BR112014000773A8 - Composições de nicotinamida e uso terapêutico das mesmas - Google Patents
Composições de nicotinamida e uso terapêutico das mesmasInfo
- Publication number
- BR112014000773A8 BR112014000773A8 BR112014000773A BR112014000773A BR112014000773A8 BR 112014000773 A8 BR112014000773 A8 BR 112014000773A8 BR 112014000773 A BR112014000773 A BR 112014000773A BR 112014000773 A BR112014000773 A BR 112014000773A BR 112014000773 A8 BR112014000773 A8 BR 112014000773A8
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- nicotinamide
- compositions
- therapeutic use
- adhd
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 title abstract 4
- 229960003966 nicotinamide Drugs 0.000 title abstract 2
- 235000005152 nicotinamide Nutrition 0.000 title abstract 2
- 239000011570 nicotinamide Substances 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 abstract 4
- 230000007812 deficiency Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 2
- 235000020776 essential amino acid Nutrition 0.000 abstract 2
- 239000003797 essential amino acid Substances 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 230000004060 metabolic process Effects 0.000 abstract 2
- 230000007170 pathology Effects 0.000 abstract 2
- 238000011321 prophylaxis Methods 0.000 abstract 2
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 abstract 1
- 208000029560 autism spectrum disease Diseases 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
COMPOSIÇÕES DE NICOTINAMIDA E O USO TERAPÊUTICO DAS MESMAS. A presente invenção se refere a composições e métodos para a profilaxia ou tratamento de deficiências na absorção e metabolismo de aminoácido essencial e/ou de uma patologia ou sintonia associado ao mesmo. Em particular, a invenção concerne o tratamento e/ou prevenção de TDAH, TDA e distúrbios do espectro autista. Os inventores atuais desenvolveram um método para a profilaxia ou tratamento de tais sintomas e/ou patologias associadas com uma deficiência na absorção e/ou metabolismo de aminoácido essencial, cujo método, declarado geralmente, depende da administração de nicotinamida, tipicamente em uma formulação de longa atuação a fim de superar as deficiências de formulações existentes, que se demonstraram inadequadas para o tratamento eficaz.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161507663P | 2011-07-14 | 2011-07-14 | |
EP11173963 | 2011-07-14 | ||
PCT/NL2012/050511 WO2013009186A1 (en) | 2011-07-14 | 2012-07-16 | Nicotinamide compositions and the therapeutic use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014000773A2 BR112014000773A2 (pt) | 2017-06-13 |
BR112014000773A8 true BR112014000773A8 (pt) | 2017-10-03 |
Family
ID=44800307
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014000773A BR112014000773A8 (pt) | 2011-07-14 | 2012-07-16 | Composições de nicotinamida e uso terapêutico das mesmas |
BR112015000971A BR112015000971A2 (pt) | 2011-07-14 | 2013-07-15 | sistema de liberação de droga flutuante (fdds); e método para prover um sistema de liberação de droga flutuante (fdds) |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015000971A BR112015000971A2 (pt) | 2011-07-14 | 2013-07-15 | sistema de liberação de droga flutuante (fdds); e método para prover um sistema de liberação de droga flutuante (fdds) |
Country Status (7)
Country | Link |
---|---|
US (4) | US20140234409A1 (pt) |
EP (1) | EP2731609A1 (pt) |
BR (2) | BR112014000773A8 (pt) |
CA (1) | CA2841731A1 (pt) |
IL (1) | IL236757B (pt) |
MX (1) | MX2014000517A (pt) |
WO (1) | WO2013009186A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2014000517A (es) * | 2011-07-14 | 2014-07-24 | Apet Holding B V | Composiciones de nicotinamida y el uso terapeutico de las mismas. |
AU2013290875A1 (en) * | 2012-07-16 | 2015-02-05 | APET Holding B.V. | Gastro-retentive drug delivery system |
US20140271845A1 (en) * | 2013-03-15 | 2014-09-18 | Cerovene, Inc. | Coated substrate compositions |
US20190201360A1 (en) | 2016-08-31 | 2019-07-04 | Ampio Pharmaceuticals, Inc. | Treatment of disease with n-acetyl kynurenine |
EP3398600A1 (en) * | 2017-05-02 | 2018-11-07 | Salmon Pharma GmbH | Modified release nicotinamide |
WO2019027372A1 (en) * | 2017-08-02 | 2019-02-07 | Nanyang Technological University | FLOATABLE PHARMACEUTICAL MICROCAPSULE COMPOSITION |
WO2023166224A1 (en) * | 2022-03-04 | 2023-09-07 | APET Holding B.V. | Gastroretentive formulations containing protein or peptide |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5512411B2 (pt) * | 1974-03-12 | 1980-04-02 | ||
US3976794A (en) | 1974-06-03 | 1976-08-24 | Scm Corporation | Encapsulation of sugar and its use in sweetened coconut |
JPH082781B2 (ja) | 1988-10-18 | 1996-01-17 | 嘉明 川島 | 中空顆粒状医薬及びその製法 |
US4980168A (en) * | 1989-10-13 | 1990-12-25 | Natrol, Inc. | Dietary supplement for children |
US4973467A (en) * | 1989-10-13 | 1990-11-27 | Natrol, Inc. | Dietary supplement for adults |
GB9116610D0 (en) * | 1991-08-01 | 1991-09-18 | Danbiosyst Uk | Preparation of microparticles |
US8728521B2 (en) * | 2005-12-27 | 2014-05-20 | Hemant N. Joshi | Physically/molecularly distributed and/or chemically bound medicaments in empty, hard capsule shells |
US8784886B2 (en) * | 2006-03-09 | 2014-07-22 | GlaxoSmithKline, LLC | Coating capsules with active pharmaceutical ingredients |
KR20090065524A (ko) * | 2006-09-04 | 2009-06-22 | 파나세아 바이오테크 리미티드 | 프로그래머블 부력전달기술 |
US20110171275A1 (en) * | 2007-08-20 | 2011-07-14 | Team Academy Of Pharmaceutical Science | Gastroretentive drug delivery system, preparation method and use thereof |
WO2009051609A1 (en) | 2007-10-19 | 2009-04-23 | Pardee Joel D | Metabolic enhancement therapy |
JP2011506077A (ja) * | 2007-12-11 | 2011-03-03 | ナンヤン テクノロジカル ユニヴァーシティー | 親水性活性化合物の送達のための中空多重層微小球 |
JP2012500230A (ja) * | 2008-08-18 | 2012-01-05 | 北京天衡▲薬▼物研究院 | 胃内滞留薬物放出システム及びその製造方法と使用 |
MX2014000517A (es) | 2011-07-14 | 2014-07-24 | Apet Holding B V | Composiciones de nicotinamida y el uso terapeutico de las mismas. |
-
2012
- 2012-07-16 MX MX2014000517A patent/MX2014000517A/es unknown
- 2012-07-16 EP EP12755925.0A patent/EP2731609A1/en active Pending
- 2012-07-16 US US14/232,245 patent/US20140234409A1/en not_active Abandoned
- 2012-07-16 CA CA2841731A patent/CA2841731A1/en not_active Abandoned
- 2012-07-16 BR BR112014000773A patent/BR112014000773A8/pt not_active IP Right Cessation
- 2012-07-16 WO PCT/NL2012/050511 patent/WO2013009186A1/en active Application Filing
-
2013
- 2013-07-15 US US14/415,114 patent/US20150202158A1/en not_active Abandoned
- 2013-07-15 BR BR112015000971A patent/BR112015000971A2/pt active Search and Examination
-
2015
- 2015-01-15 IL IL236757A patent/IL236757B/en not_active IP Right Cessation
-
2017
- 2017-09-28 US US15/718,010 patent/US20180078503A1/en not_active Abandoned
- 2017-09-28 US US15/718,000 patent/US10881614B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20180078503A1 (en) | 2018-03-22 |
US10881614B2 (en) | 2021-01-05 |
MX2014000517A (es) | 2014-07-24 |
IL236757B (en) | 2019-06-30 |
EP2731609A1 (en) | 2014-05-21 |
BR112014000773A2 (pt) | 2017-06-13 |
US20140234409A1 (en) | 2014-08-21 |
BR112015000971A2 (pt) | 2017-06-27 |
US20150202158A1 (en) | 2015-07-23 |
WO2013009186A1 (en) | 2013-01-17 |
CA2841731A1 (en) | 2013-01-17 |
US20180140553A1 (en) | 2018-05-24 |
IL236757A0 (en) | 2015-03-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112014000773A8 (pt) | Composições de nicotinamida e uso terapêutico das mesmas | |
BR112014008731A2 (pt) | tratamento de esclerose múltipla com combinação de laquinimode e fingolimode | |
BR112012011478A2 (pt) | composições fosfolipídicas terapêuticas concentradas. | |
BR112015002372A2 (pt) | composições e métodos para a redução do teor de álcool no sangue | |
UY34053A (es) | FORMULACIÓN PARA ANTICUERPO ANTI-a(alfa)4B(Beta)7 | |
BR112014009146A8 (pt) | formulações de etanercepte estabilizadas com aminoácidos | |
BR112014006220A2 (pt) | composições de galacto-ramnogalacturonato para o tratamento de esteatohepatite não alcoólica e de doença de gordura no fígado não alcoólica | |
BR112014014341A2 (pt) | Intermediário metilado, seu método de preparação e seus usos, e composição farmacêutica | |
BR112014004687A2 (pt) | imidazopiridazinas amino-substituídas | |
BR122020001787A8 (pt) | Conjugado de anticorpo-agente ativo, seus métodos de preparação, sua composição e seu uso | |
BR112012027915A2 (pt) | nitro-ácidos graxos - neuroproteção e/ou inibição do declínio cognitivo | |
BR112013017845A2 (pt) | agente antidiabético de abaixamento de lipídio | |
BR112015021931A2 (pt) | Usos de composições farmacêuticas para prevenção e/ou tratamento de complicações do pulmão induzidas por radiação e da função pulmonar | |
WO2012170899A3 (en) | Pharmaceutical compositions containing proteases and methods for the treatment of lysosomal storage diseases | |
CO6710913A2 (es) | Uso de ácido lipasa lisosomal para tratar la deficiencia de ácido lipasa lisosomal en pacientes | |
BR112013000776A2 (pt) | método e formulação para tratamento de deficiência de ácido siálico | |
BR112013020586A2 (pt) | Uso de células derivadas de tecido do cordão umbilical | |
BR112015000321A2 (pt) | formulações de laquinimod sem agente alcalinizante | |
PH12016502100A1 (en) | Liquid formulation comprising gm-csf neutralizing compound | |
BR112015005942A2 (pt) | extratos de cynara scolymus, coffea spp. e olea europaea para tratamento de síndrome metabólica | |
BR112012019921A2 (pt) | composições líquidas compreendendo um agente de resfriamento não-metol e um espessante para tratamento de um sintoma respiratório. | |
BR112014030534A2 (pt) | composições de galacto-ramnogalacturonato para o tratamento de doenças associadas com óxido nítrico sintase induzível elevada | |
BR112014027047A2 (pt) | nova formulação | |
GB2523707A (en) | Novel pharmaceutical formulations and their use in the treatment of periodontal disease | |
BR112013004455A2 (pt) | composições para fornecimento gástrico de agentes ativos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2523 DE 14-05-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
|
B350 | Update of information on the portal [chapter 15.35 patent gazette] |