BR112014001538A2 - composições farmacêuticas compreendendo 4-bromo-n-(imidazolidin-2-ilideno)-1h-benzimidazol-5-amina para tratamento de doenças retinais - Google Patents

composições farmacêuticas compreendendo 4-bromo-n-(imidazolidin-2-ilideno)-1h-benzimidazol-5-amina para tratamento de doenças retinais

Info

Publication number
BR112014001538A2
BR112014001538A2 BR112014001538A BR112014001538A BR112014001538A2 BR 112014001538 A2 BR112014001538 A2 BR 112014001538A2 BR 112014001538 A BR112014001538 A BR 112014001538A BR 112014001538 A BR112014001538 A BR 112014001538A BR 112014001538 A2 BR112014001538 A2 BR 112014001538A2
Authority
BR
Brazil
Prior art keywords
imidazolidin
ylidene
amine
benzimidazol
bromo
Prior art date
Application number
BR112014001538A
Other languages
English (en)
Inventor
W Gil Daniel
A Burke James
E Donello John
I Dibas Mohammed
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of BR112014001538A2 publication Critical patent/BR112014001538A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

abstract the present invention relates to a method for treating retinal diseases and a method for retinal neuroprotection, in a patient in need thereof which comprises of administering a therapeutically effective amount of a pharmaceutical composition comprising a therapeutically effective amount of 4-bromo-n-(imidazolidin-2-ylidene)-1h-benzimidazol-5-amine or pharmaceutically acceptable salts thereof. *************************************************************** tradução do resumo resumo patente de invenção: "composições farmacêuticas compreendendo 4-bromo-n-(imidazolidin-2-ilideno)-1h-benzimidazol-5-amina para tratamento de doenças retinais". a presente invenção refere-se a um método para tratamento de doenças retinais e um método para neuroproteção retinal em um paciente com necessidade do mesmo, o qual compreende administração de uma quantidade terapeuticamente eficaz de uma composição farmacêutica compreendendo uma quantidade terapeuticamente eficaz de 4-bromo-n-(imidazolidin-2-ilideno)-1h-benzimidazol-5-amina ou sais farmaceuticamente aceitáveis da mesma.
BR112014001538A 2011-07-22 2012-07-22 composições farmacêuticas compreendendo 4-bromo-n-(imidazolidin-2-ilideno)-1h-benzimidazol-5-amina para tratamento de doenças retinais BR112014001538A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161510743P 2011-07-22 2011-07-22
US201161510536P 2011-07-22 2011-07-22
PCT/US2012/047777 WO2013016252A1 (en) 2011-07-22 2012-07-22 Pharmaceutical compositions comprising 4-bromo-n-(imidazolidin-2-ylidene)-1h-benzimidazol-5-amine for treating retinal diseases

Publications (1)

Publication Number Publication Date
BR112014001538A2 true BR112014001538A2 (pt) 2017-02-14

Family

ID=46599017

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014001538A BR112014001538A2 (pt) 2011-07-22 2012-07-22 composições farmacêuticas compreendendo 4-bromo-n-(imidazolidin-2-ilideno)-1h-benzimidazol-5-amina para tratamento de doenças retinais

Country Status (12)

Country Link
US (1) US20130046003A1 (pt)
EP (1) EP2734202A1 (pt)
JP (1) JP2014521648A (pt)
KR (1) KR20140097106A (pt)
CN (1) CN103826631A (pt)
AU (1) AU2012287062A1 (pt)
BR (1) BR112014001538A2 (pt)
CA (1) CA2842756A1 (pt)
IL (1) IL230582A0 (pt)
MX (1) MX2014000870A (pt)
RU (1) RU2014106328A (pt)
WO (1) WO2013016252A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10752593B2 (en) 2018-12-28 2020-08-25 Endogena Therapeutics, Inc. Compounds for use as therapeutically active substances in the treatment of retinal diseases
US10807973B2 (en) 2018-12-28 2020-10-20 Endogena Therapeutics, Inc. Compounds for use as therapeutically active substances in the treatment of retinal diseases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996004270A1 (en) 1994-08-04 1996-02-15 Synaptic Pharmaceutical Corporation Novel benzimidazole derivatives
WO1998010758A1 (en) 1996-09-13 1998-03-19 The Regents Of The University Of California Methods for treatment of retinal diseases
US6495583B1 (en) * 1997-03-25 2002-12-17 Synaptic Pharmaceutical Corporation Benzimidazole derivatives
US20010049369A1 (en) * 2000-02-10 2001-12-06 Jablonski Monica M. Brimonidine compositions and methods for retinal degeneration
AU2002248284A1 (en) * 2000-11-01 2002-08-06 Allergan, Inc. Compositions for treatment of ocular neovascularization
US20020198209A1 (en) 2001-05-03 2002-12-26 Allergan Sales Inc. Compositions having enhanced pharmacokinetic characteristics
US20050244463A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular vasculopathies
JP5671459B2 (ja) * 2008-08-01 2015-02-18 アイ・セラピーズ・エル・エル・シー 血管収縮組成物および使用方法
AU2011207301A1 (en) * 2010-01-21 2012-08-09 Allergan, Inc. Alpha-2 adrenergic agonist having long duration of intraocular pressure-lowering effect

Also Published As

Publication number Publication date
EP2734202A1 (en) 2014-05-28
IL230582A0 (en) 2014-03-31
KR20140097106A (ko) 2014-08-06
WO2013016252A1 (en) 2013-01-31
JP2014521648A (ja) 2014-08-28
RU2014106328A (ru) 2015-08-27
MX2014000870A (es) 2014-06-23
US20130046003A1 (en) 2013-02-21
AU2012287062A1 (en) 2014-02-27
CN103826631A (zh) 2014-05-28
CA2842756A1 (en) 2013-01-31

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BR112014001538A2 (pt) composições farmacêuticas compreendendo 4-bromo-n-(imidazolidin-2-ilideno)-1h-benzimidazol-5-amina para tratamento de doenças retinais

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]