BR112013024657A2 - antagonistas da s1p como hipotensivos oculares adjuntos - Google Patents
antagonistas da s1p como hipotensivos oculares adjuntosInfo
- Publication number
- BR112013024657A2 BR112013024657A2 BR112013024657A BR112013024657A BR112013024657A2 BR 112013024657 A2 BR112013024657 A2 BR 112013024657A2 BR 112013024657 A BR112013024657 A BR 112013024657A BR 112013024657 A BR112013024657 A BR 112013024657A BR 112013024657 A2 BR112013024657 A2 BR 112013024657A2
- Authority
- BR
- Brazil
- Prior art keywords
- antagonists
- iop
- ocular hypotensive
- adjunctive
- adjunctive ocular
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
patente de invenção: antagonistas da s1p como hipotensivos oculares adjuntos a invenção proporciona composições e métodos para reduzir adicionalmente a iop em um paciente que já tenha atingido uma redução máxima de iop usando agentes redutores da iop conhecidos. a atividade de um regime de tratamento hipotensivo ocular pode ser aumentada por adição de um antagonista da s1p, para impedir a inversão mediada pela s1p como resultado do escoamento diminuído do humor aquoso.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161467690P | 2011-03-25 | 2011-03-25 | |
PCT/US2012/030523 WO2012135095A2 (en) | 2011-03-25 | 2012-03-26 | S1p antagonists as adjunct ocular hypotensives |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112013024657A2 true BR112013024657A2 (pt) | 2016-12-20 |
Family
ID=45929630
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013024657A BR112013024657A2 (pt) | 2011-03-25 | 2012-03-26 | antagonistas da s1p como hipotensivos oculares adjuntos |
Country Status (10)
Country | Link |
---|---|
US (1) | US20130079290A1 (pt) |
EP (1) | EP2688593A2 (pt) |
JP (1) | JP2014508813A (pt) |
KR (1) | KR20140025412A (pt) |
CN (1) | CN103561766A (pt) |
AU (1) | AU2012236850A1 (pt) |
BR (1) | BR112013024657A2 (pt) |
CA (1) | CA2831290A1 (pt) |
RU (1) | RU2013147049A (pt) |
WO (1) | WO2012135095A2 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103740831B (zh) * | 2014-01-13 | 2015-01-28 | 宁波海尔施基因科技有限公司 | 一种指导β-受体阻断药用药的引物组合物、多重基因检测试剂盒及其使用方法 |
US20210038502A1 (en) | 2017-11-08 | 2021-02-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | S1pr2 antagonists for treating diseases involving abnormal immune responses |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0656779B1 (en) * | 1992-08-28 | 2000-04-12 | Pharmos Corporation | Submicron emulsions as ocular drug delivery vehicles |
US6646001B2 (en) * | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
WO2002072105A2 (en) * | 2001-02-21 | 2002-09-19 | Alcon, Inc. | Improved prostanoid therapies for the treatment of glaucoma |
WO2008154470A1 (en) * | 2007-06-08 | 2008-12-18 | University Of Connecticut | Nhibitor of the receptor activity of the s1p2 receptor for inhibiting pathological angiogenesis in the eye |
US20090281322A1 (en) * | 2008-05-08 | 2009-11-12 | Allergan, Inc. | THERAPEUTICALLY USEFUL SUBSTITUTED 1,7-DIPHENYL-1,2,3,5,6,7-HEXAHYDROPYRIDO[3,2,1-Ij]QUINOLINE COMPOUNDS |
WO2009137342A1 (en) * | 2008-05-08 | 2009-11-12 | Allergan, Inc. | Therapeutically useful substituted 1, 7-diphenyl-l, 2, 3, 5, 6, 7-hexahydropyrido [ 3, 2, 1-i j ] quinoline compounds |
-
2012
- 2012-03-26 WO PCT/US2012/030523 patent/WO2012135095A2/en active Application Filing
- 2012-03-26 CN CN201280025491.4A patent/CN103561766A/zh active Pending
- 2012-03-26 KR KR1020137028029A patent/KR20140025412A/ko not_active Application Discontinuation
- 2012-03-26 AU AU2012236850A patent/AU2012236850A1/en not_active Abandoned
- 2012-03-26 EP EP12712199.4A patent/EP2688593A2/en not_active Withdrawn
- 2012-03-26 BR BR112013024657A patent/BR112013024657A2/pt not_active Application Discontinuation
- 2012-03-26 CA CA2831290A patent/CA2831290A1/en not_active Abandoned
- 2012-03-26 US US13/430,340 patent/US20130079290A1/en not_active Abandoned
- 2012-03-26 RU RU2013147049/15A patent/RU2013147049A/ru unknown
- 2012-03-26 JP JP2014501299A patent/JP2014508813A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2012236850A1 (en) | 2013-10-17 |
RU2013147049A (ru) | 2015-04-27 |
CN103561766A (zh) | 2014-02-05 |
EP2688593A2 (en) | 2014-01-29 |
KR20140025412A (ko) | 2014-03-04 |
WO2012135095A9 (en) | 2013-03-07 |
US20130079290A1 (en) | 2013-03-28 |
CA2831290A1 (en) | 2012-10-04 |
WO2012135095A3 (en) | 2013-01-17 |
WO2012135095A2 (en) | 2012-10-04 |
JP2014508813A (ja) | 2014-04-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR121843A2 (es) | Formulación oftálmica y método para mejorar la presbicia | |
IN2014DN09434A (pt) | ||
BR112013028907A2 (pt) | conjugados de proteína-agente ativo e método para preparar os mesmos | |
EA201490254A1 (ru) | Комбинированное лечение гепатита с | |
BR112014026703A2 (pt) | inibidores de dna-pk | |
BR112015019720A2 (pt) | inibidores de (benzil-ciano-metil)-amidas de ácido 2-aza-biciclo[2.2.1]heptano-3-carboxílico substituído da catepsina c | |
EA201590053A1 (ru) | Модуляторы пути системы комплемента и их применение | |
CR20130560A (es) | Compuestos de bezotiazol y su uso farmacéutico | |
CR20170279A (es) | Compuestos de carbamoilpiridona policíclicos y su uso farmacéutico | |
MX365939B (es) | Moduladores del transporte nuclear y usos de los mismos. | |
BR112014006297A2 (pt) | inibidores de n-[1-ciano-2-(fenil) etil]-2-azabiciclo [2.2.1] heptano-3-carboxamida de catepsina c, seus usos, e composição farmacêutica | |
BR112015000704A2 (pt) | imidazotriazinacarbonitrilas úteis como inibidores de quinase | |
EA201391108A1 (ru) | Лечение липодистрофии | |
MX2016000364A (es) | Metodos para tratar o prevenir afecciones oftalmologicas. | |
MX2011009847A (es) | Agentes antihelminticos y su uso. | |
MX345042B (es) | Composiciones y métodos para tratamiento no quirúrgico de ptosis. | |
EA201400002A1 (ru) | Способы лечения заболеваний сетчатки | |
BR112014010376A2 (pt) | medicamento para o tratamento de doença do olho anterior que compreende rebamipida e um agente de retenção de lágrima | |
TR201900863T4 (tr) | Beta-klorosiklopentanların hidrofilik ester ön ilaçlarının kullanılmasıyla merkezi korneal kalınlaşmanın azaltılması. | |
BR112014000634A2 (pt) | métodos para tratamento de incontinência associada com atividade sexual | |
CY1117458T1 (el) | Αγωνιστες αδενοσινης α1 για τη θεραπευτικη αντιμετωπιση του γλαυκωματος και της οφθαλμικης υπερτασης | |
BR112014010729A2 (pt) | métodos para tratamento de ataques de gota | |
EA201490199A8 (ru) | Терапевтические способы | |
MD20140004A2 (en) | Deuterated 1-piperazino-3-phenyl-indanes for treatment of schizophrenia | |
WO2014071168A3 (en) | Administering inhibitors of tgfbeta signaling to improve muscle function in cancer patients |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |