271114B (zh) | 2019-12-03 |
WO2013153145A1 (en) | 2013-10-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 11/04/2013, OBSERVADAS AS CONDICOES LEGAIS. |