BR112012020833A2 - tetrapeptídeos cíclicos e aplicações terapêuticas destes - Google Patents
tetrapeptídeos cíclicos e aplicações terapêuticas destesInfo
- Publication number
- BR112012020833A2 BR112012020833A2 BR112012020833A BR112012020833A BR112012020833A2 BR 112012020833 A2 BR112012020833 A2 BR 112012020833A2 BR 112012020833 A BR112012020833 A BR 112012020833A BR 112012020833 A BR112012020833 A BR 112012020833A BR 112012020833 A2 BR112012020833 A2 BR 112012020833A2
- Authority
- BR
- Brazil
- Prior art keywords
- therapeutic applications
- cyclic tetrapeptides
- cyclic
- tetrapeptides
- tretrapeptides
- Prior art date
Links
- 125000004122 cyclic group Chemical group 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
- C07K5/126—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL390493A PL219569B1 (pl) | 2010-02-19 | 2010-02-19 | Cykliczne tetrapeptydy i ich zastosowanie |
| PCT/US2011/025571 WO2011103524A2 (en) | 2010-02-19 | 2011-02-19 | Cyclic tetrapeptides and therapeutic applications thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012020833A2 true BR112012020833A2 (pt) | 2017-12-19 |
Family
ID=44483608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012020833A BR112012020833A2 (pt) | 2010-02-19 | 2011-02-19 | tetrapeptídeos cíclicos e aplicações terapêuticas destes |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20130224232A1 (https=) |
| EP (1) | EP2536732B1 (https=) |
| JP (1) | JP5901543B2 (https=) |
| KR (1) | KR101704665B1 (https=) |
| CN (1) | CN102858779B (https=) |
| AU (1) | AU2011217882B2 (https=) |
| BR (1) | BR112012020833A2 (https=) |
| CA (1) | CA2827694C (https=) |
| ES (1) | ES2611663T3 (https=) |
| IL (2) | IL221535A (https=) |
| PL (1) | PL219569B1 (https=) |
| RU (1) | RU2568436C2 (https=) |
| WO (1) | WO2011103524A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL219569B1 (pl) | 2010-02-19 | 2015-05-29 | Peptaderm Spółka Z Ograniczoną Odpowiedzialnością | Cykliczne tetrapeptydy i ich zastosowanie |
| US10421778B2 (en) | 2015-05-05 | 2019-09-24 | Washington University | Isoform-selective lysine deacetylase inhibitors |
| US10154997B2 (en) | 2015-08-04 | 2018-12-18 | Washington University | Treatment of parasitic diseases using KDAC inhibitor compounds |
| WO2018232285A1 (en) * | 2017-06-16 | 2018-12-20 | University Of Florida Research Foundation, Incorporated | Macrocyclic peptides and derivatives thereof with opioid activity |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3862925A (en) * | 1973-07-05 | 1975-01-28 | American Home Prod | Preparation of somatotropin release inhibiting factor and intermediates therefor |
| US3842067A (en) | 1973-07-27 | 1974-10-15 | American Home Prod | Synthesis of(des-asn5)-srif and intermediates |
| JPS5726506B2 (https=) | 1974-03-08 | 1982-06-04 | ||
| IT1077010B (it) * | 1976-09-01 | 1985-04-27 | Snam Progetti | Processo per la preparazione di copolimeri dell isobutilene contenenti insaturazioni ed atomi di alogeno reattivi |
| US4105603A (en) | 1977-03-28 | 1978-08-08 | The Salk Institute For Biological Studies | Peptides which effect release of hormones |
| JPH0334991A (ja) * | 1989-06-30 | 1991-02-14 | Shionogi & Co Ltd | 環状テトラペプチドおよびその製造法 |
| US5216124A (en) * | 1989-12-15 | 1993-06-01 | G. D. Searle & Co. | Substituted cyclic tetrapeptides |
| US5541287A (en) | 1992-06-09 | 1996-07-30 | Neorx Corporation | Pretargeting methods and compounds |
| US6777217B1 (en) * | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
| US6013763A (en) | 1996-06-04 | 2000-01-11 | Genentech, Inc. | Peptide variants of protein A |
| WO1999048513A1 (en) * | 1998-03-23 | 1999-09-30 | Trimeris, Inc. | Methods and compositions for peptide synthesis |
| US6281331B1 (en) | 1998-03-23 | 2001-08-28 | Trimeris, Inc. | Methods and compositions for peptide synthesis |
| DE19816922A1 (de) | 1998-04-16 | 1999-10-21 | Wolfgang Beck | Einfache Synthese von cyclischen Tetrapeptiden aus nichtaktivierten Peptidestern an Metallzentren |
| AUPP505798A0 (en) * | 1998-08-04 | 1998-08-27 | Fujisawa Pharmaceutical Co., Ltd. | Novel compound fr225497 substance |
| KR20010080142A (ko) | 1998-10-13 | 2001-08-22 | 후지야마 아키라 | 사이클릭 테트라펩티드 화합물 및 이의 용도 |
| GB9903087D0 (en) * | 1999-02-12 | 1999-03-31 | Glaxo Group Ltd | Process |
| ATE376556T1 (de) * | 2003-12-31 | 2007-11-15 | Hoffmann La Roche | Verfahren zur peptidsynthese unter verwendung einer reduzierten menge an entschützungsmittel |
| WO2006049597A1 (en) | 2004-10-27 | 2006-05-11 | Avanir Pharmaceuticals | Amino acid-derived compounds as modulators of the reverse cholesterol transport |
| CN101115495B (zh) * | 2004-12-14 | 2011-06-22 | 生物如恩克斯株式会社 | 通过runx2乙酰化作用增强bmp的骨形成活性的方法 |
| RU2450018C2 (ru) | 2006-08-23 | 2012-05-10 | Йеда Рисерч Энд Диверлопмент Ко. Лтд | Конъюгаты rgd-пептидов и фотосенсибилизаторов порфирина или (бактерио)хлорофилла и их применение |
| CA2717060C (en) | 2008-02-27 | 2016-11-01 | Avigdor Scherz | Rgd-(bacterio)chlorophyll conjugates for photodynamic therapy and imaging of necrotic tumors |
| WO2010006267A2 (en) * | 2008-07-11 | 2010-01-14 | University Of Kansas | Cyclic tetrapeptides |
| GB0918579D0 (en) | 2009-10-22 | 2009-12-09 | Imp Innovations Ltd | Gadd45beta targeting agents |
| PL219569B1 (pl) | 2010-02-19 | 2015-05-29 | Peptaderm Spółka Z Ograniczoną Odpowiedzialnością | Cykliczne tetrapeptydy i ich zastosowanie |
-
2010
- 2010-02-19 PL PL390493A patent/PL219569B1/pl unknown
-
2011
- 2011-02-19 ES ES11745399.3T patent/ES2611663T3/es active Active
- 2011-02-19 JP JP2012554079A patent/JP5901543B2/ja not_active Expired - Fee Related
- 2011-02-19 CA CA2827694A patent/CA2827694C/en not_active Expired - Fee Related
- 2011-02-19 US US13/579,933 patent/US20130224232A1/en not_active Abandoned
- 2011-02-19 AU AU2011217882A patent/AU2011217882B2/en not_active Ceased
- 2011-02-19 EP EP11745399.3A patent/EP2536732B1/en not_active Not-in-force
- 2011-02-19 BR BR112012020833A patent/BR112012020833A2/pt not_active Application Discontinuation
- 2011-02-19 RU RU2012139668/04A patent/RU2568436C2/ru not_active IP Right Cessation
- 2011-02-19 WO PCT/US2011/025571 patent/WO2011103524A2/en not_active Ceased
- 2011-02-19 KR KR1020127024471A patent/KR101704665B1/ko not_active Expired - Fee Related
- 2011-02-19 CN CN201180019907.7A patent/CN102858779B/zh not_active Expired - Fee Related
-
2012
- 2012-08-19 IL IL221535A patent/IL221535A/en not_active IP Right Cessation
- 2012-08-24 US US13/593,716 patent/US9382292B2/en not_active Expired - Fee Related
-
2013
- 2013-01-27 IL IL224410A patent/IL224410A/en not_active IP Right Cessation
-
2016
- 2016-07-04 US US15/201,565 patent/US10238713B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20130088004A (ko) | 2013-08-07 |
| WO2011103524A3 (en) | 2011-12-29 |
| US20170157204A1 (en) | 2017-06-08 |
| IL224410A (en) | 2017-07-31 |
| CA2827694A1 (en) | 2011-08-25 |
| JP2013520440A (ja) | 2013-06-06 |
| IL221535A (en) | 2016-08-31 |
| AU2011217882B2 (en) | 2015-02-05 |
| RU2568436C2 (ru) | 2015-11-20 |
| KR101704665B1 (ko) | 2017-02-08 |
| PL219569B1 (pl) | 2015-05-29 |
| WO2011103524A2 (en) | 2011-08-25 |
| CA2827694C (en) | 2018-09-18 |
| EP2536732A4 (en) | 2014-04-30 |
| AU2011217882A1 (en) | 2012-10-11 |
| WO2011103524A8 (en) | 2012-09-13 |
| CN102858779B (zh) | 2016-08-03 |
| JP5901543B2 (ja) | 2016-04-13 |
| EP2536732A2 (en) | 2012-12-26 |
| US10238713B2 (en) | 2019-03-26 |
| US20130224232A1 (en) | 2013-08-29 |
| RU2012139668A (ru) | 2014-03-27 |
| PL390493A1 (pl) | 2011-08-29 |
| US20130108655A1 (en) | 2013-05-02 |
| US9382292B2 (en) | 2016-07-05 |
| CN102858779A (zh) | 2013-01-02 |
| ES2611663T3 (es) | 2017-05-09 |
| EP2536732B1 (en) | 2016-10-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
| B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |