BR112014012031A2 - derivados de 3-fenil-isoquinolin-1(2h)-ona como inibidores de parp-1 - Google Patents
derivados de 3-fenil-isoquinolin-1(2h)-ona como inibidores de parp-1Info
- Publication number
- BR112014012031A2 BR112014012031A2 BR112014012031A BR112014012031A BR112014012031A2 BR 112014012031 A2 BR112014012031 A2 BR 112014012031A2 BR 112014012031 A BR112014012031 A BR 112014012031A BR 112014012031 A BR112014012031 A BR 112014012031A BR 112014012031 A2 BR112014012031 A2 BR 112014012031A2
- Authority
- BR
- Brazil
- Prior art keywords
- parp
- compounds
- inhibitors
- derivatives
- phenyl isoquinolin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11190687 | 2011-11-25 | ||
| EP12161489 | 2012-03-27 | ||
| PCT/EP2012/073125 WO2013076090A1 (en) | 2011-11-25 | 2012-11-20 | 3-phenyl-isoquinolin-1(2h)-one derivatives as parp-1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014012031A2 true BR112014012031A2 (pt) | 2017-05-30 |
Family
ID=47227787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014012031A BR112014012031A2 (pt) | 2011-11-25 | 2012-11-20 | derivados de 3-fenil-isoquinolin-1(2h)-ona como inibidores de parp-1 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9422243B2 (https=) |
| EP (1) | EP2788328B1 (https=) |
| JP (1) | JP6106182B2 (https=) |
| KR (1) | KR20140097457A (https=) |
| CN (1) | CN103946214B (https=) |
| AU (1) | AU2012342562B2 (https=) |
| BR (1) | BR112014012031A2 (https=) |
| CA (1) | CA2856759A1 (https=) |
| CL (1) | CL2014001323A1 (https=) |
| EA (1) | EA027800B1 (https=) |
| ES (1) | ES2676068T3 (https=) |
| IN (1) | IN2014CN04671A (https=) |
| MX (1) | MX2014006015A (https=) |
| WO (1) | WO2013076090A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2865511A1 (en) | 2012-03-07 | 2013-09-12 | Institute Of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
| US9611223B2 (en) | 2013-09-11 | 2017-04-04 | Institute Of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
| EP3094752A4 (en) * | 2014-01-16 | 2017-08-16 | Clovis Oncology, Inc. | Use of parp inhibitors to treat breast or ovarian cancer patients showing a loss of heterozygosity |
| EP3371164B1 (en) | 2015-11-06 | 2022-03-16 | Neurocrine Biosciences, Inc. | N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-(pyrazin-2-yl)-piperazine-1-carboxamide derivatives and related compounds as muscarinic receptor 4 (m4) antagonists for treating neurological diseases |
| EP4069367B1 (en) | 2019-12-06 | 2024-05-15 | Neurocrine Biosciences, Inc. | Muscarinic receptor 4 antagonists and methods of use |
| IL317573A (en) | 2022-06-15 | 2025-02-01 | Astrazeneca Ab | Combination therapy for cancer treatment |
| EP4709386A1 (en) | 2023-05-11 | 2026-03-18 | Astrazeneca AB | Combination of a parp1 inhibitor and a selective estrogen degrader for treating cancer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60218458T2 (de) * | 2001-05-08 | 2007-11-15 | Kudos Pharmaceuticals Ltd. | Isochinolinon derivate als parp inhibitoren |
| JPWO2002094790A1 (ja) * | 2001-05-23 | 2004-09-09 | 三菱ウェルファーマ株式会社 | 縮合ヘテロ環化合物およびその医薬用途 |
| MXPA05000983A (es) * | 2002-07-24 | 2005-08-18 | Kyorin Seiyaku Kk | Derivados de 4-(aril substituido)-5-hidroxiisoquinolinona. |
| AU2009216062B2 (en) * | 2008-02-22 | 2013-02-07 | Msd K.K. | Novel aminopyridine derivatives having Aurora A selective inhibitory action |
| TWI499418B (zh) * | 2009-05-21 | 2015-09-11 | Nerviano Medical Sciences Srl | 異喹啉－１（２ｈ）－酮衍生物 |
-
2012
- 2012-11-20 IN IN4671CHN2014 patent/IN2014CN04671A/en unknown
- 2012-11-20 CA CA2856759A patent/CA2856759A1/en not_active Abandoned
- 2012-11-20 ES ES12791464.6T patent/ES2676068T3/es active Active
- 2012-11-20 JP JP2014542801A patent/JP6106182B2/ja active Active
- 2012-11-20 EA EA201491026A patent/EA027800B1/ru not_active IP Right Cessation
- 2012-11-20 WO PCT/EP2012/073125 patent/WO2013076090A1/en not_active Ceased
- 2012-11-20 EP EP12791464.6A patent/EP2788328B1/en active Active
- 2012-11-20 US US14/358,537 patent/US9422243B2/en active Active
- 2012-11-20 MX MX2014006015A patent/MX2014006015A/es unknown
- 2012-11-20 AU AU2012342562A patent/AU2012342562B2/en not_active Ceased
- 2012-11-20 BR BR112014012031A patent/BR112014012031A2/pt not_active IP Right Cessation
- 2012-11-20 CN CN201280057586.4A patent/CN103946214B/zh active Active
- 2012-11-20 KR KR1020147017409A patent/KR20140097457A/ko not_active Withdrawn
-
2014
- 2014-05-20 CL CL2014001323A patent/CL2014001323A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA201491026A1 (ru) | 2014-11-28 |
| ES2676068T3 (es) | 2018-07-16 |
| JP6106182B2 (ja) | 2017-03-29 |
| EP2788328A1 (en) | 2014-10-15 |
| JP2014533709A (ja) | 2014-12-15 |
| EP2788328B1 (en) | 2018-01-31 |
| MX2014006015A (es) | 2014-06-04 |
| US9422243B2 (en) | 2016-08-23 |
| AU2012342562A1 (en) | 2014-07-10 |
| HK1200166A1 (en) | 2015-07-31 |
| EA027800B1 (ru) | 2017-09-29 |
| AU2012342562B2 (en) | 2017-02-23 |
| KR20140097457A (ko) | 2014-08-06 |
| CL2014001323A1 (es) | 2014-09-05 |
| IN2014CN04671A (https=) | 2015-09-18 |
| CN103946214B (zh) | 2016-08-17 |
| US20140336192A1 (en) | 2014-11-13 |
| CN103946214A (zh) | 2014-07-23 |
| CA2856759A1 (en) | 2013-05-30 |
| WO2013076090A1 (en) | 2013-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2494 DE 23-10-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |