BR112013002641A2 - formulação de micropartículas para administração de medicamentos pulmonares de molécula anti-infeccionais para tratamento de doenças infecciosas - Google Patents

formulação de micropartículas para administração de medicamentos pulmonares de molécula anti-infeccionais para tratamento de doenças infecciosas

Info

Publication number
BR112013002641A2
BR112013002641A2 BR112013002641A BR112013002641A BR112013002641A2 BR 112013002641 A2 BR112013002641 A2 BR 112013002641A2 BR 112013002641 A BR112013002641 A BR 112013002641A BR 112013002641 A BR112013002641 A BR 112013002641A BR 112013002641 A2 BR112013002641 A2 BR 112013002641A2
Authority
BR
Brazil
Prior art keywords
formulation
administration
pulmonary
microparticles
treatment
Prior art date
Application number
BR112013002641A
Other languages
English (en)
Inventor
Aravindan Vasudevan
Geetanjali Chandrashekhar Chimote
Girish Badrinath Mahajan
Sivaramakrishnan Hariharan
Original Assignee
Piramal Entpr Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Piramal Entpr Ltd filed Critical Piramal Entpr Ltd
Publication of BR112013002641A2 publication Critical patent/BR112013002641A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

formulação de micropartículas para administração de medicamentos pulmonares de molécula anti-infeccionais para tratamento de doenças infecciosas. a presente invenção refere-se a uma formulação de micropartículas biodegradáveis, inalável contendo um composto de fórmula i obtido por fermentação de um microrganismo da espécie streptomyces (pm626271/mtcc5447), tal como descrito na publicação de pedido pct wo2011027290, e um lípido biodegradáveis para a entrega de drogas, em que o proporção de droga (composto da fórmula i) para lípidos é 1:15 - 1:25. a presente invenção ttambém se relaciona com o processo para preparação da formulação e do método de tratamento da tuberculose pulmonar, tuberculose resistente múltiplos fármacos (mdrtb), resistentes à meticilina staphylococcus aureus (mrsa) e staphylococcus pneumonias staphylococcus aureis sensível (mssa) através da administração de pneumonias quantidade terapeuticamente eficaz da formulação a um mamífero em necessidade deste. a presente invenção diz ainda respeito a um método de entregar a formulação de micropartículas a um método de necessidade deste, em que a formulação é administrada por inalação ou por instilação intratraqueal para entrega pulmonar.
BR112013002641A 2010-08-05 2011-08-04 formulação de micropartículas para administração de medicamentos pulmonares de molécula anti-infeccionais para tratamento de doenças infecciosas BR112013002641A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37091610P 2010-08-05 2010-08-05
PCT/IB2011/053470 WO2012017405A1 (en) 2010-08-05 2011-08-04 Microparticle formulation for pulmonary drug delivery of anti-infective molecule for treatment of infectious diseases

Publications (1)

Publication Number Publication Date
BR112013002641A2 true BR112013002641A2 (pt) 2016-06-07

Family

ID=44653372

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013002641A BR112013002641A2 (pt) 2010-08-05 2011-08-04 formulação de micropartículas para administração de medicamentos pulmonares de molécula anti-infeccionais para tratamento de doenças infecciosas

Country Status (14)

Country Link
US (1) US8697653B2 (pt)
EP (1) EP2600842A1 (pt)
JP (1) JP2013532722A (pt)
KR (1) KR20130109106A (pt)
CN (1) CN103442694B (pt)
AU (1) AU2011287205A1 (pt)
BR (1) BR112013002641A2 (pt)
CA (1) CA2807357A1 (pt)
IN (1) IN2013MN00329A (pt)
MX (1) MX2013001325A (pt)
RU (1) RU2013109384A (pt)
TW (1) TW201208716A (pt)
WO (1) WO2012017405A1 (pt)
ZA (1) ZA201301662B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015107482A1 (en) * 2014-01-17 2015-07-23 Piramal Enterprises Limited Pharmaceutical combination for treatment of tuberculosis
US10335374B2 (en) 2014-12-04 2019-07-02 University System of Georgia, Valdosta State University Tablet composition for anti-tuberculosis antibiotics
CN109827875A (zh) * 2019-04-10 2019-05-31 上海市食品药品检验所 一种用于测定吸入制剂溶出度的装置和方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8601457D0 (sv) * 1986-04-01 1986-04-01 Draco Ab Compositions of liposomes and b?712-receptor active substances for inhalation
JPH0751496B2 (ja) * 1986-04-02 1995-06-05 武田薬品工業株式会社 リポソ−ムの製造法
TW497974B (en) * 1996-07-03 2002-08-11 Res Dev Foundation High dose liposomal aerosol formulations
CN100358494C (zh) * 1998-11-12 2008-01-02 弗兰克G·皮尔基威克兹 一种吸入给药系统
WO2001054693A1 (en) * 2000-01-31 2001-08-02 Eisai Co., Ltd. Use of thiostrepton as an anti-mycobacterial agent
US20030224039A1 (en) * 2002-03-05 2003-12-04 Transave, Inc. Methods for entrapment of bioactive agent in a liposome or lipid complex
ES2435197T3 (es) * 2007-01-10 2013-12-16 Board Of Regents, The University Of Texas System Administración mejorada de composiciones de fármacos inmunosupresores para la administración por vía pulmonar
US10501492B2 (en) 2009-09-02 2019-12-10 National Centre For Polar And Ocean Research (Ncpor) Antibiotic compounds

Also Published As

Publication number Publication date
AU2011287205A1 (en) 2013-03-07
EP2600842A1 (en) 2013-06-12
WO2012017405A1 (en) 2012-02-09
IN2013MN00329A (pt) 2015-05-29
CN103442694A (zh) 2013-12-11
JP2013532722A (ja) 2013-08-19
CA2807357A1 (en) 2012-02-09
US20130125879A1 (en) 2013-05-23
KR20130109106A (ko) 2013-10-07
US8697653B2 (en) 2014-04-15
MX2013001325A (es) 2013-10-28
TW201208716A (en) 2012-03-01
CN103442694B (zh) 2015-09-09
RU2013109384A (ru) 2014-09-10
ZA201301662B (en) 2014-08-27

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08G Application fees: restoration [chapter 8.7 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]