BR112012019868A2 - composição farmacêutica para uso tópico - Google Patents

composição farmacêutica para uso tópico

Info

Publication number
BR112012019868A2
BR112012019868A2 BR112012019868-8A BR112012019868A BR112012019868A2 BR 112012019868 A2 BR112012019868 A2 BR 112012019868A2 BR 112012019868 A BR112012019868 A BR 112012019868A BR 112012019868 A2 BR112012019868 A2 BR 112012019868A2
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
topical use
oligonucleotides
asdnas
sirens
Prior art date
Application number
BR112012019868-8A
Other languages
English (en)
Other versions
BR112012019868B1 (pt
Inventor
Schmidts Thomas
Garn Holger
Runkel Frank
Original Assignee
Sterna Biologicals Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterna Biologicals Gmbh & Co. Kg filed Critical Sterna Biologicals Gmbh & Co. Kg
Publication of BR112012019868A2 publication Critical patent/BR112012019868A2/pt
Publication of BR112012019868B1 publication Critical patent/BR112012019868B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/127—DNAzymes

Abstract

composição farmacêutica para uso tópico. a presente invenção refere-se a uma composição cosmética e/ou dermatológica e/ou farmacêutica para uso tópico e aplicação de oligonucleotídeos, particularmente oligonucleotídeos anti-sentido, como dnazimas, sirnas, asdnas ou ribozimas, para uso como agentes contra doenças inflamatórias, por meio de emulsões com fase aquosa dispersa, interna, descontínua.
BR112012019868-8A 2010-02-10 2011-02-11 composição farmacêutica para uso tópico BR112012019868B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102010007562.0 2010-02-10
DE102010007562A DE102010007562A1 (de) 2010-02-10 2010-02-10 Dermatologische, pharmazeutische Zusammensetzung geeignet für Oligonukleotide
PCT/EP2011/000648 WO2011098285A2 (de) 2010-02-10 2011-02-11 Dermatologische, pharmazeutische zusammensetzung geeignet für oligonukleotide

Publications (2)

Publication Number Publication Date
BR112012019868A2 true BR112012019868A2 (pt) 2018-07-31
BR112012019868B1 BR112012019868B1 (pt) 2021-06-08

Family

ID=43899573

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012019868-8A BR112012019868B1 (pt) 2010-02-10 2011-02-11 composição farmacêutica para uso tópico

Country Status (8)

Country Link
US (2) US9249413B2 (pt)
EP (1) EP2533763B1 (pt)
JP (1) JP5896921B2 (pt)
BR (1) BR112012019868B1 (pt)
CA (2) CA2827049C (pt)
DE (1) DE102010007562A1 (pt)
RU (1) RU2570378C9 (pt)
WO (1) WO2011098285A2 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010007562A1 (de) 2010-02-10 2011-08-11 sterna biologicals GmbH & Co KG, 35043 Dermatologische, pharmazeutische Zusammensetzung geeignet für Oligonukleotide
ES2753436T3 (es) * 2015-05-15 2020-04-08 Sterna Biologicals Gmbh & Co Kg Inhibidores de GATA-3 para su uso en el tratamiento del asma mediada por Th2
WO2017205506A1 (en) * 2016-05-24 2017-11-30 Emory University Particles with rna cleaving nucleobase polymers and uses for managing inflammatory disorders
GB201700257D0 (en) * 2017-01-06 2017-02-22 Atlantic Pharmaceuticals (Holdings) Ltd New formulation
EP3805242A1 (en) * 2019-10-07 2021-04-14 Sterna Biologicals GmbH & Co. KG Method for the production of a catalytically active dna molecule having improved activity and its use in a method of treating asthma
US11976282B2 (en) 2020-06-23 2024-05-07 Qatar University GATA3 inhibitors for the promotion of subcutaneous fat deposition

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6841539B1 (en) 1998-05-21 2005-01-11 Isis Pharmaceuticals, Inc. Compositions and methods for topical delivery of oligonucleotides
WO2000009673A1 (en) * 1998-08-13 2000-02-24 Johnson & Johnson Research Pty. Limited Dnazymes and methods for treating hpv-related disorders
DE19935303A1 (de) 1999-07-28 2001-02-08 Aventis Pharma Gmbh Oligonukleotide zur Inhibierung der Expression von humanem eg5
DK1562968T3 (da) 2001-11-14 2013-10-28 Janssen Biotech Inc Anti-il-6-antistoffer, sammensætninger, fremgangsmåder og anvendelser
DE10238298A1 (de) 2002-08-21 2004-03-04 Beiersdorf Ag Verwendung von Antisense-Oligonucleotiden zur Behandlung von degenerativen Hauterscheinungen
DE10254214A1 (de) 2002-11-20 2004-06-09 Beiersdorf Ag Oligoribonukleotide zur Behandlung von degenerativen Hauterscheinungen durch RNA-Interferenz
DE10346487A1 (de) 2003-10-02 2005-05-12 Transmit Technologietransfer Verfahren zur Herstellung eines Zell- und/oder Gewebe- und/oder Krankheitsphasen-spezifischen Arzneimittels
DE102004010547A1 (de) 2004-03-03 2005-11-17 Beiersdorf Ag Oligoribonukleotide zur Behandlung von irritativen und/oder entzündlichen Hauterscheinungen durch RNA-Interferenz
US20090209623A1 (en) 2005-07-25 2009-08-20 Jon Tomono Anti-sense nucleic acid derived from organism
FR2890074B1 (fr) 2005-09-01 2007-11-23 Lvmh Rech Nouveaux oligonucleotides anti-genes specifiques de la tyrosinase comme agents depigmentants
DE102007020554A1 (de) 2007-04-27 2008-10-30 Henkel Ag & Co. Kgaa Nukleinsäurehaltige kosmetische und/oder pharmazeutische Zubereitungen zur Behandlung epithelialen Deckgewebes
DE102010007562A1 (de) 2010-02-10 2011-08-11 sterna biologicals GmbH & Co KG, 35043 Dermatologische, pharmazeutische Zusammensetzung geeignet für Oligonukleotide

Also Published As

Publication number Publication date
CA2827049A1 (en) 2011-08-18
JP2013527134A (ja) 2013-06-27
US20130030038A1 (en) 2013-01-31
DE102010007562A1 (de) 2011-08-11
US9404110B2 (en) 2016-08-02
US20160115478A1 (en) 2016-04-28
CA2996580C (en) 2020-06-30
JP5896921B2 (ja) 2016-03-30
BR112012019868B1 (pt) 2021-06-08
EP2533763A2 (de) 2012-12-19
CA2996580A1 (en) 2011-08-18
RU2570378C9 (ru) 2016-03-10
EP2533763C0 (de) 2023-07-12
WO2011098285A3 (de) 2012-04-19
CA2827049C (en) 2019-08-13
RU2012137904A (ru) 2014-03-20
WO2011098285A8 (de) 2011-12-29
US9249413B2 (en) 2016-02-02
EP2533763B1 (de) 2023-07-12
WO2011098285A2 (de) 2011-08-18
RU2570378C2 (ru) 2015-12-10

Similar Documents

Publication Publication Date Title
BR112012019868A2 (pt) composição farmacêutica para uso tópico
BRPI0918139A2 (pt) composição, alimento medicinal ou funcional, suplemento alimentar ou dietético para tratamento de distúrbios de desenvolvimento pervasivos com terapêuticos redox-ativos e uso
UY33396A (es) 5-fluoro-1h-pirazolopiridinas sustituidas y su uso
BR112013011868A2 (pt) compostos de pirimidina hidróxi amida como inibidores da proteína desacetilase, composição farmacêutica e uso dos referidos compostos
CR20130259A (es) Ácidos 1-bencilcicloalquilcarboxílicos sustituidos y su uso
BR112014016649A2 (pt) composições para tratamento dos cabelos
CL2013001947A1 (es) Composicion farmaceutica que comprende pioglitazona; uso de pioglitazona para tratar alzheimer; composicion que comprende pioglitazona.
BR112013007314A2 (pt) anticorpos anti-cd48 e seus usos
CL2013001138A1 (es) Composicion que comprende anticuerpo biespecífico cd19xcd3 para tratar masa tumoral de tejido de ganglios linfáticos y/o linfoma extranodal causado por el linfoma b difuso de células grandes (lbdcg); kit farmacéutico; uso de la composición.
BR112015010772A2 (pt) composição de enxágue tópica, uso de uma composição e método para tratar ou melhorar a pele de um indivíduo contra a acne
BR112015004747A2 (pt) moléculas oligonucleotídicas de fita dupla para p53 e métodos de uso das mesmas
CL2013002123A1 (es) Composicion herbicida que comprende topramezona y pinoxaden; uso de dicha composicion para controlar vegetación indeseable; formulación indeseable.
CL2011002835A1 (es) Compuestos derivados de 7-aza-espiro[3.5]nonano-7-carboxilatos; procedimiento de preparacion; compuestos intermediarios; composicion farmaceutica; y su uso para tratar dolores agudos o cronicos de tipos neurogeno, asociados a enfermedades inflamatorias, entre otros.
BR112014010174A2 (pt) uso de uma composição para a fabricação de um produto para melhorar a função executiva de um indivíduo e para tratar o mesmo
ES2543957T3 (es) Nueva composición farmacéutica para el tratamiento de infecciones fúngicas
BR112013022556A8 (pt) composição farmacêutica aquosa semissólida contendo tapentadol, seu uso e uso de tapentadol
BR112015009892A2 (pt) Anticorpo contra il-1 beta, seu método de produção e seu uso, sequência isolada de ácido nucleico, vetor, composição cosmética, de diagnóstico ou farmacêutica, e kit
BR112013004829A2 (pt) composição de agente de dispersão de produto químico agrícola, composição química agrícola, método para produzir um produto agrícola, método para aumentar eficácia em um produto químico agrícola, e uso da composição de agente de dispersão de produto químico agrícola.
BR112014000139A2 (pt) formulação para cuidado pessoal, uso do composto ativo, composto ativo, e, método de reduzir atrito na superfície da fibra capilar
BR112015004613A2 (pt) agonistas para o receptor trpm-8; combinações de substâncias ativas de agonistas; preparações cosméticas ou dermatológicas contendo um ou mais agonistas de trpm-8, um ou mais polióis, e uma ou mais substâncias de ação antieritematosa ou inibidora de inflamação
WO2012104240A3 (de) Kosmetische verwendung
BR112013000779A2 (pt) composições farmacêuticas de combinação, métodos de tratamento de paciente e uso de forma potencializada ativada de anticorpo para receptor at1 de angiotensina ii e forma potencializada ativada de anticorpo para sintase no endotelial
BR112014011481A2 (pt) hidrolisado de colágeno e seu uso
BR112015014885A2 (pt) combinação de agentes ativos, composição cosmética e/ou dermatológica e processo para a preparação de uma composição de agentes ativos.
BR112015006692A2 (pt) formulação de nanodispersão, método para administrar uma formulação de nanodispersão líquida de taxina livre de etanol em um indivíduo, e, kit.

Legal Events

Date Code Title Description
B15I Others concerning applications: loss of priority
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25G Requested change of headquarter approved

Owner name: STERNA BIOLOGICALS GMBH AND CO. KG (DE)

B12F Other appeals [chapter 12.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 11/02/2011, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF