BR112014005221A2 - uso de materiais de fibra oca modificada para a remoção de exotoxinas produzidas por escherichia coli a partir de liquidos, de preferência a partir de sangue e de plasma, bem como seu uso para o tratamento de doenças concomitantes - Google Patents

uso de materiais de fibra oca modificada para a remoção de exotoxinas produzidas por escherichia coli a partir de liquidos, de preferência a partir de sangue e de plasma, bem como seu uso para o tratamento de doenças concomitantes

Info

Publication number
BR112014005221A2
BR112014005221A2 BR112014005221A BR112014005221A BR112014005221A2 BR 112014005221 A2 BR112014005221 A2 BR 112014005221A2 BR 112014005221 A BR112014005221 A BR 112014005221A BR 112014005221 A BR112014005221 A BR 112014005221A BR 112014005221 A2 BR112014005221 A2 BR 112014005221A2
Authority
BR
Brazil
Prior art keywords
escherichia coli
plasma
blood
treatment
well
Prior art date
Application number
BR112014005221A
Other languages
English (en)
Inventor
Roxane Jaeger Beate
Seidel Dietrich
Original Assignee
Safe Bt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Safe Bt Inc filed Critical Safe Bt Inc
Publication of BR112014005221A2 publication Critical patent/BR112014005221A2/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/76—Macromolecular material not specifically provided for in a single one of groups B01D71/08 - B01D71/74
    • B01D71/78—Graft polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403—Regulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0093—Chemical modification
    • B01D67/00931—Chemical modification by introduction of specific groups after membrane formation, e.g. by grafting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/08—Hollow fibre membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28023—Fibres or filaments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/04—Processes using organic exchangers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/08—Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/12—Macromolecular compounds
    • B01J41/13—Macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J47/00—Ion-exchange processes in general; Apparatus therefor
    • B01J47/12—Ion-exchange processes in general; Apparatus therefor characterised by the use of ion-exchange material in the form of ribbons, filaments, fibres or sheets, e.g. membranes
    • B01J47/127—Ion-exchange processes in general; Apparatus therefor characterised by the use of ion-exchange material in the form of ribbons, filaments, fibres or sheets, e.g. membranes in the form of filaments or fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2323/00—Details relating to membrane preparation
    • B01D2323/38—Graft polymerization
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04C—ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT PUMPS
    • F04C2270/00—Control; Monitoring or safety arrangements
    • F04C2270/04—Force
    • F04C2270/042—Force radial
    • F04C2270/0421—Controlled or regulated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Analytical Chemistry (AREA)
  • Cardiology (AREA)
  • Inorganic Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Transplantation (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

resumo patente de invenção: "uso de materiais de fibra oca modificada para a remoção de exotoxinas produzidas por escherichia coli a partir de liquidos, de preferência a partir de sangue e de plasma, bem como seu uso para o tratamento de doenças concomitantes". a presente invenção refere-se a materiais de fibra oca quimicamente modificada para a remoção extracorpórea de exotoxinas produzidas pela escherichia coli patogênica a partir de líquidos que contenham proteínas, especificamente a partir de sangue ou de plasma, bem como o uso no tratamento de pacientes que estejam sofrendo a partir de doenças que, por exemplo, são causadas pela bactéria escherichia coli entero-hemorrágica (infecções de ehec) ou outras escherichia coli patogênicas tais como a escherichia coli enterotoxigênica (etec) ou a escherichia coli enteroagregadora (eaec). 20673041v1
BR112014005221A 2011-09-08 2012-09-07 uso de materiais de fibra oca modificada para a remoção de exotoxinas produzidas por escherichia coli a partir de liquidos, de preferência a partir de sangue e de plasma, bem como seu uso para o tratamento de doenças concomitantes BR112014005221A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161532255P 2011-09-08 2011-09-08
EP11180558 2011-09-08
PCT/EP2012/067559 WO2013034724A1 (en) 2011-09-08 2012-09-07 Use of modified hollow fiber materials for removing exotoxins produced by escherichia coli from liquids, preferably from blood and plasma as well as their use for treating concomitant diseases

Publications (1)

Publication Number Publication Date
BR112014005221A2 true BR112014005221A2 (pt) 2017-03-28

Family

ID=47831570

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014005221A BR112014005221A2 (pt) 2011-09-08 2012-09-07 uso de materiais de fibra oca modificada para a remoção de exotoxinas produzidas por escherichia coli a partir de liquidos, de preferência a partir de sangue e de plasma, bem como seu uso para o tratamento de doenças concomitantes

Country Status (8)

Country Link
US (1) US20130090597A1 (pt)
EP (1) EP2753425B1 (pt)
CN (1) CN103842083B (pt)
BR (1) BR112014005221A2 (pt)
CA (1) CA2845091A1 (pt)
RU (1) RU2573492C2 (pt)
WO (1) WO2013034724A1 (pt)
ZA (1) ZA201400580B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102016208024A1 (de) * 2016-05-10 2017-11-16 B. Braun Avitum Ag Adsorbermaterial zur Prävention oder Behandlung von schweren Verläufen von Infektionskrankheiten
CN112048546B (zh) * 2020-06-05 2021-04-30 太古宙基因科技(深圳)有限公司 一种可快速捕获并检测病原菌的免抗体修饰磁珠及其制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955293A (en) * 1989-10-17 1999-09-21 New England Medical Center Hospitals, Inc. Assays for shiga toxin and shiga-like toxins
US5053133A (en) 1990-02-09 1991-10-01 Elias Klein Affinity separation with activated polyamide microporous membranes
DE19501726A1 (de) 1995-01-20 1996-07-25 Merck Patent Gmbh Polymerisationsfähige Derivate von Polyamiden
WO1996027614A1 (en) 1995-03-08 1996-09-12 Elias Klein Surface modified affinity separation membrane
DE59706708D1 (de) 1996-11-06 2002-04-25 Mat Adsorption Technologies Gm Membranmodul zur stoffspezifischen fluidbehandlung
WO1998028064A1 (de) 1996-12-21 1998-07-02 Akzo Nobel Nv Membranmodul mit schichtförmig angeordneten hohlfasermembranen
WO1998033581A1 (de) 1997-02-04 1998-08-06 Akzo Nobel N.V. Membranmodul enthaltend mindestens zwei gruppen von hohlfasermembranen und verfahren zu seiner herstellung
DE59805523D1 (de) 1997-06-14 2002-10-17 Mat Adsorption Technologies Gm Membranmodul mit einseitig eingebetteten hohlfasermembranen
US6007803A (en) * 1997-09-19 1999-12-28 Geltex Pharmaceuticals, Inc. Ionic polymers as toxin binding agents
IT1304828B1 (it) 1998-11-12 2001-04-05 Braun Carex Spa Filtro adsorbitore di eparina e/o endotossine nel plasma e/o nelsangue.
US6270755B1 (en) * 1999-05-13 2001-08-07 Geltex Pharmaceuticals, Inc. Anionic polymers as toxin binders
DE10258944A1 (de) * 2002-12-17 2004-07-01 B. Braun Medizintechnologie Gmbh Vorrichtung zur Entfernung von bakteriellen Lipopolysacchariden oder/und Lipoteichonsäuren aus proteinhaltigen Flüssigkeiten sowie deren Verwendung zur Behandlung von Sepsis
RU2262350C2 (ru) * 2003-12-24 2005-10-20 Государственное учреждение "Московский научно-исследовательский институт эпидемиологии и микробиологии им. Г.Н. Габричевского Министерства здравоохранения Российской Федерации" Вакцина для иммунопрофилактики и иммунотерапии заболеваний человека и животных, вызванных патогенными и условно-патогенными грамотрицательными микроорганизмами кишечной группы и их экзотоксинами, и способ ее получения (варианты), иммуноглобулиновый препарат (варианты) и способ его получения, иммунобиологический препарат, поликомпонентная вакцина
ATE356643T1 (de) * 2004-06-03 2007-04-15 Braun Medizintechnologie Gmbh Vorrichtung zur entfernung von bakteriellen lipopolysacchariden oder/und lipoteichonsäuren aus proteinhaltigen flüssigkeiten sowie verwendung zur herstellung eines mittels zur entfernung dieser stoffe
JP5282933B2 (ja) * 2007-03-14 2013-09-04 Ｄｉｃ株式会社 糖鎖固定化高分子基材およびその製造方法
JP5413648B2 (ja) * 2008-04-28 2014-02-12 Ｄｉｃ株式会社 糖鎖固定化高分子基材、その製造方法および医療器具
DE102009037015A1 (de) * 2009-08-07 2011-02-17 Michael Hajek Vorrichtung und Verfahren zur Eliminierung von bioschädlichen Stoffen aus Körperflüssigkeiten

Also Published As

Publication number Publication date
RU2014113569A (ru) 2015-10-20
CN103842083B (zh) 2016-12-21
ZA201400580B (en) 2015-01-28
RU2573492C2 (ru) 2016-01-20
CA2845091A1 (en) 2013-03-14
US20130090597A1 (en) 2013-04-11
EP2753425A1 (en) 2014-07-16
WO2013034724A1 (en) 2013-03-14
CN103842083A (zh) 2014-06-04
EP2753425B1 (en) 2020-11-18

Similar Documents

Publication Publication Date Title
BR112018003316A2 (pt) compostos e métodos para entrega transmembrana de moléculas
PE20170673A1 (es) Terapia de combinacion para tratar una paramixovirus
BR112015007366A2 (pt) derivados de acilaminopirimidina para o tratamento de infecções virais e outras doenças
BR112013032974A2 (pt) "derivados de 1,6-diazabiciclo [3,2,1]-octan-7-ona, seus usos, e composições farmacêuticas".
BR112012010270A2 (pt) mentisulfonilmetano (msm) para tratamento de micro-organismos resistentes a fármaco
BR112013028813A2 (pt) derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e seu uso no tratamento de infecções bacterianas
UA109650C2 (xx) Біс-арилзв'язані арилтриазолони та їх застосування
BR112012015916A2 (pt) derivados de pirazina e seu uso no tratamento de distúrbios neurológicos
BR112015011036A2 (pt) derivados de 2-amino-quinazolina substituídos heterocíclicos para o tratamento de infecções virais
BRPI0821027B8 (pt) 4-(4-ciano-2-tioaril)di-hidropirimidinonas para tratamento e/ou prevenção de lesões do pulmão e do sistema cardiovascular, seu processo de preparação e seu uso, e medicamento
ECSP109889A (es) Composiciones terapeuticas y usos de las mismas
CY1117705T1 (el) Νεες ενωσεις διυποκατεστημενης 3,4-διαμινο-3-κυκλοβουτενο-διονης-1,2 για χρηση στην θεραπεια προκαλουμενων απο χημειοκινη ασθενειων
BR112016016854A2 (pt) Derivados de 7-oxo-1,6-diazabiciclo[3.2.1]octana, seu processo de preparação e seu uso, composição farmacêutica e seu uso pedidos de patente relacionados
ECSP099807A (es) (oxazolidinon-5-il-metil)-2-tiofen-carboxamidas sustituidas y su uso en el campo de la coagulación sanguínea
EA201490750A1 (ru) Применение глутарилгистамина для лечения заболеваний дыхательных путей
BR112012028651A2 (pt) heterociclilbenzilpirazóis substituídos e uso do mesmo
BR112013007423A2 (pt) terapia combinada no que diz respeito ao tratamento da infecção por hcv
BR112014012983A2 (pt) derivados de pirrol
DOP2014000030A (es) Procedimientos para la fabricación de medicamentos útiles para el tratamiento de infecciones virales
NO20074780L (no) Heterocyklylamidsubstituerte imidazoler
BR112014008783A2 (pt) compostos para o tratamento e profilaxia da doença causada por vírus sincicial respiratório
MX347620B (es) Derivados de sulfonilaminopirrolidinona, su preparacion y aplicacion terapeutica.
BR112015010223A2 (pt) compostos tricíclicos para o uso no tratamento e/ou controle de obesidade
BR112014027213A8 (pt) nova composição de alfentanil para o tratamento de dor aguda
BR112014005221A2 (pt) uso de materiais de fibra oca modificada para a remoção de exotoxinas produzidas por escherichia coli a partir de liquidos, de preferência a partir de sangue e de plasma, bem como seu uso para o tratamento de doenças concomitantes

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL