BR112014017320A2 - método para determinar se um paciente é propenso a responder ao tratamento com um antagonista de vegf, método para otimizar a eficácia terapêutica de um antagonista de vegf, método para selecionar uma terapia, método para identificar um biomarcador e método para diagnosticar um distúrbio angiogênico - Google Patents
método para determinar se um paciente é propenso a responder ao tratamento com um antagonista de vegf, método para otimizar a eficácia terapêutica de um antagonista de vegf, método para selecionar uma terapia, método para identificar um biomarcador e método para diagnosticar um distúrbio angiogênicoInfo
- Publication number
- BR112014017320A2 BR112014017320A2 BR112014017320A BR112014017320A BR112014017320A2 BR 112014017320 A2 BR112014017320 A2 BR 112014017320A2 BR 112014017320 A BR112014017320 A BR 112014017320A BR 112014017320 A BR112014017320 A BR 112014017320A BR 112014017320 A2 BR112014017320 A2 BR 112014017320A2
- Authority
- BR
- Brazil
- Prior art keywords
- vegf antagonist
- biomarker
- diagnosing
- prone
- optimizing
- Prior art date
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Proteomics, Peptides & Aminoacids (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261586660P | 2012-01-13 | 2012-01-13 | |
| PCT/US2013/021306 WO2013106765A1 (en) | 2012-01-13 | 2013-01-11 | Biological markers for identifying patients for treatment with vegf antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014017320A2 true BR112014017320A2 (pt) | 2018-05-29 |
Family
ID=48781962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014017320A BR112014017320A2 (pt) | 2012-01-13 | 2013-01-11 | método para determinar se um paciente é propenso a responder ao tratamento com um antagonista de vegf, método para otimizar a eficácia terapêutica de um antagonista de vegf, método para selecionar uma terapia, método para identificar um biomarcador e método para diagnosticar um distúrbio angiogênico |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20130216533A1 (enExample) |
| EP (1) | EP2802346B1 (enExample) |
| JP (2) | JP6529261B2 (enExample) |
| KR (1) | KR20140114415A (enExample) |
| CN (1) | CN104203268A (enExample) |
| AU (2) | AU2013207778B2 (enExample) |
| BR (1) | BR112014017320A2 (enExample) |
| CA (1) | CA2862835A1 (enExample) |
| HK (1) | HK1204933A1 (enExample) |
| IL (2) | IL233467B (enExample) |
| MX (1) | MX356802B (enExample) |
| NZ (1) | NZ627443A (enExample) |
| RU (1) | RU2659173C2 (enExample) |
| SG (1) | SG11201403927XA (enExample) |
| WO (1) | WO2013106765A1 (enExample) |
| ZA (1) | ZA201405305B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2838086A1 (en) | 2011-06-02 | 2012-12-06 | Almac Diagnostics Limited | Molecular diagnostic test for cancer |
| WO2014087156A1 (en) | 2012-12-03 | 2014-06-12 | Almac Diagnostics Limited | Molecular diagnostic test for cancer |
| US10456470B2 (en) * | 2013-08-30 | 2019-10-29 | Genentech, Inc. | Diagnostic methods and compositions for treatment of glioblastoma |
| US10617755B2 (en) | 2013-08-30 | 2020-04-14 | Genentech, Inc. | Combination therapy for the treatment of glioblastoma |
| GB201409479D0 (en) * | 2014-05-28 | 2014-07-09 | Almac Diagnostics Ltd | Molecular diagnostic test for cancer |
| AU2015229270B2 (en) | 2014-03-12 | 2020-12-24 | Icahn School Of Medicine At Mount Sinai | Method for identifying kidney allograft recipients at risk for chronic injury |
| EP3134119B1 (en) | 2014-04-24 | 2018-08-22 | Pfizer Inc | Cancer treatment |
| GB201409478D0 (en) * | 2014-05-28 | 2014-07-09 | Almac Diagnostics Ltd | Pro-angiogenic signature |
| GB201409476D0 (en) * | 2014-05-28 | 2014-07-09 | Almac Diagnostics Ltd | Molecular subtype for use in prognosis |
| CN106661635B (zh) | 2014-06-26 | 2021-05-28 | 西奈山伊坎医学院 | 通过分析预示性基因集诊断亚临床和临床的急性排异的方法 |
| CN106460067A (zh) * | 2014-07-14 | 2017-02-22 | 豪夫迈·罗氏有限公司 | 诊断方法和用于治疗成胶质细胞瘤的组合物 |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| US20170248603A1 (en) * | 2014-10-06 | 2017-08-31 | Dana-Farber Cancer Institute, Inc. | Angiopoiten-2 biomarkers predictive of anti-immune checkpoint response |
| WO2016118670A1 (en) * | 2015-01-20 | 2016-07-28 | Memorial Sloan-Kettering Cancer Center | Multigene expression assay for patient stratification in resected colorectal liver metastases |
| EP3067698A1 (en) | 2015-03-11 | 2016-09-14 | Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Pd-ecgf as biomarker of cancer |
| EP3274440A4 (en) | 2015-03-27 | 2019-03-06 | Exact Sciences Corporation | Detecting esophageal disorders |
| EP3091084A1 (en) * | 2015-05-08 | 2016-11-09 | Université Catholique De Louvain | Methods for assessing the purity of a mesenchymal stem cells preparation |
| CA3007276C (en) * | 2015-12-03 | 2021-12-28 | Regeneron Pharmaceuticals, Inc. | Use of vegf inhibitor to treat macular degeneration in a patient population |
| US9845505B2 (en) | 2016-01-29 | 2017-12-19 | BluePrint Bio, Inc. | Prediction of therapeutic response in inflammatory conditions |
| WO2017180581A1 (en) * | 2016-04-15 | 2017-10-19 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
| CA3020718A1 (en) * | 2016-04-15 | 2017-10-19 | Genentech, Inc. | Methods for monitoring and treating cancer |
| JP6799146B2 (ja) * | 2016-10-07 | 2020-12-09 | ベンタナ メディカル システムズ, インコーポレイテッド | 視覚化されたスライド全域画像分析を提供するためのデジタル病理学システムおよび関連するワークフロー |
| JP2018091846A (ja) * | 2016-12-01 | 2018-06-14 | 参天製薬株式会社 | 抗vegf薬による滲出型加齢黄斑変性の処置の有効性を予測するための方法 |
| ES2953595T3 (es) | 2017-03-01 | 2023-11-14 | Hoffmann La Roche | Procedimientos diagnósticos y terapéuticos para el cáncer |
| US12016900B2 (en) | 2017-06-04 | 2024-06-25 | Rappaport Family Institute For Research In The Medical Sciences | Method of treating cancer with an immune checkpoint inhibitor in combination with another therapeutic agent |
| US12070489B2 (en) | 2018-12-12 | 2024-08-27 | Rappaport Family Institute For Research In The Medical Sciences | Method of treating cancer with a cancer therapy in combination with another therapeutic agent |
| CA3066053A1 (en) * | 2017-06-04 | 2018-12-13 | Rappaport Family Institute For Research In The Medical Sciences | Method of predicting personalized response to cancer treatment with immune checkpoint inhibitors and kits therefor |
| JP2018049015A (ja) * | 2017-09-26 | 2018-03-29 | マイクロ モーション インコーポレイテッド | 防炎性の電気フィードスルー |
| SG11202007130RA (en) | 2018-01-26 | 2020-08-28 | Univ California | Methods and compositions for treatment of angiogenic disorders using anti-vegf agents |
| EP3773718A4 (en) | 2018-04-06 | 2022-01-19 | aTyr Pharma, Inc. | COMPOSITIONS AND METHODS WITH ANTI-NRP2 ANTIBODIES |
| BR112020019972A2 (pt) | 2018-04-16 | 2021-01-05 | Icahn School Of Medicine At Mount Sinai | Métodos para identificar um receptor de aloenxerto renal e para identificar um receptor de aloenxerto renal em risco de rejeição aguda do aloenxerto antes do transplante, kit para identificar receptores de aloenxerto renal e método para selecionar um paciente com aloenxerto renal |
| US11519020B2 (en) | 2018-05-25 | 2022-12-06 | Regeneron Pharmaceuticals, Inc. | Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF |
| WO2021034091A1 (ko) * | 2019-08-19 | 2021-02-25 | 재단법인 아산사회복지재단 | 교모세포종의 진단 방법 |
| EP4037711A4 (en) | 2019-10-03 | 2024-02-14 | Atyr Pharma, Inc. | COMPOSITIONS AND METHODS USING ANTI-NRP2 ANTIBODIES |
| CA3168512A1 (en) | 2019-11-25 | 2021-06-03 | Napoleone Ferrara | Long-acting vegf inhibitors for intraocular neovascularization |
| EP4377674A4 (en) * | 2021-07-28 | 2025-08-06 | Univ California | CELLULAR TYPE OPTIMIZATION METHOD AND SCANNER |
| AU2022327751A1 (en) | 2021-08-11 | 2024-03-21 | OncoHost Ltd. | Predicting patient response |
| CN113834942B (zh) * | 2021-11-02 | 2024-02-02 | 河北特温特生物科技发展有限公司 | 一种胎盘生长因子质控品及其制备方法 |
| CN115840046A (zh) * | 2022-08-17 | 2023-03-24 | 中国药科大学 | 一种鉴别anti-VEGF抗体获得性耐药的蛋白聚糖ESM1生物学标记物及其应用 |
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-
2013
- 2013-01-11 MX MX2014008463A patent/MX356802B/es active IP Right Grant
- 2013-01-11 CN CN201380013876.3A patent/CN104203268A/zh active Pending
- 2013-01-11 EP EP13736138.2A patent/EP2802346B1/en not_active Not-in-force
- 2013-01-11 KR KR1020147021823A patent/KR20140114415A/ko not_active Ceased
- 2013-01-11 JP JP2014552348A patent/JP6529261B2/ja not_active Expired - Fee Related
- 2013-01-11 CA CA2862835A patent/CA2862835A1/en not_active Abandoned
- 2013-01-11 RU RU2014133164A patent/RU2659173C2/ru not_active IP Right Cessation
- 2013-01-11 BR BR112014017320A patent/BR112014017320A2/pt not_active IP Right Cessation
- 2013-01-11 WO PCT/US2013/021306 patent/WO2013106765A1/en not_active Ceased
- 2013-01-11 NZ NZ627443A patent/NZ627443A/en not_active IP Right Cessation
- 2013-01-11 SG SG11201403927XA patent/SG11201403927XA/en unknown
- 2013-01-11 HK HK15105537.2A patent/HK1204933A1/xx unknown
- 2013-01-11 AU AU2013207778A patent/AU2013207778B2/en not_active Ceased
- 2013-03-15 US US13/837,343 patent/US20130216533A1/en not_active Abandoned
- 2013-03-15 US US13/836,535 patent/US10364466B2/en not_active Expired - Fee Related
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2014
- 2014-06-30 IL IL233467A patent/IL233467B/en active IP Right Grant
- 2014-07-18 ZA ZA2014/05305A patent/ZA201405305B/en unknown
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2017
- 2017-12-12 JP JP2017237944A patent/JP2018082705A/ja active Pending
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2018
- 2018-01-12 AU AU2018200270A patent/AU2018200270A1/en not_active Abandoned
- 2018-01-24 IL IL257141A patent/IL257141A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2802346A4 (en) | 2015-10-21 |
| CN104203268A (zh) | 2014-12-10 |
| JP2018082705A (ja) | 2018-05-31 |
| MX2014008463A (es) | 2014-08-27 |
| EP2802346B1 (en) | 2018-09-12 |
| KR20140114415A (ko) | 2014-09-26 |
| US20130216533A1 (en) | 2013-08-22 |
| JP2015512612A (ja) | 2015-04-30 |
| IL233467B (en) | 2018-07-31 |
| AU2013207778A1 (en) | 2014-08-21 |
| ZA201405305B (en) | 2015-11-25 |
| US20140017233A1 (en) | 2014-01-16 |
| RU2659173C2 (ru) | 2018-06-28 |
| EP2802346A1 (en) | 2014-11-19 |
| SG11201403927XA (en) | 2014-08-28 |
| MX356802B (es) | 2018-06-13 |
| IL257141A (en) | 2018-03-29 |
| AU2018200270A1 (en) | 2018-02-01 |
| CA2862835A1 (en) | 2013-07-18 |
| NZ627443A (en) | 2016-10-28 |
| RU2014133164A (ru) | 2016-03-10 |
| WO2013106765A1 (en) | 2013-07-18 |
| IL233467A0 (en) | 2014-08-31 |
| US10364466B2 (en) | 2019-07-30 |
| JP6529261B2 (ja) | 2019-06-12 |
| AU2013207778B2 (en) | 2017-10-12 |
| HK1204933A1 (en) | 2015-12-11 |
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