BR112013010508A8 - composto de carboxilato de fenilcetona e usos farmacêuticos dos mesmos - Google Patents

composto de carboxilato de fenilcetona e usos farmacêuticos dos mesmos

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Publication number
BR112013010508A8
BR112013010508A8 BR112013010508A BR112013010508A BR112013010508A8 BR 112013010508 A8 BR112013010508 A8 BR 112013010508A8 BR 112013010508 A BR112013010508 A BR 112013010508A BR 112013010508 A BR112013010508 A BR 112013010508A BR 112013010508 A8 BR112013010508 A8 BR 112013010508A8
Authority
BR
Brazil
Prior art keywords
mcooh
pharmaceutical uses
phenylketone
phenylketone carboxylate
pch3
Prior art date
Application number
BR112013010508A
Other languages
English (en)
Other versions
BR112013010508B8 (pt
BR112013010508B1 (pt
BR112013010508A2 (pt
Inventor
Zacharie Boulos
Grouix Brigitte
Penney Christopher
Bienvenu Jean-Francois
Gagnon Lyne
Laurin Pierre
Abbott Shaun
Original Assignee
Prometic Biosciences Inc
Prometic Pharma Smt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45992998&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112013010508(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Prometic Biosciences Inc, Prometic Pharma Smt Ltd filed Critical Prometic Biosciences Inc
Publication of BR112013010508A2 publication Critical patent/BR112013010508A2/pt
Publication of BR112013010508A8 publication Critical patent/BR112013010508A8/pt
Publication of BR112013010508B1 publication Critical patent/BR112013010508B1/pt
Publication of BR112013010508B8 publication Critical patent/BR112013010508B8/pt

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    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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Abstract

compostos de carboxilato de fenilcetona e usos farmacêuticos dos mesmos. compostos de carboxilato de fenilcetona de fórmula i, em que n = 2 a 6; r=c (o); -oc (o)- ou -ch(oh)-; a é (ch2)mcooh, w(ch2)mcooh ou ych(cooh) ((ch2)pch3) quando b é ft b é (ch2)mcooh, w (ch2)mcooh ou ych(cooh) ((ch2)pch3) quando a é ft ou a e b formam um grupo cicloalquil de 5 a 7 membros substituídos por cooft w=0, s ou nft y=0, s, nh ou ch2; m = 0 a 2, p = 1 a 7; foram preparados. estes compostos e seus sais farmaceuticamente aceitáveis têm efeitos terapêuticos benéficos para prevenir ou tratar uma condição relacionada a (1) distúrbios no sangue, (ii) doenças e relacionadas a inflamação, (iii) distúrbios renais e/ou complicações de distúrbios renais ou (iv) disfunção de órgão relacionada a fibrose.
BR112013010508A 2010-10-27 2011-10-26 Compostos de carboxilato de fenilcetona ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica compreendendo o referido composto e uso do mesmo BR112013010508B8 (pt)

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US40706810P 2010-10-27 2010-10-27
US61/407,068 2010-10-27
PCT/CA2011/001176 WO2012055014A1 (en) 2010-10-27 2011-10-26 Phenylketone carboxylate compounds and pharmaceutical uses thereof

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WO2016027283A2 (en) * 2014-08-22 2016-02-25 Reddy G Pratap A process for preparing indacaterol and salts thereof
CN106999456B (zh) * 2014-10-10 2020-07-10 里米诺生物科学有限公司 用于预防和治疗骨质疏松症的被取代的芳族化合物和药物组合物
MY187511A (en) * 2014-10-10 2021-09-24 Prometic Pharma Smt Ltd Phenylketone carboxylate compounds and pharmaceutical compositions for the prevention and treatment of osteoporosis
RU2728782C2 (ru) 2014-11-12 2020-07-31 Лиминал Байосайенсиз Лимитед Замещенные ароматические соединения и фармацевтические композиции для ауторепарации и регенерации ткани
CN112457188B (zh) * 2020-11-24 2022-07-08 苏州博萃循环科技有限公司 一种羧酸类化合物及其制备方法与应用

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JP6055771B2 (ja) 2016-12-27
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EA201370104A1 (ru) 2013-08-30
ES2664816T3 (es) 2018-04-23
CA2816084A1 (en) 2012-05-03
AU2011320057B2 (en) 2016-02-25
AU2011320057A1 (en) 2013-05-09
JP2013545729A (ja) 2013-12-26
PT2632885T (pt) 2018-04-04
KR20130140745A (ko) 2013-12-24
US20130225681A1 (en) 2013-08-29
TWI526427B (zh) 2016-03-21
MX348253B (es) 2017-05-31
CL2013001153A1 (es) 2014-01-10
IL225600A0 (en) 2013-06-27
BR112013010508B8 (pt) 2021-12-07
CA2816084C (en) 2019-10-29
DK2632885T3 (en) 2018-04-16
MX2013004833A (es) 2013-06-03
US9475750B2 (en) 2016-10-25
ZA201303032B (en) 2014-06-25
EA022988B9 (ru) 2016-08-31
CN103298777B (zh) 2016-07-06
EA022988B1 (ru) 2016-04-29
BR112013010508B1 (pt) 2021-08-10
MY164375A (en) 2017-12-15
NZ610853A (en) 2015-05-29
CN103298777A (zh) 2013-09-11
WO2012055014A1 (en) 2012-05-03
BR112013010508A2 (pt) 2016-08-02
EP2632885B1 (en) 2018-01-03
HK1188773A1 (zh) 2014-05-16
EP2632885A1 (en) 2013-09-04
EP2632885A4 (en) 2015-08-26
SG190035A1 (en) 2013-06-28

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