BR112013001577A2 - conjugados de carboidrato e dihidorxiclorina e clorina <225>-funcionalizada e respectivos usos e método para eliminar microorganismos em ambiente de paciente real - Google Patents
conjugados de carboidrato e dihidorxiclorina e clorina <225>-funcionalizada e respectivos usos e método para eliminar microorganismos em ambiente de paciente realInfo
- Publication number
- BR112013001577A2 BR112013001577A2 BR112013001577A BR112013001577A BR112013001577A2 BR 112013001577 A2 BR112013001577 A2 BR 112013001577A2 BR 112013001577 A BR112013001577 A BR 112013001577A BR 112013001577 A BR112013001577 A BR 112013001577A BR 112013001577 A2 BR112013001577 A2 BR 112013001577A2
- Authority
- BR
- Brazil
- Prior art keywords
- conjugates
- carbohydrate
- dihydroxychlorine
- real patient
- patient environment
- Prior art date
Links
- 150000001720 carbohydrates Chemical class 0.000 title abstract 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 title abstract 2
- AWOBNGRGRKNKHJ-UHFFFAOYSA-N OClO Chemical compound OClO AWOBNGRGRKNKHJ-UHFFFAOYSA-N 0.000 title abstract 2
- 229910052801 chlorine Inorganic materials 0.000 title abstract 2
- 239000000460 chlorine Substances 0.000 title abstract 2
- 244000005700 microbiome Species 0.000 title abstract 2
- 241001465754 Metazoa Species 0.000 abstract 2
- 235000017168 chlorine Nutrition 0.000 abstract 2
- 244000000010 microbial pathogen Species 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- 125000001309 chloro group Chemical class Cl* 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- -1 serum Substances 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
conjugados de carboidrato e dihidorxiclorina e clorina <225>-funcionalizada e respectivos usos e método para eliminar microorganismos em ambiente de paciente real. são proporcionados conjugados moleculares antimicrobianos para o tratamento e prevenção de doenças infecciosas causadas por microorganismos patogênicos em pessoas humanas e em animais. a chave para estes conjugados é conectar dihidroxiclorinas ou clorinas <225>-funcionalizadas a grupamentos de carboidratos. estes conjugados são apurados serem muito efetivos para combater infecções bacterianas causadas por bactérias gram-positivas e gram-negativas, incluindo as suas cepas resistentes. de modo significativo, também são efetivos em ambientes complexos, incluindo sangue,soro e outros fluidos corpóreos que estão presentes no corpo do paciente. é também provido um método de uso para controlar microorganismos patogênicos em pessoas humanas e animais.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36671810P | 2010-07-22 | 2010-07-22 | |
US61/366,718 | 2010-07-22 | ||
PCT/US2011/045063 WO2013015774A1 (en) | 2011-07-22 | 2011-07-22 | Glyco-substituted dihydroxy-chlorins and b-functionalized chlorins for anti-microbial photodynamic therapy |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112013001577A2 true BR112013001577A2 (pt) | 2017-12-12 |
BR112013001577B1 BR112013001577B1 (pt) | 2021-05-04 |
Family
ID=47006517
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013001577-2A BR112013001577B1 (pt) | 2010-07-22 | 2011-07-22 | conjugados de carboidrato e dihidroxiclorina |
Country Status (7)
Country | Link |
---|---|
US (1) | US9308185B2 (pt) |
EP (1) | EP2616065B1 (pt) |
CN (1) | CN103096887B (pt) |
BR (1) | BR112013001577B1 (pt) |
IL (1) | IL224380A (pt) |
MX (1) | MX352281B (pt) |
PL (1) | PL2616065T3 (pt) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6041360B2 (ja) * | 2011-07-22 | 2016-12-07 | バイオリテック ウンターネーメンスベタイリグンクス ツヴァイ アクツィエンゲゼルシャフト | 抗菌性光線力学療法のための、糖−置換ジヒドロキシ−クロリン及びβ−官能化クロリン |
US9156849B2 (en) * | 2011-08-12 | 2015-10-13 | Biolitec Pharma Marketing Ltd | Application of β-functionalized dihydroxy-chlorins for PDT |
CN103285403B (zh) * | 2013-06-21 | 2015-03-04 | 苏州大学 | 一种络合卟啉含糖光敏剂及其制备方法 |
EP3201201B1 (en) | 2014-09-30 | 2022-01-26 | biolitec unternehmensbeteiligungs II AG | Specifically meso-substituted porphyrins and chlorins for photodynamic therapy |
CN108136196B (zh) | 2015-07-28 | 2020-07-17 | 诺欧生物有限责任公司 | 用于对一氧化氮的光疗调节的系统和方法 |
EP3210626A1 (en) | 2016-02-26 | 2017-08-30 | biolitec Unternehmensbeteiligungs II AG | Conjugates of porphyrinoid photosensitizers and glycerol-based polymers for photodynamic therapy |
US20220025185A1 (en) | 2018-12-10 | 2022-01-27 | Universitat Hamburg | Specifically glyco-substituted porphyrins and chlorins for photodynamic therapy |
US11986666B2 (en) | 2020-03-19 | 2024-05-21 | Know Bio, Llc | Illumination devices for inducing biological effects |
US12011611B2 (en) | 2020-03-19 | 2024-06-18 | Know Bio, Llc | Illumination devices for inducing biological effects |
US11147984B2 (en) | 2020-03-19 | 2021-10-19 | Know Bio, Llc | Illumination devices for inducing biological effects |
US11654294B2 (en) | 2021-03-15 | 2023-05-23 | Know Bio, Llc | Intranasal illumination devices |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3005025A (en) * | 1959-08-07 | 1961-10-17 | American Cyanamid Co | Preparation of neutral chlortetracycline |
FR2709491B1 (fr) * | 1993-09-03 | 1995-10-27 | Centre Nat Rech Scient | Nouveaux dérivés de porphyrines et leurs applications notamment en thérapeutique. |
EP1279676A1 (en) * | 2001-07-19 | 2003-01-29 | Institut Curie | Porphyrin derivatives for photodynamic therapy |
US7110533B2 (en) * | 2004-05-18 | 2006-09-19 | Time Warner Cable, Inc. | Telephone NID isolation module |
RU2574062C9 (ru) * | 2008-09-18 | 2016-10-27 | Биолитек Унтернеменсбетайлигунгс Ii Аг | НОВЫЙ СПОСОБ И ПРИМЕНЕНИЕ НЕСИММЕТРИЧНО мезо-ЗАМЕЩЕННЫХ ПОРФИРИНОВ И ХЛОРИНОВ ДЛЯ ФДТ |
BR112013001576A2 (pt) * | 2010-07-22 | 2016-07-19 | Ceramoptec Gmbh | composto tetrapirrólico e composição farmacêutica derivado farmacêuticamente aceitável da mesma e respectivos usos e métodos de terapia fotodinâmica e de diagnóstico e tratamento da artrite e de doenças inflamatórias semelhantes. |
-
2011
- 2011-07-22 EP EP11869827.3A patent/EP2616065B1/en active Active
- 2011-07-22 BR BR112013001577-2A patent/BR112013001577B1/pt not_active IP Right Cessation
- 2011-07-22 US US13/189,113 patent/US9308185B2/en active Active
- 2011-07-22 CN CN201180038608.8A patent/CN103096887B/zh active Active
- 2011-07-22 MX MX2013000876A patent/MX352281B/es active IP Right Grant
- 2011-07-22 PL PL11869827T patent/PL2616065T3/pl unknown
-
2013
- 2013-01-23 IL IL224380A patent/IL224380A/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP2616065B1 (en) | 2017-11-01 |
PL2616065T3 (pl) | 2018-05-30 |
BR112013001577B1 (pt) | 2021-05-04 |
CN103096887A (zh) | 2013-05-08 |
US20120263625A1 (en) | 2012-10-18 |
EP2616065A1 (en) | 2013-07-24 |
MX352281B (es) | 2017-11-16 |
EP2616065A4 (en) | 2014-05-14 |
MX2013000876A (es) | 2013-04-30 |
IL224380A (en) | 2017-06-29 |
CN103096887B (zh) | 2017-12-29 |
US9308185B2 (en) | 2016-04-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112013001577A2 (pt) | conjugados de carboidrato e dihidorxiclorina e clorina <225>-funcionalizada e respectivos usos e método para eliminar microorganismos em ambiente de paciente real | |
BR112013028813A2 (pt) | derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e seu uso no tratamento de infecções bacterianas | |
BR112013000097A2 (pt) | composições e métodos relacionados a variantes da proteína a (spa) | |
BR112014027818A2 (pt) | prevenção, ruptura e tratamento do biofilme com a lisina bacteriófaga | |
NZ593111A (en) | Antibacterial compounds | |
BR112013032974A2 (pt) | "derivados de 1,6-diazabiciclo [3,2,1]-octan-7-ona, seus usos, e composições farmacêuticas". | |
BR112015006568A2 (pt) | composições e bactéria de ácido láctico | |
Ashkenazi | Beginning and possibly the end of the antibiotic era. | |
BR112016006589A2 (pt) | composição, e composição de vacina | |
MX2021008036A (es) | Bioplaguicidas para la enfermedad tizon tardio de la papa. | |
ES2571998T3 (es) | Composiciones y usos médicos de derivados del ajoeno | |
BR112021018815A2 (pt) | Gepotidacina para uso no tratamento de infecções bacterianas do trato urinário | |
BR112019024549A2 (pt) | compostos derivados de glicopeptídeo e usos dos mesmos | |
WO2008036761A8 (en) | Anti-microbial defensin-related peptides and methods of use | |
EA201491272A1 (ru) | Нанопродукт, содержащий lactobacillus reuteri dan080, подходящий для профилактики и терапии - человеческой и ветеринарной, и его медицинское применение | |
Zmantar et al. | Modulation of drug resistance and biofilm formation of Staphylococcus aureus isolated from the oral cavity of Tunisian children | |
MX2009006325A (es) | Compuestos de heteroaril-heteroarilo como inhibidores de cdk para el tratamiento de cancer, inflamacion e infecciones virales. | |
BR112014026861A2 (pt) | antígenos de estafilococos coagulase e métodos de seu uso | |
WO2010125196A3 (en) | Bacteriophages specific to pak and cha strains of pseudomonas aeruginosa and their applications | |
Litterio et al. | Isolation of Serratia rubidaea from a mixed infection after a horse bite | |
Yang et al. | Silver nanoparticles as a smart antimicrobial agent | |
CN102754666A (zh) | 医疗机构物体表面草本消毒剂 | |
WO2016066722A3 (en) | Bacteriophage combinations for human or animal therapy | |
MX2009001074A (es) | Terapia fotodinamica antimicrobiana. | |
BR112014005221A2 (pt) | uso de materiais de fibra oca modificada para a remoção de exotoxinas produzidas por escherichia coli a partir de liquidos, de preferência a partir de sangue e de plasma, bem como seu uso para o tratamento de doenças concomitantes |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B25A | Requested transfer of rights approved |
Owner name: BIOLITEC UNTERNEHMENSBETEILIGUNGS II AG (AT) |
|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/07/2011, OBSERVADAS AS CONDICOES LEGAIS. |
|
B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 13A ANUIDADE. |