BR112013004503A2 - antagonistas de receptor de 5ht2b - Google Patents
antagonistas de receptor de 5ht2bInfo
- Publication number
- BR112013004503A2 BR112013004503A2 BR112013004503A BR112013004503A BR112013004503A2 BR 112013004503 A2 BR112013004503 A2 BR 112013004503A2 BR 112013004503 A BR112013004503 A BR 112013004503A BR 112013004503 A BR112013004503 A BR 112013004503A BR 112013004503 A2 BR112013004503 A2 BR 112013004503A2
- Authority
- BR
- Brazil
- Prior art keywords
- receptor antagonists
- 5ht2b receptor
- 5ht2b
- medicament
- prevention
- Prior art date
Links
- 102000006969 5-HT2B Serotonin Receptor Human genes 0.000 title abstract 3
- 108010072584 5-HT2B Serotonin Receptor Proteins 0.000 title abstract 3
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003053 piperidines Chemical class 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000005069 pulmonary fibrosis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10174880 | 2010-09-01 | ||
| PCT/EP2011/064906 WO2012028614A1 (en) | 2010-09-01 | 2011-08-30 | 5-ht2b receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013004503A2 true BR112013004503A2 (pt) | 2016-06-07 |
Family
ID=43127285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013004503A BR112013004503A2 (pt) | 2010-09-01 | 2011-08-30 | antagonistas de receptor de 5ht2b |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8703958B2 (https=) |
| EP (1) | EP2619180B1 (https=) |
| JP (1) | JP5845263B2 (https=) |
| KR (1) | KR101815123B1 (https=) |
| CN (1) | CN103080089B (https=) |
| AU (1) | AU2011298361B2 (https=) |
| BR (1) | BR112013004503A2 (https=) |
| CA (1) | CA2806647C (https=) |
| EA (1) | EA020967B1 (https=) |
| ES (1) | ES2525515T3 (https=) |
| MX (1) | MX2013002409A (https=) |
| SG (1) | SG188233A1 (https=) |
| WO (1) | WO2012028614A1 (https=) |
| ZA (1) | ZA201301561B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2525515T3 (es) | 2010-09-01 | 2014-12-23 | Janssen Pharmaceutica, N.V. | Antagonistas del receptor 5-HT2B |
| CN103467596A (zh) * | 2012-06-06 | 2013-12-25 | 北京大学 | 一个治疗肺动脉高压的新靶点 |
| US20170058349A1 (en) * | 2014-03-04 | 2017-03-02 | The Children's Hospital Of Philadelphia | Methods for managing care of patients predisposed to progressive mitral valve diseases |
| CN110950843B (zh) * | 2019-11-28 | 2022-12-27 | 广东东阳光药业有限公司 | 取代的苯酰胺衍生物及其用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4962115A (en) * | 1981-10-01 | 1990-10-09 | Janssen Pharmaceutica N.V. | Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
| CA1183847A (en) * | 1981-10-01 | 1985-03-12 | Georges Van Daele | N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
| GB8519707D0 (en) * | 1985-08-06 | 1985-09-11 | Fordonal Sa | Chemical compounds |
| CA1317940C (en) * | 1987-09-25 | 1993-05-18 | Georges H. P. Van Daele | Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides |
| AU2001275326C1 (en) * | 2000-06-07 | 2006-09-21 | Aryx Therapeutics | Treatment of gastroesophageal reflux disease using piperidine derivatives |
| US6444477B1 (en) * | 2000-11-28 | 2002-09-03 | Pharmagene Laboratories Limited | Assay method for detecting 5-HT2B antagonists |
| CN1918157B (zh) * | 2004-01-07 | 2010-06-23 | ARYx医疗有限公司 | 立体异构化合物及治疗胃肠道和中枢神经系统紊乱的方法 |
| JP2009520785A (ja) | 2005-12-23 | 2009-05-28 | アストラゼネカ アクチボラグ | 抗菌性のピロロピリジン、ピロロピリミジン、及びピロロアゼピン |
| WO2008139152A1 (en) * | 2007-05-11 | 2008-11-20 | Sentinel Oncology Limited | N-oxide-containing pharmaceutical compounds |
| ES2525515T3 (es) | 2010-09-01 | 2014-12-23 | Janssen Pharmaceutica, N.V. | Antagonistas del receptor 5-HT2B |
-
2011
- 2011-08-30 ES ES11748693.6T patent/ES2525515T3/es active Active
- 2011-08-30 AU AU2011298361A patent/AU2011298361B2/en not_active Ceased
- 2011-08-30 CA CA2806647A patent/CA2806647C/en active Active
- 2011-08-30 KR KR1020137005411A patent/KR101815123B1/ko not_active Expired - Fee Related
- 2011-08-30 WO PCT/EP2011/064906 patent/WO2012028614A1/en not_active Ceased
- 2011-08-30 SG SG2013011929A patent/SG188233A1/en unknown
- 2011-08-30 MX MX2013002409A patent/MX2013002409A/es active IP Right Grant
- 2011-08-30 CN CN201180041597.9A patent/CN103080089B/zh not_active Expired - Fee Related
- 2011-08-30 EP EP11748693.6A patent/EP2619180B1/en active Active
- 2011-08-30 JP JP2013526445A patent/JP5845263B2/ja not_active Expired - Fee Related
- 2011-08-30 BR BR112013004503A patent/BR112013004503A2/pt active Search and Examination
- 2011-08-30 EA EA201390312A patent/EA020967B1/ru not_active IP Right Cessation
-
2013
- 2013-02-28 ZA ZA2013/01561A patent/ZA201301561B/en unknown
- 2013-02-28 US US13/779,962 patent/US8703958B2/en active Active
-
2014
- 2014-03-04 US US14/196,502 patent/US9139523B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HK1182097A1 (zh) | 2013-11-22 |
| KR101815123B1 (ko) | 2018-01-04 |
| CN103080089A (zh) | 2013-05-01 |
| EP2619180A1 (en) | 2013-07-31 |
| AU2011298361B2 (en) | 2014-03-13 |
| US20130172386A1 (en) | 2013-07-04 |
| ES2525515T3 (es) | 2014-12-23 |
| CN103080089B (zh) | 2015-09-23 |
| ZA201301561B (en) | 2014-08-27 |
| CA2806647C (en) | 2018-09-18 |
| CA2806647A1 (en) | 2012-03-08 |
| JP2013536823A (ja) | 2013-09-26 |
| EA020967B1 (ru) | 2015-03-31 |
| US9139523B2 (en) | 2015-09-22 |
| EA201390312A1 (ru) | 2013-07-30 |
| US8703958B2 (en) | 2014-04-22 |
| SG188233A1 (en) | 2013-04-30 |
| EP2619180B1 (en) | 2014-10-08 |
| MX2013002409A (es) | 2013-04-03 |
| JP5845263B2 (ja) | 2016-01-20 |
| KR20130101503A (ko) | 2013-09-13 |
| AU2011298361A1 (en) | 2013-02-14 |
| US20140187585A1 (en) | 2014-07-03 |
| WO2012028614A1 (en) | 2012-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B11D | Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time |