BR112022014578A2 - Composição e métodos de profiláticos e terapêuticos de rnai para o tratamento de infecção respiratória aguda grave causada pelo novo coronavírus 2019 (2019-ncov) - Google Patents

Composição e métodos de profiláticos e terapêuticos de rnai para o tratamento de infecção respiratória aguda grave causada pelo novo coronavírus 2019 (2019-ncov)

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Publication number
BR112022014578A2
BR112022014578A2 BR112022014578A BR112022014578A BR112022014578A2 BR 112022014578 A2 BR112022014578 A2 BR 112022014578A2 BR 112022014578 A BR112022014578 A BR 112022014578A BR 112022014578 A BR112022014578 A BR 112022014578A BR 112022014578 A2 BR112022014578 A2 BR 112022014578A2
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BR
Brazil
Prior art keywords
treatment
methods
ncov
composition
corona virus
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Application number
BR112022014578A
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English (en)
Inventor
Tang Danny
Chen Xueping
y lu Patrick
Simonenko Vera
m evans David
Xu John
Wang Deling
Lu Alan
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Sirnaomics Inc
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Publication date
Application filed by Sirnaomics Inc filed Critical Sirnaomics Inc
Publication of BR112022014578A2 publication Critical patent/BR112022014578A2/pt

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
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    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
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    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.

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Abstract

COMPOSIÇÃO E MÉTODOS DE PROFILÁTICOS E TERAPÊUTICOS DE RNAi PARA O TRATAMENTO DE INFECÇÃO RESPIRATÓRIA AGUDA GRAVE CAUSADA PELO NOVO CORONAVÍRUS 2019 (2019-nCoV). A presente invenção refere-se as composições e métodos para o desenvolvimento de terapias de siRNA potentes para prevenção e tratamento de infecções pelo Corona Vírus (2019-nCoV; COVID-19) são fornecidas. As composições incluem uma composição farmacêutica compreendendo coquetéis de siRNA que têm como alvo os genes virais críticos e transportadores de nanopartículas poliméricas farmaceuticamente aceitáveis e veículos de nanopartículas lipossômicas. Métodos de administração para prevenção e tratamento são fornecidos, incluindo instilação nas vias aéreas, injeções subcutâneas e aerossolização por nebulização.
BR112022014578A 2020-01-23 2021-01-25 Composição e métodos de profiláticos e terapêuticos de rnai para o tratamento de infecção respiratória aguda grave causada pelo novo coronavírus 2019 (2019-ncov) BR112022014578A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062965063P 2020-01-23 2020-01-23
PCT/US2021/014962 WO2021151096A2 (en) 2020-01-23 2021-01-25 COMPOSITION AND METHODS OF RNAi PROPHYLACTICS AND THERAPEUTICS FOR TREATMENT OF SEVERE ACUTE RESPIRATORY INFECTION CAUSED BY 2019 NOVEL CORONAVIRUS (2019-nCoV)

Publications (1)

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BR112022014578A2 true BR112022014578A2 (pt) 2022-09-13

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US (1) US12006500B2 (pt)
EP (1) EP4093511A4 (pt)
JP (1) JP2023513436A (pt)
KR (1) KR20220151612A (pt)
CN (1) CN115768521A (pt)
AU (1) AU2021209995A1 (pt)
BR (1) BR112022014578A2 (pt)
CA (1) CA3165825A1 (pt)
IL (1) IL295032A (pt)
WO (1) WO2021151096A2 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202113085D0 (en) * 2021-09-14 2021-10-27 Primer Design Ltd Composition and method
WO2023049815A2 (en) * 2021-09-22 2023-03-30 Sirnaomics, Inc. Improved nanoparticle formulations formed from histidine-lysine copolymers
WO2023086386A1 (en) * 2021-11-09 2023-05-19 Sirnaomics, Inc. Treatment of 2019-ncov using sirnas against tgfb1 and cox2
WO2023086421A2 (en) * 2021-11-09 2023-05-19 Sirnaomics, Inc. METHODS FOR PROPHYLACTIC AND THERAPEUTIC TREATMENT OF 2019-nCoV USING siRNAs AGAINST ORF1AB AND N-PROTEIN
EP4180527A1 (en) * 2021-11-11 2023-05-17 Hangzhou Chichuang Biotechnology Co., Ltd. Synthesis method of targeted drug ncovshrna·2ace2
CN114591426A (zh) * 2021-11-11 2022-06-07 杭州痴创生物科技有限公司 一种人工抗体
WO2024035526A1 (en) * 2022-08-08 2024-02-15 Viron, Inc. Combined use of nanobody, cyclodextrin and quercetin for protection from enveloped viruses
WO2024059910A1 (en) * 2022-09-21 2024-03-28 Newsouth Innovations Pty Limited Antiviral sirna therapeutic for sars-cov-2

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1618127B1 (en) * 2003-04-10 2014-12-10 Novartis Vaccines and Diagnostics, Inc. Immunogenic composition comprising a spike protein of the SARS coronavirus
US7339051B2 (en) * 2003-04-28 2008-03-04 Isis Pharmaceuticals, Inc. Compositions and methods for the treatment of severe acute respiratory syndrome (SARS)
WO2005076999A2 (en) * 2004-02-05 2005-08-25 Intradigm Corporation Methods and compositions for combination rnai therapeutics
US7297786B2 (en) * 2004-07-09 2007-11-20 University Of Iowa Research Foundation RNA interference in respiratory epitheial cells
AU2005310131A1 (en) * 2004-11-17 2006-06-08 University Of Maryland, Baltimore Highly branched HK peptides as effective carriers of siRNA
WO2012016139A2 (en) * 2010-07-29 2012-02-02 Sirnaomics, Inc. Sirna compositions and methods for treatment of hpv and other infections
US9868952B2 (en) * 2012-07-08 2018-01-16 Sirnaomics, Inc. Compositions and methods for “resistance-proof” SiRNA therapeutics for influenza
WO2017044507A2 (en) * 2015-09-08 2017-03-16 Sirnaomics, Inc. Sirna/nanoparticle formulations for treatment of middle-east respiratory syndrome coronaviral infection
EP4127168A1 (en) * 2020-03-26 2023-02-08 Alnylam Pharmaceuticals, Inc. Coronavirus irna compositions and methods of use thereof
WO2021207641A1 (en) * 2020-04-10 2021-10-14 Aligos Therapeutics, Inc. Antisense oligonucleotide (aso) molecules and uses thereof for coronavirus diseases
WO2021228585A1 (en) * 2020-05-09 2021-11-18 Phyzat Biopharmaceuticals, Lda Sina molecules, methods of production and uses thereof
EP4196102A1 (en) * 2020-10-02 2023-06-21 Sirnaomics, Inc. NUCLEOSIDE CONTAINING siRNAS FOR TREATING VIRAL DISEASES

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WO2021151096A2 (en) 2021-07-29
US12006500B2 (en) 2024-06-11
WO2021151096A3 (en) 2021-10-28
EP4093511A2 (en) 2022-11-30
US20210246448A1 (en) 2021-08-12
CN115768521A (zh) 2023-03-07
EP4093511A4 (en) 2023-10-18
IL295032A (en) 2022-09-01
JP2023513436A (ja) 2023-03-31
KR20220151612A (ko) 2022-11-15
CA3165825A1 (en) 2021-07-29
AU2021209995A1 (en) 2022-09-15

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